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公开(公告)号：US07807401B2
公开(公告)日：2010-10-05
申请号：US12330725
申请日：2008-12-09
IPC分类号： C12Q1/37
CPC分类号： G01N33/723 , G01N2333/95
摘要： The present invention relates to a reagent for digestion of hemoglobin comprising a buffer, pepsin and a 1,3-dialkyl-imidazolium salt. It also discloses to the use of this reagent in a method for digesting hemoglobin, in a method for detecting HbA1c, and to a sampling tube for collection of a whole blood sample comprising said reagent for digesting hemoglobin.
摘要翻译： 本发明涉及一种用于消化血红蛋白的试剂，其包含缓冲液，胃蛋白酶和1,3-二烷基 - 咪唑鎓盐。 还公开了在用于消化血红蛋白的方法中使用该试剂，在检测HbA1c的方法中，以及用于收集包含用于消化血红蛋白的所述试剂的全血样品的采样管。
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公开(公告)号：US20090246814A1
公开(公告)日：2009-10-01
申请号：US12330725
申请日：2008-12-09
CPC分类号： G01N33/723 , G01N2333/95
摘要： The present invention relates to a reagent for digestion of hemoglobin comprising a buffer, pepsin and a 1,3-dialkyl-imidazolium salt. It also discloses to the use of this reagent in a method for digesting hemoglobin, in a method for detecting HbA1c, and to a sampling tube for collection of a whole blood sample comprising said reagent for digesting hemoglobin.
摘要翻译： 本发明涉及一种用于消化血红蛋白的试剂，其包含缓冲液，胃蛋白酶和1,3-二烷基 - 咪唑鎓盐。 还公开了在用于消化血红蛋白的方法中使用该试剂，在检测HbA1c的方法中，以及用于收集包含用于消化血红蛋白的所述试剂的全血样品的采样管。
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公开(公告)号：US5204242A
公开(公告)日：1993-04-20
申请号：US761335
申请日：1991-09-17
IPC分类号： C07C37/00 , C07C39/24 , C07C39/27 , C07C43/178 , C07C59/52 , C07C59/56 , C07C69/732 , C07C205/56 , C07C215/48 , C07C215/66 , C07C235/34 , C07C309/24 , C07C309/68 , C07C311/13 , C07C311/27 , G01N31/22 , G03C7/34
CPC分类号： C07C235/34 , C07C205/56 , C07C309/24 , C07C311/27 , C07C39/27 , C07C59/52 , C07C59/56 , G03C7/346
摘要： The present invention provides a colorimetric process for the detection of an oxidative coupling reaction in which a coupling component is reacted with a developer component in the presence of an oxidation agent to give a colored material, wherein, as coupling component, there is used a compound of the general formula: ##STR1## in which X is a bromine or chlorine atom, n is 1, 2 or 3, Y is COOR, CONRR', SO.sub.3 R, SO.sub.2 NRR', OR, NRR' or NRR'R".sym. and R, R' and R", independently of one another, are hydrogen atoms or C.sub.1 -C.sub.3 -alkyl radicals.The present invention also provides a reagent which contains the above compound, as well as new substituted phenols and a process for the preparation thereof.
摘要翻译： 本发明提供了一种用于检测氧化偶联反应的比色方法，其中偶联组分在氧化剂存在下与显影剂组分反应，得到着色材料，其中作为偶联组分，使用化合物 其中X是溴或氯原子，其中n是1,2或3，Y是COOR，CONRR'，SO3R，SO2NRR'，OR，NRR'或NRR'R “（+）”和“R”，“R”和“R”彼此独立地是氢原子或C1-C3-烷基。 本发明还提供了含有上述化合物的试剂，以及新的取代酚类及其制备方法。
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4.发明授权Process for reduction of the matrix effect in a fructosamine determination assay 失效降低木糖胺测定法中基质效应的方法
公开(公告)号：US5156947A
公开(公告)日：1992-10-20
申请号：US064336
申请日：1987-06-19
CPC分类号： C12Q1/26 , G01N33/66 , Y10S436/825 , Y10S436/904 , Y10T436/144444 , Y10T436/25125
摘要： This invention teaches a process for reducing protein matrix effects in assays for serum fructosamine. Blood or blood derived samples are used, and one adds two reagents, one of which reduces interference caused by non-specific reducing substances, the other of which eliminates turbidity. Incubation follows, and then the pH of the sample is adjusted and color forming reagent is added. In one embodiment, the incubation time is only 1-15 minutes. In another embodiment, the first reagent contains peroxidase.
