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1.发明授权Phenylalanine ammonia lyase occluded fibers for reducing phenylalanine blood-level 失效苯丙氨酸氨裂解酶封闭纤维用于降低苯丙氨酸血药浓度
公开(公告)号：US4248704A
公开(公告)日：1981-02-03
申请号：US35528
申请日：1979-05-03
CPC分类号： C12N11/04 , A23J3/30 , A61M1/3687
摘要： Phenylalanine level in blood or another medium is considerably reduced and can even be annulled by causing blood or the other medium to flow through a mass of porous fibers in which the enzyme phenylalanine ammonia lyase has been occluded: the fibers have been previously made biocompatible, if necessary.
摘要翻译： 血液或其他培养基中苯丙氨酸水平显着降低，甚至可以通过使血液或其他培养基流过其中已经封闭了苯丙氨酸氨裂解酶的多孔纤维群，甚至被消除：纤维已经被预先制成生物相容性，如果 必要。
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公开(公告)号：US4336357A
公开(公告)日：1982-06-22
申请号：US172957
申请日：1980-07-28
CPC分类号： C08J7/14 , A61L33/0076 , C08G69/48 , C08J2377/00 , Y10S128/03
摘要： Polyamide materials for the construction of protheses and surgical sundries are made biocompatible by inducing a superficial hydrolysis by treating such materials, either raw or in the form of shaped articles, with a normal multiple solution of hydrogen chloride. Thrice normal or fourfold normal solutions are preferred and the treatment time being a function of the temperature. At human body temperature (37.degree. C.) a treatment time from 30 to 60 minutes will do.
摘要翻译： 通过用原料或成型制品的形式，用正常的多氯化氢溶液处理这种材料，通过引起表面水解，将用于构造皱纹和手术杂物的聚酰胺材料生物相容。 优选正常或四倍的正常方案，治疗时间是温度的函数。 在人体体温（37℃）下，治疗时间为30〜60分钟即可。
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3.发明授权Preparation of non-thrombogenic polymeric material article with platelet anti-aggregative agent 失效制备具有血小板抗凝集剂的非血栓形成聚合物材料制品
公开(公告)号：US4243776A
公开(公告)日：1981-01-06
申请号：US917568
申请日：1978-06-21
IPC分类号： C08F8/00 , A61K47/48 , A61L27/14 , A61L27/18 , A61L33/00 , A61L33/06 , C08B15/06 , C08G18/38 , C08G85/00 , C08G69/46
CPC分类号： C08G85/00 , A61K47/48192 , A61K47/48207 , A61L27/14 , A61L27/18 , A61L33/0041 , A61L33/062 , C08B15/06 , C08G18/3844
摘要： Biocompatible articles are obtained by treating a polymeric material with a hydrolyzing agent on its surface and covalently binding thereon a biological agent, such as an anti-platelet-aggregation agent.
摘要翻译： 通过在其表面上用水解剂处理聚合物材料并在其上共价结合生物试剂如抗血小板聚集剂来获得生物相容性制品。
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4.发明授权Method for occluding sequestering agents in filamentary structure, occluded sequestering agents thus obtained and their applications 失效封闭长丝结构中的螯合剂的方法，由此获得的封闭螯合剂及其应用
公开(公告)号：US4263180A
公开(公告)日：1981-04-21
申请号：US692773
申请日：1976-06-04
IPC分类号： C09K3/00 , B01J47/12 , D01D5/00 , D01F1/02 , D01F1/10 , D01F2/28 , D01F6/54 , D01F6/94 , C08L89/00
CPC分类号： D01F1/10 , B01J47/123
摘要： A method is disclosed for embedding sequestering agents in filamentary structures, the method comprising the steps of preparing an emulsion formed by an aqueous or nearly aqueous solution of the sequestering agent and a solution of the filament-forming polymer in an appropriate solvent, and spinning the emulsion in a coagulation bath.
