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14 条记录 (耗时 0.027 秒)

    N,O-amidomalonate platinum complexes
    3.
    发明授权
    N,O-amidomalonate platinum complexes 失效
    N，O-酰氨基马来酸盐铂络合物

    公开(公告)号：US06692734B2

    公开(公告)日：2004-02-17

    申请号：US09755220

    申请日：2001-01-04

    申请人： Donald R. Stewart ,  John R. Rice ,  John V. St. John

    发明人： Donald R. Stewart ,  John R. Rice ,  John V. St. John

    IPC分类号： A61K3174

    CPC分类号： C07F15/0093 ,  A61K47/58

    摘要： The present invention relates to purified platinum complexes in which platinum is coordinated to form a single N,O- or O,O-chelate of an amidomalonate. The chelates, and pharmaceutically acceptable formulations thereof, are useful for the treatment of cancer. The platinum chelates may additionally be linked to one or more functional groups which increases water solubility and/or assists in tumor targeting of the chelate. Examples of tumor targeting moieties include polymers, in which one or more platinum chelates are attached to the polymer backbone via linkers capable of being cleaved in the body, and molecules with a high affinity for receptors which are concentrated or upregulated in tumor tissue and/or the tumor vasculature.

    摘要翻译： 本发明涉及铂络合物，其中铂被配位形成酰胺二酸单体的单一N，O-或O，O-螯合物。 螯合物及其药学上可接受的制剂可用于治疗癌症。 铂螯合物还可以连接到增加水溶性的一个或多个官能团和/或有助于螯合物的肿瘤靶向。 肿瘤靶向部分的实例包括聚合物，其中一种或多种铂螯合物通过能够在体内切割的接头连接到聚合物主链上，以及对在肿瘤组织中浓缩或上调的受体具有高亲和力的分子和/或 肿瘤脉管系统。

    Microscope system for observing moving particles
    4.
    发明授权
    Microscope system for observing moving particles 失效
    用于观察移动颗粒的显微镜系统

    公开(公告)号：US4136950A

    公开(公告)日：1979-01-30

    申请号：US739426

    申请日：1976-11-08

    申请人： Joseph H. Labrum ,  Donald R. Stewart

    发明人： Joseph H. Labrum ,  Donald R. Stewart

    IPC分类号： G01N15/02 ,  G01P3/36 ,  H04N7/18

    CPC分类号： G01N15/0205

    摘要： A microscope system for observing moving particles makes use of a television camera for producing a continuing series of images of such particles. A source of light pulses illuminate the particles with each pulse for a period short enough to stop their movement for the camera. The light source and camera are synchronized so that the light pulses occur only between times that the camera produces image-information signals. For obtaining particle size measurements, a single light pulse during a time that the camera is not producing image-information signals is sufficient. For obtaining paticle velocity measurements, two light pulses are required so that a "double exposure" occurs at the camera during a time that the camera is not producing image-information signals.

    摘要翻译： 用于观察移动颗粒的显微镜系统利用电视摄像机产生这种颗粒的连续一系列图像。 光脉冲源用每个脉冲照射颗粒一段足够短的时间以停止其相机的移动。 光源和照相机被同步，使得光脉冲仅在相机产生图像信息信号的时间之间发生。 为了获得粒度测量，在相机不产生图像信息信号的时间期间，单个光脉冲是足够的。 为了获得光斑速度测量，需要两个光脉冲，使得在相机不产生图像信息信号的时间期间在相机处发生“双重曝光”。

    Resonating electroplating anode and process
    5.
    发明授权
    Resonating electroplating anode and process 失效
    共振电镀阳极和工艺

    公开(公告)号：US5695621A

    公开(公告)日：1997-12-09

    申请号：US688907

    申请日：1996-07-31

    申请人： Mihai G. M. Pop ,  James E. Galford ,  Donald R. Stewart

    发明人： Mihai G. M. Pop ,  James E. Galford ,  Donald R. Stewart

    IPC分类号： C25D5/20 ,  C25D7/04 ,  C25D17/12 ,  C25B11/00

    CPC分类号： C25D17/12 ,  C25D5/20 ,  C25D7/04

    摘要： A resonating electroplating anode electrode for electroplating the inside surfaces of steam generator tubing. The resonating electroplating anode electrode is formed from a plurality of tubular ceramic resonating material pieces glued to the inside and/or to one end of an anode tube to create a single resonating volume. In operation, an electrolyte solution is fed to the outside of the electrode in an annulus formed between the steam generator tube and the anode and returns through a hollow center in the anode. During use, the resonating materials resonate within the electrolyte solution during the electroplating process, thus creating an ultrasound enhanced-electroplating process. As a result, the resonating electroplating anode electrode and the resulting process reduce the amount of time required for electroplating, increase the production rate, reduce the residual internal stress resulting from electroplating, improves ductility and reduce brittleness of electrode-deposited nickel, produce a less porous deposited plating layer which improves corrosion resistance, and improve the uniformity of the electroplating coating grains. The resulting plated generator tubing is of superior quality and extended durability relative to currently known techniques.

    摘要翻译： 用于电镀蒸汽发生器管道内表面的共振电镀阳极。 共振电镀阳极由多个管状陶瓷谐振材料片形成，该多个管状陶瓷谐振材料片胶合到阳极管的内部和/或一端，以产生单个共振体积。 在操作中，电解质溶液在形成于蒸汽发生器管和阳极之间的环形空间中被供给到电极的外部，并通过阳极中的中空返回。 在使用过程中，共振材料在电镀过程中在电解质溶液中共振，从而产生超声增强电镀工艺。 结果，共振电镀阳极电极和所得到的工艺减少了电镀所需的时间，提高了生产率，减少了由于电镀导致的残余内部应力，提高了延展性，并降低了电极沉积镍的脆性，产生了较少的 多孔沉积镀层，其提高耐腐蚀性，并提高电镀涂层颗粒的均匀性。 所得到的电镀发生器管道相对于目前已知的技术具有优异的质量和延长的耐久性。

    Articulated delivery system
    6.
    发明授权
    Articulated delivery system 失效
    铰接式输送系统

    公开(公告)号：US4827878A

    公开(公告)日：1989-05-09

    申请号：US193849

    申请日：1988-05-13

    申请人： Donald R. Stewart

    发明人： Donald R. Stewart

    IPC分类号： B25J18/02 ,  B25J1/00 ,  B25J17/00 ,  F22B37/00 ,  F22B37/02

    CPC分类号： F22B37/002

    摘要： An articulated delivery system for search and retrieval tooling used in recirculating steam generators. An elongated flexible snorkel is provided with at least two channels for receiving the search and retrieval tooling. Cables along the side of the snorkel and a steering device at the rear end of the snorkel provide for articulation or bending control of the forward end of the snorkel in either direction in a single plane. Rotation of the rear end of the snorkel at the steering device provides third axis control of the articulated end of the snorkel.