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    Drug-Coated Balloon With Location-Specific Plasma Treatment
    3.
    发明申请
    Drug-Coated Balloon With Location-Specific Plasma Treatment 有权
    具有位置特异性等离子体处理的药物涂层气球

    公开(公告)号：US20120064141A1

    公开(公告)日：2012-03-15

    申请号：US12883024

    申请日：2010-09-15

    申请人： Anthony S. Andreacchi ,  Stephen D. Pacetti ,  John Stankus ,  Victoria M. Gong ,  Michael J. Leonard ,  Binh Nguyen

    发明人： Anthony S. Andreacchi ,  Stephen D. Pacetti ,  John Stankus ,  Victoria M. Gong ,  Michael J. Leonard ,  Binh Nguyen

    IPC分类号： A61F2/00 ,  B05D3/06 ,  C23C14/02

    CPC分类号： B05D3/144 ,  A61F2/82 ,  B05D7/02 ,  C08J7/123

    摘要： Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.

    摘要翻译： 涂覆可膨胀构件的方法，例如 气囊，所述方法包括提供具有外表面的可扩张构件。 该方法包括在可扩张构件的外表面的至少一部分上进行气体供应的等离子体处理。 在执行等离子体处理之后，至少在可膨胀构件的外表面的等离子体处理部分上施加治疗剂。 等离子体处理可以降低治疗剂对可扩张构件表面的粘附。 还提供了通过所公开的方法制造的医疗装置。

    Direct fluid coating of drug eluting balloon
    7.
    发明授权
    Direct fluid coating of drug eluting balloon 有权
    直接液体涂层药物洗脱球囊

    公开(公告)号：US08632837B2

    公开(公告)日：2014-01-21

    申请号：US13108283

    申请日：2011-05-16

    申请人： Victoria M. Gong ,  Stephen D. Pacetti ,  Anthony S. Andreacchi ,  Shih-hsiung Albert Yuan

    发明人： Victoria M. Gong ,  Stephen D. Pacetti ,  Anthony S. Andreacchi ,  Shih-hsiung Albert Yuan

    IPC分类号： B03D3/02 ,  A61M25/10 ,  B05B7/16

    CPC分类号： A61L29/08 ,  A61M25/1027 ,  B05D1/002 ,  B05D1/26 ,  B05D3/0254

    摘要： A system and method for coating an expandable member of a medical device comprises providing a dispenser in fluid communication with a fluid source with the dispenser having at least one outlet to dispense fluid of the fluid source therefrom. The outlet(s) of the dispenser is positioned proximate a surface of an expandable member, with relative movement between the outlet(s) and the surface of the expandable member established along a coating path, and fluid is dispensed from the dispenser to form a substantially continuous bead of fluid between the at least one outlet and the surface of the expandable member along the coating path, and simultaneously drying the fluid while dispensing the fluid from the dispenser to control flow of fluid on the surface of the expandable member. The fluid source can include a variety of therapeutic agents.

    摘要翻译： 用于涂覆医疗装置的可扩张构件的系统和方法包括提供与流体源流体连通的分配器，分配器具有至少一个出口，用于从其中分配流体源的流体。 分配器的出口定位在可扩张构件的表面附近，其中出口与沿着涂覆路径建立的可膨胀构件的表面之间的相对运动，并且流体从分配器分配以形成 在所述至少一个出口和所述可扩张构件的所述表面之间沿着所述涂覆路径的基本上连续的流体珠，并且同时干燥所述流体，同时从所述分配器分配所述流体以控制所述可膨胀构件的表面上的流体的流动。 流体源可以包括各种治疗剂。

    Direct Fluid Coating Of Drug Eluting Balloon
    8.
    发明申请
    Direct Fluid Coating Of Drug Eluting Balloon 有权
    直接流体涂层药物洗脱气球

    公开(公告)号：US20110281019A1

    公开(公告)日：2011-11-17

    申请号：US13108283

    申请日：2011-05-16

    申请人： Victoria M. Gong ,  Stephen D. Pacetti ,  Anthony S. Andreacchi ,  Shih-hsiung Albert Yuan

    发明人： Victoria M. Gong ,  Stephen D. Pacetti ,  Anthony S. Andreacchi ,  Shih-hsiung Albert Yuan

    IPC分类号： B05D7/00 ,  B05D3/00 ,  B05D1/26

    CPC分类号： A61L29/08 ,  A61M25/1027 ,  B05D1/002 ,  B05D1/26 ,  B05D3/0254

    摘要： A system and method for coating an expandable member of a medical device comprises providing a dispenser in fluid communication with a fluid source with the dispenser having at least one outlet to dispense fluid of the fluid source therefrom. The outlet(s) of the dispenser is positioned proximate a surface of an expandable member, with relative movement between the outlet(s) and the surface of the expandable member established along a coating path, and fluid is dispensed from the dispenser to form a substantially continuous bead of fluid between the at least one outlet and the surface of the expandable member along the coating path, and simultaneously drying the fluid while dispensing the fluid from the dispenser to control flow of fluid on the surface of the expandable member. The fluid source can include a variety of therapeutic agents.

