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    Apparatus for separation of biologic components from heterogeneous cell populations
    4.
    发明授权
    Apparatus for separation of biologic components from heterogeneous cell populations 失效
    用于分离生物成分与异种细胞群体的装置

    公开(公告)号：US06221315B1

    公开(公告)日：2001-04-24

    申请号：US09290653

    申请日：1999-04-12

    申请人： Richard Giesler ,  John R. Chapman ,  Dale R. Ellis ,  Daniel F. Bischof

    发明人： Richard Giesler ,  John R. Chapman ,  Dale R. Ellis ,  Daniel F. Bischof

    IPC分类号： B01L1100

    CPC分类号： G01N33/56972 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  C12Q1/24 ,  G01N33/5002 ,  G01N33/5005 ,  G01N33/569 ,  Y10T436/111666 ,  Y10T436/25375 ,  Y10T436/2575

    摘要： Apparatus for separating a biological component from a biological fluid are disclosed. The apparatus includes a chamber for receiving a biological fluid including a biological component, and a rotor for creating a centrifugal field within the chamber. A source of particles may be included wherein the particles have a binding site for selectively binding to the biological component. The particles may be aseptically introduced into the chamber. The apparatus may withdraw whole blood from a donor, separate the whole blood to obtain a target cell population and return a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in conjunction with a rotatable separation device such as the apparatus described above may also be provided.

    摘要翻译： 公开了用于从生物流体分离生物组分的装置。 该装置包括用于接收包括生物组分的生物流体的腔室和用于在腔室内产生离心场的转子。 可以包括颗粒源，其中颗粒具有用于选择性结合生物组分的结合位点。 颗粒可以无菌地引入室中。 该装置可以从供体抽出全血，分离全血以获得靶细胞群并将目标细胞群体中的所选择的一个或全部血液剩余物的至少一部分返回给供体或患者。 还可以提供与诸如上述装置的可旋转分离装置结合使用的一次性分离插入件。

    Method for sterilizing
    5.
    发明授权
    Method for sterilizing 失效
    消毒方法

    公开(公告)号：US5496302A

    公开(公告)日：1996-03-05

    申请号：US876125

    申请日：1992-04-29

    申请人： Billy W. Minshall ,  John E. Nygard ,  Kwame Sintim-Damoa ,  Richard Giesler ,  Archie Woodworth ,  Kailash Purohit

    发明人： Billy W. Minshall ,  John E. Nygard ,  Kwame Sintim-Damoa ,  Richard Giesler ,  Archie Woodworth ,  Kailash Purohit

    IPC分类号： A61L2/00 ,  A61L2/04 ,  A61L2/08 ,  A61L2/20 ,  A61M1/02 ,  A61B19/00

    CPC分类号： A61L2/20 ,  A61L2/0023 ,  A61L2/08 ,  A61M1/0209

    摘要： Methods are disclosed for sterilizing a selected portion of a product and for assembling a sterile product from two or more parts which can not be sterilized with the same form of sterilization. A sterile product produced by these methods is also disclosed. The method for sterilizing may include sterilizing a selected portion of the product by exposing the selected portion to an electron beam, while shielding the remainder of the product from the radiation of the electron beam. The method of assembling a sterile product from two or more component parts may include the steps of sterilizing the first part of the product, isolating a portion of the first part from the remainder of the first part, attaching the second part to the isolated portion of the first part, and exposing the isolated portion to a form of sterilization which is deleterious to the remainder of the first part, while shielding the remainder of the first part from such form of sterilization.

    摘要翻译： 公开了用于对产品的选定部分进行灭菌并组装来自两个或更多个部件的无菌产品的方法，所述两个或更多部分不能用相同形式的灭菌灭菌。 还公开了通过这些方法生产的无菌产品。 灭菌方法可以包括通过将所选择的部分暴露于电子束来对产品的选定部分进行消毒，同时屏蔽产品的剩余部分与电子束的辐射。 从两个或多个组成部件组装无菌产品的方法可以包括以下步骤：消除产品的第一部分，将第一部分的一部分与第一部分的其余部分隔离，将第二部分附接到第 第一部分，并将分离的部分暴露于对第一部分的其余部分有害的灭菌形式，同时将第一部分的其余部分从这种形式的灭菌中屏蔽。