摘要翻译： 公开了一种将螯合剂嵌入丝状结构中的方法，该方法包括以下步骤：由多价螯合剂的水溶液或近似水溶液形成的乳液和将丝状聚合物溶于合适的溶剂中， 乳液在凝固浴中。
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公开(公告)号：US4591596A
公开(公告)日：1986-05-27
申请号：US552987
申请日：1983-11-17
IPC分类号： A61K31/42 , A61K31/421 , A61P7/02 , A61P29/00 , C07D263/46 , C07D263/48
CPC分类号： C07D263/46 , C07D263/48
摘要： This invention relates to chemical products of general formula ##STR1## wherein R is an amino group, mono or bi-hydroxyalkyl substituted, or a thio group, mono hydroxyalkyl substituted, in which one or more of the available --OH groups have been esterified with acids containing 2 to 18 carbon atoms.It is also described a process for the preparation of said products, which comprises reacting a corresponding starting compound, N or S-hydroxyalkyl substituted, with the chloride or the anhydride of the acid concerned.
摘要翻译： 本发明涉及通式为“IMAGE”的化学产品，其中R是一个氨基，一个或二个羟基烷基取代的，或一个硫基，被取代的单羟基烷基，其中一个或多个可用的-OH基已被酯化 含有2至18个碳原子的酸。 还描述了制备所述产物的方法，其包括将相应的起始化合物，取代的N或S-羟基烷基与所涉及的酸的氯化物或酸酐反应。
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6.发明授权Bio-compatible porous fibres and materials for occluding biologically interesting substances, and method for their manufacture 失效生物相容的多孔纤维和用于吸收生物感兴趣的物质的材料及其制造方法
公开(公告)号：US4353996A
公开(公告)日：1982-10-12
申请号：US189817
申请日：1980-09-23
CPC分类号： A61L33/062 , A61L33/0041 , C12N11/04 , D01F1/10
摘要： Fibres for biological uses can be produced by adding to a spinnable solution of a polymer selected from among many of the most common polymers and copolymers, a substance selected from among anti-platelet aggregation substances, anticoagulants and substances having a similar action. The substances can also be applied as a surface outer layer to articles made with the polymeric substances.
摘要翻译： 用于生物用途的纤维可以通过加入选自许多最常见的聚合物和共聚物的聚合物的可纺丝溶液，选自抗血小板聚集物质，抗凝血剂和具有相似作用的物质的物质来制备。 这些物质也可以作为表面外层施加到用聚合物质制成的制品上。
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7.发明授权
公开(公告)号：US4100029A
公开(公告)日：1978-07-11
申请号：US703968
申请日：1976-07-09
IPC分类号： C12N9/02 , C07J1/00 , C07J5/00 , C12N11/04 , C12N11/12 , C12P1/00 , C12P13/06 , C12P33/06 , C12Q1/26 , D01F1/02 , C07G7/02
CPC分类号： D01F1/02 , C07J1/0011 , C07J5/0053 , C12N11/04 , C12P1/00 , C12P13/06 , C12P33/06 , C12Q1/26
摘要： A method is disclosed for improving the activity of oxireductase enzymes, the improvement consisting in that an enzyme and a previously functionalized coenzyme are embedded in a filamentary structure, the coenzyme having previously been attached to a water-soluble, high-molecular-weight polymer.
摘要翻译： 公开了一种改善氧化还原酶活性的方法，改进之处在于将酶和预先官能化的辅酶嵌入丝状结构中，辅酶预先连接到水溶性高分子量聚合物上。
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公开(公告)号：US4396716A
公开(公告)日：1983-08-02
申请号：US334907
申请日：1981-12-28
CPC分类号： C12N11/00 , A61L33/0047
摘要： A prosthetic polymer material is made non-thrombogenic by immobilizing apyrase on its surface. Immobilization is preferably carried out by hydrolytically activating the surface of a polyamide polymer or a polyethylene terphthalate polymer, and treating the hydrolyzed polymer with a solution of cross-linking agent and a solution of apyrase. The apyrase converts adenosine diphosphate to adenosine monophosphate and adenosine whereby the formation of thrombi is inhibited.
