公开(公告)号：US20080269576A1

公开(公告)日：2008-10-30

申请号：US12096029

申请日：2006-12-05

申请人： Uk Kang ,  Garri Papayan ,  Soo Jin Bae ,  Geun Hie Rim

发明人： Uk Kang ,  Garri Papayan ,  Soo Jin Bae ,  Geun Hie Rim

IPC分类号： A61B5/00 ,  A61B18/18

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/441 ,  A61N5/062 ,  A61N2005/0654

摘要： Disclosed herein is a light source device for fluorescence diagnosis and photodynamic therapy comprising: a plurality of light source means having a wavelength range different from each other and providing selected light; a light path coupling means coupling light emitted from the light source means to the incident direction of a light guide; a filtering means selectively transmitting the emitted light based on the wavelength; and a switching device that is directed to an opening/closing means, established at a long distance to be controlled by a remote control device and selecting the kinds of light sources of the light source means to change the modes of the light. Accordingly, the device simplifies the configuration by excluding elements causing errors in the process of fluorescence diagnosis in the diagnostic region. Moreover, the light source device for fluorescence diagnosis and photodynamic therapy couples the light emitted from a combined light source to provide a sufficient light strength in the visible light region, thus improving the illumination quality to increase the accuracy of the diagnosis and further improving the therapeutic efficiency.

摘要翻译： 本文公开了一种用于荧光诊断和光动力疗法的光源装置，包括：多个光源装置，其具有彼此不同的波长范围并提供所选择的光; 将从所述光源装置发射的光耦合到光导的入射方向的光路耦合装置; 滤波装置根据波长有选择地发射发射的光; 以及开关装置，其被引导到打开/关闭装置，其建立在远距离处，由遥控装置控制，并且选择光源装置的光源的种类以改变光的模式。 因此，该装置通过排除在诊断区域中引起荧光诊断过程中的错误的元件来简化配置。 此外，用于荧光诊断和光动力学治疗的光源装置将从组合光源发射的光耦合以在可见光区域提供足够的光强度，从而提高照明质量，从而提高诊断的准确性并进一步改善治疗 效率。

公开(公告)号：US08175687B2

公开(公告)日：2012-05-08

申请号：US12096029

申请日：2006-12-05

申请人： Uk Kang ,  Garri Papayan ,  Soo Jin Bae ,  Geun Hie Rim

发明人： Uk Kang ,  Garri Papayan ,  Soo Jin Bae ,  Geun Hie Rim

IPC分类号： A61B6/00

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/441 ,  A61N5/062 ,  A61N2005/0654

摘要： Disclosed herein is a light source device for fluorescence diagnosis and photodynamic therapy comprising: a plurality of light source means having a wavelength range different from each other and providing selected light; a light path coupling means coupling light emitted from the light source means to the incident direction of a light guide; a filtering means selectively transmitting the emitted light based on the wavelength; and a switching device that is directed to an opening/closing means, established at a long distance to be controlled by a remote control device and selecting the kinds of light sources of the light source means to change the modes of the light. Accordingly, the device simplifies the configuration by excluding elements causing errors in the process of fluorescence diagnosis in the diagnostic region. Moreover, the light source device for fluorescence diagnosis and photodynamic therapy couples the light emitted from a combined light source to provide a sufficient light strength in the visible light region, thus improving the illumination quality to increase the accuracy of the diagnosis and further improving the therapeutic efficiency.

摘要翻译： 本文公开了一种用于荧光诊断和光动力疗法的光源装置，包括：多个光源装置，其具有彼此不同的波长范围并提供所选择的光; 将从所述光源装置发射的光耦合到光导的入射方向的光路耦合装置; 滤波装置根据波长有选择地发射发射的光; 以及开关装置，其被引导到打开/关闭装置，其建立在远距离处，由遥控装置控制，并且选择光源装置的光源的种类以改变光的模式。 因此，该装置通过排除在诊断区域中引起荧光诊断过程中的错误的元件来简化配置。 此外，用于荧光诊断和光动力学治疗的光源装置将从组合光源发射的光耦合以在可见光区域提供足够的光强度，从而提高照明质量，从而提高诊断的准确性并进一步改善治疗 效率。

公开(公告)号：US08162496B2

公开(公告)日：2012-04-24

申请号：US11811677

申请日：2007-06-11

申请人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri. V Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri. V Papayan

