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公开(公告)号：US08040515B2
公开(公告)日：2011-10-18
申请号：US12051245
申请日：2008-03-19
IPC分类号： G01N21/25
CPC分类号： G01N21/6452 , G02B2207/113
摘要： In order to provide a fluorescence detection apparatus having a high sensitivity, a high processing capacity and a competitive edge in cost, the fluorescence detection apparatus according to this invention irradiate the sample with light so that the aspect ratio of the form of the irradiated region by light on the arrangement surface of the sample may be 1±0.1. The preferable form of irradiate region is not limited to one and varies to some extent depending on the item to be optimized. The form of irradiated region may be, for example, a circle, an equilateral triangle, a square, a regular hexagon and the like.
摘要翻译： 为了提供具有高灵敏度，高处理能力和成本方面的竞争优势的荧光检测装置，根据本发明的荧光检测装置用光照射样品，使得照射区域的形式的纵横比由 样品排列表面上的光可能为1±0.1。 照射区域的优选形式不限于一个，并且根据要优化的项目而在一定程度上变化。 照射区域的形式可以是例如圆形，等边三角形，正方形，正六边形等。
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公开(公告)号：US20080239311A1
公开(公告)日：2008-10-02
申请号：US12051245
申请日：2008-03-19
CPC分类号： G01N21/6452 , G02B2207/113
摘要： In order to provide a fluorescence detection apparatus having a high sensitivity, a high processing capacity and a competitive edge in cost, the fluorescence detection apparatus according to this invention irradiate the sample with light so that the aspect ratio of the form of the irradiated region by light on the arrangement surface of the sample may be 1±0.1. The preferable form of irradiate region is not limited to one and varies to some extent depending on the item to be optimized. The form of irradiated region may be, for example, a circle, an equilateral triangle, a square, a regular hexagon and the like.
摘要翻译： 为了提供具有高灵敏度，高处理能力和成本方面的竞争优势的荧光检测装置，根据本发明的荧光检测装置用光照射样品，使得照射区域的形式的纵横比由 样品排列表面上的光可能为1±0.1。 照射区域的优选形式不限于一个，并且根据要优化的项目而在一定程度上变化。 照射区域的形式可以是例如圆形，等边三角形，正方形，正六边形等。
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公开(公告)号：US08680483B2
公开(公告)日：2014-03-25
申请号：US13141127
申请日：2009-12-22
IPC分类号： G01J1/58
CPC分类号： G01N21/6452 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478
摘要： A fluorescence detector in which a sample substrate is provided with a structure unit comprising a prism or a diffraction grating. After excitation light falling on the sample substrate is totally reflected at a biomolecule-immobilized face that is located in the opposite side of the structure unit, the structure unit allows the emission of the reflected light therefrom. To ensure multiple visual field measurement, a sample substrate-driving unit is provided to scan the sample substrate.
摘要翻译： 一种荧光检测器，其中样品基板设置有包括棱镜或衍射光栅的结构单元。 落在样品基板上的激发光在位于结构单元的相对侧的生物分子固定面全面反射，结构单元允许从其发射反射光。 为了确保多个视野测量，提供了样品基板驱动单元以扫描样品基板。
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公开(公告)号：US20110272596A1
公开(公告)日：2011-11-10
申请号：US13141127
申请日：2009-12-22
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N2021/6421 , G01N2021/6441 , G01N2021/6478
摘要： A fluorescence detector in which a sample substrate is provided with a structure unit comprising a prism or a diffraction grating. After excitation light falling on the sample substrate is totally reflected at a biomolecule-immobilized face that is located in the opposite side of the structure unit, the structure unit allows the emission of the reflected light therefrom. To ensure multiple visual field measurement, a sample substrate-driving unit is provided to scan the sample substrate.
摘要翻译： 一种荧光检测器，其中样品基板设置有包括棱镜或衍射光栅的结构单元。 落在样品基板上的激发光在位于结构单元的相对侧的生物分子固定面全面反射，结构单元允许从其发射反射光。 为了确保多个视野测量，提供了样品基板驱动单元以扫描样品基板。
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公开(公告)号：US07985384B2
公开(公告)日：2011-07-26
申请号：US11812156
申请日：2007-06-15
申请人： Yoshiaki Yazawa , Takashi Anazawa , Kenko Uchida
发明人： Yoshiaki Yazawa , Takashi Anazawa , Kenko Uchida
CPC分类号： G01N33/558 , G01N33/54386
摘要： There is provided a simple, inexpensive reaction analysis kit and system capable of performing highly sensitive, quantitative measurement. A chemical luminescence reaction is employed and a sensor element is used to detect the reaction in a highly sensitive manner. That is, a reaction detection plate is used to transmit a signal detected in the sensor element via a reader coil and a reader and then analyze the reaction. The reaction detection plate has a) a membrane, b) a first antibody impregnated section that is disposed such that it faces the membrane and holds a first labeled antibody that specifically binds to a substance to be analyzed, c) a second antibody immobilized section that is provided in part of the membrane and has an immobilized second antibody, the second antibody specifically binding to the substance to be analyzed, and d) a sensor element that is disposed such that it faces the second antibody immobilized section and includes a light detector and a signal transceiver.
