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1.发明授权Prevention of probe coating on automated analyzers using a non-denaturing surfactant 失效使用非变性表面活性剂防止自动分析仪上的探针涂层
公开(公告)号：US5786153A
公开(公告)日：1998-07-28
申请号：US712829
申请日：1996-09-12
IPC分类号： G01N33/531 , C11D11/00 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/78 , G01N35/10 , A61K35/14 , C07K16/00 , G01N35/02
CPC分类号： C11D11/0005 , G01N33/5306 , G01N33/54326 , G01N33/54393 , G01N33/78 , Y10T436/11
摘要： A method for substantially preventing coating of hydrophobic material on a probe of an automated analyzer during an assay is described. An automated analyzer having a probe is provided. A composition comprising a non-denaturing surfactant and a reagent for use in the assay is provided. The probe is contacted with the composition during the assay such that hydrophobic material is substantially prevented from coating the probe on the automated analyzer. Compositions for preventing such probe coating are also described. Methods and compositions comprising a non-denaturing surfactant for enhancing the stability of reagents used in an assay are also described.
摘要翻译： 描述了在测定期间基本上防止在自动分析器的探针上涂覆疏水性材料的方法。 提供了一种具有探针的自动分析仪。 提供了包含非变性表面活性剂和用于测定中的试剂的组合物。 在测定期间使探针与组合物接触，从而基本上防止疏水性材料在自动分析仪上涂覆探针。 还描述了用于防止这种探针涂层的组合物。 还描述了包含用于增强测定中使用的试剂的稳定性的非变性表面活性剂的方法和组合物。
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公开(公告)号：US08409462B2
公开(公告)日：2013-04-02
申请号：US12929707
申请日：2011-02-09
CPC分类号： A61B17/3211 , A61B17/32 , A61B2017/00526 , B28D5/022
摘要： A method for manufacturing surgical blades from either a crystalline or poly-crystalline material, preferably in the form of a wafer, is disclosed. The method includes preparing the crystalline or poly-crystalline wafers by mounting them and machining trenches into the wafers. The methods for machining the trenches, which form the bevel blade surfaces, include a diamond blade saw, laser system, ultrasonic machine, and a hot forge press. The wafers are then placed in an etchant solution which isotropically etches the wafers in a uniform manner, such that layers of crystalline or poly-crystalline material are removed uniformly, producing single or double bevel blades. Nearly any angle can be machined into the wafer which remains after etching. The resulting radii of the blade edges is 5-500 nm, which is the same caliber as a diamond edged blade, but manufactured at a fraction of the cost.
摘要翻译： 公开了一种从晶体或多晶材料制造手术刀片的方法，优选以晶片的形式。 该方法包括通过安装晶片或多晶晶片并将沟槽加工到晶片中来制备。 用于加工形成斜面刀片表面的沟槽的方法包括金刚石刀片锯，激光系统，超声波机器和热锻压机。 然后将晶片放置在蚀刻剂溶液中，其均匀地蚀刻晶片，使得均匀地去除晶体或多晶材料层，产生单斜面或双斜面叶片。 在蚀刻后保留的晶片中几乎可以加工任何角度。 叶片边缘的最终半径为5-500nm，其与金刚石边缘刀片相同的口径，但是以成本的一小部分制造。
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公开(公告)号：US20090007436A1
公开(公告)日：2009-01-08
申请号：US12213202
申请日：2008-06-16
IPC分类号： B26B9/00
CPC分类号： B26B21/58 , A61B17/3211 , A61F9/0133 , B26B21/60 , H01L21/68764
摘要： Ophthalmic surgical blades are manufactured from either a crystalline or polycrystalline material, preferably in the form of a wafer. The method comprises preparing the crystalline or polycrystalline wafers by mounting them and machining trenches into the wafers. Methods for machining the trenches, which form the bevel blade surfaces, include a diamond blade saw, laser system, ultrasonic machine, a hot forge press and a router. The wafers are then placed in an etchant solution which isotropically etches the wafers in a uniform manner, such that layers of crystalline or polycrystalline material are removed uniformly, producing single, double or multiple bevel blades. Nearly any bevel angle can be machined into the wafer which remains after etching. The resulting radii of the blade edges is 5-500 nm, which is the same caliber as a diamond edged blade, but manufactured at a fraction of the cost. The ophthalmic surgical blades can be used for cataract and refractive surgical procedures, as well as microsurgical, biological and non-medical, non-biological purposes.
