公开(公告)号：US20060233814A1

公开(公告)日：2006-10-19

申请号：US11404001

申请日：2006-04-14

申请人： Viktor Goldmakher ,  Robert Lutz ,  Ravi Chari ,  Yelena Kovtun ,  John Lambert ,  Rita Steeves ,  Hans Erickson

发明人： Viktor Goldmakher ,  Robert Lutz ,  Ravi Chari ,  Yelena Kovtun ,  John Lambert ,  Rita Steeves ,  Hans Erickson

IPC分类号： A61K39/395 ,  A61K31/5383 ,  C07K16/46 ,  A61K31/58 ,  A61K38/19

CPC分类号： C07K16/3046 ,  A61K31/5383 ,  A61K31/58 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07D498/18 ,  C07K2317/24

摘要： Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.

公开(公告)号：US20080145374A1

公开(公告)日：2008-06-19

申请号：US11927314

申请日：2007-10-29

申请人： Rita STEEVES ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

发明人： Rita STEEVES ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

IPC分类号： A61K39/44 ,  C07K16/00

CPC分类号： C07K16/3092 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/92

摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

公开(公告)号：US20080171865A1

公开(公告)日：2008-07-17

申请号：US11927235

申请日：2007-10-29

申请人： Rita Steeves ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

发明人： Rita Steeves ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

IPC分类号： C07D498/08

CPC分类号： C07K16/3092 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/92

摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

摘要翻译： 本发明公开了一种将美登木素生物素靶向选定的细胞群体的方法，所述方法包括将怀疑含有所选细胞群的细胞群体或组织与细胞粘附剂美登木素生物碱缀合物接触，其中一种或多种美登木素生物碱共价连接到 细胞结合剂通过不可切割的接头和细胞结合剂结合所选细胞群的细胞。

公开(公告)号：US20080114153A1

公开(公告)日：2008-05-15

申请号：US11927217

申请日：2007-10-29

申请人： Rita Steeves ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

发明人： Rita Steeves ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

IPC分类号： C07K14/705 ,  C07D491/14

CPC分类号： C07K16/3092 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/92

摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

公开(公告)号：US20080171856A1

公开(公告)日：2008-07-17

申请号：US11927251

申请日：2007-10-29

申请人： Rita STEEVES ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

发明人： Rita STEEVES ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

IPC分类号： C07K16/46 ,  C07D491/04

CPC分类号： C07K16/3092 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/92

摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

公开(公告)号：US20050169933A1

公开(公告)日：2005-08-04

申请号：US10960602

申请日：2004-10-08

申请人： Rita Steeves ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

发明人： Rita Steeves ,  Robert Lutz ,  Ravi Chari ,  Hongsheng Xie ,  Yelena Kovtun

IPC分类号： A61K39/395 ,  C07K16/46 ,  C07D491/04

CPC分类号： C07K16/3092 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/92

摘要： The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

摘要翻译： 本发明公开了一种将美登木素生物素靶向选定的细胞群体的方法，所述方法包括将怀疑含有所选细胞群的细胞群体或组织与细胞粘附剂美登木素生物碱缀合物接触，其中一种或多种美登木素生物碱共价连接到 细胞结合剂通过不可切割的接头和细胞结合剂结合所选细胞群的细胞。

公开(公告)号：US20060127407A1

公开(公告)日：2006-06-15

申请号：US11290249

申请日：2005-11-30

申请人： Qiming Chen ,  Mohit Trikha ,  Robert Lutz ,  Rita Steeves ,  Godfrey Amphlett

发明人： Qiming Chen ,  Mohit Trikha ,  Robert Lutz ,  Rita Steeves ,  Godfrey Amphlett

IPC分类号： A61K39/395 ,  C07K16/46

CPC分类号： A61K47/48569 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/2839 ,  C07K2317/21 ,  C07K2317/73

摘要： The invention relates to conjugates of anti-integrin specific antibodies with cytotoxic compounds, the synthesis, selection, and use of such conjugates for use in cancer therapy or other diseases mediated by cell proliferation, cell migration, or inflammation and which pathology involves angiogenesis or neovascularization of new tissue. In addition the invention relates to combination therapy of such diseases wherein the treatment comprises use of said conjugates in combination with one or more other treatment modalities including but not limited to: chemotherapy, surgery or radiation therapy. The preferred conjugates contain maytansinoid compounds linked to the antibody by a disulfide linkage, and preferred chemotherapeutic agents are doxorubicin, a taxane, a camptothecin, a podophyllotoxin, a nucleoside analog, or a pyrimidine analog.

