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    Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof
    1.
    发明授权
    Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof 有权
    由三（全氟代烃基磺酰基）甲烷或其金属甲基化物制造的生育酚

    公开(公告)号：US06369242B2

    公开(公告)日：2002-04-09

    申请号：US09802272

    申请日：2001-03-08

    申请人： Werner Bonrath ,  Alois Haas ,  Eike Hoppmann ,  Thomas Netscher ,  Horst Pauling

    发明人： Werner Bonrath ,  Alois Haas ,  Eike Hoppmann ,  Thomas Netscher ,  Horst Pauling

    IPC分类号： C07D31104

    CPC分类号： C07D311/72

    摘要： A method of making (all-rac.)-&agr;-tocopherol by the acid-catalyzed condensation of trimethylhydroquinone with isophytol or phytol wherein the condensation is carried out in the presence of a tris(perfluoroalkanesulphonyl or pentafluorobenzenesulphonyl)methane or a metal salt thereof as the catalyst in an organic solvent. In addition to the metal salt, a Bronsted acid, e.g. sulfuric acid, phosphoric acid or p-toluenesulphonic acid, may be used as a co-catalyst. The product of the method of making is the most active member of the vitamin E group.

    摘要翻译： 通过三甲基氢醌与异植醇或植醇的酸催化缩合制备（全外消旋）-α-生育酚的方法，其中缩合在三（全氟烷基磺酰基或五氟苯磺酰基）甲烷或其金属盐存在下进行，为 该催化剂在有机溶剂中。 除了金属盐，布朗斯台德酸，例如， 硫酸，磷酸或对甲苯磺酸可用作助催化剂。 制作方法的产物是维生素E组中最活跃的成员。

    Manufacture of α-tocopherol
    3.
    发明授权
    Manufacture of α-tocopherol 有权
    α-生育酚的制造

    公开(公告)号：US07153984B2

    公开(公告)日：2006-12-26

    申请号：US10535603

    申请日：2003-09-30

    申请人： Werner Bonrath ,  Alois Haas ,  Simone Hoppmann ,  Thomas Netscher ,  Horst Pauling

    发明人： Werner Bonrath ,  Alois Haas ,  Simone Hoppmann ,  Thomas Netscher ,  Horst Pauling

    IPC分类号： C07D311/72

    CPC分类号： C07D311/72

    摘要： A process for the manufacture of (all-rac)-α-tocopherol by the acid-catalyzed reaction of trimethylhydroquinone with isophytol or phytol is characterized by carrying out the reaction in the presence of methane trisulphonate as the catalyst in an organic solvent. The product of the process is the most active and industrially most important member of the vitamin E group.

    摘要翻译： 通过三甲基氢醌与异麦芽糖醇或植醇酯的酸催化反应制备（全外消旋）-α-生育酚的方法的特征在于在甲磺酸三磺酸盐作为催化剂存在下在有机溶剂中进行反应。 该过程的产物是维生素E组中最活跃和最具工业最重要的成员。

    PROCESS FOR THE MANUFACTURE OF TMHQ
    5.
    发明申请
    PROCESS FOR THE MANUFACTURE OF TMHQ 有权
    TMHQ制造流程

    公开(公告)号：US20130211080A1

    公开(公告)日：2013-08-15

    申请号：US13817012

    申请日：2011-08-25

    申请人： Werner Bonrath ,  Thomas Netscher ,  Jan Schütz ,  Bettina Wüstenberg

    发明人： Werner Bonrath ,  Thomas Netscher ,  Jan Schütz ,  Bettina Wüstenberg

    IPC分类号： C07C45/65 ,  C07D295/116 ,  C07C215/50 ,  C07D311/04 ,  C07D295/096 ,  C07C221/00 ,  C07C45/62

    CPC分类号： C07C45/65 ,  C07C37/002 ,  C07C37/07 ,  C07C45/62 ,  C07C213/00 ,  C07C215/50 ,  C07C221/00 ,  C07D295/096 ,  C07D295/116 ,  C07D311/04 ,  C07C39/08