IPC分类号： G03B15/02

CPC分类号： G01N21/6486 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/441

摘要： The present invention provides an apparatus for white light observation and fluorescence diagnosis of skin diseases. More particularly, the present invention provides an apparatus for photodynamic diagnosis in which a plurality of excitation light emitting diodes (LEDs) is provided in an image pick-up head, the excitation LEDs being arranged to illuminate the entire examination region in the form of a mosaic by setting respective illumination light axes of the excitation LEDs to illuminate preassigned individual areas of the examination region, thus uniformly illuminating the examination region in a wide field of view with excitation light. In the apparatus for photodynamic diagnosis, the respective excitation LEDs are provided at the same or different angles based on the light axis of the object lens, and thereby it is possible that the beams of the light sources composed of the LEDs illuminate the field of view of the examination region uniformly, thus improving the uniformity of illumination. Moreover, the present invention provides an apparatus for photodynamic diagnosis in which warm white LEDs and cold white LEDs as white light sources are appropriately arranged so as to deliver natural colors and thereby to reproduce natural color images.

摘要翻译： 本发明提供了一种用于白光观察和皮肤疾病荧光诊断的装置。 更具体地说，本发明提供了一种用于光动力学诊断的装置，其中多个激发发光二极管（LED）被提供在图像拾取头中，激发LED被布置成以整体形式照射整个检查区域 通过设置激发LED的各个照明光轴来照亮检查区域的预分配的各个区域，从而在激发光的宽视场内均匀地照射检查区域。 在光动力诊断装置中，基于物镜的光轴以相同或不同的角度设置各激发LED，由此，由LED组成的光源的光束可以照射视场 的检查区域均匀，从而提高了照明的均匀性。 此外，本发明提供了一种用于光动力诊断的装置，其中温白色LED和作为白光源的冷白光LED被适当地布置以便传送自然色，从而再现自然色图像。

公开(公告)号：US08496695B2

公开(公告)日：2013-07-30

申请号：US11811912

申请日：2007-06-11

申请人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B5/0071 ,  A61B5/441 ,  A61B2017/00057 ,  A61B2017/00747 ,  A61B2090/373 ,  A61N5/0616 ,  G01N21/6456 ,  G01N21/6486

摘要： A system is provided for photodynamic diagnosis and therapy of skin diseases. In particular, a camera head is provided to irradiate a white light, a fluorescent excitation light and a therapeutic light for the photodynamic therapy from the inside of a case onto the skin region being in contact with a view hole. Additionally, a digital color TV camera collects the light from the skin region and outputs a generated image signal. In particular, an image processing and analysis system receives the image signals from the camera head to process, analyze and store the same, displays a color image by the white light, a fluorescent image by the excitation light and the therapeutic light for the photodynamic therapy, obtained by the digital color TV camera, and a synthesized image thereof, and controls the general operations of the camera and the light source system.

摘要翻译： 提供一种用于光动力诊断和治疗皮肤疾病的系统。 特别地，提供一种照相机头，用于将来自外壳内部的光动力学治疗的白光，荧光激发光和治疗光照射到与观察孔接触的皮肤区域上。 此外，数字彩色电视摄像机收集来自皮肤区域的光并输出生成的图像信号。 特别地，图像处理和分析系统接收来自相机头的图像信号以进行处理，分析和存储，通过白光显示彩色图像，通过激发光显示荧光图像和用于光动力学治疗的治疗光 ，由数字彩色电视摄像机获得，并且其合成图像，并且控制照相机和光源系统的一般操作。

公开(公告)号：US20080180950A1

公开(公告)日：2008-07-31

申请号：US11811677

申请日：2007-06-11

申请人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

IPC分类号： F21S13/14

CPC分类号： G01N21/6486 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/441

摘要： The present invention provides an apparatus for white light observation and fluorescence diagnosis of skin diseases. More particularly, the present invention provides an apparatus for photodynamic diagnosis in which a plurality of excitation light emitting diodes (LEDs) is provided in an image pick-up head, the excitation LEDs being arranged to illuminate the entire examination region in the form of a mosaic by setting respective illumination light axes of the excitation LEDs to illuminate preassigned individual areas of the examination region, thus uniformly illuminating the examination region in a wide field of view with excitation light. In the apparatus for photodynamic diagnosis, the respective excitation LEDs are provided at the same or different angles based on the light axis of the object lens, and thereby it is possible that the beams of the light sources composed of the LEDs illuminate the field of view of the examination region uniformly, thus improving the uniformity of illumination. Moreover, the present invention provides an apparatus for photodynamic diagnosis in which warm white LEDs and cold white LEDs as white light sources are appropriately arranged so as to deliver natural colors and thereby to reproduce natural color images.

