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公开(公告)号：US08080416B2
公开(公告)日：2011-12-20
申请号：US12707522
申请日：2010-02-17
申请人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin
发明人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin
CPC分类号： C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N5/0697 , C12N2500/92 , C12N2500/98 , C12N2501/21 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/28 , C12N2503/04 , C12N2510/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/505 , G01N33/5052 , G01N33/5088
摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括包含T细胞，B细胞和抗原引发的树突状细胞的细胞培养物。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药物，生物制剂和其它化学品的体外试验。
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2.发明申请Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) 有权用于人造免疫系统（AIS）的共培养淋巴组织等效物（LTE）公开(公告)号：US20090117581A1
公开(公告)日：2009-05-07
申请号：US11594172
申请日：2006-11-08
申请人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin
发明人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin
CPC分类号： C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N5/0697 , C12N2500/92 , C12N2500/98 , C12N2501/21 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/28 , C12N2503/04 , C12N2510/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/505 , G01N33/5052 , G01N33/5088
摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括包含T细胞，B细胞和抗原引发的树突状细胞的细胞培养物。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药物，生物制剂和其它化学品的体外试验。
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3.发明授权Methods for testing an immune response using cultures of T cells, B cells and dendritic cells 有权使用T细胞，B细胞和树突状细胞的培养物测试免疫应答的方法公开(公告)号：US08697371B2
公开(公告)日：2014-04-15
申请号：US13288401
申请日：2011-11-03
申请人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin , John G. Tew
发明人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin , John G. Tew
IPC分类号： G01N33/567 , C12N5/00 , C12N5/08
CPC分类号： G01N33/5052 , C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N5/0697 , C12N2500/90 , C12N2501/21 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/28 , C12N2503/04 , C12N2510/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/505 , G01N33/5088
摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括包含T细胞，B细胞和抗原引发的树突状细胞的细胞培养物。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药物，生物制剂和其它化学品的体外试验。
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公开(公告)号：US07785806B2
公开(公告)日：2010-08-31
申请号：US11594172
申请日：2006-11-08
申请人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin
发明人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin
IPC分类号： G01N33/567
CPC分类号： C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N5/0697 , C12N2500/92 , C12N2500/98 , C12N2501/21 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/28 , C12N2503/04 , C12N2510/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/505 , G01N33/5052 , G01N33/5088
摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括包含T细胞，B细胞和抗原引发的树突状细胞的细胞培养物。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药物，生物制剂和其它化学品的体外试验。
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5.发明授权Methods for testing an immune response using cultures of T cells, B cells, dendritic cells and follicular dendritic cells 有权使用T细胞，B细胞，树突细胞和滤泡树突状细胞的培养物测试免疫应答的方法公开(公告)号：US08962319B2
公开(公告)日：2015-02-24
申请号：US13289024
申请日：2011-11-04
申请人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin , John G. Tew
发明人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin , John G. Tew
IPC分类号： C12N5/00 , C12N5/02 , G01N33/50 , C12N5/0781 , C12N5/0783 , C12N5/0784 , C12N5/071
CPC分类号： G01N33/5052 , C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N5/0697 , C12N2500/90 , C12N2501/21 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/28 , C12N2503/04 , C12N2510/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/505 , G01N33/5088
摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括包含T细胞，B细胞和抗原引发的树突状细胞的细胞培养物。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药物，生物制剂和其它化学品的体外试验。
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6.发明授权Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) 有权用于人造免疫系统（AIS）的共培养淋巴组织等效物（LTE）公开(公告)号：US08071373B2
公开(公告)日：2011-12-06
申请号：US11453046
申请日：2006-06-15
申请人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin , John G. Tew
发明人： William L. Warren , Donald Drake, III , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin , John G. Tew
CPC分类号： G01N33/5052 , C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N5/0697 , C12N2500/90 , C12N2501/21 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/28 , C12N2503/04 , C12N2510/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/505 , G01N33/5088
摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括包含T细胞，B细胞和抗原引发的树突状细胞的细胞培养物。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药物，生物制剂和其它化学品的体外试验。
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7.发明申请Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS) 有权用于人造免疫系统（AIS）的共培养淋巴组织等效物（LTE）公开(公告)号：US20070154956A1
公开(公告)日：2007-07-05
申请号：US11453046
申请日：2006-06-15
申请人： William Warren , Donald Drake , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin
发明人： William Warren , Donald Drake , Janice Moser , Inderpal Singh , Haifeng Song , Eric Mishkin
IPC分类号： G01N33/567 , C12N5/08 , C12N5/06
CPC分类号： G01N33/5052 , C12N5/0635 , C12N5/0636 , C12N5/0639 , C12N5/0697 , C12N2500/90 , C12N2501/21 , C12N2502/1107 , C12N2502/1114 , C12N2502/1121 , C12N2502/28 , C12N2503/04 , C12N2510/04 , C12N2531/00 , C12N2533/50 , C12N2533/54 , C12N2535/10 , G01N33/505 , G01N33/5088
摘要： The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.
摘要翻译： 本发明涉及人造免疫系统的制备方法。 人造免疫系统包括包含T细胞，B细胞和抗原引发的树突状细胞的细胞培养物。 本发明的人造免疫系统可用于疫苗，佐剂，免疫治疗候选物，化妆品，药物，生物制剂和其它化学品的体外试验。
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