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29 条记录 (耗时 0.022 秒)

    Process and catalyst for the conversion of CO/H.sub.2 O mixtures
    1.
    发明授权
    Process and catalyst for the conversion of CO/H.sub.2 O mixtures 失效
    CO / H2O混合物转化的工艺和催化剂

    公开(公告)号：US5082643A

    公开(公告)日：1992-01-21

    申请号：US257803

    申请日：1988-10-14

    申请人： Ulrich Schubert ,  Klaus Rose

    发明人： Ulrich Schubert ,  Klaus Rose

    IPC分类号： B01J31/16 ,  B01J31/20 ,  B01J31/24 ,  C01B3/16 ,  C07F15/00

    CPC分类号： C01B3/16 ,  B01J31/1675 ,  B01J31/20 ,  B01J31/2404 ,  B01J2531/822 ,  Y02P20/52

    摘要： The conversion of CO/H.sub.2 O mixtures, in particular water gas, is carr out in the presence of solid, polymer rhodium complex catalysts which are insoluble in aqueous and organic solvents and are obtainable by polycondensation of one or more rhodium complexes having at least one ligand which contains at least one group capable of coordinating to rhodium and at least one group forming an inorganic network in the polycondensation, either with itself or with one or more inorganic network-forming agents capable of undergoing polycondensation. Novel rhodium complexes of this type are also described.

    摘要翻译： CO / H 2 O混合物，特别是水煤气的转化在固体聚合物铑配合物催化剂的存在下进行，其不溶于水和有机溶剂，并且可通过一种或多种具有至少一个配体的铑络合物的缩聚获得 其包含至少一个能够在缩聚中与铑和至少一个形成无机网络的基团配位的基团，其自身或与一种或多种能够进行缩聚的无机网络形成剂。 还描述了这种类型的新型铑配合物。

    Rod-shaped element for liquid level detection and corresponding device for liquid level detection
    2.
    发明申请
    Rod-shaped element for liquid level detection and corresponding device for liquid level detection 失效
    用于液位检测的棒状元件和用于液位检测的相应装置

    公开(公告)号：US20060048570A1

    公开(公告)日：2006-03-09

    申请号：US11178571

    申请日：2005-07-11

    申请人： Heribert Eglauer ,  Gerhard Schlager ,  Uwe Kolb ,  Ulrich Schubert

    发明人： Heribert Eglauer ,  Gerhard Schlager ,  Uwe Kolb ,  Ulrich Schubert

    IPC分类号： G01F23/24 ,  H01R11/01 ,  H01R4/60

    CPC分类号： G01F23/242 ,  G01F23/24 ,  G01N2035/1025

    摘要： A metal rod-shaped element for a liquid detecting device is essentially cylindrical and has first and second ends. In at least one length, starting from the second end, the element has an isolating coating and an electrode strip is provided which extends along a longitudinal axis of the element. The electrode strip is not electrically connected to the element and the strip comprises a high impedance material. Two flattened sections are provided where the metal of the element lies openly. In a cross sectional view the electrode strip is situated between the two flattened sections. A first contact mechanism is provided in order to establish, in the range of the first end, an electrical contact to the rod-shaped element, and a second contact mechanism is provided in order to establish, within the range of the first end, an electrical contact to the electrode strip.

    摘要翻译： 用于液体检测装置的金属棒状元件基本上是圆柱形的并且具有第一和第二端。 在至少一个长度上，从第二端开始，元件具有隔离涂层，并且提供沿着元件的纵向轴线延伸的电极条。 电极条不与元件电连接，并且条带包括高阻抗材料。 提供两个扁平部分，其中元件的金属公开地放置。 在横截面图中，电极条位于两个平坦部分之间。 提供第一接触机构，以在第一端的范围内建立与杆状元件的电接触，并且提供第二接触机构，以便在第一端的范围内建立一个 电接触到电极条。

    Agents for treating <I>flaviviridae</I>infections
    3.
    发明申请
    Agents for treating flaviviridaeinfections 审中-公开
    用于治疗黄病毒感染的药剂