    摘要翻译： 用于涂覆医疗装置的可扩张构件的系统和方法包括提供与流体源流体连通的分配器，分配器具有至少一个出口，用于从其中分配流体源的流体。 分配器的出口定位在可扩张构件的表面附近，其中出口与沿着涂覆路径建立的可膨胀构件的表面之间的相对运动，并且流体从分配器分配以形成 在所述至少一个出口和所述可扩张构件的所述表面之间沿着所述涂覆路径的基本上连续的流体珠，并且同时干燥所述流体，同时从所述分配器分配所述流体以控制所述可膨胀构件的表面上的流体的流动。 流体源可以包括各种治疗剂。

    Drug Coated Balloon Surface Relaxation Process To Minimize Drug Loss
    9.
    发明申请
    Drug Coated Balloon Surface Relaxation Process To Minimize Drug Loss 审中-公开
    药物涂层气球表面松弛过程，以尽量减少药物流失

    公开(公告)号：US20120064223A1

    公开(公告)日：2012-03-15

    申请号：US12882990

    申请日：2010-09-15

    申请人： Jose Gamez ,  John Stankus ,  Stephen D. Pacetti ,  Victoria M. Gong ,  Benjamyn Serna ,  Binh Nguyen

    发明人： Jose Gamez ,  John Stankus ,  Stephen D. Pacetti ,  Victoria M. Gong ,  Benjamyn Serna ,  Binh Nguyen

    IPC分类号： B05D5/00 ,  B05C13/02 ,  B05C11/00 ,  B05D3/00

    CPC分类号： A61M25/1029 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/16 ,  A61L2300/606 ,  A61L2420/02 ,  A61M2025/1031 ,  B05D2254/02

    摘要： Method of coating an expandable member is provided. The method comprises providing an expandable member having deflated and fully expanded configurations, and inflating the expandable member with a select amount of inflation medium, the select amount of inflation medium applied at a nominal pressure, disposing a therapeutic agent on at least a portion of the expandable member; and partially deflating the expandable member, wherein partially deflating includes releasing an initial amount of inflation medium from the expandable member such that the expandable member partially re-folds. The therapeutic agent can be dried on the expandable member, and a remaining amount of inflation medium can be withdrawn such that the expandable member resumes the completely folded configuration.

    摘要翻译： 提供涂覆可膨胀构件的方法。 该方法包括提供具有放气和完全展开构造的可膨胀构件，并且用选择量的充气介质充气可膨胀构件，以标称压力施加的选择量的充气介质，将治疗剂设置在至少一部分 可扩展成员; 并且部分地膨胀所述可膨胀构件，其中部分放气包括从所述可膨胀构件释放初始量的充气介质，使得所述可扩张构件部分地重新折叠。 治疗剂可以在可膨胀构件上干燥，并且可以取出剩余量的充气介质，使得可扩张构件恢复完全折叠的构型。

    Method and system to maintain a fixed distance during coating of a medical device
    10.
    发明授权
    Method and system to maintain a fixed distance during coating of a medical device 有权
    在医疗器械涂层期间保持固定距离的方法和系统

    公开(公告)号：US09084874B2

    公开(公告)日：2015-07-21

    申请号：US13158131

    申请日：2011-06-10

    申请人： Binh Nguyen ,  Benjamyn Serna ,  Stephen D. Pacetti ,  Victoria M. Gong

    发明人： Binh Nguyen ,  Benjamyn Serna ,  Stephen D. Pacetti ,  Victoria M. Gong

    IPC分类号： B05C5/02 ,  B05B13/04 ,  B05C13/02 ,  A61M25/10

    CPC分类号： A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105 ,  B05B13/0442 ,  B05C5/02

    摘要： Method and system to coat an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A tracking mechanism maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the at least one outlet relative to the expandable member.

    摘要翻译： 涂覆医疗装置的可扩张构件的方法和系统，包括支撑结构以支撑可膨胀构件以及位于靠近可扩张构件的表面的至少一个出口的施用器。 驱动组件在至少一个出口和可膨胀构件的表面之间建立相对运动，以沿着涂覆路径向可扩张构件的表面施加流体。 跟踪机构通过相对于可扩展构件移位至少一个出口而在相对移动期间在至少一个出口和可扩张构件的表面之间保持基本固定的距离。