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1.发明授权Preparation of non-thrombogenic polymeric material article with platelet anti-aggregative agent 失效制备具有血小板抗凝集剂的非血栓形成聚合物材料制品
公开(公告)号：US4243776A
公开(公告)日：1981-01-06
申请号：US917568
申请日：1978-06-21
IPC分类号： C08F8/00 , A61K47/48 , A61L27/14 , A61L27/18 , A61L33/00 , A61L33/06 , C08B15/06 , C08G18/38 , C08G85/00 , C08G69/46
CPC分类号： C08G85/00 , A61K47/48192 , A61K47/48207 , A61L27/14 , A61L27/18 , A61L33/0041 , A61L33/062 , C08B15/06 , C08G18/3844
摘要： Biocompatible articles are obtained by treating a polymeric material with a hydrolyzing agent on its surface and covalently binding thereon a biological agent, such as an anti-platelet-aggregation agent.
摘要翻译： 通过在其表面上用水解剂处理聚合物材料并在其上共价结合生物试剂如抗血小板聚集剂来获得生物相容性制品。
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公开(公告)号：US4336357A
公开(公告)日：1982-06-22
申请号：US172957
申请日：1980-07-28
CPC分类号： C08J7/14 , A61L33/0076 , C08G69/48 , C08J2377/00 , Y10S128/03
摘要： Polyamide materials for the construction of protheses and surgical sundries are made biocompatible by inducing a superficial hydrolysis by treating such materials, either raw or in the form of shaped articles, with a normal multiple solution of hydrogen chloride. Thrice normal or fourfold normal solutions are preferred and the treatment time being a function of the temperature. At human body temperature (37.degree. C.) a treatment time from 30 to 60 minutes will do.
摘要翻译： 通过用原料或成型制品的形式，用正常的多氯化氢溶液处理这种材料，通过引起表面水解，将用于构造皱纹和手术杂物的聚酰胺材料生物相容。 优选正常或四倍的正常方案，治疗时间是温度的函数。 在人体体温（37℃）下，治疗时间为30〜60分钟即可。
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公开(公告)号：US4591596A
公开(公告)日：1986-05-27
申请号：US552987
申请日：1983-11-17
IPC分类号： A61K31/42 , A61K31/421 , A61P7/02 , A61P29/00 , C07D263/46 , C07D263/48
CPC分类号： C07D263/46 , C07D263/48
摘要： This invention relates to chemical products of general formula ##STR1## wherein R is an amino group, mono or bi-hydroxyalkyl substituted, or a thio group, mono hydroxyalkyl substituted, in which one or more of the available --OH groups have been esterified with acids containing 2 to 18 carbon atoms.It is also described a process for the preparation of said products, which comprises reacting a corresponding starting compound, N or S-hydroxyalkyl substituted, with the chloride or the anhydride of the acid concerned.
摘要翻译： 本发明涉及通式为“IMAGE”的化学产品，其中R是一个氨基，一个或二个羟基烷基取代的，或一个硫基，被取代的单羟基烷基，其中一个或多个可用的-OH基已被酯化 含有2至18个碳原子的酸。 还描述了制备所述产物的方法，其包括将相应的起始化合物，取代的N或S-羟基烷基与所涉及的酸的氯化物或酸酐反应。
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4.发明授权Bio-compatible porous fibres and materials for occluding biologically interesting substances, and method for their manufacture 失效生物相容的多孔纤维和用于吸收生物感兴趣的物质的材料及其制造方法
公开(公告)号：US4353996A
公开(公告)日：1982-10-12
申请号：US189817
申请日：1980-09-23
CPC分类号： A61L33/062 , A61L33/0041 , C12N11/04 , D01F1/10
摘要： Fibres for biological uses can be produced by adding to a spinnable solution of a polymer selected from among many of the most common polymers and copolymers, a substance selected from among anti-platelet aggregation substances, anticoagulants and substances having a similar action. The substances can also be applied as a surface outer layer to articles made with the polymeric substances.
摘要翻译： 用于生物用途的纤维可以通过加入选自许多最常见的聚合物和共聚物的聚合物的可纺丝溶液，选自抗血小板聚集物质，抗凝血剂和具有相似作用的物质的物质来制备。 这些物质也可以作为表面外层施加到用聚合物质制成的制品上。
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5.发明授权Method for occluding sequestering agents in filamentary structure, occluded sequestering agents thus obtained and their applications 失效封闭长丝结构中的螯合剂的方法，由此获得的封闭螯合剂及其应用
公开(公告)号：US4263180A
公开(公告)日：1981-04-21
申请号：US692773
申请日：1976-06-04
IPC分类号： C09K3/00 , B01J47/12 , D01D5/00 , D01F1/02 , D01F1/10 , D01F2/28 , D01F6/54 , D01F6/94 , C08L89/00
CPC分类号： D01F1/10 , B01J47/123
摘要： A method is disclosed for embedding sequestering agents in filamentary structures, the method comprising the steps of preparing an emulsion formed by an aqueous or nearly aqueous solution of the sequestering agent and a solution of the filament-forming polymer in an appropriate solvent, and spinning the emulsion in a coagulation bath.
摘要翻译： 公开了一种将螯合剂嵌入丝状结构中的方法，该方法包括以下步骤：由多价螯合剂的水溶液或近似水溶液形成的乳液和将丝状聚合物溶于合适的溶剂中， 乳液在凝固浴中。
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公开(公告)号：US4396716A
公开(公告)日：1983-08-02
申请号：US334907
申请日：1981-12-28
CPC分类号： C12N11/00 , A61L33/0047
摘要： A prosthetic polymer material is made non-thrombogenic by immobilizing apyrase on its surface. Immobilization is preferably carried out by hydrolytically activating the surface of a polyamide polymer or a polyethylene terphthalate polymer, and treating the hydrolyzed polymer with a solution of cross-linking agent and a solution of apyrase. The apyrase converts adenosine diphosphate to adenosine monophosphate and adenosine whereby the formation of thrombi is inhibited.
