SELF-SUSTAINED FLUIDIC DROPLET CASSETTE AND SYSTEM FOR BIOCHEMICAL ASSAYS
    1.
    发明申请
    SELF-SUSTAINED FLUIDIC DROPLET CASSETTE AND SYSTEM FOR BIOCHEMICAL ASSAYS 审中-公开
    自主持续流体液体和生物化学测定系统

    公开(公告)号:US20130096035A1

    公开(公告)日:2013-04-18

    申请号:US13805625

    申请日:2011-07-26

    IPC分类号: C12Q1/68

    摘要: A fluidic cartridge for biochemical assays includes a cartridge body defining a first droplet region and a second droplet region with a droplet restraining barrier therebetween. The droplet restraining barrier has a gap between the first and the second droplet regions. The fluidic cartridge also includes a first droplet dispensed in the first droplet region. The first droplet includes a plurality of magnetic particles dispersed therein. The fluidic cartridge also includes a second droplet disposed in the second droplet region. The plurality of magnetic particles are sufficiently small to be drawn through the gap between the first and second droplet regions when compelled by an applied magnetic field, and the first droplet is restrained by the restraining barrier while the plurality of magnetic particles are drawn through the gap. A biochemical assay system includes a stage adapted to receive a fluidic cartridge, and a magnetic control assembly that includes a magnet. The magnet of the magnetic control assembly is movable to direct motion of magnetic particles contained within the fluidic cartridge.

    摘要翻译: 用于生物化学测定的流体盒包括限定第一液滴区域的盒体和在其间具有液滴限制屏障的第二液滴区域。 液滴限制屏障在第一和第二液滴区域之间具有间隙。 流体盒还包括分配在第一液滴区域中的第一液滴。 第一液滴包括分散在其中的多个磁性颗粒。 流体盒还包括设置在第二液滴区域中的第二液滴。 当被施加的磁场强迫时,多个磁性颗粒足够小以便被吸入第一和第二液滴区域之间的间隙,并且第一液滴被约束屏障约束,同时多个磁性颗粒被吸引通过间隙 。 生物化学测定系统包括适于接收流体盒的阶段和包括磁体的磁性控制组件。 磁性控制组件的磁体可移动以引导包含在流体盒内的磁性颗粒的运动。

    Video-on-demand satellite system
    3.
    发明申请
    Video-on-demand satellite system 审中-公开
    视频点播卫星系统

    公开(公告)号:US20050273822A1

    公开(公告)日:2005-12-08

    申请号:US11024500

    申请日:2004-12-28

    IPC分类号: H04N7/173 H04N7/20

    摘要: A satellite video on demand system and method provide videos or other files on demand using a satellite in earth orbit. The satellite includes at least one uplink and multiple downlinks to multiple cells distributed over a geographic region. Multiple requests for video files from multiple users in multiple cells in the geographic region are received at a control station. The requests may include multiple requests from users in multiple cells for a first video file, and multiple other requests for one or more other video files from other users. The requests for the first video file are accumulated over a time period, and at least portions of the other video files are transmitted to the other users via the satellite during the time period. After the time period, the first video file is transmitted to the users who requested it with simultaneous transmissions over the satellite.

    摘要翻译: 卫星视频点播系统和方法使用地球轨道上的卫星按需提供视频或其他文件。 该卫星包括分布在地理区域上的多个小区的至少一个上行链路和多个下行链路。 在控制站接收对地理区域中的多个小区中的来自多个用户的视频文件的多个请求。 请求可以包括用于第一视频文件的多个单元中的用户的多个请求,以及来自其他用户的一个或多个其他视频文件的多个其他请求。 对第一视频文件的请求在一段时间内被累积,并且在该时间段期间,其他视频文件的至少一部分经由卫星发送给其他用户。 在该时间段之后,第一个视频文件被传送到通过卫星同时发送请求的用户。

    Scanning projective lensless microscope system
    6.
    发明授权
    Scanning projective lensless microscope system 有权
    扫描投影镜头无显微镜系统

    公开(公告)号:US09426429B2

    公开(公告)日:2016-08-23

    申请号:US13281287

    申请日:2011-10-25

    IPC分类号: H04N7/18 G02B21/06 G02B21/36

    摘要: A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest.

