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公开(公告)号：US5010057A
公开(公告)日：1991-04-23
申请号：US395392
申请日：1989-08-17
IPC分类号： A61K38/55 , A61P5/38 , A61P9/00 , A61P9/12 , C07C323/65 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/02 , C07K14/81
CPC分类号： C07K5/0227 , C07K5/0205 , C07K7/02 , Y02P20/55
摘要： Renin-inhibiting aminomethyl peptides of the formula ##STR1## in which A is H, an alkyl radical, a sulphonyl radical or an amino-protecting group,B, D, E and F each independently is a direct bond or an amino-organo-carbonyl group,R.sup.1 is an optionally substituted alkyl or aryl radical,R.sup.2 is H, alkyl or acyl,R.sup.3 is H, alkyl, aryl or acyl, andR.sup.4 is alkyl, alkoxy, aryl or amino,and physiologically acceptable salts thereof.
摘要翻译： 其中A为H，烷基，磺酰基或氨基保护基的式（I）所示的抑制N-羟基抑制性氨基甲基肽，B，D，E和F各自独立地为直接键或氨基 - 有机 - 羰基，R 1是任选取代的烷基或芳基，R 2是H，烷基或酰基，R 3是H，烷基，芳基或酰基，R 4是烷基，烷氧基，芳基或氨基，和其生理上可接受的盐 。
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公开(公告)号：US4818748A
公开(公告)日：1989-04-04
申请号：US22710
申请日：1987-03-06
IPC分类号： C07K14/81 , A61K38/00 , A61K38/55 , A61P9/12 , C07C67/00 , C07C223/06 , C07C229/22 , C07C231/00 , C07C233/36 , C07C233/43 , C07C237/02 , C07C237/06 , C07C237/12 , C07C237/22 , C07C239/00 , C07C253/00 , C07C255/58 , C07C255/59 , C07C269/00 , C07C273/10 , C07C301/00 , C07C303/30 , C07C303/40 , C07C311/00 , C07D233/54 , C07D249/08 , C07D521/00 , C07K20060101 , C07K1/00 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/02 , A61K37/02 , C07K7/06
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07K5/0227 , C07C2103/18 , Y10S530/86
摘要： Anti-hypertensive compounds of the formula ##STR1## in which A represents hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.7 -C.sub.14 -aralkyl, phenylsulphonyl, tolylsulphonyl or C.sub.1 -C.sub.8 -alkylsulfphonyl, or represents an aminoprotective group,B represents a direct bond, or represents sarcosyl, or represents a group of the formula ##STR2## D represents a direct bond, or represents a group of the formula ##STR3## wherein X represents methylene, ethylene or sulphur,E, G, J, K, L and M independently have the same meanings as B,R.sup.1 is an optionally substituted phenyl radical, andQ is a hydroxy, alkoxy or amino group, or a physiologically acceptable salt thereof.
摘要翻译： 其中A表示氢，C 1 -C 8 - 烷基，C 7 -C 14 - 芳烷基，苯基磺酰基，甲苯磺酰基或C 1 -C 8 - 烷基磺酰基，或表示氨基保护基的式（I）的抗高血压化合物，B表示 或直接键合，或表示肌氨酰基，或表示下式的基团：D表示直接键，或表示下式的基团：其中X表示亚甲基，亚乙基或硫，E，G，J，K， L和M独立地具有与B相同的含义，R 1是任选取代的苯基，Q是羟基，烷氧基或氨基或其生理上可接受的盐。
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公开(公告)号：US5122610A
公开(公告)日：1992-06-16
申请号：US467719
申请日：1990-01-19
IPC分类号： A61K38/55 , A61P5/38 , A61P9/00 , A61P9/12 , C07C323/65 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/02 , C07K14/81
CPC分类号： C07K5/0227 , C07K5/0205 , C07K7/02 , Y02P20/55
摘要： Renin-inhibiting aminomethyl peptides of the formula ##STR1## in which A is H, an alkyl radical, a sulphony radical or an amino-protecting group,B, D, E and F each independently is a direct bond or an amino-organo-carbonyl group,R.sup.1 is an optionally substituted alkyl or aryl radical,R.sup.2 is H, alyl or acyl,R.sup.3 is H, alkyl, aryl or acyl, andR.sup.4 is alkyl, alkoxy, aryl or amino, and physiologically acceptable salts thereof.