摘要翻译： 辅助聚合物材料通过在其表面上固定apyr酶而制成非血栓形成。 固定化优选通过水解活化聚酰胺聚合物或聚对苯二甲酸乙二醇酯聚合物的表面进行，并用交联剂溶液和脱酰酶溶液处理水解的聚合物。 腺苷二磷酸腺苷二磷酸腺苷转化为腺苷一磷酸和腺苷，从而抑制血栓的形成。
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7.发明授权Phenylalanine ammonia lyase occluded fibers for reducing phenylalanine blood-level 失效苯丙氨酸氨裂解酶封闭纤维用于降低苯丙氨酸血药浓度
公开(公告)号：US4248704A
公开(公告)日：1981-02-03
申请号：US35528
申请日：1979-05-03
CPC分类号： C12N11/04 , A23J3/30 , A61M1/3687
摘要： Phenylalanine level in blood or another medium is considerably reduced and can even be annulled by causing blood or the other medium to flow through a mass of porous fibers in which the enzyme phenylalanine ammonia lyase has been occluded: the fibers have been previously made biocompatible, if necessary.
摘要翻译： 血液或其他培养基中苯丙氨酸水平显着降低，甚至可以通过使血液或其他培养基流过其中已经封闭了苯丙氨酸氨裂解酶的多孔纤维群，甚至被消除：纤维已经被预先制成生物相容性，如果 必要。
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公开(公告)号：US4242461A
公开(公告)日：1980-12-30
申请号：US941682
申请日：1978-09-12
摘要： For effecting enzymic reaction, a reactor is disclosed, in which the flow of the solution to be treated through the catalytic bed material takes place radially. It is preferred to have the catalytic bed in the form of coils of enzyme-occluding fibers. The coils are variously piled up within the reactor. High outputs, low pressure drops and more than satisfactory conversion rates are obtained.
摘要翻译： 为了进行酶反应，公开了一种反应器，其中通过催化床材料处理的溶液的流动径向地进行。 优选使催化床成为封闭纤维线圈的形式。 线圈被堆放在反应器内。 获得了高输出，低压降和超过令人满意的转换率。
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公开(公告)号：US4879036A
公开(公告)日：1989-11-07
申请号：US60120
申请日：1987-06-09
CPC分类号： B01D71/56
摘要： An asymmetrical membrane for use in dialysis and ultra-filtration is prepared using a polyester-amide (TATE).sub.n, wherein T represents a radical of terephthalic acid, A represents a radical of hexamethylenediamine, and E represents a radical of hexanediol, in a solvent of formic acid or in a solvent comprising a solution of lithium chloride in dimethylformamide or dimethylacetamide. The polyester-amide (TATE).sub.n is formed into a thin layer and placed into an aqueous coagulation bath to coagulate the resulting membrane. The membrane has a thickness of from 15 to 190 .mu.m, a water permeability of from about 3 up to about 9 liters/m.sup.2 /hour for a .DELTA.P of 300 mm.sub.HG and is permeable for substances having a molecular weight of up to about 17,000.
摘要翻译： 用于透析和超滤的不对称膜使用聚酯酰胺（TATE）n制备，其中T表示对苯二甲酸的基团，A表示六亚甲基二胺的基团，E表示己二醇的基团，在溶剂中 的甲酸或在包含氯化锂在二甲基甲酰胺或二甲基乙酰胺中的溶液的溶剂中。 将聚酯酰胺（TATE）n形成薄层并置于含水凝固浴中以使得到的膜凝结。 对于300mmHG的DELTA P，膜具有15至190μm的厚度，约3至约9升/ m 2 /小时的透水性，并且对于分子量高达约17,000的物质是可渗透的 。
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公开(公告)号：US4830796A
公开(公告)日：1989-05-16
申请号：US60247
申请日：1987-06-09
摘要： A hollow fibre of polyester-amide, useful in the process of dialysis and in ultra-filtration processes in general, is formed by a polyester-amide with repetitive units (TATE).sub.n (wherein T is the terephthalic acid radical; A is the ethylenediamine radical; and E is the hexanediol radical).Such a fibre is obtained by a process which comprises the following steps, carried out sequentially:preparation of a solution of polyesteramide (TATE).sub.n in a solvent constituted by formic acid at a concentration higher than about 99%, or constituted by a solution of lithium chloride in dimethylformamide or dimethylacetamide;extrusion of said solution through a spinnerette having a cross section of annular shape and coagulation of the fibre in an aqueous coagulation bath, with the possible introduction of an aqueous coagulating liquid to the interior of the annular opening of the spinnerette;washing with water and recovery of the so-obtained hollow fibre.
摘要翻译： 一般在透析和超滤方法中有用的聚酯酰胺中空纤维由具有重复单元（TATE）n的聚酯酰胺（其中T是对苯二甲酸基团; A是乙二胺）形成 自由基; E是己二醇基团）。 这样的纤维通过以下步骤获得，其顺序进行：在由甲酸浓度高于约99％的甲酸溶液中制备聚酯酰胺（TATE）n溶液，或者由 氯化锂在二甲基甲酰胺或二甲基乙酰胺中; 通过具有环形横截面的纺丝板和在水性凝固浴中使纤维凝结的所述溶液挤出，同时可能将水凝固液体引入喷丝板的环形开口的内部; 用水洗涤并回收如此获得的中空纤维。
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