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    Production of spherical polymers
    1.
    发明授权
    Production of spherical polymers 失效
    球形聚合物的生产

    公开(公告)号：US06294623B1

    公开(公告)日：2001-09-25

    申请号：US09459297

    申请日：1999-12-10

    申请人： Wolfgang Podszun ,  David Byran Harrison ,  Frank Louwet

    发明人： Wolfgang Podszun ,  David Byran Harrison ,  Frank Louwet

    IPC分类号： C08F238

    CPC分类号： C08F2/06 ,  C08F2/38

    摘要： The process for producing bead polymers having a mean particle size of 0.5 to 50 &mgr;m and a narrow particle size distribution by polymerisation of monomers dissolved in a solvent that constitutes a precipitation agent for the polymers obtained from these monomers is characterized in that the solvent contains 5 to 3000 ppm of sulfur-free radical interceptors.

    摘要翻译： 平均粒径为0.5〜50μm的珠粒聚合物的制造方法以及溶解在由这些单体得到的聚合物构成沉淀剂的溶剂中的单体的聚合的窄粒径分布的特征在于，溶剂含有5 至3000ppm的无硫自由基拦截器。

    Production of monodisperse spherical polymers using seed polymers with a comb structure
    2.
    发明授权
    Production of monodisperse spherical polymers using seed polymers with a comb structure 有权
    使用具有梳结构的种子聚合物生产单分散球形聚合物

    公开(公告)号：US06291553B1

    公开(公告)日：2001-09-18

    申请号：US09419413

    申请日：1999-10-15

    申请人： David Bryan Harrison ,  Wolfgang Podszun ,  Frank Louwet

    发明人： David Bryan Harrison ,  Wolfgang Podszun ,  Frank Louwet

    IPC分类号： C08F29100

    CPC分类号： C08F291/00 ,  B29C64/00 ,  B29C67/04 ,  B41M5/5254 ,  C08F265/04 ,  G02F1/13392

    摘要： Producing spherical polymers having a weight-averaged average particle diameter of 1 to 50 &mgr;m using a seed/feed process comprising the following steps: a) suspension of a monodisperse spherical seed in an aqueous phase, b) addition of at least one monomer and an initiator, c) polymerization of the monomer, of which there is at least one, wherein the seed consists of a polymer having a comb structure, gives rise to products having a particularly narrow grain size distribution.

    摘要翻译： 使用种子/进料方法生产重均粒径为1-50μm的球形聚合物，其包括以下步骤：a）将单分散球形种子悬浮于水相中，b）加入至少一种单体和 引发剂，c）其中存在至少一种的单体的聚合，其中种子由具有梳结构的聚合物组成，产生具有特别窄的粒度分布的产物。

    Synthetic polymer particles for use as standards and calibrators in flow cytometry
    3.
    发明授权
    Synthetic polymer particles for use as standards and calibrators in flow cytometry 失效
    合成聚合物颗粒，用作流式细胞仪中的标准品和校准品

    公开(公告)号：US6074879A

    公开(公告)日：2000-06-13

    申请号：US099233

    申请日：1998-06-17

    申请人： David Zelmanovic ,  William Moskalski ,  Ronny DeClercq ,  Frank Louwet ,  Eberhard Kuckert ,  Wolfgang Podszun

    发明人： David Zelmanovic ,  William Moskalski ,  Ronny DeClercq ,  Frank Louwet ,  Eberhard Kuckert ,  Wolfgang Podszun

    IPC分类号： G01N33/49 ,  G01N15/00 ,  G01N15/10 ,  G01N15/14 ,  G01N31/00

    CPC分类号： G01N15/1012 ,  G01N2015/1062 ,  G01N2015/1486 ,  G01N2015/149 ,  Y10T436/10 ,  Y10T436/101666

    摘要： The invention describes novel methods for calibrating or standardizing flow cytometry instruments using synthetic polymer particles or beads having physical properties which provide advantages for their use in such instruments. The polymer particles or beads employed in the calibration methods are spherical, have an average particle diameter of from about 1 to about 8 microns, a relatively narrow particle distribution, and a low refractive index, i.e., from about 1.35 to about 1.45. The particles are safe, stable for long time periods and are particularly suitable for employment as hematology analyzer calibration substances. The invention provides an advantageous improvement over the types of standards currently used to calibrate a variety of instruments that rely on light scatter combined with other parameters to identify and measure biological particles or cells, as well as nonbiological particles. In particular, using the calibration/standardization method and polymer particles according to the present invention allows hematology instruments to be calibrated and standardized for subsequent accurate and reliable determinations of red blood cells, reticulocytes, white blood cells and platelets in whole blood samples.