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公开(公告)号：US5095006A
公开(公告)日：1992-03-10
申请号：US553493
申请日：1990-07-13
IPC分类号： A61K31/19 , A61K31/215 , A61K38/00 , A61K38/55 , A61P9/12 , A61P43/00 , C07C229/22 , C07C229/34 , C07C237/22 , C07C271/22 , C07C311/19 , C07D207/08 , C07D209/48 , C07D233/54 , C07D233/64 , C07D263/22 , C07D263/26 , C07K1/06 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/08 , C07K14/81
CPC分类号： C07D209/48 , C07C229/34 , C07C271/22 , C07C311/19 , C07D207/08 , C07D233/64 , C07D263/26 , C07K5/0205 , C07K5/06147 , A61K38/00 , C07C2101/14
摘要： Renin-inhibiting peptides of the formula ##STR1## in which X represents a group of the formula ##STR2## represents hydroxyl, alkoxy having up to 8 carbon atoms, benzyloxy or a group of the formula --NR.sup.4 R.sup.5,A, B, D and E are identical or different and in each caserepresent a direct bond,represent a radical of the formula ##STR3## in which Q1 denotes oxygen, sulphur or the methylene grouprepresent a grouping of the formula ##STR4## m represents a number 0, 1 or 2, and L represents a group of the formula --CH.sub.2 NR.sup.2 R.sup.3and physiologically acceptable salts thereof.
摘要翻译： 式（I）的肾素抑制肽，其中X表示下式的基团：表示羟基，具有至多8个碳原子的烷氧基，苄氧基或式-NR4R5基团，A ，B，D和E相同或不同，并且在每种情况下代表直接键，表示式为“IMAGE”的基团，其中Q1表示氧，硫或亚甲基表示下式的基团：m表示 数字0,1或2，L表示式-CH2NR2R3的基团及其生理上可接受的盐。
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公开(公告)号：US5242903A
公开(公告)日：1993-09-07
申请号：US771077
申请日：1991-10-02
IPC分类号： A61K38/00 , C07C229/34 , C07C271/22 , C07C311/19 , C07D207/08 , C07D209/48 , C07D233/54 , C07D263/26 , C07K5/02 , C07K5/078
CPC分类号： C07D209/48 , C07C229/34 , C07C271/22 , C07C311/19 , C07D207/08 , C07D233/54 , C07D233/64 , C07D263/26 , C07K5/0205 , C07K5/06147 , A61K38/00 , C07C2101/14
摘要： Renin-inhibiting peptides of the formula ##STR1## in which X represents a group of the formula ##STR2## represents hydroxyl, alkoxy having up to 8 carbon atoms, benzyloxy or a group of the formula --NR.sup.4 R.sup.5,A, B, D and E are identical or different and in each caserepresent a direct bond,represent a radical of the formula ##STR3## in which Z denotes oxygen, sulphur or the methylene grouprepresents a grouping of the formula ##STR4## m represents a number 0, 1 or 2, and L represents a group of the formula --CH.sub.2 --NR2R.sub.3and physiologically acceptable salts thereof.
