公开(公告)号：US09068030B2

公开(公告)日：2015-06-30

申请号：US13574435

申请日：2011-01-21

申请人： Wenbo Song ,  Meifang Guo ,  Shijun Zhang ,  Wenjun Wei ,  Honghong Huang ,  Luqiang Yu ,  Tao Liu ,  Huijie Hu ,  Huan Xu ,  Peiqian Yu ,  Xiaomeng Zhang

发明人： Wenbo Song ,  Meifang Guo ,  Shijun Zhang ,  Wenjun Wei ,  Honghong Huang ,  Luqiang Yu ,  Tao Liu ,  Huijie Hu ,  Huan Xu ,  Peiqian Yu ,  Xiaomeng Zhang

IPC分类号： C08F4/16 ,  C08F4/58 ,  C08F2/38 ,  C08F110/06

CPC分类号： C08F110/06 ,  C08F2/001 ,  C08F2500/01 ,  C08F2500/04 ,  C08F2500/11 ,  C08F2500/12 ,  C08F4/6465 ,  C08F4/6492

摘要： The present invention provides a process for preparing high melt strength propylene polymer by direct polymerization, comprising that a propylene polymer with wide molecular weight distribution and containing “very high molecular weight fraction” can be prepared by controlling the species and ratios of the external electron donors in the Ziegler-Natta catalyst system at different reaction stages according to the requirement for different molecular weight fractions in the different propylene polymerization stage of the series operation, and said polymer has excellent mechanical properties, especially with very high melt strength. The present invention also provides a propylene homopolymer with high melt strength, comprising the following features: (1) the MFR is 0.2-10 g/10 min at 230° C. with a load of 2.16 kg; (2) the molecular weight distribution Mw/Mn is 6-20; (3) the content of the fraction with a molecular weight higher than 5,000,000 is higher than or equal to 0.8 wt %; (4) Mz+1/Mn is higher than or equal to 70. Said homopolymer can be used in the preparation of foam products, thermoforming products, biaxial stretching films, blown films and blow-molded products.

摘要翻译： 本发明提供了一种通过直接聚合制备高熔体强度丙烯聚合物的方法，包括具有宽分子量分布并含有“非常高分子量级分”的丙烯聚合物可以通过控制外部电子给体的种类和比例 在不同反应阶段的齐格勒 - 纳塔催化剂体系中，根据在不同的丙烯聚合反应阶段对不同分子量馏分的要求，所述聚合物具有优异的机械性能，特别是具有非常高的熔体强度。 本发明还提供具有高熔体强度的丙烯均聚物，其特征在于：（1）在230℃，2.16kg负荷下，MFR为0.2-10g / 10min; （2）分子量分布Mw / Mn为6〜20; （3）分子量高于5,000,000的级分的含量高于或等于0.8wt％; （4）Mz + 1 / Mn大于或等于70.所述均聚物可用于制备泡沫产品，热成型产品，双轴拉伸膜，吹塑薄膜和吹塑产品。

公开(公告)号：US20130023598A1

公开(公告)日：2013-01-24

申请号：US13574435

申请日：2011-01-21

申请人： Wenbo Song ,  Meifang Guo ,  Shijun Zhang ,  Wenjun Wei ,  Honghong Huang ,  Luqiang Yu ,  Tao Liu ,  Huijie Hu ,  Huan Xu ,  Peiqian Yu ,  Xiaomeng Zhang

发明人： Wenbo Song ,  Meifang Guo ,  Shijun Zhang ,  Wenjun Wei ,  Honghong Huang ,  Luqiang Yu ,  Tao Liu ,  Huijie Hu ,  Huan Xu ,  Peiqian Yu ,  Xiaomeng Zhang

IPC分类号： C08F2/01 ,  C08F110/06

CPC分类号： C08F110/06 ,  C08F2/001 ,  C08F2500/01 ,  C08F2500/04 ,  C08F2500/11 ,  C08F2500/12 ,  C08F4/6465 ,  C08F4/6492

摘要： The present invention provides a process for preparing high melt strength propylene polymer by direct polymerization, comprising that a propylene polymer with wide molecular weight distribution and containing “very high molecular weight fraction” can be prepared by controlling the species and ratios of the external electron donors in the Ziegler-Natta catalyst system at different reaction stages according to the requirment for different molecular weight fractions in the different propylene polymerization stage of the series operation, and said polymer has excellent mechnical properties, especially with very high melt strength. The present invention also provides a propylene homopolymer with high melt strength, comprising the following features: (1) the MFR is 0.2-10 g/10 min at 230° C. with a load of 2.16 kg; (2) the molecular weight distribution Mw/Mn is 6-20; (3) the content of the fraction with a molecular weight higher than 5,000,000 is higher than or equal to 0.8 wt %; (4) Mz+1/Mn is higher than or equal to 70. Said homopolymer can be used in the preparation of foam products, thermoforming products, biaxial stretching films, blown films and blow-molded products.