    公开(公告)号：US20050203029A1

    公开(公告)日：2005-09-15

    申请号：US10510355

    申请日：2003-04-04

    申请人： Ulrich Schubert ,  Hans Will ,  Huseyin Sirma

    发明人： Ulrich Schubert ,  Hans Will ,  Huseyin Sirma

    IPC分类号： A61K31/11 ,  A61K31/16 ,  A61K31/69 ,  A61K38/06 ,  A61P31/12 ,  A61K31/366 ,  A61K38/04

    CPC分类号： A61K31/69 ,  A61K31/11 ,  A61K31/16 ,  A61K38/06

    摘要： The invention relates to agents for the treatment, therapy and inhibition of Flaviviridae virus infections, which agents comprise proteasome inhibitors as the active component. The agents which are used for inhibiting the release, maturation and replication of Flaviviridae comprise, as the active component in pharmaceutical preparations, substance classes which share the common property of inhibiting the 26S proteasome in cells. These substance classes include, in particular, proteasome inhibitors which affect the activities of the ubiquitin/proteasome pathway, in particular the enzymic activities of the 26S and the 20S proteasome complex. The application of the invention lies in the antiviral therapy of Flaviviridae infections, especially in preventing the establishment and maintenance of a chronic hepatitis C virus infection and a hepatopathogenesis which is associated therewith.

    摘要翻译： 本发明涉及用于治疗，治疗和抑制黄病毒科病毒感染的药剂，该药物包含作为活性成分的蛋白酶体抑制剂。 用于抑制黄病毒科的释放，成熟和复制的药物包含作为药物制剂中的活性成分的具有抑制细胞中26S蛋白酶体的共同性质的物质类别。 这些物质类别特别包括影响泛素/蛋白酶体途径的活性的蛋白酶体抑制剂，特别是26S和20S蛋白酶体复合物的酶活性。 本发明的应用在于黄病毒科感染的抗病毒治疗，特别是在预防慢性丙型肝炎病毒感染的建立和维持以及与之相关的肝癌发病。

    Organofunctionalized aerogels
    5.
    发明授权
    Organofunctionalized aerogels 失效
    有机官能化气凝胶

    公开(公告)号：US6127306A

    公开(公告)日：2000-10-03

    申请号：US43054

    申请日：1998-07-06

    申请人： Nicola Husing ,  Ulrich Schubert

    发明人： Nicola Husing ,  Ulrich Schubert

    IPC分类号： B01J21/08 ,  B01J31/02 ,  B01J31/16 ,  B01J31/20 ,  B01J31/24 ,  B01J37/03 ,  C01B33/158 ,  C09K5/06 ,  B01J31/00 ,  C01B33/12

    CPC分类号： C09K5/063 ,  B01J21/08 ,  B01J31/1633 ,  B01J31/20 ,  B01J31/2404 ,  B01J37/033 ,  C01B33/1585 ,  B01J2531/822

    摘要： The invention relates to aerogels containing functional residues of the formula (I)--Y--Z, wherein Y is a straight-chained or branched alkylene group with 1 to 22 carbon atoms; Z is halogen, pseudohalogen, SR.sup.1, PR.sup.2 R.sup.3, colorant residue or metal complex residue; R.sup.1 is H, a straight-chained or branched alkyl group with 1 to 22 carbon atoms or an aryl group with 4 to 10 carbon atoms; and R.sup.2 and R.sup.3 are identical or different, a straight-chained or branched alkyl group with 1 to 22 carbon atoms, or an aryl group with 4 to 10 carbon atoms. The aerogels are suitable, for example, as catalyst stayes and/or sensors. They can be obtained by metal alcoholates and metal alcoholates in which at least one alcoholate residue is replaced by the --Y--Z group being converted into a lyogel by hydrolysis and condensation, and subsequently being dried.

    摘要翻译： PCT No.PCT / EP96 / 03999 Sec。 371日期：1998年7月6日 102（e）1998年7月6日PCT PCT 1996年9月12日PCT公布。 公开号WO97 / 10178 日期：1997年3月20日本发明涉及含有式（I）-Y-Z的功能性残基的气凝胶，其中Y是具有1至22个碳原子的直链或支链亚烷基; Z是卤素，假卤素，SR1，PR2R3，着色剂残基或金属络合物残基; R1是H，具有1至22个碳原子的直链或支链烷基或具有4至10个碳原子的芳基; R2和R3相同或不同，具有1至22个碳原子的直链或支链烷基或具有4至10个碳原子的芳基。 气凝胶例如作为催化剂残留物和/或传感器是合适的。 它们可以通过金属醇化物和金属醇化物获得，其中至少一个醇化物残基被-Y-Z基团替代，通过水解和缩合转化成lyogel，随后被干燥。

