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公开(公告)号：US07186822B2
公开(公告)日：2007-03-06
申请号：US11025791
申请日：2004-12-28
申请人： Vasulinga Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei P. Guzaev
发明人： Vasulinga Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei P. Guzaev
IPC分类号： C07H21/00
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
摘要翻译： 提供合成方法，其中制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯或其它共价键的低聚化合物。 低聚物具有显着减少的衍生自丙烯腈或相关污染物的环加成物。
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公开(公告)号：US07199236B2
公开(公告)日：2007-04-03
申请号：US10940360
申请日：2004-09-14
申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
发明人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC分类号： C07H21/00
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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公开(公告)号：US07041816B2
公开(公告)日：2006-05-09
申请号：US10760940
申请日：2004-01-20
申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
发明人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC分类号： C07H21/00
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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公开(公告)号：US06858715B2
公开(公告)日：2005-02-22
申请号：US10232881
申请日：2002-08-30
申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
发明人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
摘要翻译： 提供合成方法，其中制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯或其它共价键的低聚化合物。 低聚物具有显着减少的衍生自丙烯腈或相关污染物的环加成物。
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公开(公告)号：US07227016B2
公开(公告)日：2007-06-05
申请号：US11024958
申请日：2004-12-28
申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
发明人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC分类号： C07H21/00
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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公开(公告)号：US06465628B1
公开(公告)日：2002-10-15
申请号：US09288679
申请日：1999-04-09
申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
发明人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC分类号： C02H2100
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
摘要翻译： 提供合成方法，其中制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯或其它共价键的低聚化合物。 低聚物具有显着减少的衍生自丙烯腈或相关污染物的环加成物。
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公开(公告)号：US07759480B2
公开(公告)日：2010-07-20
申请号：US11668174
申请日：2007-01-29
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.
摘要翻译： 制造寡核苷酸的方法包括5-去封闭步骤，其中5-封闭基团用基本上不含氯醛的二氯乙酸除去。 该方法可用于制备基本上不含氯醛加合物的寡核苷酸。
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公开(公告)号：US5902881A
公开(公告)日：1999-05-11
申请号：US811233
申请日：1997-03-03
IPC分类号： C07H21/04 , C07C329/14 , C07H21/00 , C07H21/02
CPC分类号： C07H21/00 , C07C329/14
摘要： The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
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公开(公告)号：US06649750B1
公开(公告)日：2003-11-18
申请号：US09477878
申请日：2000-01-05
IPC分类号： C07H2100
CPC分类号： C07H21/00 , C07B2200/11
摘要： Synthetic processes are provided wherein high purity oligomers are prepared using support bound phosphoramidite protocols starting with a nucleoside or larger synthon linked to a support media through a nucleosidic heterocyclic base moiety. Intermediates undergoing depurination at the support linkage site are removed during the wash cycle. Also provided are compositions useful in such processes.
摘要翻译： 提供了合成方法，其中使用支持结合的亚磷酰胺方案制备高纯度低聚物，起始于通过核苷酸杂环碱基部分与支持介质连接的核苷或更大的合成子。 在洗涤循环期间，在载体连接位点处经历去血的中间体被去除。 还提供了可用于这些方法的组合物。
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公开(公告)号：US5959099A
公开(公告)日：1999-09-28
申请号：US103399
申请日：1998-06-24
IPC分类号： C07C253/00 , C07C255/50 , C07H19/10 , C07H19/20 , C07H21/00 , C07H19/04
CPC分类号： C07H19/10 , C07C253/00 , C07H19/20 , C07H21/00 , Y02P20/55
摘要： A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with phosphoramidite (1) in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl protecting group can be removed easily under standard conditions.
摘要翻译： 式（1）的2-N-酰氨基保护的核苷类似物亚磷酰胺：可用于合成多种寡核苷酸类似物。 在溶液或固相寡核苷酸类似物合成中，亚磷酰胺（1）的偶联产率高，在标准条件下可以容易地除去2-N-酰氨基乙基保护基。
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