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    Biological photometric device and biological photometry method using same
    1.
    发明授权
    Biological photometric device and biological photometry method using same 有权
    生物光度测定装置及其生物测光方法

    公开(公告)号：US09198624B2

    公开(公告)日：2015-12-01

    申请号：US13806790

    申请日：2011-07-06

    申请人： Tsukasa Funane ,  Hirokazu Atsumori ,  Takusige Katura ,  Masashi Kiguchi ,  Tsuyoshi Takatera ,  Michiyuki Fujiwara

    发明人： Tsukasa Funane ,  Hirokazu Atsumori ,  Takusige Katura ,  Masashi Kiguchi ,  Tsuyoshi Takatera ,  Michiyuki Fujiwara

    IPC分类号： A61B6/00 ,  A61B5/00 ,  G01N21/359 ,  G01N21/49

    CPC分类号： A61B6/00 ,  A61B5/0042 ,  A61B5/0075 ,  A61B5/6814 ,  G01N21/359 ,  G01N21/49

    摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.

    摘要翻译： 本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。 此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。 一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而 分离脑起始信号和皮肤起始信号。 对各个测量点获得的数据进行单独分量分析（ICA）。 然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

    BIOLOGICAL PHOTOMETRIC DEVICE AND BIOLOGICAL PHOTOMETRY METHOD USING SAME
    2.
    发明申请
    BIOLOGICAL PHOTOMETRIC DEVICE AND BIOLOGICAL PHOTOMETRY METHOD USING SAME 有权
    生物光学设备和使用相同的生物光度测定方法

    公开(公告)号：US20130102907A1

    公开(公告)日：2013-04-25

    申请号：US13806790

    申请日：2011-07-06

    申请人： Tsukasa Funane ,  Hirokazu Atsumori ,  Takusige Katura ,  Masashi Kiguchi ,  Tsuyoshi Takatera ,  Michiyuki Fujiwara

    发明人： Tsukasa Funane ,  Hirokazu Atsumori ,  Takusige Katura ,  Masashi Kiguchi ,  Tsuyoshi Takatera ,  Michiyuki Fujiwara

    IPC分类号： A61B6/00

    CPC分类号： A61B6/00 ,  A61B5/0042 ,  A61B5/0075 ,  A61B5/6814 ,  G01N21/359 ,  G01N21/49

    摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.

    摘要翻译： 本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。 此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。 一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而 分离脑起始信号和皮肤起始信号。 对各个测量点获得的数据进行单独分量分析（ICA）。 然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

    Optical bioinstrumentation devices
    3.
    发明授权
    Optical bioinstrumentation devices 有权
    光学生物仪器

    公开(公告)号：US08229531B2

    公开(公告)日：2012-07-24

    申请号：US11914701

    申请日：2006-02-13

    申请人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

    发明人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/0059 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

    摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

    摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

    Ultrasonic Diagnostic Apparatus
    4.
    发明申请
    Ultrasonic Diagnostic Apparatus 有权
    超声诊断仪

    公开(公告)号：US20090088616A1

    公开(公告)日：2009-04-02

    申请号：US11914701

    申请日：2006-02-13

    申请人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

    发明人： Hirokazu Atsumori ,  Masashi Kiguchi ,  Atsushi Maki ,  Michiyuki Fujiwara

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/6814 ,  A61B2562/0233 ,  A61B2562/046

    摘要： There is provided an optical bioinstrumentation device, with which measurement data reflect more correctly the information inside the living body with less noise even the subject moves when the information inside the living body is measured by using the light.In the present invention, the means for fixing the part other than the tips of the optical fibers for irradiation and detection on the fixing member which is to fix the tips of the optical fiber for irradiation and detection on the subject, or, the means for fixing the optical fiber is fixed on the fixing member which is to fix the end of the optical fiber on the subject, or the means for fixing the optical fiber at two or more positions on the subject.