    摘要翻译: 一种扫描投影镜头无显微镜装置,包括一个样品表面,一个带有光元件的扫描照明源,在样品表面外部的光检测器和一个处理器。 扫描照明源将光元件扫描到多个扫描位置以向样品表面上的物体提供照明。 光检测器对与多个扫描位置对应的子像素偏移投影对象图像序列进行采样。 处理器基于子像素移位的投影图像的序列和感兴趣的平面上的投影的运动矢量来构建对象的高分辨率图像。

    SUPER RESOLUTION OPTOFLUIDIC MICROSCOPES FOR 2D AND 3D IMAGING
    7.
    发明申请
    SUPER RESOLUTION OPTOFLUIDIC MICROSCOPES FOR 2D AND 3D IMAGING 有权
    超分辨率光学显微镜2D和3D成像

    公开(公告)号:US20110234757A1

    公开(公告)日:2011-09-29

    申请号:US13069651

    申请日:2011-03-23

    IPC分类号: H04N13/02 H04N7/18

    摘要: A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.

    摘要翻译: 超分辨率光流体显微镜装置包括限定具有纵向轴线的流体通道的主体并且包括靠近流体通道的表面层。 表面层具有二维光检测器阵列,其构造成当物体移动通过流体通道时,接收通过流体通道的光并采样一系列子像素偏移的投影框。 超分辨率光流体显微镜装置还包括与二维光检测器阵列电子通信的处理器。 处理器被配置为使用超分辨率算法,并且基于子像素偏移的投影帧的序列和对象的运动矢量来生成对象的高分辨率图像。

    Quantitative assay for the simultaneous detection and speciation of bacterial infections
    8.
    发明授权
    Quantitative assay for the simultaneous detection and speciation of bacterial infections 有权
    用于细菌感染的同时检测和形态的定量测定

    公开(公告)号:US06699670B2

    公开(公告)日:2004-03-02

    申请号:US10085134

    申请日:2002-03-01

    IPC分类号: C12Q168

    摘要: An adaptation of the real-time PCR assay allows for highly sensitive detection of any eubacterial species with simultaneous speciation. The assay relies on a ‘multiprobe’ design in which a single set of highly conserved sequences encoded by the 16S rRNA gene serves as the primer pair, and it is used in combination with both an internal highly conserved sequence, the universal probe, and an internal variable region, the species-specific probe. A pre-PCR ultrafiltration step can be used to effectively decontaminate or remove background DNA. The real-time system reliably identifies 14 common bacterial species with a detection limit of 50 fg.

    摘要翻译: 实时PCR测定的适应性允许对具有同时形态的任何真细菌物种进行高度敏感的检测。 该测定依赖于“多探针”设计,其中由16S rRNA基因编码的单组高度保守序列用作引物对,并且其与内部高度保守序列,通用探针和 内部可变区,物种特异性探针。 可以使用预PCR超滤步骤来有效地净化或除去背景DNA。 实时系统可靠地识别14种常见细菌,检出限为50 fg。

    SCANNING PROJECTIVE LENSLESS MICROSCOPE SYSTEM
    10.
    发明申请
    SCANNING PROJECTIVE LENSLESS MICROSCOPE SYSTEM 有权
    扫描投影无线显微镜系统

    公开(公告)号:US20120098950A1

    公开(公告)日:2012-04-26

    申请号:US13281287

    申请日:2011-10-25

    IPC分类号: H04N7/18

    摘要: A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest.

    摘要翻译: 一种扫描投影镜头无显微镜装置,包括一个样品表面,一个带有光元件的扫描照明源,在样品表面外部的光检测器和一个处理器。 扫描照明源将光元件扫描到多个扫描位置以向样品表面上的物体提供照明。 光检测器对与多个扫描位置对应的子像素偏移投影对象图像序列进行采样。 处理器基于子像素移位的投影图像的序列和感兴趣的平面上的投影的运动矢量来构建对象的高分辨率图像。