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公开(公告)号:US20060009472A1
公开(公告)日:2006-01-12
申请号:US11158574
申请日:2005-06-20
申请人: Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
发明人: Weibo Wang , Paul Barsanti , Yi Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan Phillips , Kris Mendenhall , Kelly Wayman , Liana Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul Renhowe , Kenneth Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent Le
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/427 , A61K31/4178 , C07D417/02 , C07D43/02
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
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公开(公告)号:US20130017196A1
公开(公告)日:2013-01-17
申请号:US13613977
申请日:2012-09-13
申请人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号: A61K31/4174 , C07D401/12 , A61K31/454 , C07D403/12 , A61K31/496 , A61K31/4439 , C07D405/12 , A61K31/4178 , C07D417/12 , A61K31/427 , C07D413/12 , A61K31/422 , A61K31/5377 , C07D498/10 , A61P35/00 , A61K31/4745 , A61K31/7068 , A61K39/395 , A61K33/24 , A61K31/664 , A61P35/02 , C07D233/64
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐,酯或前药,新化合物的组合物和药学上可接受的载体,以及新化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US07576221B2
公开(公告)日:2009-08-18
申请号:US11158574
申请日:2005-06-20
申请人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号: A61K31/4174 , C07D233/64
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
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公开(公告)号:US08318791B2
公开(公告)日:2012-11-27
申请号:US12455798
申请日:2009-06-05
申请人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号: A61K39/395 , A61K31/4178 , A61K31/427 , A61K31/5386 , A61K31/4174
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐,酯或前药,新化合物的组合物和药学上可接受的载体,以及新化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US20090258016A1
公开(公告)日:2009-10-15
申请号:US12455798
申请日:2009-06-05
申请人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人: Weibo Wang , Paul A. Barsanti , Yia Xia , Rustum Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagniton , Ryan Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号: A61K39/395 , A61K31/4178 , A61K31/427 , A61K31/5386 , A61K31/4174 , A61P35/00
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐,酯或前药,新化合物的组合物和药学上可接受的载体,以及新化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US08735599B2
公开(公告)日:2014-05-27
申请号:US13613977
申请日:2012-09-13
申请人: Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
发明人: Weibo Wang , Paul A. Barsanti , Xia Yia , Rustum S. Boyce , Sabina Pecchi , Nathan Brammeier , Megan C. Phillips , Kris Mendenhall , Kelly Wayman , Liana Marie Lagnition , Ryan N. Constantine , Hong Yang , Elizabeth Mieuli , Savithri Ramurthy , Elisa Jazan , Anu Sharma , Rama Jain , Sharadha Subramanian , Paul A. Renhowe , Kenneth W. Bair , David Duhl , Annette Walter , Tinya Abrams , Kay Huh , Eric Martin , Mark Knapp , Vincent P. Le
IPC分类号: A61K31/4174 , C07D233/00 , C07D233/54
CPC分类号: C07D233/54 , C07D233/24 , C07D233/64 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D498/10
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐,酯或前药,新化合物的组合物和药学上可接受的载体,以及新化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US20070037853A1
公开(公告)日:2007-02-15
申请号:US11502303
申请日:2006-08-09
申请人: Paul Barsanti , Yi Xia , Weibo Wang , Kris Mendenhall , Liana Lagniton , Savithri Ramurthy , Megan Phillips , Sharadha Subramanian , Rustum Boyce , Nathan Brammeier , Ryan Constantine , David Duhl , Annette Walter , Tinya Abrams , Paul Renhowe
发明人: Paul Barsanti , Yi Xia , Weibo Wang , Kris Mendenhall , Liana Lagniton , Savithri Ramurthy , Megan Phillips , Sharadha Subramanian , Rustum Boyce , Nathan Brammeier , Ryan Constantine , David Duhl , Annette Walter , Tinya Abrams , Paul Renhowe
