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公开(公告)号：US20230152283A1
公开(公告)日：2023-05-18
申请号：US17990059
申请日：2022-11-18
IPC分类号： G01N30/60
CPC分类号： G01N30/6078 , G01N30/6017 , G01N30/6082 , G01N2030/027
摘要： A flow cell for a liquid chromatography detector comprises a substrate formed of a glass material; a fluidic channel extending through the substrate; and at least one gas filled region formed in the substrate along at least a portion of a length of the fluidic channel. A portion of the glass material separates the fluidic channel and the gas filled region. An interface between the gas filled region and the portion of the glass material separating the fluidic channel and the gas filled region enables total internal reflection of light propagating along the fluidic channel.
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2.发明申请公开(公告)号：US20200158605A1
公开(公告)日：2020-05-21
申请号：US16684930
申请日：2019-11-15
发明人： Abhijit Tarafder , Sebastien Besner , Mark Basile , Martin Gilar
摘要： Exemplary embodiments are directed to methods and systems for controlling fluid parameters within a detector. A first and second fluid pump manager control the flow of a first and second fluid to one or more heating/cooling devices, and a mixer receives and mixes the first and second fluids. An optical detector flow cell receives the fluid mixture from the mixer, and a pressure regulator controls the pressure at the optical detector flow cell. Thus, the composition, temperature, and pressure of a fluid mixture entering an optical detector flow cell can be controlled in real time.
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公开(公告)号：US11994500B2
公开(公告)日：2024-05-28
申请号：US17084998
申请日：2020-10-30
发明人： Mark J. Basile , Jeffrey Musacchio , Michael O. Fogwill , Sebastien Besner , Joseph D. Michienzi , Wade P. Leveille
CPC分类号： G01N30/74 , G01N30/30 , G01N2030/027 , G01N2030/3038 , G01N2030/746
摘要： Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.
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4.发明授权公开(公告)号：US11604174B2
公开(公告)日：2023-03-14
申请号：US16684930
申请日：2019-11-15
发明人： Abhijit Tarafder , Sebastien Besner , Mark Basile , Martin Gilar
摘要： Exemplary embodiments are directed to methods and systems for controlling fluid parameters within a detector. A first and second fluid pump manager control the flow of a first and second fluid to one or more heating/cooling devices, and a mixer receives and mixes the first and second fluids. An optical detector flow cell receives the fluid mixture from the mixer, and a pressure regulator controls the pressure at the optical detector flow cell. Thus, the composition, temperature, and pressure of a fluid mixture entering an optical detector flow cell can be controlled in real time.
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公开(公告)号：US20210132012A1
公开(公告)日：2021-05-06
申请号：US17084998
申请日：2020-10-30
发明人： Mark J. Basile , Jeffrey Musacchio , Michael O. Fogwill , Sebastien Besner , Joseph D. Michienzi , Wade P. Leveille
摘要： Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.
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