摘要翻译： 提供了一种简单，便宜的反应分析试剂盒和系统，能够进行高灵敏度，定量测量。 采用化学发光反应，使用传感器元件以高度敏感的方式检测反应。 也就是说，反应检测板用于通过读取器线圈和读取器传输在传感器元件中检测到的信号，然后分析反应。 反应检测板具有a）膜，b）第一抗体浸渍部分，其被设置为使其面向膜并保持特异性结合待分析物质的第一标记抗体，c）第二抗体固定化部分，其中 提供在膜的一部分中并且具有固定的第二抗体，特异性结合待分析物质的第二抗体，以及d）设置成使得其面向第二抗体固定化部分并且包括光检测器的传感器元件， 一个信号收发器。
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公开(公告)号：US20070292897A1
公开(公告)日：2007-12-20
申请号：US11812156
申请日：2007-06-15
申请人： Yoshiaki Yazawa , Takashi Anazawa , Kenko Uchida
发明人： Yoshiaki Yazawa , Takashi Anazawa , Kenko Uchida
IPC分类号： G01N33/542 , G01N33/53 , C12M3/00
CPC分类号： G01N33/558 , G01N33/54386
摘要： There is provided a simple, inexpensive reaction analysis kit and system capable of performing highly sensitive, quantitative measurement. A chemical luminescence reaction is employed and a sensor element is used to detect the reaction in a highly sensitive manner. That is, a reaction detection plate is used to transmit a signal detected in the sensor element via a reader coil and a reader and then analyze the reaction. The reaction detection plate has a) a membrane, b) a first antibody impregnated section that is disposed such that it faces the membrane and holds a first labeled antibody that specifically binds to a substance to be analyzed, c) a second antibody immobilized section that is provided in part of the membrane and has an immobilized second antibody, the second antibody specifically binding to the substance to be analyzed, and d) a sensor element that is disposed such that it faces the second antibody immobilized section and includes a light detector and a signal transceiver.
摘要翻译： 提供了一种简单，便宜的反应分析试剂盒和系统，能够进行高灵敏度，定量测量。 采用化学发光反应，使用传感器元件以高度敏感的方式检测反应。 也就是说，反应检测板用于通过读取器线圈和读取器传输在传感器元件中检测到的信号，然后分析反应。 反应检测板具有a）膜，b）第一抗体浸渍部分，其被设置为使其面向膜并保持特异性结合待分析物质的第一标记抗体，c）第二抗体固定化部分，其中 提供在膜的一部分中，并且具有固定的第二抗体，特异性结合待分析物质的第二抗体，和d）设置为使得其面对第二抗体固定化部分并且包括光检测器的传感器元件， 一个信号收发器。
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公开(公告)号：US08293191B2
公开(公告)日：2012-10-23
申请号：US11675749
申请日：2007-02-16
CPC分类号： B01L3/0244 , B01F7/00258 , B01F11/0071 , B01F11/0258 , B01F13/0071 , B01L3/0251 , B01L3/0255 , B01L3/50 , B01L2300/0845 , B01L2300/089 , B01L2300/12 , G01N21/03 , G01N21/64 , G01N2021/0346 , G01N2021/035 , G01N2035/1037 , G01N2035/1046
摘要： The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
摘要翻译： 本发明提供一种方法，其中使用由线形成的环形或螺旋液滴保持器将其悬挂在其中或被容纳在其中的状态。 用于移动液滴保持器的装置被添加到液滴保持器以使液滴转移。 为了合并两个液滴，它们被接触。 为了滴落由线形成的液滴保持器保持的液滴，液滴保持器使用外力而变形。 设置通过液滴的光路以进行光学测量。 本发明可实现廉价的简单的液滴转印。 根据本发明，可以实现用于处理化学分析，生化分析和自动血液分析领域中的液滴的廉价，简单的构造。
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公开(公告)号：US20070207064A1
公开(公告)日：2007-09-06
申请号：US11675749
申请日：2007-02-16
IPC分类号： B01L3/02
CPC分类号： B01L3/0244 , B01F7/00258 , B01F11/0071 , B01F11/0258 , B01F13/0071 , B01L3/0251 , B01L3/0255 , B01L3/50 , B01L2300/0845 , B01L2300/089 , B01L2300/12 , G01N21/03 , G01N21/64 , G01N2021/0346 , G01N2021/035 , G01N2035/1037 , G01N2035/1046
摘要： The invention provides a method in which an annular or spiral droplet holder formed of wire is used to hold a droplet in a state of being hung therefrom or being contained therein. A means for moving the droplet holder is added to the droplet holder to enable droplet transfer. To merge two droplets, they are brought into contact. To drip the droplet held by a droplet holder formed of wire, the droplet holder is deformed using an external force. A light path which passes through a droplet is set to enable optical measurement. The present invention enables inexpensive, simple droplet transfer. An inexpensive, simple configuration for handling droplets in the fields of chemical analysis, biochemical analysis, and automatic blood analysis can be realized according to the present invention.