IPC分类号: A61K31/454 , A61K31/4439 , A61K31/42 , A61K31/4178 , A61K31/4172 , C07D413/02 , C07D403/02 , C07D409/02
CPC分类号: C07D401/14 , C07D233/64 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses of the compounds. The compounds of the invention have the following general formula:
摘要翻译: 本发明涉及新的取代的咪唑化合物及其药学上可接受的盐,酯或前药,衍生物的组合物和药学上可接受的载体,以及该化合物的用途。 本发明的化合物具有以下通式:
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公开(公告)号:US20050215580A1
公开(公告)日:2005-09-29
申请号:US11042474
申请日:2005-01-24
申请人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan Phillips , Elisa Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
发明人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan Phillips , Elisa Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
IPC分类号: A61K31/4745 , C07D471/02 , C07D471/04
CPC分类号: C07D471/04
摘要: Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要翻译: 四氢咔啉化合物,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种四氢咔啉化合物的组合物,单独或与至少一种另外的治疗剂组合。 单独使用四氢咔啉化合物或与至少一种另外的治疗剂组合使用的方法可用于预防或治疗增殖性疾病。
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公开(公告)号:US07855295B2
公开(公告)日:2010-12-21
申请号:US11042474
申请日:2005-01-24
申请人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan C. Phillips , Eliza Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
发明人: Weibo Wang , Zhi-Jie Ni , Paul Barsanti , Sabina Pecchi , Yi Xia , Nathan Brammeier , Megan C. Phillips , Eliza Jazan , Kelly Wayman , David Dibble , Jie-Kai Cheng
IPC分类号: A61K31/437 , C07D487/04
CPC分类号: C07D471/04
摘要: Tetrahydrocarboline compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent. Methods of using the tetrahydrocarboline compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases.
摘要翻译: 四氢咔啉化合物,其药学上可接受的盐和前药; 包括药学上可接受的载体和一种或多种四氢咔啉化合物的组合物,单独或与至少一种另外的治疗剂组合。 单独使用四氢咔啉化合物或与至少一种另外的治疗剂组合使用的方法可用于预防或治疗增殖性疾病。
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公开(公告)号:US20050069555A1
公开(公告)日:2005-03-31
申请号:US10748071
申请日:2003-12-29
申请人: Paul Barsanti , Nathan Brammeier , Anthony Diebes , Liana Lagniton , Simon Ng , Zhi-Jie Ni , Keith Pfister , Casey Philbin , Nicholas Valiante , Allan Wagman , Weibo Wang , Amy Weiner
发明人: Paul Barsanti , Nathan Brammeier , Anthony Diebes , Liana Lagniton , Simon Ng , Zhi-Jie Ni , Keith Pfister , Casey Philbin , Nicholas Valiante , Allan Wagman , Weibo Wang , Amy Weiner
IPC分类号: A61K20060101 , A61K6/00 , A61K31/175 , A61K31/40 , A61K31/44 , A61K39/00 , A61K39/39 , A61P31/12 , C07D207/06 , C07D207/09 , C07D207/14 , C07D207/32 , C07D207/335 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/10 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D413/10 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04
CPC分类号: C07D207/335 , A61K31/175 , A61K39/39 , A61K2039/55511 , C07D207/06 , C07D207/09 , C07D207/14 , C07D209/14 , C07D209/88 , C07D211/14 , C07D211/18 , C07D211/28 , C07D211/46 , C07D211/56 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/53 , C07D213/74 , C07D215/12 , C07D217/04 , C07D231/12 , C07D233/24 , C07D235/14 , C07D239/48 , C07D241/04 , C07D241/08 , C07D243/08 , C07D277/28 , C07D277/42 , C07D295/096 , C07D295/135 , C07D295/15 , C07D295/155 , C07D295/192 , C07D307/14 , C07D307/52 , C07D307/54 , C07D307/66 , C07D307/79 , C07D307/81 , C07D317/58 , C07D333/68 , C07D401/04 , C07D401/10 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D497/04 , A61K2300/00
摘要: The present invention is directed to novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, novel methods for treating viral infections, including HCV, by administering the compounds, and novel methods for modulating an immune response by administering the compounds.
摘要翻译: 本发明涉及新型免疫增强剂,新型疫苗佐剂,新化合物和药物组合物,通过施用化合物治疗病毒感染(包括HCV)的新方法,以及通过施用化合物调节免疫应答的新方法。
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