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公开(公告)号：US07956191B2
公开(公告)日：2011-06-07
申请号：US11665651
申请日：2005-10-19
申请人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
发明人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
IPC分类号： C07D213/72 , C07D213/46
CPC分类号： C07D405/12 , C07D213/79 , C07D213/81 , C07D213/89 , C07D295/125 , C07D295/13 , C07D295/32 , C07D401/12
摘要： The invention provides novel, substituted 3-arylamino pyridine compounds (I) pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供新的取代的3-芳基氨基吡啶化合物（I）其药学上可接受的盐，溶剂合物和前药化合物，其中W，R 1，R 2，R 9，R 10，R 11，R 12，R 13，R 14如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗过度增殖性疾病，如癌症，再狭窄和炎症。 还公开了这样的化合物在哺乳动物，特别是人类中过度增殖性疾病的治疗和含有这些化合物的药物组合物中的应用。
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公开(公告)号：US08524911B2
公开(公告)日：2013-09-03
申请号：US13472721
申请日：2012-05-16
申请人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
发明人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
IPC分类号： C07D213/72 , C07D213/46
CPC分类号： C07D405/12 , C07D213/79 , C07D213/81 , C07D213/89 , C07D295/125 , C07D295/13 , C07D295/32 , C07D401/12
摘要： The invention provides novel, substituted 3-arylamino pyridine compounds pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供新的取代的3-芳基氨基吡啶化合物其药学上可接受的盐，溶剂合物和前药化合物，其中W，R 1，R 2，R 9，R 10，R 11，R 12，R 13，R 14如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗过度增殖性疾病，如癌症，再狭窄和炎症。 还公开了这样的化合物在哺乳动物，特别是人类中过度增殖性疾病的治疗和含有这些化合物的药物组合物中的应用。
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公开(公告)号：US20110224192A1
公开(公告)日：2011-09-15
申请号：US13112490
申请日：2011-05-20
申请人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
发明人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
IPC分类号： A61K31/55 , A61K31/44 , A61K31/443 , A61K31/5377 , A61K31/4545 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K31/4709 , A61K31/496 , A61K31/4433 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P17/00 , A61P17/06 , A61P3/10 , A61P27/02 , A61P9/10
CPC分类号： C07D405/12 , C07D213/79 , C07D213/81 , C07D213/89 , C07D295/125 , C07D295/13 , C07D295/32 , C07D401/12
摘要： The invention provides novel, substituted 3-arylamino pyridine compounds pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供新的取代的3-芳基氨基吡啶化合物其药学上可接受的盐，溶剂合物和前药化合物，其中W，R 1，R 2，R 9，R 10，R 11，R 12，R 13，R 14如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗过度增殖性疾病，如癌症，再狭窄和炎症。 还公开了这样的化合物在哺乳动物，特别是人类中过度增殖性疾病的治疗和含有这些化合物的药物组合物中的应用。
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公开(公告)号：US20120295889A1
公开(公告)日：2012-11-22
申请号：US13472721
申请日：2012-05-16
申请人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
发明人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
IPC分类号： C07D213/81 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/4709 , A61K31/4545 , A61K31/444 , A61K31/443 , A61K31/4439 , A61K31/44 , C07D413/12 , C07D401/12 , C07D413/04 , C07D405/12 , C07D213/79 , A61P9/10 , A61K31/4433 , C07D413/06 , C07D213/89 , C07D401/06 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P17/00 , A61P9/00 , A61P13/08 , A61P17/06 , A61P3/10 , A61P27/02 , A61P1/00 , A61K31/55
