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    Drug Coated Balloon Surface Relaxation Process To Minimize Drug Loss
    1.
    发明申请
    Drug Coated Balloon Surface Relaxation Process To Minimize Drug Loss 审中-公开
    药物涂层气球表面松弛过程，以尽量减少药物流失

    公开(公告)号：US20120064223A1

    公开(公告)日：2012-03-15

    申请号：US12882990

    申请日：2010-09-15

    申请人： Jose Gamez ,  John Stankus ,  Stephen D. Pacetti ,  Victoria M. Gong ,  Benjamyn Serna ,  Binh Nguyen

    发明人： Jose Gamez ,  John Stankus ,  Stephen D. Pacetti ,  Victoria M. Gong ,  Benjamyn Serna ,  Binh Nguyen

    IPC分类号： B05D5/00 ,  B05C13/02 ,  B05C11/00 ,  B05D3/00

    CPC分类号： A61M25/1029 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/16 ,  A61L2300/606 ,  A61L2420/02 ,  A61M2025/1031 ,  B05D2254/02

    摘要： Method of coating an expandable member is provided. The method comprises providing an expandable member having deflated and fully expanded configurations, and inflating the expandable member with a select amount of inflation medium, the select amount of inflation medium applied at a nominal pressure, disposing a therapeutic agent on at least a portion of the expandable member; and partially deflating the expandable member, wherein partially deflating includes releasing an initial amount of inflation medium from the expandable member such that the expandable member partially re-folds. The therapeutic agent can be dried on the expandable member, and a remaining amount of inflation medium can be withdrawn such that the expandable member resumes the completely folded configuration.

    摘要翻译： 提供涂覆可膨胀构件的方法。 该方法包括提供具有放气和完全展开构造的可膨胀构件，并且用选择量的充气介质充气可膨胀构件，以标称压力施加的选择量的充气介质，将治疗剂设置在至少一部分 可扩展成员; 并且部分地膨胀所述可膨胀构件，其中部分放气包括从所述可膨胀构件释放初始量的充气介质，使得所述可扩张构件部分地重新折叠。 治疗剂可以在可膨胀构件上干燥，并且可以取出剩余量的充气介质，使得可扩张构件恢复完全折叠的构型。

    Drug-Coated Balloon With Location-Specific Plasma Treatment
    2.
    发明申请
    Drug-Coated Balloon With Location-Specific Plasma Treatment 有权
    具有位置特异性等离子体处理的药物涂层气球

    公开(公告)号：US20120064141A1

    公开(公告)日：2012-03-15

    申请号：US12883024

    申请日：2010-09-15

    申请人： Anthony S. Andreacchi ,  Stephen D. Pacetti ,  John Stankus ,  Victoria M. Gong ,  Michael J. Leonard ,  Binh Nguyen

    发明人： Anthony S. Andreacchi ,  Stephen D. Pacetti ,  John Stankus ,  Victoria M. Gong ,  Michael J. Leonard ,  Binh Nguyen

    IPC分类号： A61F2/00 ,  B05D3/06 ,  C23C14/02

    CPC分类号： B05D3/144 ,  A61F2/82 ,  B05D7/02 ,  C08J7/123

    摘要： Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.

    摘要翻译： 涂覆可膨胀构件的方法，例如 气囊，所述方法包括提供具有外表面的可扩张构件。 该方法包括在可扩张构件的外表面的至少一部分上进行气体供应的等离子体处理。 在执行等离子体处理之后，至少在可膨胀构件的外表面的等离子体处理部分上施加治疗剂。 等离子体处理可以降低治疗剂对可扩张构件表面的粘附。 还提供了通过所公开的方法制造的医疗装置。

    Methods for uniform crimping and deployment of a polymer scaffold
    8.
    发明授权
    Methods for uniform crimping and deployment of a polymer scaffold 有权
    均匀压接和展开聚合物支架的方法

    公开(公告)号：US08726483B2

    公开(公告)日：2014-05-20

    申请号：US13194162

    申请日：2011-07-29

    申请人： John Stankus ,  Benjamyn Serna

    发明人： John Stankus ,  Benjamyn Serna

    IPC分类号： B21D39/00 ,  B23P11/00 ,  A61M29/00 ,  A61F2/06

    CPC分类号： A61F2/915 ,  A61F2/958 ,  A61F2002/91566 ,  A61F2002/9522 ,  A61F2240/001 ,  Y10T29/49908 ,  Y10T29/49925 ,  Y10T29/49936

    摘要： A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon while retaining, at least partially, the original balloon folds as the balloon is pressurized and de-pressurized within a crimper head. By at least partially retaining the original balloon folds, a uniformity of scaffold expansion by the balloon is improved.

    摘要翻译： 一种医疗装置 - 包括卷曲到具有膨胀气囊的导管的支架。 支架通过包括一个或多个气囊加压步骤的过程卷曲到气囊。 选择气囊加压步骤以增强对球囊的支架保留，同时至少部分地保持原始气囊折叠，当气囊在压接头内进行加压和减压时。 通过至少部分地保持原始的气球褶皱，改善了球囊的支架膨胀的均匀性。