摘要翻译： 本发明提供了一种用于白光观察和皮肤疾病的荧光诊断的装置。 更具体地说，本发明提供了一种用于光动力学诊断的装置，其中多个激发发光二极管（LED）被提供在图像拾取头中，激发LED被布置成以整体形式照射整个检查区域 通过设置激发LED的各个照明光轴来照亮检查区域的预分配的各个区域，从而在激发光的宽视场内均匀地照射检查区域。 在光动力诊断装置中，基于物镜的光轴以相同或不同的角度设置各激发LED，由此，由LED组成的光源的光束可以照射视场 的检查区域均匀，从而提高了照明的均匀性。 此外，本发明提供了一种用于光动力诊断的装置，其中温白色LED和作为白光源的冷白光LED被适当地布置以便传送自然色，从而再现自然色图像。

公开(公告)号：US20080147053A1

公开(公告)日：2008-06-19

申请号：US11811912

申请日：2007-06-11

申请人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geun Hie Rim ,  Guang Hoon Kim ,  Geri V. Papayan

IPC分类号： A61B18/18

CPC分类号： A61N5/062 ,  A61B5/0071 ,  A61B5/441 ,  A61B2017/00057 ,  A61B2017/00747 ,  A61B2090/373 ,  A61N5/0616 ,  G01N21/6456 ,  G01N21/6486

摘要： The present invention provides an apparatus and method for photodynamic diagnosis and therapy of skin diseases and a light source system thereof that can improve the efficiency of skin diagnosis by accurately analyzing skin conditions using fluorescence and white light simultaneously and further carry out fluorescent diagnosis and photodynamic therapy in the same skin region simultaneously. The apparatus for photodynamic diagnosis and therapy of skin diseases of the present invention includes: a camera head including a case having a view hole, provided in front thereof, to be in contact with a skin region, a white light source provided so as to irradiate a white light from the inside of the case through the view hole onto the skin region, a digital color TV camera provided in the rear of the case, the camera head being provided to irradiate the white light, a fluorescence excitation light and a therapeutic light for the photodynamic therapy from the inside of the case onto the skin region being in contact with the view hole, and the digital color TV camera collecting the light from the skin region and outputting a generated image signal; a light source system, connected to the case of the camera head through a light guide capable of light transmission, for providing the fluorescence excitation light, the therapeutic light for the photodynamic therapy and the white light to be irradiated onto the skin region to the camera head; and an image processing and analysis system for receiving the image signal from the camera head to process, analyze and store to same, for displaying a color image by the white light, a fluorescence image by the excitation light and the therapeutic light for the photodynamic therapy, obtained by the digital color TV camera, and a synthesized image thereof, and for controlling the general operations of the camera head and the light source system.

公开(公告)号：US20080095669A1

公开(公告)日：2008-04-24

申请号：US11810915

申请日：2007-06-07

申请人： Uk Kang ,  Soo Jin Bae ,  Geri V Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geri V Papayan

IPC分类号： B32B5/02 ,  G01N21/76

CPC分类号： G01N21/6452 ,  G01N21/648 ,  G01N2201/063

摘要： Disclosed herein is an apparatus for and method of measuring bio-chips, which can implement an illumination method of a novel type that illuminates a bio sample (which may be also referred to as a “bio specimen”) through a side face of a substrate using a diffusion plate to form an evanescent field by the illumination light over the entire surface of a substrate so as to uniformly secure brightness of the illuminated light over a wide area of a substrate, thereby more efficiently measuring fluorescence information of a bio-chip over a wide field of view.

摘要翻译： 本文公开了一种测量生物芯片的装置和方法，其可以实现通过衬底的侧面照射生物样品（其也可以称为“生物样本”）的新型照明方法 使用扩散板通过在基板的整个表面上的照明光形成消逝场，从而均匀地将照明光的亮度保持在基板的宽阔区域上，从而更有效地测量生物芯片的荧光信息 广泛的视野。

公开(公告)号：US08017079B2

公开(公告)日：2011-09-13

申请号：US11810915

申请日：2007-06-07

申请人： Uk Kang ,  Soo Jin Bae ,  Geri V Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geri V Papayan

IPC分类号： G01N21/00

CPC分类号： G01N21/6452 ,  G01N21/648 ,  G01N2201/063

摘要： Disclosed herein is an apparatus for and method of measuring bio-chips, which can implement an illumination method of a novel type that illuminates a bio sample (which may be also referred to as a “bio specimen”) through a side face of a substrate using a diffusion plate to form an evanescent field by the illumination light over the entire surface of a substrate so as to uniformly secure brightness of the illuminated light over a wide area of a substrate, thereby more efficiently measuring fluorescence information of a bio-chip over a wide field of view.

