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    Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm
    1.
    发明授权
    Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm 有权
    使用粒子群优化算法改进重组蛋白表达的序列优化方法

    公开(公告)号：US08326547B2

    公开(公告)日：2012-12-04

    申请号：US12894401

    申请日：2010-09-30

    申请人： Xiaowu Liu ,  Yun He ,  Zhuying Wang ,  Chunjiao Wang ,  Zhibing Liu ,  Tianhui Xia ,  Luquan Wang ,  Fang Liang Zhang

    发明人： Xiaowu Liu ,  Yun He ,  Zhuying Wang ,  Chunjiao Wang ,  Zhibing Liu ,  Tianhui Xia ,  Luquan Wang ,  Fang Liang Zhang

    IPC分类号： G06F19/10 ,  G06F19/00

    CPC分类号： G06F19/22 ,  G06F19/20

    摘要： An improved gene sequence optimization method, the systematic optimization method, is described for boosting the recombinant expression of genes in bacteria, yeast, insect and mammalian cells. This general method takes into account of multiple, preferably most or all, of the parameters and factors affecting protein expression including codon usage, tRNA usage, GC-content, ribosome binding sequences, promoter, 5′-UTR, ORF and 3′-UTR sequences of the genes to improve and optimize the gene sequences to boost the protein expression of the genes in bacteria, yeast, insect and mammalian cells. In particular, the invention relates to a system and a method for sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm. The improved systematic optimization method can be incorporated into a software for more efficient optimization.

    摘要翻译： 描述了改进的基因序列优化方法，该系统优化方法用于增强细菌，酵母，昆虫和哺乳动物细胞中基因的重组表达。 这种一般方法考虑了影响蛋白质表达的参数和因子的多个，优选大多数或全部，包括密码子使用，tRNA使用，GC含量，核糖体结合序列，启动子，5'-UTR，ORF和3'-UTR 改进和优化基因序列以增强细菌，酵母，昆虫和哺乳动物细胞中基因的蛋白质表达的基因序列。 特别地，本发明涉及使用粒子群优化算法改进重组蛋白表达的序列优化的系统和方法。 改进的系统优化方法可以被并入软件中以进行更有效的优化。

    Binarizing method and device thereof
    9.
    发明授权
    Binarizing method and device thereof 有权
    二价法及其装置

    公开(公告)号：US07564384B2

    公开(公告)日：2009-07-21

    申请号：US12132959

    申请日：2008-06-04

    申请人： Yun He ,  Ping Yang ,  Wei Yu ,  Xinjian Meng ,  Jianhua Zheng

    发明人： Yun He ,  Ping Yang ,  Wei Yu ,  Xinjian Meng ,  Jianhua Zheng

    IPC分类号： H03M7/00

    CPC分类号： H04N19/517 ,  H04N19/139 ,  H04N19/50 ,  H04N19/91

    摘要： A binary coding and decoding method and apparatus for MVD (Motion Vector Difference) absolute values, includes: dividing symbols for MVD absolute values to be coded into a plurality of subsets according to probability distribution properties; assigning a binary codeword for each subset; assigning a binary codeword for each symbol in each subset; concatenating and outputting the binary codeword for each subset and the binary codeword for each symbol in the subset, as the binary coding result. At the decoding side, decoding operations are performed by using a principle corresponding to that at the coding side. In this manner, the invention makes full use of the source properties on one hand, and effectively prevents the codeword length from being too long on the other hand. It has been experimentally testified that a better compression effect may be achieved during arithmetic coding process and thus the image coding performance may be improved effectively.

    摘要翻译： 用于MVD（运动矢量差）绝对值的二进制编码和解码方法和装置包括：根据概率分布特性将要编码的MVD绝对值的符号划分成多个子集; 为每个子集分配二进制码字; 为每个子集中的每个符号分配二进制码字; 作为二进制编码结果，连接并输出每个子集的二进制码字和子集中每个符号的二进制码字。 在解码侧，通过使用与编码侧对应的原理进行解码操作。 以这种方式，本发明一方面充分利用了源特性，另一方面有效地防止了码字长度过长。 已经通过实验证明，在算术编码过程中可以获得更好的压缩效果，因此可以有效地提高图像编码性能。