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公开(公告)号：US12133728B2
公开(公告)日：2024-11-05
申请号：US18094206
申请日：2023-01-06
Inventor： John R. Chevillet , Tatiana D. Khokhlova , George R. Schade , Joo Ha Hwang , Muneesh Tewari
Abstract: The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.
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公开(公告)号：US20190117243A1
公开(公告)日：2019-04-25
申请号：US16169945
申请日：2018-10-24
Applicant: University of Washington
Inventor： Tatiana Khokhlova , Vera Khoklova , Oleg A. Sapozhnikov , Wayne Kreider , Adam D. Maxwell , Joo Ha Hwang
Abstract: Apparatus and method for improved cavitation-induced drug delivery is disclosed. In one embodiment, a method for delivering a treatment composition to a target tissue using ultrasound includes: directing ultrasound waveforms toward the target tissue of a patient; generating ultrasound shock fronts at the target tissue of a patient; generating a cavitation inside the target tissue of a patient by the ultrasound shock front; and delivering the treatment composition to the patient. Absorption of the treatment composition by the target tissue is increased by the cavitation inside the target tissue. In some embodiments, the treatment composition may be delivered within a time period of +/−1 week from generating the cavitation.
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Patent Agency Ranking
3.发明申请METHODS AND SYSTEMS FOR NON-INVASIVE TREATMENT OF TISSUE USING HIGH INTENSITY FOCUSED ULTRASOUND THERAPY 有权使用高强度聚焦超声治疗非组织治疗组织的方法和系统公开(公告)号：US20150119763A1
公开(公告)日：2015-04-30
申请号：US14516442
申请日：2014-10-16
Inventor： Michael S. Canney , Michael R. Bailey , Lawrence A. Crum , Vera A. Khokhlova , Tatiana D. Khokhlova , Wayne Kreider , Joo Ha Hwang , Oleg A. Sapozhnikov
IPC: A61N7/02
CPC classification number: A61N7/02 , A61B2017/00084 , A61B2018/00005 , A61B2090/374 , A61B2090/378
Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.
Abstract translation: 使用高强度聚焦超声（“HIFU”）治疗非侵入性治疗组织的方法和系统。 例如，根据本技术的实施例的非侵入性治疗组织的方法可以包括将超声源的焦平面定位在组织中的目标部位。 超声波源可被配置为发射HIFU波。 该方法还可以包括将来自超声源的超声能量脉冲向目标部位，并在组织内产生冲击波，以在毫秒内诱导目标部位的组织沸腾。 组织的沸腾至少基本上乳化组织。
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公开(公告)号：US09700742B2
公开(公告)日：2017-07-11
申请号：US14516442
申请日：2014-10-16
Inventor： Michael S. Canney , Michael R. Bailey , Lawrence A. Crum , Vera A. Khokhlova , Tatiana D. Khokhlova , Wayne Kreider , Joo Ha Hwang , Oleg A. Sapozhnikov
CPC classification number: A61N7/02 , A61B2017/00084 , A61B2018/00005 , A61B2090/374 , A61B2090/378
Abstract: Methods and systems for non-invasive treatment of tissue using high intensity focused ultrasound (“HIFU”) therapy. A method of non-invasively treating tissue in accordance with an embodiment of the present technology, for example, can include positioning a focal plane of an ultrasound source at a target site in tissue. The ultrasound source can be configured to emit HIFU waves. The method can further include pulsing ultrasound energy from the ultrasound source toward the target site, and generating shock waves in the tissue to induce boiling of the tissue at the target site within milliseconds. The boiling of the tissue at least substantially emulsifies the tissue.
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公开(公告)号：US20240041358A1
公开(公告)日：2024-02-08
申请号：US18094206
申请日：2023-01-06
Inventor： John R. Chevillet , Tatiana D. Khokhlova , George R. Schade , Joo Ha Hwang , Muneesh Tewari
CPC classification number: A61B5/14546 , A61B8/08 , A61B8/5223 , A61B5/145 , C12Q1/6886 , A61B5/14507 , A61B5/15 , A61B5/4836 , A61B10/0038 , A61B10/007 , A61N7/022 , A61N7/02 , C12Q2600/118 , C12Q2600/158 , A61B2010/0077
Abstract: The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.
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公开(公告)号：US20210038135A1
公开(公告)日：2021-02-11
申请号：US16936095
申请日：2020-07-22
Inventor： John R. Chevillet , Tatiana D. Khokhlova , George R. Schade , Joo Ha Hwang , Muneesh Tewari
Abstract: The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.
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公开(公告)号：US09743909B1
公开(公告)日：2017-08-29
申请号：US14278197
申请日：2014-05-15
Inventor： Oleg A. Sapozhnikov , Michael R. Bailey , Joo Ha Hwang , Tatiana D. Khokhlova , Vera Khokhlova , Matthew O'Donnell , Tong Li
CPC classification number: A61B8/481 , A61B5/0051 , A61B5/0062 , A61B5/0507 , A61N7/00
Abstract: A method for imaging a cavitation bubble includes producing a vibratory wave that induces a cavitation bubble in a medium, producing one or more detection waves directed toward the induced cavitation bubble, receiving one or more reflection waves, identifying a change in one or more characteristics of the induced cavitation bubble, and generating an image of the induced cavitation bubble using a computing device on the basis of the identified change in the one or more characteristics. The one or more received reflection waves correspond to at least one of the one or more produced detection waves reflection from the induced cavitation bubble. The identified change in one or more characteristics corresponds to the one or more received reflection waves.
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