摘要翻译： 眼科手术刀片由晶体或多晶材料制成，优选以晶片的形式制造。 该方法包括通过将晶片或多晶晶片安装并将沟槽加工到晶片中来制备晶体或多晶晶片。 用于加工形成斜面刀片表面的沟槽的方法包括金刚石锯片锯，激光系统，超声波机器，热锻压机和路由器。 然后将晶片放置在蚀刻剂溶液中，其均匀地蚀刻晶片，使得均匀地去除晶体或多晶材料层，产生单个，双重或多个斜面叶片。 蚀刻后保留的晶片中几乎可以加工任何斜角。 叶片边缘的最终半径为5-500nm，其与金刚石边缘刀片相同的口径，但是以成本的一小部分制造。 眼科手术刀片可用于白内障和屈光手术，以及显微手术，生物和非医学，非生物学目的。
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公开(公告)号：US07105103B2
公开(公告)日：2006-09-12
申请号：US10383573
申请日：2003-03-10
CPC分类号： A61B17/3211 , A61B17/32 , A61B2017/00526 , B28D5/022
摘要： A method for manufacturing surgical blades from either a crystalline or poly-crystalline material, preferably in the form of a wafer, is disclosed. The method includes preparing the crystalline or poly-crystalline wafers by mounting them and machining trenches into the wafers. The methods for machining the trenches, which form the bevel blade surfaces, include a diamond blade saw, laser system, ultrasonic machine, and a hot forge press. The wafers are then placed in an etchant solution which isotropically etches the wafers in a uniform manner, such that layers of crystalline or poly-crystalline material are removed uniformly, producing single or double bevel blades. Nearly any angle can be machined into the wafer which remains after etching. The resulting radii of the blade edges is 5–500 nm, which is the same caliber as a diamond edged blade, but manufactured at a fraction of the cost.
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5.发明授权Methods of fabricating complex blade geometries from silicon wafers and strengthening blade geometries 有权从硅晶片制造复杂刀片几何形状和加强刀片几何形状的方法公开(公告)号：US07396484B2
公开(公告)日：2008-07-08
申请号：US11117730
申请日：2005-04-29
IPC分类号： B24C1/22
CPC分类号： A61B17/3211
摘要： Ophthalmic surgical blades are manufactured from either a single crystal or poly-crystalline material, preferably in the form of a wafer. The method comprises preparing the single crystal or poly-crystalline wafers by mounting them and etching trenches into the wafers using one of several processes. Methods for machining the trenches, which form the bevel blade surfaces, include a diamond blade saw, laser system, ultrasonic machine, a hot forge press and a router. Other processes include wet etching (isotropic and anisotropic) and dry etching (isotropic and anisotropic, including reactive ion etching), and combinations of these etching steps. The wafers are then placed in an etchant solution which isotropically etches the wafers in a uniform manner, such that layers of crystalline or poly-crystalline material are removed uniformly, producing single, double or multiple bevel blades. Nearly any angle can be machined into the wafer, and the machined angle remains after etching. The resulting radii of the blade edges is 5-500 nm, which is the same caliber as a diamond edged blade, but manufactured at a fraction of the cost. A range of radii may be 30 to 60 nm, with a specific implementation being about 40 nm. The blade profile may have an angle of, for example, about 60°. The ophthalmic surgical blades can be used for cataract and refractive surgical procedures, as well as microsurgical, biological and non-medical, non-biological purposes. Surgical and non-surgical blades and mechanical devices manufactured as described herein can also exhibit substantially smoother surfaces than metal blades.
