公开(公告)号：US11764049B2

公开(公告)日：2023-09-19

申请号：US17230793

申请日：2021-04-14

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Sylvain Gilles Cormier

IPC: H01J49/00 ,  H01J49/04 ,  G01N30/72 ,  H01J49/16

CPC classification number: H01J49/0495 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/0009 ,  H01J49/165

Abstract: Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.

公开(公告)号：US11717770B2

公开(公告)日：2023-08-08

申请号：US17716367

申请日：2022-04-08

Applicant: Waters Technologies Corporation

Inventor： Zongren Shang ,  Stanislaw Koziol ,  Joseph D. Michienzi ,  Michael Eggertson ,  Keith Fadgen

IPC: B01D15/16 ,  G01N30/32

CPC classification number: B01D15/163 ,  G01N30/32 ,  G01N2030/324 ,  G01N2030/328

Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.

公开(公告)号：US20230152283A1

公开(公告)日：2023-05-18

申请号：US17990059

申请日：2022-11-18

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Sebastien Besner ,  Brett G. Cook ,  Peter O'Brien

IPC: G01N30/60

CPC classification number: G01N30/6078 ,  G01N30/6017 ,  G01N30/6082 ,  G01N2030/027

Abstract: A flow cell for a liquid chromatography detector comprises a substrate formed of a glass material; a fluidic channel extending through the substrate; and at least one gas filled region formed in the substrate along at least a portion of a length of the fluidic channel. A portion of the glass material separates the fluidic channel and the gas filled region. An interface between the gas filled region and the portion of the glass material separating the fluidic channel and the gas filled region enables total internal reflection of light propagating along the fluidic channel.

公开(公告)号：US20220236234A1

公开(公告)日：2022-07-28

申请号：US17583559

申请日：2022-01-25

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Charles T. Murphy ,  Joseph D. Michienzi

IPC: G01N30/20

Abstract: Described is a rotary valve that includes a stator, a rotor and a plurality of sample channels. The stator includes a stator surface having an inlet port, an outlet port and a plurality of selectable ports. The rotor includes a rotor surface having a first rotor channel and a second rotor channel. The rotor is configurable in a plurality of rotor positions, each of which couples the inlet port to one of the selectable ports through the first rotor channel and couples the outlet port to another one of the selectable ports through the second rotor channel. The two selectable ports are coupled to each other through one of the sample channels. The rotor has a bypass state defined by a rotor position, or angular range of rotor positions, at which the inlet port is coupled to the outlet port through the second rotor channel.

公开(公告)号：US11325055B2

公开(公告)日：2022-05-10

申请号：US16545845

申请日：2019-08-20

Applicant: Waters Technologies Corporation

Inventor： Zongren Shang ,  Stanislaw Koziol ,  Joseph D. Michienzi ,  Michael Eggertson ,  Keith Fadgen

IPC: B01D15/16 ,  G01N30/32

Abstract: A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.

公开(公告)号：US20210199630A1

公开(公告)日：2021-07-01

申请号：US17057242

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/60 ,  G01N30/06

Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.

公开(公告)号：US10953346B2

公开(公告)日：2021-03-23

申请号：US15873280

申请日：2018-01-17

Applicant: Waters Technologies Corporation

Inventor： Xiangjin Song ,  James P. Murphy ,  Keith Fadgen ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder

IPC: B01D15/14 ,  B01L3/00 ,  B65D1/02 ,  B65D23/14 ,  G01N35/00 ,  G01N30/80 ,  B01L9/00 ,  G01N30/26

Abstract: Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.

公开(公告)号：US10852279B2

公开(公告)日：2020-12-01

申请号：US16092264

申请日：2017-04-19

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  Geoff Gerhardt

IPC: G01N30/68 ,  G01N30/30 ,  G01N30/02

Abstract: A method for detecting an analyte in a chromatography system includes performing a separation using a mobile phase that includes an organic component. The separation is performed with a primary separation module such as a chromatographic column. A first effluent, from the primary separation module, is modulated so that a fluidic plug containing an amount of the organic component and an analyte is provided to a secondary separation module where a secondary separation is performed. A second effluent, from the secondary separation module, includes temporally-resolved organic component and analyte peaks due to selective retention of the analyte. The second effluent is provided to a flame-based detector which is disabled when the organic modifier peak is received and enabled at least during the time when the analyte peak is received. Thus the analyte can be detected without interference from any response of the detector to the organic component peak.

公开(公告)号：US10371673B2

公开(公告)日：2019-08-06

申请号：US15909264

申请日：2018-03-01

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph A. Jarrell ,  Joseph D. Michienzi ,  Thomas S. McDonald

IPC: G01N30/32 ,  G01N30/34 ,  G01N30/72 ,  G01N30/36 ,  B01D15/16 ,  B01D15/40 ,  G01N30/62

Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO2-based chromatography system. A first CO2 pump operates in constant flow mode and delivers CO2 to a chromatography column, and liquid modifier is introduced to the chromatography column according to a gradient. A second CO2 pump is disposed downstream of the column and operates in constant pressure mode to introduce CO2 into a flow stream at an output of the column. Liquid modifier is also introduced into the flow stream at the output of the column according to a reverse gradient compared to the gradient entering the chromatography column.

公开(公告)号：US10274463B2

公开(公告)日：2019-04-30

申请号：US15062430

申请日：2016-03-07

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Abhijit Tarafder ,  Joseph D. Michienzi ,  Joshua A. Shreve

IPC: G01N30/30

Abstract: Analytical-scale separation column assemblies include a tube with a bore packed with a stationary phase through which a mobile phase flows. In one embodiment, thermal elements are disposed remotely from and unattached to the tube. The thermal elements are in thermal communication with an external surface of the tube for producing a spatial thermal gradient outside of and along a length of the tube. In another embodiment, discrete, spatially separated strips of thermally conductive material are disposed on and wrapped around an external surface of the tube. Thermal elements are disposed remotely from the tube. Each thermal element is in thermal communication with one strip of thermally conductive material by a heat-transfer device. The thermal elements produce a spatial thermal gradient outside of and along a tube length by controlling temperature of each strip of thermally conductive material disposed on and wrapped around the external surface of the tube.