    摘要： The present invention is directed to a process for the manufacture of 2,3,5-trimethyl-hydro-p-benzoquinone comprising the following steps: a) hydrogenating 2,6-dimethyl-p-benzoquinone with hydrogen in the presence of a hydrogenation catalyst in an organic solvent to obtain 2,6-dimethyl-hydro-p-benzoquinone; b) reacting 2,6-dimethyl-hydro-p-benzoquinone with a secondary amine and formal-dehyde in an organic solvent to obtain 2,6-dimethyl-3-(N,N-disubstituted aminomethyl)-hydro-p-benzoquinone; c) reacting 2,6-dimethyl-3-(N,N-disubstituted aminomethyl)-hydro-p-benzoquinone with hydrogen in the presence of a hydrogenolysis catalyst in an organic solvent to obtain 2,3,5-trimethylhydro-p-benzoquinone; wherein the organic solvent in all steps a), b) and c) is independently selected from the group consisting of methyl tert.-butyl ether, ethyl tert.-butyl ether, tert.-amyl ether, methoxycyclopentane and any mixtures thereof. Preferably the organic solvent used in all steps a), b) and c) is the same.

    摘要翻译： 本发明涉及一种制备2,3,5-三甲基 - 氢 - 对苯醌的方法，包括以下步骤：a）在氢化存在下用氢气氢化2,6-二甲基对苯醌 催化剂在有机溶剂中得到2,6-二甲基 - 氢 - 对苯醌; b）使2,6-二甲基 - 对苯醌与仲胺和正型脱水在有机溶剂中反应，得到2,6-二甲基-3-（N，N-二取代氨基甲基） - 氢对苯醌 ; c）在氢解催化剂存在下，在有机溶剂中使2,6-二甲基-3-（N，N-二取代氨基甲基） - 氢对苯醌与氢气反应，得到2,3,5-三甲基氢对 - 苯醌 其中所有步骤a），b）和c）中的有机溶剂独立地选自甲基叔丁基醚，乙基叔丁基醚，叔戊基醚，甲氧基环戊烷及其任何混合物。 在所有步骤a），b）和c）中使用的有机溶剂优选是相同的。

    ISOMERIZATION OF BETA-KETO-ALLENES
    6.
    发明申请
    ISOMERIZATION OF BETA-KETO-ALLENES 有权
    BETA-KETO-ALLENES的异构体

    公开(公告)号：US20130197272A1

    公开(公告)日：2013-08-01

    申请号：US13642047

    申请日：2011-04-18

    申请人： Werner Bonrath ,  Reinhard Karge ,  Thomas Netscher ,  Yann Pressel

    发明人： Werner Bonrath ,  Reinhard Karge ,  Thomas Netscher ,  Yann Pressel

    IPC分类号： C07C45/67

    CPC分类号： C07C45/67 ,  B01J31/08 ,  B01J2231/52 ,  C07C49/203

    摘要： Isomerization of β-keto-allenes of the general formula I wherein R1 is hydrogen, methyl or ethyl, in particular hydrogen or methyl; R2 is hydrogen or methyl; R3 is hydrogen or methyl, in particular methyl and R4 is an aliphatic hydrocarbon residue containing 1-37 carbon atoms, into corresponding α,γ-dienones of formula II by treatment with a basic ion exchange resin.

    摘要翻译： 其中R 1是氢，甲基或乙基，特别是氢或甲基的通式I的β-酮 - 双烯异构化; R2是氢或甲基; R3是氢或甲基，特别是甲基，R4是含有1-37个碳原子的脂族烃残基，通过用碱性离子交换树脂处理，转化为相应的式II的α，γ-二烯酮。

    Process for the manufacture of chroman derivatives, especially α-tocopherol and alka-noates thereof
    7.
    发明授权
    Process for the manufacture of chroman derivatives, especially α-tocopherol and alka-noates thereof 有权