公开(公告)号：US20060177455A1

公开(公告)日：2006-08-10

申请号：US11400241

申请日：2006-04-10

申请人： Mary Hoffee ,  Daniel Tavares ,  Robert Lutz

发明人： Mary Hoffee ,  Daniel Tavares ,  Robert Lutz

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06 ,  C07K16/30

CPC分类号： C07K16/2803 ,  A61K39/3955 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/92

摘要： The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of said antibodies, humanized and resurfaced versions of said antibodies, functional equivalents and improved versions of said antibodies, immunoconjugates and compositions comprising said antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding the antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing the antibodies.

摘要翻译： 本发明涉及结合CD33的抗体。 更具体地说，本发明涉及抗CD33抗体，所述抗体的片段和同系物，所述抗体的人源化和表面化形式，所述抗体的功能等同物和改进形式，免疫偶联物和包含所述抗体的组合物及其在诊断中的用途 ，研究和治疗应用。 本发明还涉及编码抗体的多核苷酸，包含多核苷酸的载体，用多核苷酸转化的宿主细胞和产生抗体的方法。

公开(公告)号：US20060022212A1

公开(公告)日：2006-02-02

申请号：US11202424

申请日：2005-08-11

申请人： Gunter Waitl ,  Robert Lutz ,  Herbert Brunner

发明人： Gunter Waitl ,  Robert Lutz ,  Herbert Brunner

IPC分类号： H01L33/00 ,  H01L31/0232

CPC分类号： H01L33/486 ,  H01L31/0203 ,  H01L31/02325 ,  H01L33/58 ,  H01L2224/48247 ,  H01L2224/48091 ,  H01L2924/00014

摘要： A method for producing a surface mounting optoelectronic component comprises the following steps: readying a base body with the optoelectronic transmitter and/or receiver arranged in a recess of the base body, filling the recess of the base body with a transparent, curable casting compound, and placing the optical device onto the base body, whereby the optical device comes into contact with the casting compound.

摘要翻译： 一种用于制造表面安装光电子部件的方法包括以下步骤：利用布置在基体的凹部中的光电发射器和/或接收器准备基体，用透明的可固化铸塑料填充基体的凹部， 并将光学装置放置在基体上，由此光学装置与铸塑料接触。

公开(公告)号：US06610563B1

公开(公告)日：2003-08-26

申请号：US09581585

申请日：2000-10-05

申请人： Günter Waitl ,  Robert Lutz ,  Herbert Brunner

发明人： Günter Waitl ,  Robert Lutz ,  Herbert Brunner

IPC分类号： H01L2120

CPC分类号： H01L33/486 ,  H01L31/0203 ,  H01L31/02325 ,  H01L33/58 ,  H01L2224/48247 ,  H01L2224/48091 ,  H01L2924/00014

摘要： A method for producing a surface mounting optoelectronic component having comprises the following steps: readying a base body with the optoelectronic transmitter and/or receiver arranged in a recess of the base body, filling the recess of the base body with a transparent, curable casting compound, and placing the optical device onto the base body, so whereby the optical device comes into contact with the casting compound.

摘要翻译： 一种用于制造表面安装光电子部件的方法，包括以下步骤：用设置在基体的凹部中的光电发射器和/或接收器准备基体，用透明的可固化铸塑料填充基体的凹部 并且将光学装置放置在基体上，由此光学装置与铸塑料接触。