-
公开(公告)号：US11691016B2
公开(公告)日：2023-07-04
申请号：US17048955
申请日：2019-04-19
发明人： Susan J. Harkema , Yangsheng Chen , Claudia Angeli , Douglas J. Jackson , Manikandan Ravi , John Naber , Robert S. Keynton , Thomas Roussel , Saliya Kirigeeganage
IPC分类号： A61N1/36
CPC分类号： A61N1/36175 , A61N1/36062
摘要： Patients with spinal cord injuries have benefited from neurostimulation therapy comprising delivery of electrical stimulation to enable or excite neurological responses using an implantable neurostimulator having an electrode array. Dangerous levels of charge are avoided while providing multiple, simultaneous stimulation waveforms by inducing a short in an electrode when a monitored value reaches or exceeds a predetermined threshold.
-
公开(公告)号：US20200346015A1
公开(公告)日：2020-11-05
申请号：US16960447
申请日：2019-01-11
发明人： Susan J. Harkema , Claudia Angeli , Yangsheng Chen
摘要： Methods for normalization of blood pressure for individuals with spinal cord injuries include providing such individuals with spinal cord electrical stimulation optimized for cardiovascular function. An electrode array provides specific stimulation configurations identified to maintain systolic blood pressure within targeted normative ranges without skeletal muscle activity.
-
公开(公告)号：US20230414290A1
公开(公告)日：2023-12-28
申请号：US18253780
申请日：2021-11-22
CPC分类号： A61B34/10 , G16H30/40 , G16H20/30 , A61N1/0553 , A61B2034/105 , A61B2034/107 , G16H50/50
摘要： Methods for optimization of surgical placement of an implantable electrode for spinal cord epidural stimulation of a subject include creating a computational model of the subject spinal cord based on medical imagery, determining the position of the lumbosacral enlargement, and determining an optimal placement to maximize volumetric coverage of the lumbosacral enlargement by the implantable electrode.
-
公开(公告)号：US20210228884A1
公开(公告)日：2021-07-29
申请号：US17048955
申请日：2019-04-19
发明人： Susan J. Harkema , Yangsheng Chen , Claudia Angeli , Douglas J. Jackson , Manikandan Ravi , John Naber , Robert S. Keynton , Thomas Roussel , Saliya Kirigeeganage
IPC分类号： A61N1/36
摘要： Patients with spinal cord injuries have benefited from neurostimulation therapy comprising delivery of electrical stimulation to enable or excite neurological responses using an implantable neurostimulator having an electrode array. Dangerous levels of charge are avoided while providing multiple, simultaneous stimulation waveforms by inducing a short in an electrode when a monitored value reaches or exceeds a predetermined threshold.
-
公开(公告)号：US20180229038A1
公开(公告)日：2018-08-16
申请号：US15940473
申请日：2018-03-29
申请人： California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca, JR. , Yangsheng Chen
IPC分类号： A61N1/36 , A61N1/05 , A61B5/00 , A61B5/11 , A61B5/0492
CPC分类号： A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要： Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.
-
公开(公告)号：US20200316378A1
公开(公告)日：2020-10-08
申请号：US16840353
申请日：2020-04-04
摘要： The present invention relates to methods for improvement in lower urinary tract function in an individual with neurogenic urological dysfunction through epidural stimulation of the spinal cord. In certain embodiments, the methods comprise applying a pattern of epidural electrical stimulation to the spinal cord of an individual with impaired lower urinary tract under stimulation parameters sufficient to improve the storage of fluid in the bladder, sensations of fullness and/or emptying, detrusor over-activity, high detrusor pressure, voiding the bladder, transitioning from a storage state to a voiding state, and decreasing detrusor-external urethral sphincter dyssynergia. In certain embodiments, additional patterns of epidural electrical stimulation may be applied simultaneously, such as to maintain a normotensive cardiovascular state of the individual.
-
公开(公告)号：US10737095B2
公开(公告)日：2020-08-11
申请号：US15940473
申请日：2018-03-29
申请人： California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca, Jr. , Yangsheng Chen
IPC分类号： A61N1/36 , A61N1/05 , A61B5/00 , A61B5/0492 , A61B5/11
摘要： Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord. The neurostimulator device also includes an interface and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the interface and performing a machine learning algorithm on the at least one complex stimulation pattern.
-
公开(公告)号：US20160310739A1
公开(公告)日：2016-10-27
申请号：US15199580
申请日：2016-06-30
申请人： California Institute of Technology , University of Louisville Research Foundation, Inc. , The Regents of the University of California
发明人： Joel W. Burdick , Yu-Chong Tai , John F. Naber , Robert S. Keynton , Victor Reggie Edgerton , Roland R. Roy , Yury Gerasimenko , Susan J. Harkema , Jonathan Hodes , Claudia A. Angeli , Mandheerej S. Nandra , Thomas Anthony Desautels , Steven L. Upchurch , Douglas J. Jackson , Nicholas A. Terrafranca , Yangsheng Chen
CPC分类号： A61N1/36103 , A61B5/0492 , A61B5/1106 , A61B5/407 , A61B5/4076 , A61B5/4836 , A61B2505/09 , A61N1/0551 , A61N1/0553 , A61N1/36003 , A61N1/36007 , A61N1/36067 , A61N1/36082 , A61N1/36107 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36139
摘要： Neurostimulator devices and methods of using these devices are described. The neurostimulator devices can include a stimulation assembly connectable to a plurality of electrodes; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern.
摘要翻译： 描述神经刺激装置和使用这些装置的方法。 神经刺激器装置可以包括可连接到多个电极的刺激组件; 一个或多个传感器; 以及配置成修改至少一个复杂刺激模式的至少一个处理器。
-
公开(公告)号：US11813446B2
公开(公告)日：2023-11-14
申请号：US16840353
申请日：2020-04-04
CPC分类号： A61N1/36007 , A61N1/0551
摘要： The present invention relates to methods for improvement in lower urinary tract function in an individual with neurogenic urological dysfunction through epidural stimulation of the spinal cord. In certain embodiments, the methods comprise applying a pattern of epidural electrical stimulation to the spinal cord of an individual with impaired lower urinary tract under stimulation parameters sufficient to improve the storage of fluid in the bladder, sensations of fullness and/or emptying, detrusor over-activity, high detrusor pressure, voiding the bladder, transitioning from a storage state to a voiding state, and decreasing detrusor-external urethral sphincter dyssynergia. In certain embodiments, additional patterns of epidural electrical stimulation may be applied simultaneously, such as to maintain a normotensive cardiovascular state of the individual.
-
公开(公告)号：US20220339450A1
公开(公告)日：2022-10-27
申请号：US17670025
申请日：2022-02-11
摘要： Disclosed herein are devices and methods used with neurostimulation therapy for spinal cord injury. More particularly, embodiments of the present invention relate to a sync pulse detector and methods for synchronizing signals from an implanted neurostimulator with measured physiological responses and other data.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.021 秒)
