公开(公告)号：US08980075B2

公开(公告)日：2015-03-17

申请号：US13560448

申请日：2012-07-27

Applicant: Xing Cheng ,  Kamran Entesari

Inventor： Xing Cheng ,  Kamran Entesari

IPC: G02B1/06 ,  G01N13/00 ,  B01L3/00

CPC classification number: B01L3/502792 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0427

Abstract: A digital microfluidic platform utilizes dual active matrix circuitry to actuate and heat liquid droplets on a biochip. Liquid droplets are introduced into a droplet handling area of the biochip where they can be actuated by electrodes residing in pixels of an actuating active matrix array according to the electrowetting on dielectric phenomenon and heated by heating elements residing in pixels of a heating active matrix array. Pixels of the actuating active matrix array and the heating active matrix array are independently addressable such that droplets in the droplet handling area can be selectively heated and actuated according to their location. The actuating active matrix array and heating active matrix array can be formed on the same or different substrates with the droplet handling area disposed above or between the substrates.

Abstract translation: 数字微流体平台利用双有源矩阵电路来驱动和加热生物芯片上的液滴。 液滴被引入到生物芯片的液滴处理区域中，其中它们可以由位于致动有源矩阵阵列的像素中的电极根据介电现象上的电润湿而被驱动，并由加热有源矩阵阵列的像素中的加热元件加热。 致动有源矩阵阵列和加热有源矩阵阵列的像素可独立寻址，使得液滴处理区域中的液滴可以根据其位置选择性地加热和致动。 致动有源矩阵阵列和加热有源矩阵阵列可以形成在相同或不同的基板上，液滴处理区域设置在基板之上或之间。

公开(公告)号：US20130026040A1

公开(公告)日：2013-01-31

申请号：US13560448

申请日：2012-07-27

Applicant: Xing Cheng ,  Kamran Entesari

Inventor： Xing Cheng ,  Kamran Entesari

IPC: C25B9/00

CPC classification number: B01L3/502792 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0427

Abstract: A digital microfluidic platform utilizes dual active matrix circuitry to actuate and heat liquid droplets on a biochip. Liquid droplets are introduced into a droplet handling area of the biochip where they can be actuated by electrodes residing in pixels of an actuating active matrix array according to the electrowetting on dielectric phenomenon and heated by heating elements residing in pixels of a heating active matrix array. Pixels of the actuating active matrix array and the heating active matrix array are independently addressable such that droplets in the droplet handling area can be selectively heated and actuated according to their location. The actuating active matrix array and heating active matrix array can be formed on the same or different substrates with the droplet handling area disposed above or between the substrates.

Abstract translation: 数字微流体平台利用双有源矩阵电路来驱动和加热生物芯片上的液滴。 液滴被引入到生物芯片的液滴处理区域中，其中它们可以由位于致动有源矩阵阵列的像素中的电极根据介电现象上的电润湿而被驱动，并由加热有源矩阵阵列的像素中的加热元件加热。 致动有源矩阵阵列和加热有源矩阵阵列的像素可独立寻址，使得液滴处理区域中的液滴可根据其位置选择性地加热和致动。 致动有源矩阵阵列和加热有源矩阵阵列可以形成在相同或不同的基板上，液滴处理区域设置在基板之上或之间。

公开(公告)号：US07648767B2

公开(公告)日：2010-01-19

申请号：US10598943

申请日：2005-06-01

Applicant: Peng Fei Fu ,  Lingjie Jay Guo ,  Xing Cheng

Inventor： Peng Fei Fu ,  Lingjie Jay Guo ,  Xing Cheng

IPC: B32B17/06 ,  C08G59/68

CPC classification number: G03F7/0382 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03F7/038 ,  G03F7/0755 ,  Y10T428/31612

Abstract: A material composition, which is used as a liquid resist, includes a first component comprising a monomer portion and at least one cationically polymerizable functional group, and a crosslinker reactive with the first component and comprising at least three cationically polymerizable functional groups. The material composition also includes a cationic photoinitiator. Upon exposure to UV light, the material composition crosslinks via cure to form a cured resist film that is the reaction product of the first component, the crosslinker, and the cationic photoinitiator. An article includes a substrate layer and a resist layer formed on the substrate layer from the material composition.