摘要翻译： 本文公开了一种测量生物芯片的装置和方法，其可以实现通过衬底的侧面照射生物样品（其也可以称为“生物样本”）的新型照明方法 使用扩散板通过在基板的整个表面上的照明光形成消逝场，从而均匀地将照明光的亮度保持在基板的宽阔区域上，从而更有效地测量生物芯片的荧光信息 广泛的视野。

公开(公告)号：US08192686B2

公开(公告)日：2012-06-05

申请号：US13221482

申请日：2011-08-30

申请人： Uk Kang ,  Soo Jin Bae ,  Geri V. Papayan

发明人： Uk Kang ,  Soo Jin Bae ,  Geri V. Papayan

IPC分类号： G01N21/00

CPC分类号： G01N21/6452 ,  G01N21/648 ,  G01N2201/063

摘要： Disclosed herein is an apparatus for and method of measuring bio-chips, which can implement an illumination method of a novel type that illuminates a bio sample (which may be also referred to as a “bio specimen”) through a side face of a substrate using a diffusion plate to form an evanescent field by the illumination light over the entire surface of a substrate so as to uniformly secure brightness of the illuminated light over a wide area of a substrate, thereby more efficiently measuring fluorescence information of a bio-chip over a wide field of view.

摘要翻译： 本文公开了一种测量生物芯片的装置和方法，其可以实现通过衬底的侧面照射生物样品（其也可以称为“生物样本”）的新型照明方法 使用扩散板通过在基板的整个表面上的照明光形成消逝场，从而均匀地将照明光的亮度保持在基板的宽阔区域上，从而更有效地测量生物芯片的荧光信息 广泛的视野。

公开(公告)号：US20110270092A1

公开(公告)日：2011-11-03

申请号：US13016642

申请日：2011-01-28

申请人： Uk KANG ,  Soo Jin Bae ,  Guang Hoon Kim ,  Seung Yup Lee ,  Garry V. Papayan

发明人： Uk KANG ,  Soo Jin Bae ,  Guang Hoon Kim ,  Seung Yup Lee ,  Garry V. Papayan

IPC分类号： A61B6/00 ,  A61N5/06

CPC分类号： A61B5/0071 ,  A61N5/062 ,  A61N2005/0628 ,  G01J3/2823 ,  G01J3/4406 ,  G01J2003/1213

摘要： The present invention provides a fluorescence detection and photodynamic therapy apparatus including: a combined light source unit 10 including a plurality of coherent and non-coherent light sources 11, 12 and 13 configured to irradiate light onto a to-be-observed object while performing continuous illumination; an optical imaging unit 20 configured to form an image of the to-be-observed object 70 and project the image to an image processing/controlling system 34; a multispectral imaging unit 30 including a one-chip multispectral sensor and the image processing/controlling system 34; a blocking filter 40 installed between the to-be-observed object 70 and the one-chip multispectral sensor 32, the blocking filter being configured to block some light reflected off from the to-be-observed object 70 while allowing some light and fluorescent light to pass therethrough; a computer system 50 configured to process, analyze, reproduce and store the image acquired from the multispectral imaging unit 30, and transfer the image to a display device 60 and control the overall operation of all the related elements; and the display device 60 configured to display a processing result of the image by the computer system 50.

摘要翻译： 本发明提供了一种荧光检测和光动力治疗装置，其包括：组合光源单元10，包括多个相干和非相干光源11,12和13，其被配置为将光照射到被观察物体上，同时执行连续 照明; 光学成像单元20，被配置为形成待观察对象70的图像，并将图像投影到图像处理/控制系统34; 包括单芯片多光谱传感器和图像处理/控制系统34的多光谱成像单元30; 安装在被观察物体70和单芯片多光谱传感器32之间的阻挡滤光器40，阻挡滤光器被配置为阻挡从被观察物体70反射的一些光，同时允许一些光和荧光灯 通过; 被配置为处理，分析，再现和存储从多光谱成像单元30获取的图像的计算机系统50，并将图像传送到显示设备60并控制所有相关元件的整体操作; 并且显示装置60被配置为通过计算机系统50显示图像的处理结果。