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12 条记录 (耗时 0.046 秒)

    Models for vaccine assessment
    7.
    发明授权
    Models for vaccine assessment 有权
    疫苗评估模型

    公开(公告)号：US07709257B2

    公开(公告)日：2010-05-04

    申请号：US11819335

    申请日：2007-06-27

    申请人： John G. Tew ,  Mohey Eldin M. El Shikh ,  Inderpal Singh ,  Eric Mishkin ,  Donald Drake, III ,  Haifeng Song ,  William L Warren

    发明人： John G. Tew ,  Mohey Eldin M. El Shikh ,  Inderpal Singh ,  Eric Mishkin ,  Donald Drake, III ,  Haifeng Song ,  William L Warren

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N5/16

    CPC分类号： A01K67/0271 ,  A01K2267/0337 ,  A61K49/0008

    摘要： The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. The present invention comprises both in vivo and in vitro models of aspects of human immunity that are useful for assessing the interaction of substances with the immune system, and thus can be used to accelerate and improve the accuracy and predictability of, for example, vaccine, drug, biologic, immunotherapy, cosmetic and chemical development. The invention is also useful for the generation of human monoclonal and polyclonal antibodies.

    摘要翻译： 本发明涉及用于构建和使用人体免疫方面的体内和体外模型的方法，特别是建立用于例如疫苗，佐剂，免疫治疗候选物，化妆品的测试的人类免疫系统模型 ，药物，生物制剂等化学品。 本发明包括可用于评估物质与免疫系统的相互作用的人体免疫方面的体内和体外模型，因此可用于加速和提高例如疫苗的准确性和可预测性， 药物，生物，免疫治疗，化妆品和化学发展。 本发明也可用于产生人单克隆抗体和多克隆抗体。

    Models for vaccine assessment
    9.
    发明申请
    Models for vaccine assessment 有权
    疫苗评估模型

    公开(公告)号：US20080008653A1

    公开(公告)日：2008-01-10

    申请号：US11819335

    申请日：2007-06-27

    申请人： John Tew ,  Mohey Eldin El Shikh ,  Inderpal Singh ,  Eric Mishkin ,  Donald Drake ,  Haifeng Song ,  William Warren

    发明人： John Tew ,  Mohey Eldin El Shikh ,  Inderpal Singh ,  Eric Mishkin ,  Donald Drake ,  Haifeng Song ,  William Warren

    IPC分类号： A61K39/00 ,  A01K67/00 ,  A61K49/00 ,  A61P43/00 ,  C12N5/06

    CPC分类号： A01K67/0271 ,  A01K2267/0337 ,  A61K49/0008

    摘要： The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for the testing of, for example, vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals. The present invention comprises both in vivo and in vitro models of aspects of human immunity that are useful for assessing the interaction of substances with the immune system, and thus can be used to accelerate and improve the accuracy and predictability of, for example, vaccine, drug, biologic, immunotherapy, cosmetic and chemical development. The invention is also useful for the generation of human monoclonal and polyclonal antibodies.

    摘要翻译： 本发明涉及用于构建和使用人体免疫方面的体内和体外模型的方法，特别是建立用于例如疫苗，佐剂，免疫治疗候选物，化妆品的测试的人类免疫系统模型 ，药物，生物制剂等化学品。 本发明包括可用于评估物质与免疫系统的相互作用的人体免疫方面的体内和体外模型，因此可用于加速和提高例如疫苗的准确性和可预测性， 药物，生物，免疫治疗，化妆品和化学发展。 本发明也可用于产生人单克隆抗体和多克隆抗体。

    METHOD FOR THE PRODUCTION OF ETHYLENE GLYCOL
    10.
    发明申请
    METHOD FOR THE PRODUCTION OF ETHYLENE GLYCOL 有权
    乙二醇生产方法

    公开(公告)号：US20130338406A1

    公开(公告)日：2013-12-19

    申请号：US14001120

    申请日：2012-02-24

    申请人： Juntao Liu ,  Weimin Yang ,  Lei Li ,  Wanmin Wang ,  Linna Zhang ,  Haifeng Song

    发明人： Juntao Liu ,  Weimin Yang ,  Lei Li ,  Wanmin Wang ,  Linna Zhang ,  Haifeng Song

    IPC分类号： C07C29/149

    CPC分类号： C07C29/149 ,  B01J8/067 ,  B01J2208/0053 ,  Y02P20/52 ,  C07C31/202

    摘要： The present invention relates to a method for the production of ethylene glycol using a feedstock comprising an oxalate and a catalyst containing copper and/or a copper oxide, comprising contacting the feedstock with the catalyst in a reactor under the conditions of a temperature in the range from about 170 to about 270° C., a weight hourly space velocity of the oxalate in the range from about 0.2 to about 5 h−1, a molar ratio of hydrogen to the oxalate in the range from about 40:1 to about 200:1 and a reaction pressure in the range from about 1.5 to about 10 MPa, to produce an effluent containing ethylene glycol, in which the reactor is a tube-array reactor using partitioned heat exchange and adopting outer and inner tubes configured in a double-tube structure to facilitate the heat exchange of the catalyst.

    摘要翻译： 本发明涉及使用包含草酸盐和含有铜和/或氧化铜的催化剂的原料生产乙二醇的方法，包括在反应器中在等温范围内的温度条件下将反应器与催化剂接触 约170至约270℃，草酸盐的重时空速在约0.2至约5小时-1的范围内，氢与草酸的摩尔比在约40:1至约200的范围内 ：1，反应压力在约1.5至约10MPa的范围内，以产生含有乙二醇的流出物，其中反应器是使用分隔热交换的管阵列反应器，并采用配置在双组分中的外管和内管， 管结构以促进催化剂的热交换。