    摘要翻译： 本发明描述了使用具有物理性质的合成聚合物颗粒或珠粒来校准或标准化流式细胞仪器的新方法，其提供了在这些仪器中使用的优点。 在校准方法中使用的聚合物颗粒或珠粒是球形的，平均粒径为约1至约8微米，相对较窄的颗粒分布和低折射率，即约1.35至约1.45。 颗粒安全，长时间稳定，特别适合用作血液分析仪校准物质。 本发明提供了相对于目前用于校准依赖于光散射的各种仪器与其他参数相结合以识别和测量生物颗粒或细胞以及非生物颗粒的标准类型的有利改进。 特别地，使用根据本发明的校准/标准化方法和聚合物颗粒允许血液仪器被校准和标准化，用于随后准确可靠地测定全血样品中的红细胞，网织红细胞，白细胞和血小板。

    Monodisperse fluorine-containing synthetic polymer particles having a defined refractive index for use as standards and calibrators in flow cytometry
    5.
    发明授权
    Monodisperse fluorine-containing synthetic polymer particles having a defined refractive index for use as standards and calibrators in flow cytometry 失效
    具有限定折射率的单分散含氟合成聚合物颗粒用作流式细胞术中的标准物和校准物

    公开(公告)号：US06521729B1

    公开(公告)日：2003-02-18

    申请号：US09432905

    申请日：1999-11-02

    申请人： David Zelmanovic ,  William Moskalski ,  Ronny DeClercq ,  Frank Louwet ,  Eberhard Kuckert ,  Wolfgang Podszun

    发明人： David Zelmanovic ,  William Moskalski ,  Ronny DeClercq ,  Frank Louwet ,  Eberhard Kuckert ,  Wolfgang Podszun

    IPC分类号： C08F12024

    CPC分类号： G01N15/1012 ,  G01N2015/1062 ,  G01N2015/1486 ,  G01N2015/149 ,  Y10T436/10 ,  Y10T436/101666

    摘要： The invention describes novel methods for calibrating or standardizing flow cytometry instruments using synthetic polymer particles or beads having physical properties which provide advantages for their use in such instruments. The polymer particles or beads employed in the calibration methods are spherical, have an average particle diameter of from about 1 to about 8 microns, a relatively narrow particle distribution, and a low refractive index, i.e., from about 1.35 to about 1.45. The particles are safe, stable for long time periods and are particularly suitable for employment as hematology analyzer calibration substances. The invention provides an advantageous improvement over the types of standards currently used to calibrate a variety of instruments that rely on light scatter combined with other parameters to identify and measure biological particles or cells, as well as nonbiological particles. In particular, using the calibration/standardization method and polymer particles according to the present invention allows hematology instruments to be calibrated and standardized for subsequent accurate and reliable determinations of red blood cells, reticulocytes, white blood cells and platelets in whole blood samples.

    摘要翻译： 本发明描述了使用具有物理性质的合成聚合物颗粒或珠粒来校准或标准化流式细胞仪器的新方法，其提供了在这些仪器中使用的优点。 在校准方法中使用的聚合物颗粒或珠粒是球形的，平均粒径为约1至约8微米，相对较窄的颗粒分布和低折射率，即约1.35至约1.45。 颗粒安全，长时间稳定，特别适合用作血液分析仪校准物质。 本发明提供了相对于目前用于校准依赖于光散射的各种仪器与其他参数相结合以识别和测量生物颗粒或细胞以及非生物颗粒的标准类型的有利改进。 特别地，使用根据本发明的校准/标准化方法和聚合物颗粒允许血液仪器被校准和标准化，用于随后准确可靠地测定全血样品中的红细胞，网织红细胞，白细胞和血小板。