    摘要翻译： 提供了一种光学生物仪器装置，通过使用光来测量生物体内部的信息，即使被检体移动，测量数据也能更准确地反映生物体内部的信息，噪音较小。 在本发明中，将用于照射和检测的光纤的末端以外的部分固定在固定部件上的装置，该固定部件用于将用于照射和检测的光纤的前端固定在被检体上， 固定光纤被固定在将光纤端部固定在被摄体上的固定部件上，或将光纤固定在被检体上的两个以上位置的装置。

    Optical measurement system for living bodies and method thereof
    5.
    发明授权
    Optical measurement system for living bodies and method thereof 失效
    生物体光学测量系统及其方法

    公开(公告)号：US07285790B2

    公开(公告)日：2007-10-23

    申请号：US11044040

    申请日：2005-01-28

    申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

    发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

    IPC分类号： A61B5/00

    CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

    摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

    摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

    Optical measurement apparatus for a living body
    6.
    发明授权
    Optical measurement apparatus for a living body 有权
    生物体光学测量装置

    公开(公告)号：US07150717B2

    公开(公告)日：2006-12-19

    申请号：US10764561

    申请日：2004-01-27

    申请人： Takusige Katura ,  Atsushi Maki ,  Masashi Kiguchi

    发明人： Takusige Katura ,  Atsushi Maki ,  Masashi Kiguchi

    IPC分类号： A61B5/00

    CPC分类号： A61B5/4884 ,  A61B5/02055 ,  A61B5/021 ,  A61B5/0261 ,  A61B5/0816 ,  A61B5/14553

    摘要： Disclosed is an optical measurement apparatus for a living body to provide a means for measuring blood flow activity within a short time inside the body, even if the test subject cannot distinguish between the active task period and the rest period. An optical measurement apparatus for a living body comprises a light irradiating section, and a light detecting section for detecting light transmitting through or reflected from the interior of the body. The concentration of carbon dioxide gas taken into the body is controlled by the respiration of the test subject and the resulting change in output from the light detecting section is then evaluated.

    摘要翻译： 公开了一种生物体的光学测量装置，即使被检体不能区分活动任务期间和休止期间，也能够在体内短时间内测定血液流动活动的手段。 用于生物体的光学测量装置包括光照射部分和用于检测透射到身体内部或从身体内部反射的光的光检测部分。 进入身体的二氧化碳气体的浓度由受检对象的呼吸控制，然后评估所得到的光检测部分的输出变化。

    Optical measurement system for living bodies and method thereof
    7.
    发明申请
    Optical measurement system for living bodies and method thereof 失效
    生物体光学测量系统及其方法

    公开(公告)号：US20060006343A1

    公开(公告)日：2006-01-12

    申请号：US11044040

    申请日：2005-01-28

    申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

    发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

    IPC分类号： A61B8/06

    CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

    摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

    摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

    BIOLOGICAL OPTICAL MEASUREMENT DEVICE, STIMULUS PRESENTATION METHOD, AND STIMULUS PRESENTATION PROGRAM
    9.
    发明申请
    BIOLOGICAL OPTICAL MEASUREMENT DEVICE, STIMULUS PRESENTATION METHOD, AND STIMULUS PRESENTATION PROGRAM 审中-公开
    生物光学测量设备，STIMULUS演示方法和STIMULUS演示程序

    公开(公告)号：US20140107439A1

    公开(公告)日：2014-04-17

    申请号：US14117154

    申请日：2012-06-15

    申请人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

    发明人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

    IPC分类号： A61B5/16 ,  A61B5/1455

    CPC分类号： A61B5/165 ,  A61B5/14551

    摘要： Disclosed is a device using a biological optical measurement technology to evaluate mood states in daily life of an examinee by presenting a first task once or a plurality of times and then presents a second task a plurality of times, calculating a hemoglobin signal of a predetermined measurement point for the first task and a hemoglobin signal of a predetermined measurement point for the second task, and calculating quantitative values using the obtained hemoglobin signals.

    摘要翻译： 公开了一种使用生物光学测量技术的装置，通过呈现第一任务一次或多次来评估受试者的日常生活中的情绪状态，然后多次呈现第二任务，计算预定测量的血红蛋白信号 指定第一任务和第二任务的预定测量点的血红蛋白信号，以及使用获得的血红蛋白信号计算定量值。