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    Process for preparing 2,5-dichlorophenylthioglycollic acid
    7.
    发明授权
    Process for preparing 2,5-dichlorophenylthioglycollic acid 失效
    制备2,5-二氯苯硫基乙醇酸的方法

    公开(公告)号：US4918221A

    公开(公告)日：1990-04-17

    申请号：US186638

    申请日：1988-04-27

    申请人： Wolfgang Bauer ,  Willi Steckelberg

    发明人： Wolfgang Bauer ,  Willi Steckelberg

    IPC分类号： B01J27/055 ,  B01J21/08 ,  B01J21/18 ,  C07B61/00 ,  C07C67/00 ,  C07C313/00 ,  C07C319/14 ,  C07C323/22 ,  C07C323/52 ,  C07C335/36 ,  C09B7/00

    CPC分类号： C07C323/00

    摘要： A valuable starting material for the manufacture of tetrachlorothioindigo pigments is 2,5-dichlorophenylthioglycollic acid which is prepared by:(a) diazotizing 2,5-dichloroaniline with aqueous alkali metal nitrite at acidic pH to produce 2,5-dichlorophenyl-diazonium salt,(b) reacting the 2,5-dichlorophenyl-diazonium salt from (a) with thiourea in an aqueous medium at acidic pH in the presence of a catalyst to produce 2,5-dichlorophenyl-isothiuronium salt of the formula ##STR1## wherein X.sup..crclbar. is an anion of a mineral acid, (c) hydroloyzing the 2,5-dichlorophenylisothiuronium salt from (b), without intermediate isolation, at alkaline pH to produce 2,5-dichlorothiophenol and(d) condensing the 2,5-dichlorothiophenol with monochloroacetic acid to produce 2,5-dichlorophenylthioglycollic acid.

    摘要翻译： 用于制造四氯硫靛素颜料的有价值的起始原料是2,5-二氯苯硫乙醇酸，其通过以下制备：（a）在酸性pH下用碱金属亚硝酸盐水溶液重氮化2,5-二氯苯胺，得到2,5-二氯苯基重氮盐， （b）在酸性pH下，在催化剂存在下，使来自（a）的2,5-二氯苯基重氮盐与硫脲在水性介质中反应，得到下式的2,5-二氯苯基 - 异硫脲鎓盐，其中X （ - ）是无机酸的阴离子，（c）在碱性pH下不经中间体分离从（b）中氢化2,5-二氯苯基异硫脲鎓盐，得到2,5-二氯苯硫酚，和（d）冷凝2.5 - 二氯苯硫酚与一氯乙酸反应生成2,5-二氯苯硫基乙醇酸。

    System and method for preparing educational materials
    9.
    发明授权
    System and method for preparing educational materials 有权
    制作教材的制度和方法

    公开(公告)号：US08504482B1

    公开(公告)日：2013-08-06

    申请号：US10130864

    申请日：2000-09-12

    申请人： Gerd Kortemeyer ,  Wolfgang Bauer

    发明人： Gerd Kortemeyer ,  Wolfgang Bauer

    IPC分类号： G06F21/00 ,  G06F17/00

    CPC分类号： G09B5/12 ,  G06Q20/1235 ,  G09B5/065 ,  G09B7/00

    摘要： Systems and methods are described for interactive, adaptive, customized and individualized computer-assisted instruction of students, preferably implemented on network connected computers. An assembly tool is provided for bringing diverse educational resources together to create customized course material for the instruction of students. A replication element is configured to update each resource and assure access to each updated resource. The system and method of the present invention responds to the instructor's creativity, allowing the instructor to shape and control the instructional materials and process, and allowing instructors from diverse institutions to exchange, share, modify and improve educational materials.

    摘要翻译： 描述了系统和方法，用于互动，自适应，定制和个性化的学生计算机辅助教学，优选在网络连接的计算机上实现。 提供了一个装配工具，用于将不同的教育资源集中在一起，为学生的指导创建定制的课程材料。 复制元素被配置为更新每个资源并确保访问每个更新的资源。 本发明的系统和方法响应教师的创造力，允许教师形成和控制教学材料和过程，并允许来自不同机构的教师交换，共享，修改和改进教材。

    System and Method for Manufacturing a Medication
    10.
    发明申请
    System and Method for Manufacturing a Medication 审中-公开
    制造药物的制剂和方法

    公开(公告)号：US20110156315A1

    公开(公告)日：2011-06-30

    申请号：US13056662

    申请日：2009-07-30

    申请人： Johannes Khinast ,  Günter Brenn ,  Andreas Zimmer ,  Rudolf Eichinger ,  Wolfgang Bauer

    发明人： Johannes Khinast ,  Günter Brenn ,  Andreas Zimmer ,  Rudolf Eichinger ,  Wolfgang Bauer

    IPC分类号： B29C39/36 ,  B05C5/00 ,  B05C11/00 ,  A61K9/28 ,  B29C53/00

    CPC分类号： A61J3/00 ,  B05B9/002 ,  B05B12/14 ,  B05B17/0607

    摘要： An apparatus for manufacturing a medication comprising an ejector unit adapted for ejecting a predefined amount of a drug having a liquid component to a solid carrier substrate. The ejector unit comprises a capillary and a tubular piezoelectric actuator surrounding at least a part of the capillary. The apparatus further comprises a control unit adapted for applying an electric signal to the piezoelectric actuator which, in response to the electric signal, is adapted to generate a compressional wave in the capillary for ejecting the predefined amount of the drug via an orifice of the capillary. Moreover, a method of manufacturing a medication is provided, the method comprising ejecting a predefined amount of a drug having a liquid component to a solid carrier substrate. Furthermore, a medication is provided comprising a solid carrier substrate, and a predefined amount of a drug ejected with a liquid component to the solid carrier substrate by an ejector unit.

    摘要翻译： 一种用于制造药物的装置，包括适于将预定量的具有液体组分的药物喷射到固体载体基底的喷射器单元。 喷射器单元包括毛细管和围绕毛细管的至少一部分的管状压电致动器。 该装置还包括适于向压电致动器施加电信号的控制单元，压电致动器响应于电信号适于在毛细管中产生压缩波，以经由毛细孔的喷口喷射预定量的药物 。 此外，提供了一种制造药物的方法，所述方法包括将预定量的具有液体成分的药物喷射到固体载体基质上。 此外，提供了一种药物，其包括固体载体基质和预定量的用液体组分喷射的药物通过喷射器单元固体载体基质。