-
公开(公告)号：US20060009472A1
公开(公告)日：2006-01-12
申请号：US11158574
申请日：2005-06-20
申请人： Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
发明人： Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/427 , A61K31/4178 , C07D417/02 , C07D43/02
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
-
公开(公告)号：US20130017196A1
公开(公告)日：2013-01-17
申请号：US13613977
申请日：2012-09-13
申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号： A61K31/4174 , C07D401/12 , A61K31/454 , C07D403/12 , A61K31/496 , A61K31/4439 , C07D405/12 , A61K31/4178 , C07D417/12 , A61K31/427 , C07D413/12 , A61K31/422 , A61K31/5377 , C07D498/10 , A61P35/00 , A61K31/4745 , A61K31/7068 , A61K39/395 , A61K33/24 , A61K31/664 , A61P35/02 , C07D233/64
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。 本发明的化合物具有以下通式：
-
公开(公告)号：US07576221B2
公开(公告)日：2009-08-18
申请号：US11158574
申请日：2005-06-20
申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号： A61K31/4174 , C07D233/64
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
-
公开(公告)号：US08318791B2
公开(公告)日：2012-11-27
申请号：US12455798
申请日：2009-06-05
申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号： A61K39/395 , A61K31/4178 , A61K31/427 , A61K31/5386 , A61K31/4174
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。 本发明的化合物具有以下通式：
-
公开(公告)号：US20090258016A1
公开(公告)日：2009-10-15
申请号：US12455798
申请日：2009-06-05
申请人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人： Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号： A61K39/395 , A61K31/4178 , A61K31/427 , A61K31/5386 , A61K31/4174 , A61P35/00
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。 本发明的化合物具有以下通式：
-
公开(公告)号：US08735599B2
公开(公告)日：2014-05-27
申请号：US13613977
申请日：2012-09-13
申请人： Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人： Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号： A61K31/4174 , C07D233/00 , C07D233/54
CPC分类号： C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要： The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译： 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐，酯或前药，新化合物的组合物和药学上可接受的载体，以及新化合物的用途。 本发明的化合物具有以下通式：
-
公开(公告)号：US07932262B2
公开(公告)日：2011-04-26
申请号：US12295967
申请日：2007-04-05
申请人： Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice Rico , Xiaojong M. Wang , Rama Jain , Jeremy M. Murray , Stephen E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
发明人： Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice Rico , Xiaojong M. Wang , Rama Jain , Jeremy M. Murray , Stephen E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
IPC分类号： A61K31/517
CPC分类号： C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
摘要： The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译： 本发明提供作为PDK1抑制剂的喹唑啉化合物。 还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。
-
公开(公告)号：US20100048561A1
公开(公告)日：2010-02-25
申请号：US12295967
申请日：2007-04-05
申请人： Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice C. Rico , Xiaojing M. Wang , Rama Jain , Jeremy M. Murray , Steven E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
发明人： Savithri Ramurthy , Xiaodong Lin , Sharadha Subramanian , Alice C. Rico , Xiaojing M. Wang , Rama Jain , Jeremy M. Murray , Steven E. Basham , Robert L. Warne , Wei Shu , Yasheen Zhou , Jeffrey Dove , Mina Aikawa , Payman Amiri , Weibo Wang , Johanna M. Jansen , Allan S. Wagman , Keith B. Pfister , Simon Ng
IPC分类号： A61K31/517 , C07D401/12 , C07D401/14 , C07D239/84 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D239/94 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D451/06 , C07D453/02
摘要： The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译： 本发明提供作为PDK1抑制剂的喹唑啉化合物。 还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。
-
公开(公告)号：US20100216767A1
公开(公告)日：2010-08-26
申请号：US12448390
申请日：2007-12-20
申请人： Mina Aikawa , Payman Amiri , Steven Bashman , Jeffrey Dove , Rama Jain , Xiaodong Lin , Jeremy Murray , Savithri Ramurthy , Alice Rico , Wei Shu , Sharadha Subramanian , Xiaojing Michael Wang , Robert L. Warne , Yasheen Zhou
发明人： Mina Aikawa , Payman Amiri , Steven Bashman , Jeffrey Dove , Rama Jain , Xiaodong Lin , Jeremy Murray , Savithri Ramurthy , Alice Rico , Wei Shu , Sharadha Subramanian , Xiaojing Michael Wang , Robert L. Warne , Yasheen Zhou
IPC分类号： A61K31/337 , C07D239/84 , A61K31/517 , C07D401/12 , A61K31/496 , C07D403/10 , C07D413/10 , A61K31/5377 , C07D413/14 , C07D403/12 , A61P35/00
CPC分类号： C07D239/84 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D411/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译： 本发明提供了作为PDK1抑制剂的新型化合物。 还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。
-
公开(公告)号：US20100121052A1
公开(公告)日：2010-05-13
申请号：US12456032
申请日：2009-06-09
申请人： Rama Jain , Xiaodong Lin , Simon C. Ng , Keith B. Pfister , Savithri Ramurthy , Alice Rico , Sharadha Subramanian , Xiaojing Michael Wang
发明人： Rama Jain , Xiaodong Lin , Simon C. Ng , Keith B. Pfister , Savithri Ramurthy , Alice Rico , Sharadha Subramanian , Xiaojing Michael Wang
IPC分类号： C07D239/84 , C07D417/10 , C07D401/12 , C07D413/12 , C07D401/14 , C07D413/14
CPC分类号： C07D417/04 , C07D239/84 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The invention provides novel compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
摘要翻译： 本发明提供了作为PDK1抑制剂的新型化合物。 还提供了包含该化合物的药物组合物，以及用化合物或组合物治疗增殖性疾病如癌症的方法。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.155 秒)
