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    System for administering a combination of therapies to a body lumen
    1.
    发明申请
    System for administering a combination of therapies to a body lumen 有权
    用于将治疗组合施用于体腔的系统

    公开(公告)号：US20050222485A1

    公开(公告)日：2005-10-06

    申请号：US11131001

    申请日：2005-05-16

    申请人： William Shaw ,  James Barry ,  Paul Goll ,  Maria Palasis

    发明人： William Shaw ,  James Barry ,  Paul Goll ,  Maria Palasis

    IPC分类号： A61B17/22 ,  A61B18/02 ,  A61B18/04 ,  A61K9/00 ,  A61K9/22 ,  A61N5/10 ,  A61N5/00

    CPC分类号： A61K9/0024 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/046 ,  A61F2/82 ,  A61N5/1002

    摘要： The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.

    摘要翻译： 本发明提供了一种系统，其包括递送治疗组合的医疗装置。 这些疗法包括辐射，生物活性物质，冷冻疗法和热疗法的管理。 本发明还涉及使用本发明的系统来治疗体腔表面的方法。 提供了一种用于将生物活性材料递送到暴露于放射源的体腔表面的系统。 一方面，该系统包括可植入医疗装置，其具有两个相对的端部，每个端部具有表面和中间部分。 两个相对端包括生物活性材料，并且医疗装置的中间部分基本上不含任何生物活性物质。 在另一方面，系统将遗传物质递送到暴露于放射源的体腔表面。 提供了一种用于处理体腔表面的另一系统，其中该系统包括可植入医疗装置，其包括生物活性材料和用于将治疗源施加到与相对侧接触的体腔表面部分的装置 医疗器械的末端。 治疗源可以是冷冻治疗源或热疗源。

    Rotatable multi-port therapeutic delivery device
    3.
    发明申请
    Rotatable multi-port therapeutic delivery device 有权

    公开(公告)号：US20060206062A1

    公开(公告)日：2006-09-14

    申请号：US11074850

    申请日：2005-03-09

    申请人： Wendy Naimark ,  Maria Palasis ,  Toby Freyman ,  William Shaw

    发明人： Wendy Naimark ,  Maria Palasis ,  Toby Freyman ,  William Shaw

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0069

    摘要： A therapeutic delivery device is provided wherein a delivery body is supported by an elongate member such that the body may rotate as it delivers therapeutic to a target site. Therapeutic may be delivered by deploying delivery heads into a target site as well as by dispensing therapeutic from the delivery head. The delivery body may be cylindrically shaped, spherically shaped or shaped in various other configurations. In one embodiment the delivery body contains tracks that may roll back and forth over a target site to dispense therapeutic. In another embodiment, the delivery heads of the delivery body have internal valves that open and close in order to dispense therapeutic.

    Biocompatible medical devices
    4.
    发明申请
    Biocompatible medical devices 有权
    生物相容性医疗器械

    公开(公告)号：US20070197980A1

    公开(公告)日：2007-08-23

    申请号：US11451634

    申请日：2006-06-12

    申请人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    发明人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    IPC分类号： A61M25/00

    CPC分类号： A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L31/10

    摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

    摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

    Biocompatible medical devices
    7.
    发明授权
    Biocompatible medical devices 有权
    生物相容性医疗器械

    公开(公告)号：US08808272B2

    公开(公告)日：2014-08-19

    申请号：US11451634

    申请日：2006-06-12

    申请人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    发明人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    IPC分类号： A61M25/00

    CPC分类号： A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L31/10

    摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

    摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

    System for administering a combination of therapies to a body lumen
    9.
    发明授权
    System for administering a combination of therapies to a body lumen 有权
    用于将治疗组合施用于体腔的系统

    公开(公告)号：US07344490B2

    公开(公告)日：2008-03-18

    申请号：US11131001

    申请日：2005-05-16

    申请人： William J. Shaw ,  James Barry ,  Paul J. Goll ,  Maria Palasis

    发明人： William J. Shaw ,  James Barry ,  Paul J. Goll ,  Maria Palasis

    IPC分类号： A61N5/00

    CPC分类号： A61K9/0024 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/046 ,  A61F2/82 ,  A61N5/1002

    摘要： The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.

    摘要翻译： 本发明提供了一种系统，其包括递送治疗组合的医疗装置。 这些疗法包括辐射，生物活性物质，冷冻疗法和热疗法的管理。 本发明还涉及使用本发明的系统来治疗体腔表面的方法。 提供了一种用于将生物活性材料递送到暴露于放射源的体腔表面的系统。 一方面，该系统包括可植入医疗装置，其具有两个相对的端部，每个端部具有表面和中间部分。 两个相对端包括生物活性材料，并且医疗装置的中间部分基本上不含任何生物活性物质。 在另一方面，系统将遗传物质递送到暴露于放射源的体腔表面。 提供了一种用于处理体腔表面的另一系统，其中该系统包括可植入医疗装置，其包括生物活性材料和用于将治疗源施加到与相对侧接触的体腔表面部分的装置 医疗器械的末端。 治疗源可以是冷冻治疗源或热疗源。

    System for administering a combination of therapies to a body lumen
    10.
    发明授权
    System for administering a combination of therapies to a body lumen 有权

    公开(公告)号：US06918869B2

    公开(公告)日：2005-07-19

    申请号：US10307917

    申请日：2002-12-02

    申请人： William J. Shaw ,  James Barry ,  Paul J. Goll ,  Maria Palasis

    发明人： William J. Shaw ,  James Barry ,  Paul J. Goll ,  Maria Palasis

    IPC分类号： A61B17/22 ,  A61B18/02 ,  A61B18/04 ,  A61K9/00 ,  A61K9/22 ,  A61N5/10 ,  A61N5/00 ,  A61B9/22

    CPC分类号： A61K9/0024 ,  A61B2017/22051 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/046 ,  A61F2/82 ,  A61N5/1002

    摘要： The invention provides a system which comprises a medical device that delivers a combination of therapies. These therapies include the administration of radiation, biologically active materials, cryotherapy, and thermotherapy. The present invention is also directed to a method of treating body lumen surfaces using the system of the invention. A system is provided for delivering a biologically active material to a surface of a body lumen being exposed to a radioactive source. In one aspect, the system comprises an implantable medical device which has two opposing ends, each having a surface, and a middle portion. The two opposing ends comprise a biologically active material and the middle portion of the medical device is substantially free of any biologically active material. In another aspect, the system delivers a genetic material to a surface of a body lumen which is exposed to a radioactive source. Another system is provided for treating a surface of a body lumen in which the system comprises an implantable medical device which comprises a biologically active material and a device for applying a therapy source to the parts of the body lumen surface that are in contact with the opposing ends of the medical device. The therapy source may be a cryotherapy source or a thermotherapy source.