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公开(公告)号：US09090561B2
公开(公告)日：2015-07-28
申请号：US13614838
申请日：2012-09-13
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： C07D471/04 , A61K31/4375 , C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US20140045826A1
公开(公告)日：2014-02-13
申请号：US14009565
申请日：2012-04-06
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , A61K31/495 , C07D471/04
摘要： The invention discloses methods and compositions for treating or preventing neurodegenerative disease by administering a compound of Formula I: or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the variables are defined as herein.
摘要翻译： 本发明公开了通过给予式I化合物或其药学上可接受的盐，溶剂合物或水合物来治疗或预防神经变性疾病的方法和组合物，其中变量如本文所定义。
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公开(公告)号：US20130018046A1
公开(公告)日：2013-01-17
申请号：US13614838
申请日：2012-09-13
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zou , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A61K31/4439 , C07D403/12 , A61K31/506 , C07D401/12 , A61K31/496 , C07D471/04 , A61K31/4375 , C07D413/12 , A61K31/4725 , A61K31/502 , A61K31/497 , C07D498/04 , A61K31/5383 , A61K31/551 , A61K31/5377 , A61K31/53 , A61P35/00 , C07D401/14
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：US08278307B2
公开(公告)日：2012-10-02
申请号：US12227130
申请日：2007-05-08
申请人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
发明人： William C. Shakespeare , Wei-Sheng Huang , David C. Dalgarno , Xiaotian Zhu , R. Mathew Thomas , Yihan Wang , Jiwei Qi , Rajeswari Sundaramoorthi , Dong Zou , Chester A. Metcalf, III , Tomi K. Sawyer , Jan Antoinette C. Romero
IPC分类号： A61K31/496 , A61K31/4178 , C07D403/12
CPC分类号： C07D231/12 , C07D233/64 , C07D233/90 , C07D277/40 , C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。
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公开(公告)号：US20090156596A1
公开(公告)日：2009-06-18
申请号：US11990299
申请日：2006-08-11
申请人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
发明人： Yihan Wang , Wei-Sheng Huang , Rajeswari Sundaramoorthi , Xiaotian Zhu , R. Mathew Thomas , William C. Shakespeare , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/5355 , C07D473/00 , C07D413/14 , A61P35/00 , A61K31/52
CPC分类号： C07F9/65616
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。
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公开(公告)号：US07019139B2
公开(公告)日：2006-03-28
申请号：US10715794
申请日：2003-11-17
申请人： Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Yihan Wang , Regine Bohacek , Rajeswari Sundaramoorthi
发明人： Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Yihan Wang , Regine Bohacek , Rajeswari Sundaramoorthi
IPC分类号： C07D221/18 , C07D215/16
CPC分类号： C07F9/65583 , A61K31/47 , A61K45/06 , C07F9/4012 , C07F9/58 , C07F9/60 , A61K2300/00
摘要： The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及通式（及其药学上可接受的衍生物）的化合物：其中R A，R B，R B，R C，R R 5，R 9，R 9，R 9，R 9，R 9，R 9， ，p，q，r和X如本文所定义，以及它们的制备和用途。
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公开(公告)号：US06713462B2
公开(公告)日：2004-03-30
申请号：US10177500
申请日：2002-06-21
申请人： Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Yihan Wang , Regine Bohacek , Rajeswari Sundaramoorthi
发明人： Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Yihan Wang , Regine Bohacek , Rajeswari Sundaramoorthi
IPC分类号： A61K31675
CPC分类号： C07F9/65583 , A61K31/47 , A61K45/06 , C07F9/4012 , C07F9/58 , C07F9/60 , A61K2300/00
摘要： The invention relates to compounds of the general formula (and pharmaceutically acceptable derivatives thereof): in which RA, RB, RC, RD, R5, R7, R9, R9a, AK, p, q, r and X are as defined herein, and to their preparation and use.
摘要翻译： 本发明涉及通式（及其药学上可接受的衍生物）的化合物：其中R A，R B，R C，R D，R 5，R 7，R R 9，R 9a，AK，p，q，r和X如本文所定义，以及它们的制备和用途。
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公开(公告)号：US06197963B1
公开(公告)日：2001-03-06
申请号：US09133546
申请日：1998-08-13
申请人： Ralph Hirschmann , John Hynes, Jr. , Maria A. Cichy-Knight , Rachel D. van Rijn , Paul A. Sprengeler , P. Grant Spoors , William C. Shakespeare , Sherrie Pietranico-Cole , Amos B. Smith, III
发明人： Ralph Hirschmann , John Hynes, Jr. , Maria A. Cichy-Knight , Rachel D. van Rijn , Paul A. Sprengeler , P. Grant Spoors , William C. Shakespeare , Sherrie Pietranico-Cole , Amos B. Smith, III
IPC分类号： C07D20910
CPC分类号： C07H3/02
摘要： Compounds are provided which are crossreactive with peptides such as those which bind G-protein-linked receptors, together with preparative and therapeutic methods therefor. The compounds have the general structure: wherein at least one of R1, R2, R3, R4, or R5 comprises a functional group which is chemically similar to that found in the peptide of interest.
摘要翻译： 提供了与肽结合反应的化合物，例如结合G蛋白连接的受体的那些，以及与其制备和治疗方法。 所述化合物具有以下通式结构：其中R 1，R 2，R 3，R 4或R 5中的至少一个包含与目的肽中发现的化学相似的官能团。
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公开(公告)号：US20160024024A1
公开(公告)日：2016-01-28
申请号：US14774359
申请日：2014-03-13
申请人： Stephan G. ZECH , Anna KOHLMANN , Feng LI , Yihan WANG , Tianjun ZHOU , David C. DALGARNO , William C. SHAKESPEARE , Xiaotian ZHU , ARIAD PHARMACEUTICALS, INC.
发明人： Stephan G. Zech , Anna Kohlmann , Feng Li , Yihan Wang , Tianjun Zhou , David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu
IPC分类号： C07D243/08 , C07D401/10 , C07D413/10 , C07D401/14 , C07D403/14 , C07D417/10 , C07D403/10 , C07F9/645 , C07D413/14
CPC分类号： C07D243/08 , A61K31/551 , C07D245/02 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07F9/645
摘要： This invention relates to compounds of the general formula (I): in which the variable groups are as identified herein, and to preparation and use of the compounds.
摘要翻译： 本发明涉及通式（I）的化合物：其中可变基团如本文所鉴定，以及化合物的制备和使用。
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公开(公告)号：US20140066434A1
公开(公告)日：2014-03-06
申请号：US14009511
申请日：2012-04-06
IPC分类号： C07D487/04 , C07D473/34 , C07D471/04
CPC分类号： C07D487/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/5025 , A61K31/519 , C07D471/04 , C07D473/34
摘要： The invention discloses methods and compositions for treating or preventing Parkinson's disease by administering a compound of Formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the variables are defined as herein.
摘要翻译： 本发明公开了通过给予式（I）化合物或其药学上可接受的盐，溶剂化物或水合物来治疗或预防帕金森病的方法和组合物，其中变量如本文所定义。
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