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    Light bar providing illumination from inside a vehicle
    1.
    发明申请
    Light bar providing illumination from inside a vehicle 审中-公开
    灯条从车内提供照明

    公开(公告)号：US20060187670A1

    公开(公告)日：2006-08-24

    申请号：US11399932

    申请日：2006-04-07

    申请人： William Dalton ,  Steven Neufeglise

    发明人： William Dalton ,  Steven Neufeglise

    IPC分类号： B60Q1/26

    CPC分类号： B60Q1/268 ,  B60Q1/28 ,  B60Q3/252 ,  B60Q3/51 ,  B60Q3/74 ,  B60Q3/78 ,  B60Q3/80 ,  B60Q3/88 ,  Y10S362/80

    摘要： A light bar contains one or more rows of light-emitting diodes (LED's) in a housing which extends across substantially the entire width of a windshield of a vehicle and is narrow in width to minimize interference with visibility through the windshield. The housing has an interior forming a channel with a throat; the throat acting as a hood which directs the illumination out of the windshield and minimizes stray light. The LED's are arranged in banks generally symmetrically arrayed about the center of the length of the housing. Two of the banks, preferably equidistant from the center, are tilted in opposite directions to each other so as to project light toward the right side and left side of the vehicle. The LED's may be illuminated continuously or in selected sequence, as established by the user with a switch on the housing. Attached to the housing in a separate compartment is another bank of LED's which may direct light inside the vehicle for use as a dome or map light. A mechanism is provided for displacing and tilting the housing and may use pivotal arms attached to the end of the housing or adjustable Z-shaped hangers attached preferably to clamps such as visor clips already on the vehicle.

    摘要翻译： 灯条在壳体中包含一排或多排发光二极管（LED），其延伸跨越车辆的挡风玻璃的基本上整个宽度，并且宽度窄，以最小化对通过挡风玻璃的可见性的干扰。 壳体具有形成具有喉部的通道的内部; 喉咙作为引擎罩，将照明引导到挡风玻璃上，并最大限度地减少杂散光。 LED围绕容器的长度的中心大致对称排列。 优选地与中心相等的两个堤岸中的两个堤坝彼此相反地倾斜，以便朝向车辆的右侧和左侧突出。 LED可以按照用户在壳体上的开关建立的连续或按照选定顺序照亮。 在另一个隔间内连接到外壳的另一个LED组，可以将车内的光引导为穹顶或地图光。 提供了用于移动和倾斜壳体的机构，并且可以使用附接到壳体的端部的枢转臂或者优选地连接到诸如已经在车辆上的护目镜夹具的可调节的Z形衣架。

    Underwater release apparatus, underwater release system and method
    4.
    发明授权
    Underwater release apparatus, underwater release system and method 失效
    水下释放装置，水下释放系统及方法

    公开(公告)号：US5022013A

    公开(公告)日：1991-06-04

    申请号：US489457

    申请日：1990-03-06

    申请人： William Dalton ,  Al Billings

    发明人： William Dalton ,  Al Billings

    IPC分类号： B63B22/06 ,  H04B13/02

    CPC分类号： H04B13/02 ,  B63B22/06

    摘要： An improved underwater release apparatus, underwater release system and method of controlled release of an underwater object employing the underwater release apparatus. The underwater release apparatus comprises a housing release means mounted on a housing, a securing means for holding the housing at a defined position, the housing release means comprising a pair of load-balanced clamping jaws mounted for movement between a clamping position and a load releasing position, a coupling means attached to a water balanced shaft means slideably mounted on a nonexplosive drive means for driving the shaft between an engaged position and a disengaged position and for releasing the housing from the mooring. The housing release apparatus may be employed in an underwater release system including a transmitter adapted to transmit command signals to a receiver mounted in a housing attached to a mooring means adapted to secure the housing at a defined depth in the water and a buoy means to provide positive flotation for the housing for positioning at a defined depth and for retrieval upon release from the mooring by upon the command from the transmitter and released by the housing release means.