摘要翻译： 本发明教导了一种在血清果糖胺测定中降低蛋白质基质效应的方法。 使用血液或血液来源的样品，并加入两种试剂，其中之一减少了由非特异性还原物质引起的干扰，另外一种可以消除浊度。 进行培养，然后调节样品的pH并加入成色试剂。 在一个实施方案中，孵育时间仅为1-15分钟。 在另一个实施方案中，第一试剂含有过氧化物酶。
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5.发明授权Process and reagent composition for determination of fructosamine in body fluids 失效体液中木糖胺的测定方法及试剂组合物
公开(公告)号：US5055388A
公开(公告)日：1991-10-08
申请号：US190600
申请日：1988-05-05
CPC分类号： C12Q1/26 , C12Q1/54 , Y10S436/904 , Y10T436/144444 , Y10T436/25 , Y10T436/25125
摘要： A process for the determination of fructosamine in body fluids by the reaction of a sample solution with a color reagent, wherein the sample liquid is mixed with a buffer solution having a pH value of from 9 to 12, a color-forming reagent and uricase, as well as with at least one detergent, and the chronological change of the extinction is measured kinetically in a temperature range of from 20.degree. to 40.degree. C. at the earliest after 5 minutes.
摘要翻译： 通过将样品溶液与着色试剂反应来测定体液中的果糖胺的方法，其中将样品液与pH值为9〜12的缓冲溶液，成色剂和尿酸酶混合， 以及至少一种洗涤剂，并且在5分钟后最早在20℃至40℃的温度范围内动态地测量消光的时间顺序变化。
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公开(公告)号：US20140144570A1
公开(公告)日：2014-05-29
申请号：US14232037
申请日：2012-07-26
申请人： Erwin Herre , Bernd Vogt
发明人： Erwin Herre , Bernd Vogt
CPC分类号： B32B37/14 , F24S23/82 , F24S25/632 , F24S80/00 , F24S2023/832 , F24S2025/601 , G02B7/183 , Y02E10/40
摘要： A method and a device for producing mirror units for heliostats, comprising a main body as a carrier of a reflective surface and a fixing carriage to ensure stress-free mounting of the main body during production, comprising the following features: a) a feed for main bodies (13) by means of a mirror-carrier delivery feed (3), b) a feed for fixing carriages (2) by means of running rails (4), c) a device for transferring a main body (13) into a fixing carriage, d) a mirror feed (8), e) an adhesive bonding device (5), f) a device for pressing a main body (13) together with a plurality of mirrors (11) and g) a measuring device (9) for checking relevant tolerances of the production process.
摘要翻译： 一种用于生产定日镜的反射镜单元的方法和装置，包括作为反射表面的载体的主体和用于在生产过程中确保主体无应力安装的固定托架，包括以下特征：a） 主体（13），b）用于通过运行轨道（4）固定托架（2）的进给，c）用于将主体（13）传送到 固定托架，d）反射镜进给器（8），e）粘合装置（5），f）用于将主体（13）与多个反射镜（11）一起挤压的装置，以及g）测量装置 （9）检查生产过程的相关公差。
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7.发明授权
公开(公告)号：US5116762A
公开(公告)日：1992-05-26
申请号：US377603
申请日：1989-07-10
CPC分类号： G01N33/96 , G01N33/66 , Y10S436/904 , Y10T436/10 , Y10T436/104998 , Y10T436/105831 , Y10T436/144444
摘要： The present invention provides a process for the determination of fructosamine in body fluids using as a standard, a solution which contains a peptide or protein, the amino acid units of which consist of at least 25% of lysine and/or ornithine and is present in glycosylated form.The present invention also provides a standard solution for the determination of fructosamine containing a peptide or protein, the amino acid unit content of which consists of at least 25% lysine and/or ornithine and is present in glycosylated form, and a method of calibrating such a standard solution.