    AGENTS FOR TREATING FLAVIVIRIDAE INFECTIONS
    8.
    发明申请
    AGENTS FOR TREATING FLAVIVIRIDAE INFECTIONS 审中-公开
    用于治疗感冒的药剂

    公开(公告)号：US20100135966A1

    公开(公告)日：2010-06-03

    申请号：US12624271

    申请日：2009-11-23

    申请人： Ulrich Schubert ,  Hans Will ,  Hüseyin Sirma

    发明人： Ulrich Schubert ,  Hans Will ,  Hüseyin Sirma

    IPC分类号： A61K35/12 ,  A61K31/40 ,  A61K31/336

    CPC分类号： A61K31/69 ,  A61K31/11 ,  A61K31/16 ,  A61K38/06

    摘要： The invention relates to agents for the treatment, therapy and inhibition of Flaviviridae virus infections, which agents comprise proteasome inhibitors as the active component. The agents which are used for inhibiting the release, maturation and replication of Flaviviridae comprise, as the active component in pharmaceutical preparations, substance classes which share the common property of inhibiting the 26S proteasome in cells. These substance classes include, in particular, proteasome inhibitors which affect the activities of the ubiquitin/proteasome pathway, in particular the enzymic activities of the 26S and the 20S proteasome complex. The application of the invention lies in the antiviral therapy of Flaviviridae infections, especially in preventing the establishment and maintenance of a chronic hepatitis C virus infection and a hepatopathogenesis which is associated therewith.

    摘要翻译： 本发明涉及用于治疗，治疗和抑制黄病毒科病毒感染的药剂，该药物包含作为活性成分的蛋白酶体抑制剂。 用于抑制黄病毒科的释放，成熟和复制的药物包含作为药物制剂中的活性成分的具有抑制细胞中26S蛋白酶体的共同性质的物质类别。 这些物质类别特别包括影响泛素/蛋白酶体途径的活性的蛋白酶体抑制剂，特别是26S和20S蛋白酶体复合物的酶活性。 本发明的应用在于黄病毒科感染的抗病毒治疗，特别是在预防慢性丙型肝炎病毒感染的建立和维持以及与之相关的肝癌发病。

    Methods of identifying agents for inhibiting lentivirus replication
    10.
    发明授权
    Methods of identifying agents for inhibiting lentivirus replication 有权
    识别抑制慢病毒复制的药物的方法

    公开(公告)号：US07108988B2

    公开(公告)日：2006-09-19

    申请号：US10285263

    申请日：2002-10-30

    申请人： Michael Sherman ,  Warner Greene ,  Ulrich Schubert ,  Victor Wray ,  Uwe Tessmer ,  Peter Henklein ,  Karsten Bruns

    发明人： Michael Sherman ,  Warner Greene ,  Ulrich Schubert ,  Victor Wray ,  Uwe Tessmer ,  Peter Henklein ,  Karsten Bruns

    IPC分类号： C12Q1/70

    CPC分类号： G01N33/56983 ,  C12Q1/18 ,  C12Q1/533 ,  G01N2333/163 ,  G01N2500/04

    摘要： The present invention provides screening methods for identifying a compound that induces loss of the lentiviral protein Vpr; screening methods for identifying compounds that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr; and compounds identified by the screening methods. The compounds are useful for treating a lentiviral infection. The present invention further provides methods of inducing loss of the lentiviral protein Vpr; methods of inhibiting lentivirus viral replication; and methods of treating a lentivirus infection in an individual. The methods generally involve administering to an individual infected with the lentivirus an effective amount of a compound that induces Vpr loss and/or that inhibits PPIase activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr.

    摘要翻译： 本发明提供用于鉴定诱导慢病毒蛋白Vpr的缺失的化合物的筛选方法; 用于鉴定抑制Vpr中顺式 - 反式异构化顺式 - 反式异构化的蛋白质的蛋白质的肽基 - 脯氨酰顺/反异构酶（PPIase）活性的化合物的筛选方法; 和通过筛选方法鉴定的化合物。 该化合物可用于治疗慢病毒感染。 本发明还提供诱导慢病毒蛋白Vpr的损失的方法; 抑制慢病毒病毒复制的方法; 以及治疗个体慢病毒感染的方法。 所述方法通常涉及向感染了慢病毒的个体施用有效量的诱导Vpr损失的化合物和/或抑制在Vpr中催化顺式 - 肽基脯氨酸键顺式 - 反式异构化的蛋白质的PPIase活性。