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公开(公告)号：US4004981A
公开(公告)日：1977-01-25
申请号：US573655
申请日：1975-05-01
摘要： Apparatus for physically removing cells in sterile manner from a disc stack on which the cells have been cultured comprises a substantially shaft-like member having at least one rod-like member mounted at substantially a right angle to the axis of the shaft.
摘要翻译： 用于以消毒方式物理去除细胞已经培养的盘堆叠的细胞的装置包括具有至少一个棒状部件的大致轴状部件，所述杆状部件以与轴的轴线大致成直角的角度安装。
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公开(公告)号：US4022206A
公开(公告)日：1977-05-10
申请号：US600983
申请日：1975-08-01
摘要： Vaccine delivery system having a lyophilized vaccine in human dosage concentration loaded into presterilized single dosage syringe having a squeezable body portion and a separate package containing enough water for injection to reconstitute the single dose of lyophilized vaccine.
摘要翻译： 将具有人体剂量浓度的冻干疫苗的疫苗递送系统装载到具有可挤压主体部分的预杀灭的单剂量注射器中，以及包含足够的注射用水的单独包装以重构单剂量的冻干疫苗。
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公开(公告)号：US4018222A
公开(公告)日：1977-04-19
申请号：US577244
申请日：1975-05-13
摘要： Vaccine delivery system wherein an aqueous vaccine diluted to human dosage concentration is loaded into presterilized single dosage syringes having a squeezable body portion and wherein a plurality of these syringes are sealed inside a bag and the contents of the syringes are frozen to preserve the titer of the vaccine.
摘要翻译： 疫苗递送系统，其中将稀释至人的剂量浓度的水性疫苗装载到具有可挤压主体部分的预灭灭的单剂量注射器中，并且其中将多个这些注射器密封在袋内，并将注射器的内容物冷冻以保持 疫苗。
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公开(公告)号：US5024836A
公开(公告)日：1991-06-18
申请号：US423658
申请日：1989-10-19
IPC分类号： A61K39/245 , A61K39/295
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , A61K2039/70 , A61K39/0015 , C12N2710/16734
摘要： The invention comprises a lyophilized live herpes virus vaccine that comprises from about 0.5% to about 8% moisture.
摘要翻译： 本发明包括冻干的活疱疹病毒疫苗，其包含约0.5％至约8％的水分。
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公开(公告)号：US4707542A
公开(公告)日：1987-11-17
申请号：US636514
申请日：1984-08-01
申请人： Arthur Friedman , E. Dale Lehman , William J. McAleer , Ted F. Schaefer , Edward M. Scolnick , D. Eugene Wampler
发明人： Arthur Friedman , E. Dale Lehman , William J. McAleer , Ted F. Schaefer , Edward M. Scolnick , D. Eugene Wampler
CPC分类号： C07K14/005 , A61K39/12 , A61K39/292 , A61K2039/55505 , A61K39/00 , C12N2730/10122 , C12N2730/10134 , Y10S435/803 , Y10S436/82 , Y10S530/806 , Y10S530/826
摘要： The surface antigen protein of human Hepatitis B virus is synthesized in Saccharomyces cerevisiae as a 23,000-26,000 dalton polypeptide, essentially free of intermolecular disulfide bonds. This antigen is a poor immunogen in animals and man. No prior precedent or method exists for efficiently converting the non-disulfide bonded antigen to a fully intermolecular disulfide bonded particle. We describe the first example of such a conversion in vitro and show that the act of this conversion enhances the immunogenicity of the antigen about 10-fold. The in vitro conversion makes practical the production of hepatitis B surface antigen from microorganisms using recombinant DNA methods.
摘要翻译： 人类乙型肝炎病毒的表面抗原蛋白在酿酒酵母中合成为23,000-26,000道尔顿多肽，基本上不含分子间二硫键。 这种抗原是动物和人类的不良免疫原。 没有先前的先例或方法有效地将非二硫键合抗原转化成完全分子间二硫键合的颗粒。 我们在体外描述了这种转化的第一个例子，并表明这种转化的作用增强了抗原的免疫原性约10倍。 体外转化使得使用重组DNA方法从微生物生产乙型肝炎表面抗原成为可能。
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公开(公告)号：US4337242A
公开(公告)日：1982-06-29
申请号：US242195
申请日：1981-03-10
IPC分类号： A61K39/12 , A61K39/165 , A61K39/13 , A61K39/245
CPC分类号： A61K39/12 , A61K47/183 , A61K47/26 , A61K47/42 , A61K9/0019 , A61K2039/525 , C12N2760/18434
摘要： An improved stabilized liquid live viral vaccine contains a live virus, partially hydrolyzed gelatin, a monosaccharide or disaccharide, a cell culture medium, L-glutamic acid, L-arginine and sufficient physiologically acceptable acidic buffer to maintain the pH at from about 6.0 to about 6.5.