    Blood component collection systems and methods using an integral sampling device
    6.
    发明授权
    Blood component collection systems and methods using an integral sampling device 失效
    血液成分收集系统和使用整体取样装置的方法

    公开(公告)号：US5702383A

    公开(公告)日：1997-12-30

    申请号：US664806

    申请日：1996-06-17

    申请人： Richard Giesler ,  Ulrich C. Geissler ,  Margaret E. Stanford ,  William E. Johnson

    发明人： Richard Giesler ,  Ulrich C. Geissler ,  Margaret E. Stanford ,  William E. Johnson

    IPC分类号： A61J1/00 ,  A61J1/05 ,  A61J1/12 ,  A61J1/14 ,  A61M1/02 ,  A61B19/00

    CPC分类号： A61M1/0236 ,  A61J1/10 ,  A61J1/12

    摘要： A squeezable, resilient pouch is used for collecting a blood sample. The walls of the pouch are moved together in response to the application of an external squeezing force. The squeezing force collapses the pouch and expels fluid from it. Upon removal of the squeezing force, the resilience of the pouch walls moves them apart. The resilient expansion of the pouch creates suction that draws a fluid sample into the pouch. The pouch can be attached to a blood collection and/or storage container by flexible tubing in a way that prevents communication with the atmosphere. By squeezing the pouch, the user obtain a sample of the blood without using special tools and with no danger of activating or damaging the blood component being sampled.

    摘要翻译： 可挤压弹性袋用于收集血液样本。 响应于外部挤压力的应用，袋的壁被移动在一起。 挤压力使小袋折叠并从中排出流体。 在移除挤压力时，袋壁的弹性使它们分开。 袋的弹性膨胀产生将流体样品吸入袋中的吸力。 该袋可以通过柔性管连接到血液收集和/或储存容器，以防止与大气相通。 通过挤压小袋，用户可以在不使用特殊工具的情况下获得血液样本，并且没有激活或损坏被采样的血液成分的危险。

    Sterile product and method for sterilizing and assembling such product
    7.
    发明授权
    Sterile product and method for sterilizing and assembling such product 失效
    无菌产品及灭菌方法

    公开(公告)号：US5009654A

    公开(公告)日：1991-04-23

    申请号：US321698

    申请日：1989-03-10

    申请人： Billy W. Minshall ,  Kailash Purohit ,  John E. Nygard ,  Kwame Sintim-Damoa ,  Richard Giesler ,  Archie Woodworth

    发明人： Billy W. Minshall ,  Kailash Purohit ,  John E. Nygard ,  Kwame Sintim-Damoa ,  Richard Giesler ,  Archie Woodworth

    IPC分类号： A61L2/00 ,  A61L2/04 ,  A61L2/08 ,  A61L2/20 ,  A61M1/02

    CPC分类号： A61L2/20 ,  A61L2/0023 ,  A61L2/08 ,  A61M1/0209

    摘要： Methods are disclosed for sterilizing a selected portion of a product and for assembling a sterile product from two or more parts which can not be sterilized with the same form of sterilization. A sterile product produced by these methods is also disclosed. The method for sterilizing may include sterilizing a selected portion of the product by exposing the selected portion to an electron beam, while shielding the remainder of the product from the radiation of the electron beam. The method of assembling a sterile product from two or more component parts may include the steps of sterilizing the first part of the product, isolating a portion of the first part from the remainder of the first part, attaching the second part to the isolated portion of the first part, and exposing the isolated portion to a form of sterilization which is deleterious to the remainder of the first part, while shielding the remainder of the first part from such form of sterilization.

    摘要翻译： 公开了用于对产品的选定部分进行灭菌并组装来自两个或更多个部件的无菌产品的方法，所述两个或更多部分不能用相同形式的灭菌灭菌。 还公开了通过这些方法生产的无菌产品。 灭菌方法可以包括通过将所选择的部分暴露于电子束来对产品的选定部分进行消毒，同时屏蔽产品的剩余部分与电子束的辐射。 从两个或多个组成部件组装无菌产品的方法可以包括以下步骤：消除产品的第一部分，将第一部分的一部分与第一部分的其余部分隔离，将第二部分附接到第 第一部分，并将分离的部分暴露于对第一部分的其余部分有害的灭菌形式，同时将第一部分的其余部分从这种形式的灭菌中屏蔽。