    摘要翻译： 一种改进的水下释放装置，水下释放系统和使用该水下释放装置的水下物体的控制释放方法。 水下释放装置包括安装在壳体上的壳体释放装置，用于将壳体保持在限定位置的固定装置，壳体释放装置包括一对负载平衡的夹爪，其安装成在夹紧位置和负载释放之间移动 位置，附接到水平衡轴的联接装置，其可滑动地安装在非易失性驱动装置上，用于在接合位置和脱离位置之间驱动轴并且用于将系统从系泊释放。 壳体释放装置可以用在水下释放系统中，包括发射器，其适于将指令信号发送到安装在附接到系泊装置的壳体中的接收器，该系泊装置适于将壳体固定在水中的限定深度，以及浮标装置， 用于定位在限定深度处的壳体的正浮选，并且在从发射器发出并由壳体释放装置释放时从系泊释放时进行检索。

    Hydraulic lock for axial motion output device
    6.
    发明申请
    Hydraulic lock for axial motion output device 审中-公开
    液压锁定轴向运动输出装置

    公开(公告)号：US20070081909A1

    公开(公告)日：2007-04-12

    申请号：US11441422

    申请日：2006-05-25

    申请人： William Dalton ,  Paul Smedley

    发明人： William Dalton ,  Paul Smedley

    IPC分类号： F04B35/04

    CPC分类号： F02C9/263 ,  F02C7/22 ,  F02C7/232 ,  F02C9/46 ,  F05D2260/902 ,  F05D2270/09

    摘要： A system for locking the axial position of an axial motion output device upon the loss of an electrical input signal includes a locking device operatively associated with the output device and adapted for movement between a neutral position in which the output device can move freely relative to the locking device and a locking position in which the locking device frictionally engages the output device with a sufficient amount of force to prevent further movement thereof upon the loss of an electrical input signal.

    摘要翻译： 用于在损失电输入信号时锁定轴向运动输出装置的轴向位置的系统包括与输出装置可操作地相关联并适于在空档位置之间运动的锁定装置，在该中间位置，输出装置可相对于输入装置自由移动 锁定装置和锁定位置，其中锁定装置以足够的力摩擦地接合输出装置，以防止在电输入信号的损失时的进一步移动。

    Computer systems and methods for providing health care
    8.
    发明申请
    Computer systems and methods for providing health care 有权
    用于提供医疗保健的计算机系统和方法

    公开(公告)号：US20050256745A1

    公开(公告)日：2005-11-17

    申请号：US10846977

    申请日：2004-05-14

    申请人： William Dalton

    发明人： William Dalton

    IPC分类号： G06F15/173 ,  G06Q10/00 ,  G06F17/60

    CPC分类号： G06Q10/00 ,  G06F19/00 ,  G06Q40/08 ,  G06Q50/22 ,  G06Q50/24

    摘要： The invention provides a computer network comprising a first computer and one or more second computers that are in electronic communication with each other. The first computer is associated with a first health care facility and has instructions for retrieving, over a network, one or more data structures for a patient enrolled in a health care program. The one or more data structures for the patient collectively comprise (i) a patient identifier, (ii) a molecular profile from a biological specimen obtained from the patient at the first health care facility; and (iii) a clinical characterization of the patient that was made at the first health care facility. The first computer has instructions for retrieving, over the network connection, one or a plurality of treatment regimens that are deemed suitable for the patient based upon the molecular profile and the clinical characterization of the patient. The one or more second computers are at one or more locations other than the first health care facility and have one or more data structures for each patient in a plurality of patients enrolled in the health care program

    摘要翻译： 本发明提供一种包括第一计算机和彼此电子通信的一个或多个第二计算机的计算机网络。 第一计算机与第一保健设施相关联并且具有用于通过网络检索登记在医疗保健程序中的患者的一个或多个数据结构的指令。 用于患者的一个或多个数据结构共同包括（i）患者标识符，（ii）来自第一保健设施中的患者获得的生物样本的分子谱; 和（iii）在第一个保健设施制造的患者的临床表征。 第一计算机具有用于通过网络连接检索基于患者的分子特征和临床表征被认为适合于患者的一种或多种治疗方案的指令。 一个或多个第二计算机位于除了第一保健设施之外的一个或多个位置处，并且在登记在医疗保健程序中的多个患者中具有每个患者的一个或多个数据结构

    Multi-mode shutdown system for a fuel metering unit
    9.
    发明申请
    Multi-mode shutdown system for a fuel metering unit 有权
    燃油计量单元的多模式停机系统