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公开(公告)号：US4234564A
公开(公告)日：1980-11-18
申请号：US861809
申请日：1977-12-19
CPC分类号： C07K14/005 , G01N33/5762 , A61K39/00 , C12N2730/10122 , Y10S436/82
摘要： Compositions comprising HB.sub.s Ag and a physiologically acceptable medium are useful as diagnostic and immunologic agents.
摘要翻译： 包含HBsAg和生理学上可接受的培养基的组合物可用作诊断和免疫剂。
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公开(公告)号：US4118477A
公开(公告)日：1978-10-03
申请号：US830291
申请日：1977-09-02
CPC分类号： C07K14/005 , C12N2730/10122
摘要： An improved process for the preparation of hepatitis B antigen by subjecting biological fluid containing heptatitis B surface antigen to isopycanic banding wherein the step gradient is NaBr. Faster and more economical processing is obtained by multiple loading of the step gradient, either NaBr or conventional gradients.
摘要翻译： 通过使含有乙型肝炎表面抗原的生物液体经受等位基带的制备来改善乙肝抗原的改进方法，其中梯度梯度为NaBr。 通过多次加载阶跃梯度（NaBr或常规梯度）可获得更快更经济的加工。
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公开(公告)号：US4102996A
公开(公告)日：1978-07-25
申请号：US789033
申请日：1977-04-20
CPC分类号： C07K14/005 , G01N33/5762 , A61K39/00 , C12N2730/10122 , Y10S435/961
摘要： HB.sub.c Ag is prepared by isolating Dane particles by isopycnic banding of fluid from HB.sub.s Ag positive donors, optionally but preferably pelleting the Dane particles, and then removing the surface antigen by contacting the Dane particles with a nonionic surfactant having from about 15 to about 35 oxyethylene units in the presence of a reducing agent such as mercaptoethanol. The isolated core antigen is used as a diagnostic and immunologic agent.
摘要翻译： HBcAg通过用HBsAg阳性供体的流体的等压条带分离来分离丹烷颗粒，任选但优选地颗粒化丹麦颗粒，然后通过使丹烷颗粒与具有约15至约35个氧化乙烯单元的非离子表面活性剂接触来除去表面抗原 存在还原剂如巯基乙醇。 分离的核心抗原用作诊断和免疫剂。
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公开(公告)号：US4008991A
公开(公告)日：1977-02-22
申请号：US623664
申请日：1975-10-20
申请人： William J. McAleer
发明人： William J. McAleer
CPC分类号： F23C99/00
摘要： A power plant for producing heat. A frame is rotatably mounted within a container with an inertia wheel mounted to and rotatable with the frame. A fuel storage tank mounted within the frame is connected between and to an external source of fuel and a plurality of fuel injectors mounted to the inertia wheel. Cooling means within the container cover the frame and at least a portion of the inertia wheel with a combustion chamber provided within the container above the cooling means. Igniting means mounted to the container projects into the combustion chamber and is operable to ignite fuel intermittently injected into the combustion chamber by the injectors mounted to the inertia wheel. Pumping means provided on the frame is operable to pump fuel from the storage tank to the injectors in a timed relationship to the position of the injectors relative to the cooling means and combustion chamber. Heat is withdrawn from the container resulting from the combustion of the fuel.
摘要翻译： 一个用于生产热量的发电厂。 框架可旋转地安装在容器内，其中惯性轮安装到框架上并与框架一起旋转。 安装在框架内的燃料储罐连接在外部燃料源之间并连接到安装在惯性轮上的多个燃料喷射器。 容器内的冷却装置覆盖框架和至少一部分惯性轮，其中燃烧室设置在冷却装置上方的容器内。 安装到容器上的点火装置突出到燃烧室中，并且可操作地通过安装到惯性轮的喷射器点燃间歇地喷射到燃烧室中的燃料。 设置在框架上的抽吸装置可操作以将燃料以与定影关系相对于喷射器相对于冷却装置和燃烧室的定时关系从储罐泵送到喷射器。 从燃料的燃烧产生的热量从容器中取出。
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