摘要翻译： 式（I）的肾素抑制肽，其中X表示下式的基团：表示羟基，具有至多8个碳原子的烷氧基，苄氧基或式-NR4R5基团，A ，B，D和E相同或不同，并且在每种情况下都代表直接键，表示式为“IMAGE”的基团，其中Z表示氧，硫或亚甲基表示下式的基团：m表示 数字0,1或2，L表示式-CH 2 -NR 2 R 3的基团及其生理上可接受的盐。
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公开(公告)号：US10189856B2
公开(公告)日：2019-01-29
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： A61K31/437 , A61K31/197 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D495/04 , C07D471/04 , A61K31/426 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D487/04
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
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公开(公告)号：US20140148433A1
公开(公告)日：2014-05-29
申请号：US13819337
申请日：2011-08-31
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Lars Bärfacker , Stefan Weigand
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Lars Bärfacker , Stefan Weigand
IPC分类号： C07D471/04 , A61K31/522 , A61K31/517 , C07D495/04 , A61K31/519 , A61K45/06 , C07D498/04 , C07D487/04 , A61K31/551 , C07D475/06 , A61K31/5377 , C07D473/28 , C07D513/04
CPC分类号： C07D471/04 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D473/28 , C07D475/06 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present application relates to novel bicyclic azaheterocycles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型双环氮杂环，其制备方法，单独或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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8.发明申请Use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc). 审中-公开使用sGC刺激剂，sGC激活剂，单独使用和与PDE5抑制剂的组合治疗系统性硬化症（SSc）。公开(公告)号：US20140038956A1
公开(公告)日：2014-02-06
申请号：US13816020
申请日：2011-05-24
申请人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
发明人： Claudia Hirth-Dietrich , Peter Sandner , Johannes-Peter Stasch , Andreas Knorr , Georges Von Degenfeld , Michael Hahn , Markus Follmann
IPC分类号： C07D495/04 , C07C229/38 , C07D333/34 , C07D261/10 , C07D401/04 , C07D417/06 , C07D277/30 , C07D487/04 , A61K31/5377 , A61K31/506 , A61K31/197 , A61K31/4439 , A61K31/427 , A61K31/426 , A61K31/519 , A61K45/06 , C07D471/04
CPC分类号： C07D495/04 , A61K31/197 , A61K31/426 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K45/06 , C07C229/38 , C07D261/10 , C07D277/30 , C07D333/34 , C07D401/04 , C07D417/06 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The use of sGC stimulators, sGC activators alone, or in combination with PDE5 inhibitors for the prevention and treatment of fibrotic diseases, such as systemic sclerosis, scleroderma, and the concomitant fibrosis of internal organs.
摘要翻译： 单独使用sGC刺激剂，sGC激活剂或与PDE5抑制剂联合用于预防和治疗纤维化疾病，如系统性硬化症，硬皮病和伴随的内脏纤维化。
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公开(公告)号：US08173704B2
公开(公告)日：2012-05-08
申请号：US12083509
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
IPC分类号： A61K31/19 , A61K31/195 , C07C59/00 , C07C65/03 , C07C321/00
CPC分类号： C07C59/68 , C07C229/14 , C07D249/12 , C07D257/04 , C07D271/07 , C07D271/113
摘要： The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二氟苯酚衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防的药物的用途 的心血管疾病。
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公开(公告)号：US07700653B2
公开(公告)日：2010-04-20
申请号：US11210131
申请日：2005-08-22
申请人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
发明人： Michael Härter , Michael G. Hahn , Claudia Hirth-Dietrich , Andreas Knorr , Elke Stahl , Johannes-Peter Stasch , Frank Wunder
IPC分类号： A61K31/195
CPC分类号： C07C229/38 , A61K31/197
摘要： This invention relates to methods for treating cardiovascular disorders selected from heart failure, thromboembolic disorders, venous diseases, and fibriotic disorders other than fibrosis of the liver, comprising administering an effective amount of a compound of formula (I) wherein the several variables are as defined in the specification and claims.
摘要翻译： 本发明涉及治疗选自心脏衰竭，血栓栓塞性疾病，静脉疾病和肝纤维化以外的纤维化疾病的心血管疾病的方法，包括施用有效量的式（I）化合物，其中若干变量如上所定义 在说明书和权利要求中。
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