摘要:
This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-β-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-β-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
摘要:
This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-β-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-β-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
摘要:
Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要:
Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要:
Systems and methods for providing compact dispersion compensation modules. In one implementation, a dispersion compensation module includes a polarizer having a first port, a second port, and a third port. The dispersion compensation module also includes a reflection etalon and a quarter-waveplate positioned between the reflection etalon and the second port of the polarizer.
摘要:
Methods and compositions are provided for in vivo heterologous nucleic acid delivery using genetically modified microflora. Specifically, compositions and related methods for the delivery of heterologous nucleic acids to the intestinal mucosa of animals are provided. Specifically, genetically modified microflora are used to deliver transforming heterologous nucleic acids directly, or genetically modified microflora expressing at least one heterologous nucleic acid are provided. Representative microflora include bacteria, bacterial fusions, and yeast. The heterologous nucleic acid may encode for immunoprotective epitopes (antigens) or other gene therapy applications.
摘要:
A grating-in-etalon wavelength division multiplexing device is disclosed. In one aspect the device includes an etalon structure with a single volume (or Bragg) diffraction grating, multiple superimposed volume diffraction gratings or a binary volume supergrating is interposed between the reflective opposed faces of the etalon. The etalon includes a tilt mechanism for tilting one or both of the reflective faces at a preselected angle with respect to each other from the parallel. A multiple wavelength light beam is directed through the volume grating in different preselected directions so that light of wavelengths satisfying the Bragg condition on each traversal of the grating is diffracted in a direction different from the direction of the incident beam. The diffracted beam exits the etalon and is wavelength interrogated in a detector while the undiffracted wavelengths propagate through the grating to be reflected from the opposed mirror face back through the volume grating. On this traversal the diffracted light exits through the other side of the etalon and is wavelength interrogated in another wavelength sensitive light detector. In another aspect of the invention the WDM device is fabricated from an etalon waveguide with reflective opposed faces and having a Bragg grating (or multiple gratings) written into the waveguide between the reflective faces. Polarization insensitivity is achieved by writing in two sets of gratings, one set to diffract ordinary polarized light and the other to diffract extraordinary polarized light so that when polarization state of light changes, the diffraction efficiencies are relatively the same.
摘要:
Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.