摘要翻译： 眼科手术刀片由单晶或多晶材料制成，优选为晶片形式。 该方法包括通过使用几种方法之一安装它们并将沟槽蚀刻到晶片中来准备单晶或多晶晶片。 用于加工形成斜面刀片表面的沟槽的方法包括金刚石锯片锯，激光系统，超声波机器，热锻压机和路由器。 其他工艺包括湿蚀刻（各向同性和各向异性）和干蚀刻（各向同性和各向异性，包括反应离子蚀刻）以及这些蚀刻步骤的组合。 然后将晶片放置在蚀刻剂溶液中，其均匀地蚀刻晶片，使得均匀地去除晶体或多晶材料层，产生单个，双重或多个斜面叶片。 几乎任何角度可以加工到晶片中，并且在蚀刻之后保留加工角度。 叶片边缘的最终半径为5-500nm，其与金刚石边缘刀片相同的口径，但是以成本的一小部分制造。 半径范围可以为30至60nm，具体实施方案为约40nm。 刀片轮廓可以具有例如约60°的角度。 眼科手术刀片可用于白内障和屈光手术，以及显微手术，生物和非医学，非生物学目的。 如本文所述制造的手术和非手术刀片和机械装置也可以表现出比金属刀片更基本平滑的表面。
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公开(公告)号：US20110192819A1
公开(公告)日：2011-08-11
申请号：US12929707
申请日：2011-02-09
IPC分类号： C23F1/00
CPC分类号： A61B17/3211 , A61B17/32 , A61B2017/00526 , B28D5/022
摘要： A method for manufacturing surgical blades from either a crystalline or poly-crystalline material, preferably in the form of a wafer, is disclosed. The method includes preparing the crystalline or poly-crystalline wafers by mounting them and machining trenches into the wafers. The methods for machining the trenches, which form the bevel blade surfaces, include a diamond blade saw, laser system, ultrasonic machine, and a hot forge press. The wafers are then placed in an etchant solution which isotropically etches the wafers in a uniform manner, such that layers of crystalline or poly-crystalline material are removed uniformly, producing single or double bevel blades. Nearly any angle can be machined into the wafer which remains after etching. The resulting radii of the blade edges is 5-500 nm, which is the same caliber as a diamond edged blade, but manufactured at a fraction of the cost.
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公开(公告)号：US07906437B2
公开(公告)日：2011-03-15
申请号：US11495895
申请日：2006-07-31
IPC分类号： H01L21/302 , H01L21/461
CPC分类号： A61B17/3211 , A61B17/32 , A61B2017/00526 , B28D5/022
摘要： A method for manufacturing surgical blades from either a crystalline or poly-crystalline material, preferably in the form of a wafer, is disclosed. The method includes preparing the crystalline or poly-crystalline wafers by mounting them and machining trenches into the wafers. The methods for machining the trenches, which form the bevel blade surfaces, include a diamond blade saw, laser system, ultrasonic machine, and a hot forge press. The wafers are then placed in an etchant solution which isotropically etches the wafers in a uniform manner, such that layers of crystalline or poly-crystalline material are removed uniformly, producing single or double bevel blades. Nearly any angle can be machined into the wafer which remains after etching. The resulting radii of the blade edges is 5-500 nm, which is the same caliber as a diamond edged blade, but manufactured at a fraction of the cost.