摘要翻译： 本发明提供了使用标准测定体液中的果糖胺的方法，该方法含有肽或蛋白质，其氨基酸单元由赖氨酸和/或鸟氨酸的至少25％组成，并存在于 糖基化形式。 本发明还提供了用于测定含有肽或蛋白质的果糖胺的标准溶液，所述肽或蛋白质的氨基酸单元含量由至少25％的赖氨酸和/或鸟氨酸组成并且以糖基化形式存在，并且其校准方法 一个标准的解决方案。
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公开(公告)号：US09315005B2
公开(公告)日：2016-04-19
申请号：US14232037
申请日：2012-07-26
申请人： Erwin Herre , Bernd Vogt
发明人： Erwin Herre , Bernd Vogt
CPC分类号： B32B37/14 , F24S23/82 , F24S25/632 , F24S80/00 , F24S2023/832 , F24S2025/601 , G02B7/183 , Y02E10/40
摘要： A method and a device for producing mirror units for heliostats, comprising a main body as a carrier of a reflective surface and a fixing carriage to ensure stress-free mounting of the main body during production, comprising the following features: a) a feed for main bodies (13) by means of a mirror-carrier delivery feed (3), b) a feed for fixing carriages (2) by means of running rails (4), c) a device for transferring a main body (13) into a fixing carriage, d) a mirror feed (8), e) an adhesive bonding device (5), f) a device for pressing a main body (13) together with a plurality of mirrors (11) and g) a measuring device (9) for checking relevant tolerances of the production process.
摘要翻译： 一种用于生产定日镜的反射镜单元的方法和装置，包括作为反射表面的载体的主体和用于在生产过程中确保主体无应力安装的固定托架，包括以下特征：a） 主体（13），b）用于通过运行轨道（4）固定托架（2）的进给，c）用于将主体（13）传送到 固定托架，d）反射镜进给器（8），e）粘合装置（5），f）用于将主体（13）与多个反射镜（11）一起挤压的装置，以及g）测量装置 （9）检查生产过程的相关公差。
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9.发明授权Process and reagent for the specific determination of fructosamine content in blood and samples obtained from blood 失效用于特异性测定血液中血凝素含量的过程和试剂和血液中获得的样品
公开(公告)号：US5149633A
公开(公告)日：1992-09-22
申请号：US249381
申请日：1988-09-26
CPC分类号： C12Q1/26 , C12Q1/34 , G01N33/66 , G01N33/96 , C12Q2326/92 , Y10S436/904 , Y10T436/144444 , Y10T436/173845 , Y10T436/25 , Y10T436/25125
摘要： Process for the specific determination of the serum fructosamine content in blood or in samples obtained from blood by reaction with an appropriate color reagent and measurement of the color change thereby brought about, in which before the color reaction sample components with a non-specific reducing action and/or causing turbidity are removed and subsequently the color reagent is added at a pH value of from 10 to 12. The sample components are removed by treatment at approximately neutral pH value with a reagent composition comprising at least one enzymatic oxidation agent, optionally together with peroxidase and/or catalase and/or lipase, as well as with at least one SH group-blocking substance. A kit for the specific determination of the serum fructosamine content in blood or samples obtained from blood, comprises said reagent composition, a rebuffering reagent with a buffer which has an alkaline pH value and a color reagent for the detection of fructosamine.
摘要翻译： 通过与适当的着色剂反应，测定血液中或血液中得到的样品中的血清果糖胺含量的特异性测定方法，由此产生颜色变化，其中在着色反应之前，具有非特异性还原作用的样品成分 和/或引起浊度被除去，随后在10至12的pH值下加入显色试剂。通过用大约中性pH值处理的样品组分除去，试剂组合物包含至少一种酶氧化剂，任选地一起 与过氧化物酶和/或过氧化氢酶和/或脂肪酶，以及至少一种SH基团阻断物质。 用于特异性测定血液或血液中的血清果糖胺含量的试剂盒包括所述试剂组合物，具有碱性pH值的缓冲液的再吸附剂和用于检测果糖胺的显色剂。
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10.发明授权
公开(公告)号：US5071767A
公开(公告)日：1991-12-10
申请号：US375746
申请日：1989-07-05
申请人： Rudolf Portenhauser , Bernd Vogt
发明人： Rudolf Portenhauser , Bernd Vogt
CPC分类号： G01N33/96 , G01N33/66 , Y10T436/10 , Y10T436/104998 , Y10T436/105831 , Y10T436/144444
摘要： For the determination of fructosamine in body fluids a solution containing fructosamine and albumin is used as the standard solution for calibration which standard solution is essentially free of glucose and which has a pH between 5.0 and 6.0 and contains at least 10 mmol/l buffer.
摘要翻译： 为了测定体液中的果糖胺，使用含有果糖胺和白蛋白的溶液作为标准溶液，其标准溶液基本上不含葡萄糖，其pH在5.0至6.0之间并且含有至少10mmol / l缓冲液。
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