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    MICROBE-COLLECTING CARRIER CARTRIDGE, CARRIER TREATING APPARATUS, AND METHOD OF MEASURING MICROBES
    2.
    发明申请
    MICROBE-COLLECTING CARRIER CARTRIDGE, CARRIER TREATING APPARATUS, AND METHOD OF MEASURING MICROBES 有权
    MICROBE收集载体盒，载体处理装置和测量微阵列的方法

    公开(公告)号：US20110183371A1

    公开(公告)日：2011-07-28

    申请号：US13001465

    申请日：2009-06-25

    申请人： Hideyuki Noda ,  Masahiro Okanojo ,  Kenko Uchida ,  Norihito Kuno

    发明人： Hideyuki Noda ,  Masahiro Okanojo ,  Kenko Uchida ,  Norihito Kuno

    IPC分类号： C12Q1/06 ,  C12M1/00 ,  C12M1/34

    CPC分类号： C12Q1/008 ,  B01L3/502 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/1805 ,  B01L2400/0487 ,  G01N1/2208 ,  G01N1/2273

    摘要： A disposable microbe-collecting carrier cartridge and a carrier treating apparatus which efficiently convert microbes collected on a carrier into a solution and prevent variations in the amount of retrieval of microbes upon concentration on a filter are provided. A cartridge formed of an upper lid having a plurality of through holes, a container in an inverted-cone shape having both of a liquid storage sink unit having a filter at the bottom and an air suction path, and a support base for setting up a thermoplastic carrier, such as gelatin, and a carrier treating apparatus formed of a dispensing nozzle for liquid supply, a liquid supply mechanism, a liquid heating mechanism, and a suction pump for filtration are prepared. Warm water is supplied onto the filter set up on a bottom surface of the inverted-cone-shaped container and is stored in the liquid storage sink, thereby causing the carrier to make contact with the warm water. The contact with the warm water causes the carrier to be solated, and mixed and diluted with the warm water. Then, the suction pump of the filtration device is activated for suction and filtration of the mixed liquid through the filter. By using the filter having a shape not allowing microbes to pass through and having a gap, only microbes are captured on the filter after suction and filtration. Polymers and dust to be a background upon an ATP measurement pass through the filter by filtration to be cleanly eliminated.

    摘要翻译： 提供一种一次性微生物收集载体盒和载体处理装置，其将收集在载体上的微生物有效地转化为溶液并防止在过滤器上浓缩时微生物的回收量的变化。 由具有多个通孔的上盖形成的盒，具有倒置锥形的容器，其具有在底部具有过滤器的液体储存槽单元和空气吸入路径，以及用于设置 制备诸如明胶的热塑性载体，以及由用于液体供应的分配喷嘴形成的载体处理装置，液体供给机构，液体加热机构和用于过滤的抽吸泵。 向设置在倒锥形容器的底面上的过滤器供给温水，并将其储存在液体储存槽中，从而使载体与温水接触。 与温水接触导致载体被溶解，并与温水混合并稀释。 然后，过滤装置的抽吸泵被激活，以通过过滤器抽吸和过滤混合液体。 通过使用具有不允许微生物通过并具有间隙的形状的过滤器，在抽吸和过滤之后仅在过滤器上捕获微生物。 聚合物和粉尘作为ATP测量的背景，通过过滤通过过滤器，以便清洁地消除。

    APPARATUS FOR CHEMILUMINESCENT ASSAY AND DETECTION
    3.
    发明申请
    APPARATUS FOR CHEMILUMINESCENT ASSAY AND DETECTION 有权
    用于荧光测定和检测的装置

    公开(公告)号：US20080261294A1

    公开(公告)日：2008-10-23

    申请号：US12034880

    申请日：2008-02-21

    申请人： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

    发明人： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

    IPC分类号： G01N21/76 ,  C12M1/36

    CPC分类号： C12Q1/04 ,  G01N21/76

    摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.

    摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。 虽然没有实现测量，但是关闭快门单元以阻止杂散光入射到光电检测器，并且在实施测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入通孔 使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

    Apparatus for chemiluminescent assay and detection
    4.
    发明授权
    Apparatus for chemiluminescent assay and detection 有权
    用于化学发光测定和检测的装置

    公开(公告)号：US08334144B2

    公开(公告)日：2012-12-18

    申请号：US13478527

    申请日：2012-05-23

    申请人： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

    发明人： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

    IPC分类号： G01N21/76 ,  G01N21/00 ,  G01N21/75

    CPC分类号： C12Q1/04 ,  G01N21/76

    摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.

    摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光箱，其具有样本容器保持器和其中的快门单元，所述快门单元包括部分地由板构件的运动形成的顶板和在其中具有光电检测器的第二遮光箱。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

    Apparatus for chemiluminescent assay and detection
    5.
    发明授权
    Apparatus for chemiluminescent assay and detection 有权

    公开(公告)号：US08197751B2

    公开(公告)日：2012-06-12

    申请号：US12976031

    申请日：2010-12-22

    申请人： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

    发明人： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

    IPC分类号： G01N21/76 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N21/00 ,  G01N21/75

    CPC分类号： C12Q1/04 ,  G01N21/76

    摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member, and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.

    Apparatus for chemiluminescent assay and detection
    6.
    发明授权
    Apparatus for chemiluminescent assay and detection 有权
    用于化学发光测定和检测的装置

    公开(公告)号：US07879290B2

    公开(公告)日：2011-02-01

    申请号：US12034880

    申请日：2008-02-21

    申请人： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

    发明人： Hideyuki Noda ,  Satoshi Ozawa ,  Masahiro Okanojo ,  Kenko Uchida

    IPC分类号： G01N21/76 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N21/00 ,  G01N21/75

    CPC分类号： C12Q1/04 ,  G01N21/76

    摘要： An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement of a plate member and a second light shielding BOX having a photodetector therein. While a measurement is not implemented, the shutter unit is closed to block entrance of stray light to the photodetector, and while a measurement is implemented, the plate member is moved to open the shutter unit, and the tip of the photodetector is inserted into a through hole formed in the top plate, so that the distance between the bottom of the sample container and a sensitive area of the photodetector is reduced to several millimeters or less.

    摘要翻译： 一种装置包括用于引导化学发光的系统和用于防止暗电流变化的系统。 该装置包括：第一遮光盒，其具有样品容器保持器和其中的快门单元，所述快门单元包括顶板，该顶板部分地通过板构件的运动和在其中具有光电检测器的第二遮光箱而形成。 虽然没有实现测量，但是快门单元被关闭以阻止杂散光入射到光电检测器，并且在实现测量的同时，移动板构件以打开快门单元，并且将光电检测器的末端插入到 通孔形成在顶板中，使得样品容器的底部与光电检测器的敏感区域之间的距离减小到几毫米或更小。

    REAGENT SPLITTING / DISPENSING METHOD BASED ON REAGENT DISPENSING NOZZLE AND REAGENT SPLITTING / DISPENSING MECHANISM
    7.
    发明申请
    REAGENT SPLITTING / DISPENSING METHOD BASED ON REAGENT DISPENSING NOZZLE AND REAGENT SPLITTING / DISPENSING MECHANISM 失效
    试剂分选/分配方法基于试剂分配喷嘴和试剂分选/分配机构