    公开(公告)号：US20050066648A1

    公开(公告)日：2005-03-31

    申请号：US10657828

    申请日：2003-09-09

    申请人： William Dalton

    发明人： William Dalton

    IPC分类号： F01D21/02 ,  F02C7/22 ,  F02C9/26 ,  F02C9/32 ,  F02C9/46

    CPC分类号： F02C7/22 ,  F01D21/02 ,  F02C9/263 ,  F02C9/32 ,  F02C9/46 ,  F05D2270/09

    摘要： A multi-mode shutdown system in combination with a fuel metering unit of an engine to prevent normal fuel delivery during engine malfunction such as the engine overspeeding. The multi-mode shutdown system includes a shutdown solenoid capable of closing a pressurizing valve to prevent fuel flow to the engine for creating a shutdown mode of operation with no fuel flow to the engine. The multi-mode shutdown system also includes a minimum flow solenoid in fluid communication a source of fuel at a minimum flow rate for creating a minimum flow mode of operation with fuel provided to the engine at the minimal flow rate. In the minimum flow mode, the shutdown solenoid and minimum flow solenoid establish a flow path for the fuel to the engine manifold at the minimal flow rate. During normal operation, the fuel metering unit regulates the fuel flow to the engine.

    摘要翻译： 多模式停机系统与发动机的燃料计量单元结合，以防止诸如发动机超速的发动机故障期间的正常燃料输送。 多模式停机系统包括能够关闭加压阀的关闭螺线管，以防止燃料流向发动机以产生没有燃料流向发动机的关闭运行模式。 多模式关闭系统还包括最小流量电磁阀，其以最小流量使燃料源流体连通，以最小流量产生提供给发动机的燃料的最小流动模式。 在最小流量模式中，关闭电磁阀和最小流量电磁阀以最小的流量建立到发动机歧管的燃料的流路。 在正常操作期间，燃料计量单元调节到发动机的燃料流量。

    HYD1 Peptides as Anti-Cancer Agents
    10.
    发明申请
    HYD1 Peptides as Anti-Cancer Agents 失效
    HYD1肽作为抗癌剂

    公开(公告)号：US20080108552A1

    公开(公告)日：2008-05-08

    申请号：US11852177

    申请日：2007-09-07

    申请人： Lori Hazlehurst ,  William Dalton ,  Anne Cress ,  Kit Lam

    发明人： Lori Hazlehurst ,  William Dalton ,  Anne Cress ,  Kit Lam

    IPC分类号： A61K38/00 ,  A61P35/00 ,  C07H21/02 ,  C07K7/06 ,  C12N15/00 ,  C12N5/00

    CPC分类号： G01N33/5011 ,  C07K7/06

    摘要： The present invention concerns fragments and variants of the HYD1 peptide; polynucleotides encoding the peptides; host cells genetically modified with the polynucleotides; vectors comprising the polynucleotides; compositions containing these peptides, polynucleotides, vectors, or host cells; and methods of using the peptides, polynucleotides, vectors, and host cells as inhibitors of aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as myeloma. The present invention further includes a method of increasing the efficacy of chemotherapy and radiation therapy, comprising administering an agent that binds β1 integrin to a patient in need thereof. In one embodiment, the β1 integrin binding agent is the HYD1 peptide, or a functional fragment or variant thereof. In another aspect, the invention pertains to a composition (an adhesion trap) comprising a substrate (also referred to as a surface or support) with a HYD1 peptide, or fragment or variant thereof, immobilized to the substrate, and a method of removing circulating tumor cells (CTC) from blood by contacting a subject's blood with the immobilized peptide. Another aspect of the invention concerns a method of identifying modulators of peptide binding. Another aspect of the invention concerns a method for detecting CTC.

    摘要翻译： 本发明涉及HYD1肽的片段和变体; 编码肽的多核苷酸; 用多核苷酸遗传修饰的宿主细胞; 包含多核苷酸的载体; 含有这些肽，多核苷酸，载体或宿主细胞的组合物; 以及使用肽，多核苷酸，载体和宿主细胞作为体外或体内异常细胞生长的抑制剂的方法，例如用作治疗癌症如骨髓瘤的抗癌剂。 本发明进一步包括增加化学疗法和放射治疗功效的方法，其包括向有需要的患者施用结合β1整联蛋白的药剂。 在一个实施方案中，β1整联蛋白结合剂是HYD1肽或其功能片段或变体。 另一方面，本发明涉及一种组合物（粘附陷阱），其包含固定在基底上的HYD1肽或其片段或变体的底物（也称为表面或载体），以及除去循环的方法 通过使受试者的血液与固定的肽接触，从血液中获得肿瘤细胞（CTC）。 本发明的另一方面涉及鉴定肽结合调节剂的方法。 本发明的另一方面涉及一种检测CTC的方法。