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1.发明申请公开(公告)号：US20220213465A1
公开(公告)日：2022-07-07
申请号：US17526743
申请日：2021-11-15
摘要： The present invention relates to a method for concentrating a biological sample containing nucleic acids by using magnetic chitosan microparticles and subsequently performing a PCR reaction on the nucleic acids captured on the microparticles. The chitosan microparticles added to the biological sample at a PCR compatible pH are mechanically agitated to provide for cell lysis and simultaneous DNA capture, and then serve as a solid support for the nucleic acid template during the PCR reaction. As the chitosan microparticles are utilized for lysis and the nucleic acids do not need to be removed from the microparticles before PCR, the ease of the sample preparation procedure is dramatically improved.
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2.发明申请ADVANCED FUNCTIONAL BIOCOMPATIBLE POLYMERIC MATRIX USED AS A HEMOSTATIC AGENT AND SYSTEM FOR DAMAGED TISSUES AND CELLS 审中-公开用作破坏性组织和细胞的HEMOSTATIC AGENT和系统的高级功能生物易化聚合物基质公开(公告)号：US20150175718A1
公开(公告)日：2015-06-25
申请号：US14595542
申请日：2015-01-13
IPC分类号： C08B37/00
摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.
摘要翻译： 公开了止血组织密封剂海绵和用于急性创伤的喷雾剂。 海绵包括疏水改性的聚合物，其将自身锚定在伤口附近的细胞膜内。 该密封足够坚固以基本上防止海绵边界内的血液损失，但足够弱到基本上防止在恢复和随后去除海绵时对新形成的组织的损伤。 在实例中，聚合物固有地防止微生物感染并且适合于正常伤口代谢期间所需的氧传递。 喷雾剂包含疏水改性的聚合物，其形成具有血细胞的固体凝胶网络以产生物理凝结机制以防止血液流失。 在一个实例中，喷雾剂还包含至少一种增加凝块的机械完整性的试剂。 在另一个实例中，试剂防止伤口的微生物感染。
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3.发明授权公开(公告)号：US10183291B2
公开(公告)日：2019-01-22
申请号：US15857754
申请日：2017-12-29
摘要： The invention relates to a method and system for generating droplets of an aqueous solution on a microfluidic chip with an air continuous phase. Specifically, the droplet generator according to the present invention is integrated into a microfluidic chip to generate and introduce droplets of an aqueous solution into the microfluidic chip. The droplets travelling in a network of chip channels may be captured in on-chip traps in a manner defined by hydrodynamic resistances of chip channels. A biological reaction may be performed on a droplet trapped on the microfluidic chip.
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4.发明申请公开(公告)号：US20180117589A1
公开(公告)日：2018-05-03
申请号：US15857754
申请日：2017-12-29
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2200/0621 , B01L2200/0642 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0858 , B01L2300/0864 , B01L2300/088 , B01L2300/10 , B01L2300/14 , B01L2300/18 , B01L2400/0487 , B01L2400/0666 , B01L2400/0688
摘要： The invention relates to a method and system for generating droplets of an aqueous solution on a microfluidic chip with an air continuous phase. Specifically, the droplet generator according to the present invention is integrated into a microfluidic chip to generate and introduce droplets of an aqueous solution into the microfluidic chip. The droplets travelling in a network of chip channels may be captured in on-chip traps in a manner defined by hydrodynamic resistances of chip channels. A biological reaction may be performed on a droplet trapped on the microfluidic chip.
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公开(公告)号：US10179145B2
公开(公告)日：2019-01-15
申请号：US15001215
申请日：2016-01-19
IPC分类号： A61K31/722 , A61K47/56 , A61K47/61 , A61L27/20 , A61L26/00 , A61K9/127 , A61K9/70 , A61K47/69
摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.
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6.发明申请公开(公告)号：US20160206777A1
公开(公告)日：2016-07-21
申请号：US15001215
申请日：2016-01-19
IPC分类号： A61L26/00
CPC分类号： A61K31/722 , A61K9/127 , A61K9/1271 , A61K9/7007 , A61K47/56 , A61K47/61 , A61K47/69 , A61L26/0023 , A61L27/20 , A61L2300/216 , A61L2300/232 , A61L2300/418 , A61L2300/626 , A61L2400/04 , A61L2400/12 , C08L5/08
摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.
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7.发明授权公开(公告)号：US10675624B2
公开(公告)日：2020-06-09
申请号：US16252020
申请日：2019-01-18
摘要： The invention relates to a method and system for generating droplets of an aqueous solution on a microfluidic chip with an air continuous phase. Specifically, the droplet generator according to the present invention is integrated into a microfluidic chip to generate and introduce droplets of an aqueous solution into the microfluidic chip. The droplets travelling in a network of chip channels may be captured in on-chip traps in a manner defined by hydrodynamic resistances of chip channels. A biological reaction may be performed on a droplet trapped on the microfluidic chip.
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8.发明申请公开(公告)号：US20190224672A1
公开(公告)日：2019-07-25
申请号：US16252020
申请日：2019-01-18
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/502784 , B01L2200/0621 , B01L2200/0642 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0858 , B01L2300/0864 , B01L2300/088 , B01L2300/10 , B01L2300/14 , B01L2300/18 , B01L2400/0487 , B01L2400/0666 , B01L2400/0688
摘要： The invention relates to a method and system for generating droplets of an aqueous solution on a microfluidic chip with an air continuous phase. Specifically, the droplet generator according to the present invention is integrated into a microfluidic chip to generate and introduce droplets of an aqueous solution into the microfluidic chip. The droplets travelling in a network of chip channels may be captured in on-chip traps in a manner defined by hydrodynamic resistances of chip channels. A biological reaction may be performed on a droplet trapped on the microfluidic chip.
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9.发明申请公开(公告)号：US20190160092A1
公开(公告)日：2019-05-30
申请号：US16195770
申请日：2018-11-19
IPC分类号： A61K31/722 , A61K47/56 , A61K9/70 , A61K47/61 , A61K47/69 , A61K9/127 , A61L27/20 , A61L26/00
摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.
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10.发明申请公开(公告)号：US20150175714A1
公开(公告)日：2015-06-25
申请号：US14595551
申请日：2015-01-13
IPC分类号： C08B15/00
摘要： A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.
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