    公开(公告)号：US20110176975A1

    公开(公告)日：2011-07-21

    申请号：US13009037

    申请日：2011-01-19

    申请人： Noe MIYASHITA ,  Hideyuki Noda ,  Masahiro Okanojo

    发明人： Noe MIYASHITA ,  Hideyuki Noda ,  Masahiro Okanojo

    IPC分类号： B01L3/00

    CPC分类号： B01L3/52 ,  F17D3/00 ,  G01N21/763 ,  G01N35/1002 ,  G01N35/1011 ,  G01N2035/102 ,  G01N2035/1032 ,  Y10T137/0324 ,  Y10T436/118339 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： The present invention provides a reagent splitting/dispensing method that can prevent contamination of an operation fluid when a reagent dispensing nozzle is in a waiting state and prevent falling of a droplet. The reagent splitting/dispensing method includes a waiting process of disposing a first air layer between an interface of the operation fluid and a nozzle tip end in the reagent dispensing nozzle, a first moving process of moving the reagent dispensing nozzle to the position right above the reagent, a second moving process of depositing the nozzle tip end in the reagent, a reagent splitting process of filling the reagent into the reagent dispensing nozzle, a third moving process of evacuating the tip end of the reagent dispensing nozzle from the reagent, a reagent protecting process of disposing a second air layer in the nozzle tip end, a fourth moving process of moving the reagent dispensing nozzle to the reagent dispensation position, a reagent dispensing process of ejecting the split reagent, an operation fluid protecting process of disposing the first air layer in the nozzle tip end, after dispensing the reagent, and a fifth moving process of evacuating the reagent dispensing nozzle to the waiting position, in a state where the first air layer is disposed in the nozzle tip end.

    摘要翻译： 本发明提供一种试剂分注方法，其能够防止试剂分注喷嘴处于等待状态时的工作液的污染，防止液滴的下降。 试剂分注/分注方法包括在试剂分注喷嘴的操作流体的界面和喷嘴前端之间设置第一空气层的等待处理，将试剂分注喷嘴移动到 试剂，将试剂分注喷嘴的前端从试剂抽出的第三移动处理，将试剂分注喷嘴从试剂抽出的第三移动处理， 在喷嘴前端设置第二空气层的保护过程，将试剂分配喷嘴移动到试剂分配位置的第四移动处理，喷射分离试剂的试剂分注处理，将第一空气配置的操作流体保护处理 在分配试剂之后的喷嘴尖端中的层，以及抽空试剂分配喷嘴的第五移动过程 e到第一空气层设置在喷嘴前端的状态下的等待位置。

    Capturing carrier, capturing device, analysis system using the same, and method for capturing and testing microorganisms
    8.
    发明授权
    Capturing carrier, capturing device, analysis system using the same, and method for capturing and testing microorganisms 有权
    捕获载体，捕获装置，使用其的分析系统以及捕获和测试微生物的方法

    公开(公告)号：US08628953B2

    公开(公告)日：2014-01-14

    申请号：US12292626

    申请日：2008-11-21

    申请人： Noe Osato ,  Ryusuke Gotoda ,  Satoshi Ozawa ,  Hideyuki Noda ,  Masahiro Okanojo

    发明人： Noe Osato ,  Ryusuke Gotoda ,  Satoshi Ozawa ,  Hideyuki Noda ,  Masahiro Okanojo

    IPC分类号： C12M1/00

    CPC分类号： C12Q1/04 ,  G01N1/2208 ,  G01N1/2214 ,  G01N2001/4088

    摘要： In order to make a process of capturing and testing air-borne microorganisms more convenient and quick, a capturing device which comprises the capturing carrier comprising a polymer which is in a gel phase at the time of capturing the microorganisms but undergoes a phase transition under heating to a sol phase at the temperature at or less than 40° C. (especially in the temperature range between 15° C. and 37° C.), and a vessel to contain the capturing carrier is used. Further, by comprising a test reagent in the polymer, the test reagent can be eluted upon said phase transition from a gel phase to a sol phase. By heating the capturing carrier, a phase transition to a sol phase can occur at or less than 40° C. As such, since recovery of microorganisms and addition of a test reagent to the microorganisms can be carried out simultaneously, the process can be simplified and the process time can be shortened.

    摘要翻译： 为了更方便快捷地捕获和测试空气传播的微生物的过程，捕获装置包括捕获载体，捕获载体包含在捕获微生物时处于凝胶相的聚合物，但在加热下经历相变 在等于或低于40℃的温度下（特别是在15℃至37℃的温度范围内）的溶胶相，并且使用容纳捕获载体的容器。 此外，通过在聚合物中包含测试试剂，在从凝胶相到溶胶相的所述相转变时，可以洗脱测试试剂。 通过加热捕获载体，可以在40℃以下发生溶胶相的相变。因此，由于可以同时进行微生物的回收和微生物的添加试验，因此可以简化该过程 并且可以缩短处理时间。