Abstract translation: 用作液体抗蚀剂的材料组合物包括包含单体部分和至少一种阳离子可聚合官能团的第一组分和与第一组分反应并包含至少三个可阳离子聚合的官能团的交联剂。 该材料组合物还包括阳离子光引发剂。 在暴露于UV光下时，材料组合物通过固化交联以形成固化的抗蚀剂膜，其是第一组分，交联剂和阳离子光引发剂的反应产物。 一种制品包括从该材料组合物形成在基底层上的基底层和抗蚀剂层。

公开(公告)号：US08613935B2

公开(公告)日：2013-12-24

申请号：US12699108

申请日：2010-02-03

Applicant: Hong Jin ,  Xing Cheng ,  Kanta Subbarao

Inventor： Hong Jin ,  Xing Cheng ,  Kanta Subbarao

IPC: A61K39/145 ,  A61P31/16 ,  C12N7/01 ,  C12N7/02

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5258 ,  C12N7/00 ,  C12N2760/16134

Abstract: Polypeptides, polynucleotides, reassortant viruses, immunogenic compositions and vaccines comprising influenza hemagglutinin and neuraminidase variants and method using thereof are provided.

公开(公告)号：US08163530B2

公开(公告)日：2012-04-24

申请号：US12508075

申请日：2009-07-23

Applicant: Xing Cheng ,  Hyun Jung Park ,  Hong Jin

Inventor： Xing Cheng ,  Hyun Jung Park ,  Hong Jin

IPC: C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  A61K39/155

CPC classification number: C07K14/005 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K16/1027 ,  C12N2760/18522

Abstract: The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

Abstract translation: 提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。 还提供了由该多核苷酸序列编码的蛋白质。 还提供了分离或重组的RSV（例如减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，包含这种分离的或重组的RSV，核酸和多肽的免疫原性组合物也是如此。 还描述了相关方法。

公开(公告)号：US20060237881A1

公开(公告)日：2006-10-26

申请号：US10545456

申请日：2004-02-13

Applicant: Lingjie Guo ,  Xing Cheng

Inventor： Lingjie Guo ,  Xing Cheng

IPC: B29C35/08

CPC classification number: G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  G03F1/50

Abstract: A method of fabricating a device including imprinting a mold having a protrusion against a substrate having a resist layer such that the protrusion engages the resist layer. The mold further has a mask member positioned generally adjacent the resist layer. Radiation energy is then transmitted through the mold and into the resist layer; however, the mask member substantially prevents transmission of the radiation energy therethrough, thereby defining an unexposed area in the resist layer. Once the mold is removed from the substrate, which consequently forms a first feature from nanoimprinting, the unexposed area of resist layer is removed through dissolving in a developer solution.

Abstract translation: 一种制造器件的方法，包括将具有突起的模具压印在具有抗蚀剂层的基底上，使得突起与抗蚀剂层接合。 模具还具有通常邻近抗蚀剂层定位的掩模构件。 然后将辐射能量透过模具并进入抗蚀剂层; 然而，掩模构件基本上防止辐射能量透过，从而在抗蚀剂层中限定未曝光区域。 一旦将模具从基底上移除，从而形成纳米压印的第一特征，则通过溶解在显影剂溶液中去除抗蚀剂层的未曝光区域。

公开(公告)号：US20120263744A1

公开(公告)日：2012-10-18

申请号：US13449087

申请日：2012-04-17

Applicant: Xing Cheng ,  Hyun Jung Park ,  Hong Jin

Inventor： Xing Cheng ,  Hyun Jung Park ,  Hong Jin

IPC: A61K39/155 ,  A61P31/14

CPC classification number: C07K14/005 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K16/1027 ,  C12N2760/18522