摘要翻译： 辅助聚合物材料通过在其表面上固定apyr酶而制成非血栓形成。 固定化优选通过水解活化聚酰胺聚合物或聚对苯二甲酸乙二醇酯聚合物的表面进行，并用交联剂溶液和脱酰酶溶液处理水解的聚合物。 腺苷二磷酸腺苷二磷酸腺苷转化为腺苷一磷酸和腺苷，从而抑制血栓的形成。
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公开(公告)号：US4042495A
公开(公告)日：1977-08-16
申请号：US630670
申请日：1975-11-10
申请人： Walter Marconi , Nicola Oddo , Ludwig Degen
发明人： Walter Marconi , Nicola Oddo , Ludwig Degen
CPC分类号： C02F1/681 , B01D17/047 , C02F3/344 , Y10S210/922
摘要： Oily hydrocarbons which pollute the surface of water are removed therefrom by scattering over the polluted surface solid particles of nutrient salt containing nitrogen and phosphorous in a form that is readily assimilable by aqueous microorganisms capable of metabolizing hydrocarbons. The particles of nutrient salt are given a surface pretreatment with paraffine so that they are buoyant and only slowly soluble in water and lipophilic.
摘要翻译： 通过在含有氮和磷的营养盐的污染表面固体颗粒上散布易于通过能够代谢烃代谢的含水微生物的形式而将污染水表面的油性碳氢化合物除去。 营养盐颗粒用石蜡进行表面预处理，使其具有浮力，仅缓慢溶于水和亲油。
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公开(公告)号：US4489208A
公开(公告)日：1984-12-18
申请号：US348707
申请日：1982-02-16
申请人： Roberto Olivieri , Giancarlo Eletti Bianchi , Eugenio Fascetti , Felice Centini , Ludwig Degen , Walter Marconi
发明人： Roberto Olivieri , Giancarlo Eletti Bianchi , Eugenio Fascetti , Felice Centini , Ludwig Degen , Walter Marconi
IPC分类号： C12P7/42 , C12P13/00 , C12P41/00 , C12R1/025 , C12R1/04 , C12R1/07 , C12R1/13 , C12R1/15 , C12R1/22 , C12R1/265 , C12R1/32 , C12R1/34 , C12R1/37 , C12R1/38 , C12R1/425 , C12R1/465 , C12R1/72 , C07C59/50
CPC分类号： C12P13/02
摘要： This invention relates to a process for the preparation of D(-) mandelic acid by the acid hydrolysis of the corresponding carbamate in an aqueous environment at a temperature of between 40.degree. and 100.degree. C. and at a pH of between 1 and 3.5.The invention also relates to a process for the enzymatic hydrolysis of racemic 5-substituted 2,4-oxazolidinediones to give only one of the two possible optical isomers, i.e., the D-carbamyl-.alpha.-hydroxy acid. The free D-.alpha.-hydroxy acid can be obtained from the optically active carbamyl derivative by simple hydrolysis. Of particular interest is the case in which the D-.alpha.-hydroxy acid is D(-)mandelic acid. The enzymatic activity required for preparing the carbamyl derivative of D(-)mandelic acid has been found both in homogenised veal liver and in a series of microorganisms, including Agrobacterium radiobacter, Bacillus brevis, Bacillus stearothermophilus, Pseudomonas sp., Pseudomonas desmolytica, Pseudomonas fluorescens, Pseudomonas putida.
摘要翻译： 本发明涉及通过在40〜100℃的温度和1〜3.5之间的酸性水溶液中水解相应的氨基甲酸酯来制备D（ - ）扁桃酸的方法。 本发明还涉及外消旋的5-取代的2,4-恶唑烷二酮的酶水解方法，以仅给出两种可能的光学异构体之一，即D-氨基甲酰-α-羟基酸。 游离的D-α-羟基酸可以通过简单的水解从光学活性的氨基甲酰基衍生物获得。 特别令人感兴趣的是D-羟基酸是D（ - ）扁桃酸的情况。 已经在均质的小牛肝脏和一系列微生物中发现制备D（ - ）扁桃酸的氨基甲酰基衍生物所需的酶活性，包括农杆菌，短芽孢杆菌，嗜热脂肪芽孢杆菌，假单胞菌，解脂假单胞菌（Pseudomonas desmolytica），荧光假单胞菌 ，恶臭假单胞菌（Pseudomonas putida）。
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