摘要翻译： 本发明提供了一种通过直接聚合制备高熔体强度丙烯聚合物的方法，包括具有宽分子量分布且含有非常高分子量级分的丙烯聚合物可以通过控制外部电子给体的种类和比例来制备 齐格勒 - 纳塔催化剂体系在不同反应阶段根据不同分子量馏分在不同丙烯聚合反应阶段的操作要求，所述聚合物具有优异的机械性能，特别是具有非常高的熔体强度。 本发明还提供具有高熔体强度的丙烯均聚物，其特征在于：（1）在230℃，2.16kg负荷下，MFR为0.2-10g / 10min; （2）分子量分布Mw / Mn为6〜20; （3）分子量高于5,000,000的级分的含量高于或等于0.8wt％; （4）Mz + 1 / Mn大于或等于70.所述均聚物可用于制备泡沫产品，热成型产品，双轴拉伸膜，吹塑薄膜和吹塑产品。

公开(公告)号：US20060182987A1

公开(公告)日：2006-08-17

申请号：US11338619

申请日：2006-01-24

申请人： Luqiang Yu ,  Meifang Guo ,  Shijun Zhang ,  Jinliang Qiao ,  Wenbo Song ,  Qingshan Ma ,  Wei Zhang ,  Liangshi Wang ,  Xi Wang ,  Hao Tang ,  Rongmei Liu

发明人： Luqiang Yu ,  Meifang Guo ,  Shijun Zhang ,  Jinliang Qiao ,  Wenbo Song ,  Qingshan Ma ,  Wei Zhang ,  Liangshi Wang ,  Xi Wang ,  Hao Tang ,  Rongmei Liu

IPC分类号： B32B27/32

CPC分类号： C08F210/06 ,  C08F10/00 ,  C08F110/06 ,  C08L23/12 ,  C08L23/142 ,  Y10T428/31855 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31938 ,  C08F4/6465 ,  C08F2/001 ,  C08L2666/06 ,  C08F2500/12 ,  C08F2500/04 ,  C08F2500/15 ,  C08F2500/26 ,  C08F210/16

摘要： The present invention provides a propylene polymer composition for producing a biaxially oriented film, comprising propylene random copolymer and propylene homopolymer; wherein the propylene random copolymer is a copolymer of propylene and ethylene, optionally comprising one or more alpha-olefins of C4-C10; the propylene polymer composition has an overall isotacticity index, as determined by nuclear magnetic resonance method, of greater than or equal to 96.5%, and an ethylene content of greater than 0.3 wt %; and wherein, the melt flow rate of the propylene random copolymer is lower than that of the propylene homopolymer. The biaxially oriented polypropylene film produced by the propylene polymer composition of the present invention exhibits excellent physical properties, and has, in the absence of any stiffening agent, relatively higher modulus and stiffness. Moreover, the process for producing the biaxially oriented polypropylene film is featured with a good film-forming stability and a high film-forming stretching speed.

摘要翻译： 本发明提供一种用于生产双轴取向膜的丙烯聚合物组合物，其包含丙烯无规共聚物和丙烯均聚物; 其中所述丙烯无规共聚物是丙烯和乙烯的共聚物，任选地包含一种或多种C 4 -C 10α-烯烃的α-烯烃; 丙烯聚合物组合物具有通过核磁共振方法测定的大于或等于96.5％的总体等规度指数，并且乙烯含量大于0.3重量％; 丙烯无规共聚物的熔体流动速率低于丙烯均聚物的熔体流动速率。 由本发明的丙烯聚合物组合物制造的双轴取向聚丙烯膜显示出优异的物理性能，并且在没有任何硬化剂的情况下，具有相对较高的模量和刚度。 此外，制造双轴取向聚丙烯膜的方法具有良好的成膜稳定性和高成膜拉伸速度。