Abstract: The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

Abstract translation: 提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。 还提供了由该多核苷酸序列编码的蛋白质。 还提供了分离或重组的RSV（例如减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，包含这种分离的或重组的RSV，核酸和多肽的免疫原性组合物也是如此。 还描述了相关方法。

公开(公告)号：US07572904B2

公开(公告)日：2009-08-11

申请号：US10811508

申请日：2004-03-26

Applicant: Xing Cheng ,  Hyun Jung Park ,  Hong Jin

Inventor： Xing Cheng ,  Hyun Jung Park ,  Hong Jin

IPC: C07H21/00 ,  A61K39/155

CPC classification number: C07K14/005 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K16/1027 ,  C12N2760/18522

Abstract: The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

Abstract translation: 提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。 还提供了由该多核苷酸序列编码的蛋白质。 还提供了分离的或重组的RSV（例如，减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，以及包含这种分离或重组的RSV，核酸和多肽的免疫原性组合物。 还描述了相关方法。

公开(公告)号：US20070196589A1

公开(公告)日：2007-08-23

申请号：US10598943

申请日：2005-06-01

Applicant: Peng Fu ,  Lingjie Guo ,  Xing Cheng

Inventor： Peng Fu ,  Lingjie Guo ,  Xing Cheng

IPC: C08G59/68

CPC classification number: G03F7/0382 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  G03F7/038 ,  G03F7/0755 ,  Y10T428/31612

Abstract: A material composition, which is used as a liquid resist, includes a first component comprising a monomer portion and at least one cationically polymerizable functional group, and a crosslinker reactive with the first component and comprising at least three cationically polymerizable functional groups. The material composition also includes a cationic photoinitiator. Upon exposure to UV light, the material composition crosslinks via cure to form a cured resist film that is the reaction product of the first component, the crosslinker, and the cationic photoinitiator. An article includes a substrate layer and a resist layer formed on the substrate layer from the material composition.

Abstract translation: 用作液体抗蚀剂的材料组合物包括包含单体部分和至少一种阳离子可聚合官能团的第一组分和与第一组分反应并包含至少三个可阳离子聚合的官能团的交联剂。 该材料组合物还包括阳离子光引发剂。 在暴露于UV光下时，材料组合物通过固化交联以形成固化的抗蚀剂膜，其是第一组分，交联剂和阳离子光引发剂的反应产物。 一种制品包括从该材料组合物形成在基底层上的基底层和抗蚀剂层。

公开(公告)号：US20090035469A1

公开(公告)日：2009-02-05

申请号：US12112675

申请日：2008-04-30

Applicant: Hung-Jue Sue ,  Xing Cheng ,  Dazhi Sun ,  Huifeng Li ,  Chien-Chia Chu

Inventor： Hung-Jue Sue ,  Xing Cheng ,  Dazhi Sun ,  Huifeng Li ,  Chien-Chia Chu

IPC: B05D1/32 ,  C09D1/00

CPC classification number: B82Y30/00 ,  C08K3/041 ,  C08K3/22 ,  C08K3/346 ,  C09D7/70 ,  C08L63/00

Abstract: A dispersible nanocomposite comprising nanotubes associated with nanoplatelets. A method for creating an exfoliated nanotubes solution, aligning nanotubes and depositing them on a substrate or in matrix. In one embodiment, the method includes a nanocomposite of at least one nanotube electrostatically associated with at least one nanoplatelet. The nanoplatelets may be removed from the suspension by altering the ionic strength to create an exfoliated nanotube solution. The exfoliated nanotube solution for injection into microchannel templates and aligned deposition.

Abstract translation: 包含与纳米片相关的纳米管的可分散的纳米复合材料。 一种用于产生剥离的纳米管溶液的方法，将纳米管排列并将其沉积在基底或基质上。 在一个实施方案中，该方法包括与至少一个纳米血小板静电相关的至少一个纳米管的纳米复合物。 可以通过改变离子强度从悬浮液中除去纳米片，以产生剥离的纳米管溶液。 用于注入微通道模板和对准沉积的剥离的纳米管溶液。