CPC分类号： C07D405/12 , C07D213/79 , C07D213/81 , C07D213/89 , C07D295/125 , C07D295/13 , C07D295/32 , C07D401/12
摘要： The invention provides novel, substituted 3-arylamino pyridine compounds pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供新的取代的3-芳基氨基吡啶化合物其药学上可接受的盐，溶剂合物和前药化合物，其中W，R 1，R 2，R 9，R 10，R 11，R 12，R 13，R 14如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗过度增殖性疾病，如癌症，再狭窄和炎症。 还公开了这样的化合物在哺乳动物，特别是人类中过度增殖性疾病的治疗和含有这些化合物的药物组合物中的应用。
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公开(公告)号：US08198457B2
公开(公告)日：2012-06-12
申请号：US13112490
申请日：2011-05-20
申请人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
发明人： Ulrich Abel , Holger Deppe , Achim Feurer , Ulrich Grädler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
IPC分类号： C07D213/72 , C07D211/70 , A01N43/58
CPC分类号： C07D405/12 , C07D213/79 , C07D213/81 , C07D213/89 , C07D295/125 , C07D295/13 , C07D295/32 , C07D401/12
摘要： The invention provides novel, substituted 3-arylamino pyridine compounds pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供新的取代的3-芳基氨基吡啶化合物其药学上可接受的盐，溶剂合物和前药化合物，其中W，R 1，R 2，R 9，R 10，R 11，R 12，R 13，R 14如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗过度增殖性疾病，如癌症，再狭窄和炎症。 还公开了这样的化合物在哺乳动物，特别是人类中过度增殖性疾病的治疗和含有这些化合物的药物组合物中的应用。
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公开(公告)号：US20090093462A1
公开(公告)日：2009-04-09
申请号：US11665651
申请日：2005-10-19
申请人： Ulricn Abel , Holger Deppe , Achim Feurer , Ulrich Gradler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
发明人： Ulricn Abel , Holger Deppe , Achim Feurer , Ulrich Gradler , Kerstin Otte , Renate Sekul , Meinolf Thiemann , Andreas Goutopoulos , Matthias Schwarz , Xuliang Jiang
IPC分类号： A61K31/44 , C07D405/12 , C07D213/72 , C07D413/12 , C07D401/12 , A61P29/00 , A61K31/4545 , A61K31/55 , A61K31/506 , A61K31/4439 , A61K31/5377 , A61P25/00 , A61P17/00 , C07D413/04 , A61K31/443
CPC分类号： C07D405/12 , C07D213/79 , C07D213/81 , C07D213/89 , C07D295/125 , C07D295/13 , C07D295/32 , C07D401/12
摘要： The invention provides novel, substituted 3-arylamino pyridine compounds (I) pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10, R11, R12, R13, R14 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
摘要翻译： 本发明提供新的取代的3-芳基氨基吡啶化合物（I）其药学上可接受的盐，溶剂合物和前药化合物，其中W，R 1，R 2，R 9，R 10，R 11，R 12，R 13，R 14如说明书中所定义。 这些化合物是MEK抑制剂，可用于治疗过度增殖性疾病，如癌症，再狭窄和炎症。 还公开了这样的化合物在哺乳动物，特别是人类中过度增殖性疾病的治疗和含有这些化合物的药物组合物中的应用。
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7.发明申请LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY 审中-公开通过亲和色谱法进行抗体和Fc融合蛋白纯化的配体公开(公告)号：US20130131321A1
公开(公告)日：2013-05-23
申请号：US13813860
申请日：2011-08-03
申请人： Holger Bittermann , Klaus Burkert , Marc Arnold , Oliver Keil , Thomas Neumann , Inge Ott , Kristina Schmidt , Daniel Schwizer , Renate Sekul
发明人： Holger Bittermann , Klaus Burkert , Marc Arnold , Oliver Keil , Thomas Neumann , Inge Ott , Kristina Schmidt , Daniel Schwizer , Renate Sekul