公开(公告)号：US07611776B2

公开(公告)日：2009-11-03

申请号：US11338619

申请日：2006-01-24

申请人： Luqiang Yu ,  Meifang Guo ,  Shijun Zhang ,  Jinliang Qiao ,  Wenbo Song ,  Qingshan Ma ,  Wei Zhang ,  Liangshi Wang ,  Xi Wang ,  Hao Tang ,  Rongmei Liu

发明人： Luqiang Yu ,  Meifang Guo ,  Shijun Zhang ,  Jinliang Qiao ,  Wenbo Song ,  Qingshan Ma ,  Wei Zhang ,  Liangshi Wang ,  Xi Wang ,  Hao Tang ,  Rongmei Liu

IPC分类号： B32B27/00 ,  B32B27/08 ,  C08L23/00

CPC分类号： C08F210/06 ,  C08F10/00 ,  C08F110/06 ,  C08L23/12 ,  C08L23/142 ,  Y10T428/31855 ,  Y10T428/31909 ,  Y10T428/31913 ,  Y10T428/31938 ,  C08F4/6465 ,  C08F2/001 ,  C08L2666/06 ,  C08F2500/12 ,  C08F2500/04 ,  C08F2500/15 ,  C08F2500/26 ,  C08F210/16

摘要： The present invention provides a propylene polymer composition for producing a biaxially oriented film, comprising propylene random copolymer and propylene homopolymer; wherein the propylene random copolymer is a copolymer of propylene and ethylene, optionally comprising one or more alpha-olefins of C4-C10; the propylene polymer composition has an overall isotacticity index, as determined by nuclear magnetic resonance method, of greater than or equal to 96.5%, and an ethylene content of greater than 0.3 wt %; and wherein, the melt flow rate of the propylene random copolymer is lower than that of the propylene homopolymer. The biaxially oriented polypropylene film produced by the propylene polymer composition of the present invention exhibits excellent physical properties, and has, in the absence of any stiffening agent, relatively higher modulus and stiffness. Moreover, the process for producing the biaxially oriented polypropylene film is featured with a good film-forming stability and a high film-forming stretching speed.

摘要翻译： 本发明提供一种用于生产双轴取向膜的丙烯聚合物组合物，其包含丙烯无规共聚物和丙烯均聚物; 其中所述丙烯无规共聚物是丙烯和乙烯的共聚物，任选地包含一种或多种C 4 -C 10的α-烯烃; 丙烯聚合物组合物具有通过核磁共振方法测定的大于或等于96.5％的总体等规度指数，并且乙烯含量大于0.3重量％; 丙烯无规共聚物的熔体流动速率低于丙烯均聚物的熔体流动速率。 由本发明的丙烯聚合物组合物制造的双轴取向聚丙烯膜显示出优异的物理性能，并且在没有任何硬化剂的情况下，具有相对较高的模量和刚度。 此外，制造双轴取向聚丙烯膜的方法具有良好的成膜稳定性和高成膜拉伸速度。

公开(公告)号：US20090326171A1

公开(公告)日：2009-12-31

申请号：US12297857

申请日：2007-04-20

申请人： Wenbo Song ,  Meifang Guo ,  Jinliang Qiao ,  Zhichao Yang ,  Shijun Zhang ,  Luqiang Yu

发明人： Wenbo Song ,  Meifang Guo ,  Jinliang Qiao ,  Zhichao Yang ,  Shijun Zhang ,  Luqiang Yu

IPC分类号： C08F2/01 ,  C08F4/42

CPC分类号： C08F110/02 ,  C08F10/00 ,  C08F110/06 ,  Y02P20/52 ,  Y10T428/139 ,  C08F2/001 ,  C08F2500/04 ,  C08F2500/15 ,  C08F4/6465

摘要： The invention discloses a process for preparing high-performance propylene polymers, the process utilizing a high activity, highly stereoselective Ziegler-Natta catalyst and two or more stages of polymerization carried out under different hydrogen concentrations to prepare propylene polymers having broad molecular weight distribution, wherein non-unifomess of isotacticity of molecular chains of the final propylene polymers is improved by adjusting or controlling stereoselectivity of catalytic active sites under different hydrogen concentrations, namely, making the low molecular weight fraction of the polymers having a higher isotacticity and making the high molecular weight fraction of the polymers having a lower isotacticity, thereby overcoming the drawbacks of the propylene polymers having broad molecular weight distribution known in the art. The resulting final polymers have excellent combined properties, in particular, remarkably improved mechanical properties.