    公开(公告)号：US08431727B2

    公开(公告)日：2013-04-30

    申请号：US12381127

    申请日：2009-03-06

    申请人： Werner Bonrath ,  Yann Foricher ,  Thomas Netscher ,  Angela Wildermann

    发明人： Werner Bonrath ,  Yann Foricher ,  Thomas Netscher ,  Angela Wildermann

    IPC分类号： C07D311/00 ,  B01J27/06 ,  B01J27/135

    CPC分类号： C07D311/72

    摘要： The present invention relates to novel processes for the manufacture of chroman derivatives such as α-tocopherol (TCP) and alkanoates thereof, especially α-tocopheryl acetate (TCPA), whereby at least one step of the processes is carried out in the presence of a Lewis acid or a mixture of a Lewis acid with a Bronsted acid as the catalyst under pressure, preferably at an absolute pressure of at least 1.1 bar.As starting materials for the manufacture of TCP and its alkanoates either a mixture of 2,3,5-trimethylhydroquinone (TMHQ) or 2,3,6-trimethylhydroquinone-1-alkanoate (TMHQA) and a compound selected from the group consisting of phytol (PH), isophytol (IP) and (iso)phytol derivatives or 2-phytyl-3,5,6-trimethyl-hydroquinone (PTMHQ)/3-phytyl-2,5,6-trimethylhydroquinone-1-alkanoate (PTMHQA) and/or an isomer thereof are used.Suitable Lewis acids are indium(III) salts and scandium(III) salts. Suitable acid mixtures are iron/iron(II) chloride/hydrogen chloride and zinc(II) chloride/hydrogen chloride.

    Isomerization of β-keto-allenes
    9.
    发明授权
    Isomerization of β-keto-allenes 有权
    异构化和共聚物

    公开(公告)号：US08802898B2

    公开(公告)日：2014-08-12

    申请号：US13642047

    申请日：2011-04-18

    申请人： Werner Bonrath ,  Reinhard Karge ,  Thomas Netscher ,  Yann Pressel

    发明人： Werner Bonrath ,  Reinhard Karge ,  Thomas Netscher ,  Yann Pressel

    IPC分类号： C07C45/67

    CPC分类号： C07C45/67 ,  B01J31/08 ,  B01J2231/52 ,  C07C49/203

    摘要： Isomerization of β-keto-allenes of the general formula I wherein R1 is hydrogen, methyl or ethyl, in particular hydrogen or methyl; R2 is hydrogen or methyl; R3 is hydrogen or methyl, in particular methyl and R4 is an aliphatic hydrocarbon residue containing 1-37 carbon atoms, into corresponding α,γ-dienones of formula II by treatment with a basic ion exchange resin.

    摘要翻译： 其中R 1是氢，甲基或乙基，特别是氢或甲基的通式I的双 - 二烯的异构化; R2是氢或甲基; R3是氢或甲基，特别是甲基，R4是含有1-37个碳原子的脂族烃残基，通过碱性离子交换树脂的处理转化为相应的式II的α，γ-二烯酮。

    Process for the manufacture of alkenylated hydroxylated aromatic compounds, of chroman compounds and of their acylated derivatives
    10.
    发明授权
    Process for the manufacture of alkenylated hydroxylated aromatic compounds, of chroman compounds and of their acylated derivatives 有权
    烯基化羟基化芳族化合物，色满化合物及其酰化衍生物的制备方法

    公开(公告)号：US07696364B2

    公开(公告)日：2010-04-13

    申请号：US11005402

    申请日：2004-12-06

    申请人： Werner Bonrath ,  Yann Foricher ,  Thomas Netscher ,  Angela Wildermann

    发明人： Werner Bonrath ,  Yann Foricher ,  Thomas Netscher ,  Angela Wildermann

    IPC分类号： C07D311/11 ,  B01J27/06 ,  B01J27/138

    CPC分类号： C07D311/72 ,  Y02P20/582

    摘要： The present invention relates to a process for the manufacture of alkenylated aromatic compounds featuring at least one hydroxy group, their ring-closure reactions to 5 chroman derivatives, as well as the acylation of the latter and the aromatic compounds featuring at least one hydroxy group themselves. The present invention relates especially to a process for the manufacture of tocol, tocopherols and their alkanoates such as (x-tocopherol (TCP) and alkanoates (TCPA) thereof, preferably (x-toeopheryl acetate (TCPAc). The processes of the present invention are characterized in that at least one step of the processes is carried out in the presence of an indium salt as the catalyst.

    摘要翻译： 本发明涉及一种制备具有至少一个羟基的烯基化芳族化合物的方法，它们与5种苯并二氢吡喃衍生物的闭环反应，以及后者的酰化和具有至少一个羟基的芳族化合物本身 。 本发明特别涉及一种制造多孔，生育酚及其链烷酸酯的方法，例如（x-生育酚（TCP）和链烷酸酯（TCPA）），优选（x-toeopheryl acetate（TCPAc））。本发明的方法 其特征在于，在作为催化剂的铟盐的存在下进行该方法的至少一个步骤。