摘要翻译： 公开了一种从晶体或多晶材料制造手术刀片的方法，优选以晶片的形式。 该方法包括通过安装晶片或多晶晶片并将沟槽加工到晶片中来制备。 用于加工形成斜面刀片表面的沟槽的方法包括金刚石刀片锯，激光系统，超声波机器和热锻压机。 然后将晶片放置在蚀刻剂溶液中，其均匀地蚀刻晶片，使得均匀地去除晶体或多晶材料层，产生单斜面或双斜面叶片。 在蚀刻后保留的晶片中几乎可以加工任何角度。 叶片边缘的最终半径为5-500nm，其与金刚石边缘刀片相同的口径，但是以成本的一小部分制造。
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8.发明授权System and method for creating linear and non-linear trenches in silicon and other crystalline materials with a router 有权在硅和其他结晶材料中用路由器创建线性和非线性沟槽的系统和方法公开(公告)号：US07785485B2
公开(公告)日：2010-08-31
申请号：US10943229
申请日：2004-09-17
IPC分类号： B44C1/22
CPC分类号： A61B17/32 , A61B17/3211 , A61B2017/00526 , B26B21/58
摘要： A method for manufacturing blades for surgical and other uses from either a crystalline or polycrystalline material, preferably in the form of a wafer, comprises preparing the crystalline or polycrystalline wafers by mounting them and machining trenches into the wafers. The methods for machining the trenches, which form the bevel blade surfaces, include a diamond blade saw, laser system, ultrasonic machine, a hot forge press and a router. When a router is used, through-holes are drilled in the wafer to define the starting locations of the trenches. After the trenches are formed, the wafers are placed in an etchant solution which isotropically etches the wafers in a uniform manner, such that layers of crystalline or polycrystalline material are removed uniformly, producing single or double bevel blades, with each bevel having one or more facets. Nearly any bevel angle can be machined into the wafer which remains after etching. The resulting radii of the blade edges is 5-500 nm, which is the same caliber as a diamond edged blade, but manufactured at a fraction of the cost.
摘要翻译： 用于从晶体或多晶材料制造用于手术和其它用途的刀片的方法，优选以晶片的形式，包括通过将晶片或多晶晶片安装并将沟槽加工到晶片中来制备晶体或多晶晶片。 用于加工形成斜面刀片表面的沟槽的方法包括金刚石锯片锯，激光系统，超声波机器，热锻压机和路由器。 当使用路由器时，在晶片中钻出通孔以定义沟槽的起始位置。 在形成沟槽之后，将晶片放置在蚀刻剂溶液中，其均匀地蚀刻晶片，使得均匀地去除晶体或多晶材料层，产生单或双斜面叶片，每个斜面具有一个或多个 方面 蚀刻后保留的晶片中几乎可以加工任何斜角。 叶片边缘的最终半径为5-500nm，其与金刚石边缘刀片相同的口径，但是以成本的一小部分制造。
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公开(公告)号：US07387742B2
公开(公告)日：2008-06-17
申请号：US10943227
申请日：2004-09-17
IPC分类号： B44C1/22
CPC分类号： A61B17/3211 , A61B2017/00526 , A61F9/0133
摘要： Ophthalmic surgical blades are manufactured from either a crystalline or polycrystalline material, preferably in the form of a wafer. The method comprises preparing the crystalline or polycrystalline wafers by mounting them and machining trenches into the wafers. Methods for machining the trenches, which form the bevel blade surfaces, include a diamond blade saw, laser system, ultrasonic machine, a hot forge press and a router. The wafers are then placed in an etchant solution which isotropically etches the wafers in a uniform manner, such that layers of crystalline or polycrystalline material are removed uniformly, producing single, double or multiple bevel blades. Nearly any bevel angle can be machined into the wafer which remains after etching. The resulting radii of the blade edges is 5-500 nm, which is the same caliber as a diamond edged blade, but manufactured at a fraction of the cost. The ophthalmic surgical blades can be used for cataract and refractive surgical procedures, as well as microsurgical, biological and non-medical, non-biological purposes.
摘要翻译： 眼科手术刀片由晶体或多晶材料制成，优选以晶片的形式制造。 该方法包括通过将晶片或多晶晶片安装并将沟槽加工到晶片中来制备晶体或多晶晶片。 用于加工形成斜面刀片表面的沟槽的方法包括金刚石锯片锯，激光系统，超声波机器，热锻压机和路由器。 然后将晶片放置在蚀刻剂溶液中，其均匀地蚀刻晶片，使得均匀地去除晶体或多晶材料层，产生单个，双重或多个斜面叶片。 蚀刻后保留的晶片中几乎可以加工任何斜角。 叶片边缘的最终半径为5-500nm，其与金刚石边缘刀片相同的口径，但是以成本的一小部分制造。 眼科手术刀片可用于白内障和屈光手术，以及显微手术，生物和非医学，非生物学目的。
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