摘要翻译： 本发明公开了一种制备高性能丙烯聚合物的方法，该方法利用高活性，高立体选择性齐格勒 - 纳塔催化剂和在不同氢气浓度下进行的两个或多个阶段的聚合，以制备具有宽分子量分布的丙烯聚合物，其中 通过在不同氢浓度下调节或控制催化活性位点的立体选择性，即使得聚合物的低分子量分数具有更高的全同立构规整度并使其具有高分子量，从而提高了最终丙烯聚合物分子链全同立构规整度的非均匀性 具有较低全同立构规整度的聚合物部分，从而克服了本领域已知的具有宽分子量分布的丙烯聚合物的缺点。 所得的最终聚合物具有优异的组合性能，特别是显着提高的机械性能。

公开(公告)号：US08835134B2

公开(公告)日：2014-09-16

申请号：US12678025

申请日：2008-09-08

申请人： Yingmei Han ,  Guangping Xia ,  Weiren Xu ,  Zhuanyou Zhao ,  Wulin Liu ,  Naxia Zhao ,  Peng Liu ,  Shijun Zhang ,  Xiaoli Fu ,  Yuli Wang ,  Weiting Wang ,  Lida Tang

发明人： Yingmei Han ,  Guangping Xia ,  Weiren Xu ,  Zhuanyou Zhao ,  Wulin Liu ,  Naxia Zhao ,  Peng Liu ,  Shijun Zhang ,  Xiaoli Fu ,  Yuli Wang ,  Weiting Wang ,  Lida Tang

IPC分类号： C12P19/44 ,  A61K36/481 ,  A61K31/7048 ,  C12P19/56 ,  C07J17/00

CPC分类号： A61K36/481 ,  A61K31/7048 ,  C07J17/005 ,  C12P19/56

摘要： This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-β-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-β-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.

摘要翻译： 本发明提供了一种制备环草酮醇一葡萄糖苷CMG（环星形胶原蛋白-6-O-＆bgr-D-葡萄糖苷）的方法，包括以下步骤：a。 使用常规方法制备的黄芪甲苷或黄芪提取物作为原料，并加入适当的溶剂以形成原料溶液; b。 加入水解酶并允许在恒温下水解得到水解产物; C。 用大孔吸附树脂分离水解产物; 和d。 通过纯化和分离获得产物。 本发明还提供了根据本发明的方法制备的环状天门菊胶-6-O-和bgr-D-葡萄糖苷及其在制备用于治疗心血管疾病的药物中的用途以及包含其的药物组合物。

公开(公告)号：US07790759B2

公开(公告)日：2010-09-07

申请号：US12090169

申请日：2006-10-16

申请人： Jianwu Wang ,  Weiren Xu ,  Jianping Wong ,  Lida Tang ,  Shijun Zhang ,  Lijun Liu ,  Yuli Wang ,  Xiaowen Ren

发明人： Jianwu Wang ,  Weiren Xu ,  Jianping Wong ,  Lida Tang ,  Shijun Zhang ,  Lijun Liu ,  Yuli Wang ,  Xiaowen Ren

IPC分类号： A61K31/42 ,  C07D261/06

CPC分类号： C07D261/08 ,  A61K31/415 ,  C07D413/04

摘要： The present invention relates to the field of a medicine for treating diseases associated with inflammation, immunity or infection, and in particular, to glycyrrhetinic acid-30-amide derivatives of general formula I and their preparation, and a pharmaceutical composition containing the same. Said derivatives and composition exhibit anti-inflammatory, analgesic, anti-allergic, cough-preventing, liver-protecting and anti-viral properties, wherein each group is as defined in the description.

摘要翻译： 本发明涉及用于治疗与炎症，免疫或感染有关的疾病的药物领域，特别涉及通式I的甘草次酸 - 酰胺衍生物及其制备方法及含有该药物的药物组合物。 所述衍生物和组合物表现出抗炎，镇痛，抗过敏，咳嗽预防，肝保护和抗病毒性质，其中每组如说明书中所定义。

公开(公告)号：US20110166191A1

公开(公告)日：2011-07-07

申请号：US12984825

申请日：2011-01-05

申请人： Shijun Zhang ,  Tai Liang Guo

发明人： Shijun Zhang ,  Tai Liang Guo

IPC分类号： A61K31/426 ,  C07D277/34 ,  A61P35/00 ,  C12N5/02 ,  C12N9/99

CPC分类号： A61K31/426 ,  C07D277/34

摘要： 3-(2-amino-ethyl)-5-(3-cyclohexyl-propylidene)-thiazolidine-2,4-dione and derivatives thereof are provided for use as dual inhibitors of the Raf/MEK/ERK and PI3K/Akt pathways and for use in the treatment of cancer.