IPC分类号： C07K1/22 , C07D405/04 , C07D409/04 , C07D231/14 , C07D231/56 , C07D213/82 , C07D403/04 , C07D209/42 , C07D261/20 , C07D307/87 , C07D217/26 , C07D513/04 , C07D471/04 , C07D417/04 , C07D413/04 , C07D235/24 , C07D487/04 , C07D261/18 , C07D271/06 , C07D277/68 , C07D277/56 , C08B37/00
CPC分类号： C07K1/22 , B01D15/3804 , B01J20/289 , B01J20/3251 , B01J20/3253 , B01J20/3255 , C07D209/42 , C07D213/82 , C07D217/26 , C07D231/14 , C07D231/56 , C07D235/24 , C07D261/18 , C07D261/20 , C07D271/06 , C07D277/46 , C07D277/56 , C07D277/68 , C07D277/82 , C07D307/87 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , C07K16/00 , C08B37/0039
摘要： The present invention relates to the use for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) wherein Sp is a spacer group; v is 0 or 1; Am is an amide group —NR1—C(O)—, and wherein either NR1 is attached to Ar1 and —C(O)— is attached to Ar2, or —C(O)— is attached to Ar1 and NR1 is attached to Ar2; and R1 is hydrogen or C1 to C4 alkyl, preferably hydrogen or methyl; and more preferably hydrogen; Ar1 is a divalent 5- or 6-membered substituted or unsubstituted aromatic ring; Ar2 is 5- or 6-membered heterocyclic aromatic ring which is (a) attached to a further 5- or 6-membered aromatic ring via a single bond; or (b) fused to a further 5- or 6-membered aromatic ring as part of a multicyclic ring system; or (c) attached to at least one substituent selected from C1 to C4 alkyl; C2 to C4 alkenyl; C2 to C4 alkynyl; a halogen; C1 to C4 haloalkyl; hydroxyl-substituted C1 to C4 alkyl; C1 to C4 alkoxy; hydroxyl-substituted C1 to C4 alkoxy; C1 to C4 alkylamino; C1 to C4 alkylthio; and combinations thereof.
摘要翻译： 本发明涉及用于亲和纯化抗体或抗体片段的配体取代基质，其包含载体材料和至少一种与载体材料共价结合的配体，所述配体由式（I ）其中Sp为间隔基; v为0或1; Am是酰胺基-NR1-C（O） - ，并且其中NR1与Ar1连接，-C（O） - 连接到Ar2上，或-C（O） - 连接到Ar1上，并且NR1连接到 Ar2; 并且R 1是氢或C 1至C 4烷基，优选氢或甲基; 更优选氢; Ar1是二价的5-或6-元取代或未取代的芳环; Ar 2是5-或6-元杂环芳环，其是（a）通过单键与另一个5-或6-元芳环相连; 或（b）作为多环系统的一部分与另一个5-或6-元芳环稠合; 或（c）连接至至少一个选自C 1至C 4烷基的取代基; C2至C4烯基; C2至C4炔基; 卤素 C1至C4卤代烷基; 羟基取代的C1至C4烷基; C1至C4烷氧基; 羟基取代的C1至C4烷氧基; C1至C4烷基氨基; C1〜C4烷硫基; 及其组合。
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公开(公告)号：US06900177B1
公开(公告)日：2005-05-31
申请号：US09465718
申请日：1999-12-17
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K48/00 , A61P3/06 , A61P9/00 , A61P9/10 , C07K14/00 , C07K14/775 , A61K38/10 , C07K7/08
CPC分类号： A61K38/1709 , A61K48/00 , C07K7/08 , C07K14/001 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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公开(公告)号：US06376464B1
公开(公告)日：2002-04-23
申请号：US09453838
申请日：1999-12-01
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
IPC分类号： A61K3800
CPC分类号： C07K14/775 , A61K38/1709 , C07K7/08
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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公开(公告)号：US6046166A
公开(公告)日：2000-04-04
申请号：US940096
申请日：1997-09-29
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K48/00 , A61P3/06 , A61P9/00 , A61P9/10 , C07K14/00 , C07K14/775
CPC分类号： A61K38/1709 , C07K14/001 , C07K14/775 , C07K7/08 , A61K48/00
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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