摘要翻译： 本发明提供一种方法，其中使用由线形成的环形或螺旋液滴保持器将其悬挂在其中或被容纳在其中的状态。 用于移动液滴保持器的装置被添加到液滴保持器以使液滴转移。 为了合并两个液滴，它们被接触。 为了滴落由线形成的液滴保持器保持的液滴，液滴保持器使用外力而变形。 设置通过液滴的光路以进行光学测量。 本发明可实现廉价的简单的液滴转印。 根据本发明，可以实现用于处理化学分析，生化分析和自动血液分析领域中的液滴的廉价，简单的构造。
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9.发明授权公开(公告)号：US09834806B2
公开(公告)日：2017-12-05
申请号：US13001465
申请日：2009-06-25
申请人： Hideyuki Noda , Masahiro Okanojo , Kenko Uchida , Norihito Kuno
发明人： Hideyuki Noda , Masahiro Okanojo , Kenko Uchida , Norihito Kuno
CPC分类号： C12Q1/008 , B01L3/502 , B01L2300/0681 , B01L2300/069 , B01L2300/1805 , B01L2400/0487 , G01N1/2208 , G01N1/2273
摘要： A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through holes, a container in an inverted-cone shape having both of a liquid storage sink unit having a filter at the bottom and an air suction path, and a support base for setting up a thermoplastic carrier, and a carrier treating apparatus formed of a dispensing nozzle for liquid supply, a liquid supply mechanism, a liquid heating mechanism, and a suction pump for filtration are prepared. Warm water is supplied onto the filter set up on a bottom surface of the inverted-cone-shaped. The contact with the warm water causes the carrier to be solated filtered through the filter.
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公开(公告)号：US07932486B2
公开(公告)日：2011-04-26
申请号：US12330374
申请日：2008-12-08
申请人： Akihiro Sano , Atsumu Hirabayashi , Yasushi Terui , Kinya Kobayashi , Kiyomi Yoshinari , Kenko Uchida , Toshiyuki Yokosuka
发明人： Akihiro Sano , Atsumu Hirabayashi , Yasushi Terui , Kinya Kobayashi , Kiyomi Yoshinari , Kenko Uchida , Toshiyuki Yokosuka
IPC分类号： H01J49/26
CPC分类号： G01N33/6851 , G01N33/6848 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： During the structural analysis of a protein or peptide by tandem mass spectroscopy, a peptide ion derived from a protein that has already been measured and that is expressed in great quantities is avoided as a tandem mass spectroscopy target. A peptide derived from a minute amount of protein, which has heretofore been difficult to analyze, can be automatically determined as a tandem mass spectroscopy target within the real time of measurement. Data concerning a protein that has already been measured and a peptide derived from the protein is automatically stored in an internal database. The stored data is collated with measured data with high accuracy to determine an isotope peak. In this way, the process of selecting a peptide peak that has not been measured as the target for the next tandem analysis can be performed within the real time of measurement and a redundant measurement of peptides derived from the same protein can be avoided. The information contained in the MSn spectrum is effectively utilized in each step of the MSn involving a multi-stage dissociation and mass spectroscopy (MSn), so that the flows for the determination of the next analysis content and the selection of the parent ion for the MSn+1 analysis, for example, can be optimized within the real time of measurement and with high efficiency and accuracy. Thus, a target of concern to the user can be subjected to tandem mass spectroscopy without wasteful measurement.
摘要翻译： 在通过串联质谱法对蛋白质或肽进行结构分析期间，作为串联质谱目标，可以避免衍生自已经测量并且大量表达的蛋白质的肽离子。 迄今为止难以分析的，从微量蛋白质衍生的肽可以在实时测定中作为串联质谱图目标自动确定。 关于已经测量的蛋白质和来自蛋白质的肽的数据被自动存储在内部数据库中。 存储的数据与测量数据高精度对照以确定同位素峰。 以这种方式，可以在测量的实际时间内进行未被测定为下一个串联分析的靶标的肽峰的过程，并且可以避免衍生自相同蛋白质的肽的冗余测量。 包含在MSn谱中的信息在涉及多级解离和质谱（MSn）的MSn的每个步骤中被有效地利用，使得用于确定下一个分析内容的流程和为母体离子的选择 例如，MSn + 1分析可以在实时测量和高效率和精确度下进行优化。 因此，用户关注的目标可以进行串联质谱，无需浪费测量。
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