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公开(公告)号：US20170281607A1
公开(公告)日：2017-10-05
申请号：US15474430
申请日：2017-03-30
发明人： Mark Davies
IPC分类号： A61K31/437 , A61K45/06
CPC分类号： A61K31/437 , A61K31/155 , A61K31/428 , A61K31/451 , A61K38/28 , A61K45/06 , A61K47/542 , A61K2300/00
摘要： This invention relates to compositions and methods for treating type I diabetes. Compositions of the invention include active compounds such as harmine, INDY, or derivatives thereof to induce reproduction of beta cells. These active compounds are provided in amounts that have poor clinical efficacy on their own, but when administered at a sub-threshold dose in combination with compounds such as insulin, which helps to maintain steady levels of insulin in the body; metformin, which decreases glucose levels; and repaglinide, which increases insulin production, allow for the slow and steady increase of beta cells.
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公开(公告)号：US20170080426A1
公开(公告)日：2017-03-23
申请号：US15310613
申请日：2015-05-14
发明人： Mark Davies
CPC分类号： B01L3/50857 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01F13/0083 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/5025 , B01L3/502738 , B01L3/502784 , B01L7/525 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/12 , B01L2300/021 , B01L2300/0627 , B01L2300/0654 , B01L2300/0663 , B01L2300/0829 , B01L2300/0864 , B01L2300/0874 , B01L2300/088 , B01L2300/16 , B01L2300/165 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/022 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , B01L2400/065 , B01L2400/0688 , C12M23/12 , C12M23/16 , C12Q1/18 , G01N33/5011 , G01N33/5044
摘要： The invention provides mechanical devices that can be used to combine reagents and discover their effects on living cells. A device of the invention holds liquids in open-ended channels and transfers liquids from one channel to another by bringing a second channel into proximity and alignment with an open end of a first channel. Channels of the device can include fluid partitions (e.g., water-oil-water emulsions) that include living cells. The device includes a mechanical system the operation of which causes a receiving channel to pass among supply channels, aligning with each in turn, to pick up chemicals from those channels and make new combinations within the receiving channel. The device then presents those new chemical combinations to the living cells within their respective partitions, thereby allowing for the determination of the effects of those combinations on living cells.
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3.发明申请公开(公告)号：US20170080417A1
公开(公告)日：2017-03-23
申请号：US15310600
申请日：2015-05-14
发明人： Mark Davies
CPC分类号： B01L3/50857 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01F13/0083 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/5025 , B01L3/502738 , B01L3/502784 , B01L7/525 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/12 , B01L2300/021 , B01L2300/0627 , B01L2300/0654 , B01L2300/0663 , B01L2300/0829 , B01L2300/0864 , B01L2300/0874 , B01L2300/088 , B01L2300/16 , B01L2300/165 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/022 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , B01L2400/065 , B01L2400/0688 , C12M23/12 , C12M23/16 , C12Q1/18 , G01N33/5011 , G01N33/5044
摘要： The invention generally relates to microfluidic devices that include channels that are slidable relative to each other and methods of use thereof. In certain embodiments, the invention provides a microfluidic device that includes a first channel having an open end, and a second channel having an open end. The first and second channels are slidable relative to each other such that when the open end of the first channel and the open end of the second channel are aligned with each other, fluid flows from the first channel into the second channel.
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公开(公告)号：US20180304223A1
公开(公告)日：2018-10-25
申请号：US15738026
申请日：2016-06-23
发明人： Mark Davies , Michael Galvin
CPC分类号： B01J19/0093 , B01F13/0071 , B01J19/0046 , B01J19/28 , B01J2219/00286 , B01J2219/00288 , B01J2219/00313 , B01J2219/00326 , C40B60/14
摘要： The present invention provides a rotating microfluidic device capable of combining portions of various liquids into a single droplet, thus generating millions of droplets with differing compositions.
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公开(公告)号：US20170216838A1
公开(公告)日：2017-08-03
申请号：US15310607
申请日：2015-05-14
发明人： Mark Davies
CPC分类号： B01L3/50857 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01F13/0083 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/5025 , B01L3/502738 , B01L3/502784 , B01L7/525 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/12 , B01L2300/021 , B01L2300/0627 , B01L2300/0654 , B01L2300/0663 , B01L2300/0829 , B01L2300/0864 , B01L2300/0874 , B01L2300/088 , B01L2300/16 , B01L2300/165 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/022 , B01L2400/0406 , B01L2400/0415 , B01L2400/043 , B01L2400/0457 , B01L2400/0487 , B01L2400/065 , B01L2400/0688 , C12M23/12 , C12M23/16 , C12Q1/18 , G01N33/5011 , G01N33/5044
摘要： The invention generally relates to microfluidic devices that include orthogonally positioned channels that are slidable relative to each other and methods of use thereof. In certain embodiments, the invention provides a microfluidic device that includes a first channel having an open end, and an open second channel. The first and second channels are slidable relative to each other such that when the open end of the first channel and the open portion of the open second channel are aligned with each other, fluid flows from the first channel into the second channel.
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