摘要翻译： 提供3-（2-氨基 - 乙基）-5-（3-环己基 - 亚丙基） - 噻唑烷-2,4-二酮及其衍生物作为Raf / MEK / ERK和PI3K / Akt途径的双重抑制剂， 用于治疗癌症。

公开(公告)号：US09062087B2

公开(公告)日：2015-06-23

申请号：US13575258

申请日：2011-01-14

申请人： Guilong Zhao ,  Hua Shao ,  Weiren Xu ,  Wei Liu ,  Yuli Wang ,  Lida Tang ,  Chubing Tan ,  Bingni Liu ,  Shijun Zhang

发明人： Guilong Zhao ,  Hua Shao ,  Weiren Xu ,  Wei Liu ,  Yuli Wang ,  Lida Tang ,  Chubing Tan ,  Bingni Liu ,  Shijun Zhang

IPC分类号： C07H7/04 ,  C07H7/06 ,  A61K31/70 ,  A61K31/351 ,  C07D309/10 ,  C07D409/10

CPC分类号： C07H7/04 ,  A61K31/351 ,  A61K31/70 ,  C07D309/10 ,  C07D409/10 ,  C07H7/06

摘要： The present invention relates to a sodium glucose cotransporter 2 (SGLT2) inhibitor with a phenyl C-glucoside structure, its preparation method, a pharmaceutical composition containing the same, and its use in treating diabetes and preparing an anti-diabetes medicament. The invention provides a compound with the structure of general formula I and a pharmaceutically acceptable salt and prodrug ester thereof,wherein, the definitions of R5 and R6 are selected from the following:(1) R5=R6=Me; (2) R5=Me, R6=OMe; (3) R5=Me, R6=H; (4) R5=Me, R6=F; (5) R5=F, R6=H; and (6) R5=OMe, R6=H.

摘要翻译： 本发明涉及具有苯基C-葡萄糖苷结构的钠葡萄糖协同转运蛋白2（SGLT2）抑制剂及其制备方法，含有该葡糖苷结构的药物组合物及其在治疗糖尿病中的用途以及制备抗糖尿病药物。 本发明提供具有通式I结构的化合物及其药学上可接受的盐和前药酯，其中R5和R6的定义选自如下：（1）R5 = R6 = Me; （2）R5 = Me，R6 = OMe; （3）R5 = Me，R6 = H; （4）R5 = Me，R6 = F; （5）R5 = F，R6 = H; 和（6）R5 = OMe，R6 = H。

公开(公告)号：US06423760B1

公开(公告)日：2002-07-23

申请号：US09702038

申请日：2000-10-30

申请人： Jinliang Qiao ,  Genshuan Wei ,  Xiaohong Zhang ,  Shijun Zhang ,  Jianming Gao ,  Wei Zhang ,  Yiqun Liu ,  Jiuqiang Li ,  Fengru Zhang ,  Renli Zhai ,  Jingbo Shao ,  Kunkai Yan ,  Hua Yin

发明人： Jinliang Qiao ,  Genshuan Wei ,  Xiaohong Zhang ,  Shijun Zhang ,  Jianming Gao ,  Wei Zhang ,  Yiqun Liu ,  Jiuqiang Li ,  Fengru Zhang ,  Renli Zhai ,  Jingbo Shao ,  Kunkai Yan ,  Hua Yin

IPC分类号： C08F246

CPC分类号： C08J3/26 ,  C08J3/28 ,  C08J2321/00 ,  Y10T428/2982

摘要： The present invention provides a fully vulcanized powdery rubber having a particle size of from 20 to 2000 nm, its preparation and use. The vulcanized powdery rubber is obtained by irradiating a rubber latex having a particle size of from 20 to 2000 nm with a high-energy irradiation. The vulcanized powdery rubber is very easily to be dispersed into various plastics, and thus can be mixed with various plastics to prepare toughened plastics and fully valcanized thermoplastic elastomers.

摘要翻译： 本发明提供了粒径为20〜2000nm的完全硫化粉末状橡胶，其制备和用途。 通过高能量照射照射粒径为20〜2000nm的橡胶胶乳，得到硫化粉末状橡胶。 硫化粉末状橡胶非常容易分散在各种塑料中，因此可以与各种塑料混合，制备增韧塑料和完全硫化的热塑性弹性体。