公开(公告)号：US20050143636A1

公开(公告)日：2005-06-30

申请号：US10751327

申请日：2003-12-30

申请人： Yanan Zhang ,  Lu Wang ,  Rajiv Shah

发明人： Yanan Zhang ,  Lu Wang ,  Rajiv Shah

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61M31/00 ,  A61K9/22

CPC分类号： A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  G06F19/00

摘要： A system and method for calibrating a sensor. The method may include, without limitation, compiling an array of data relating to the sensor; adjusting a sensor parameter a first time based on data in the array; adjusting a curve representing the sensor output based on data in the array; and adjusting the sensor parameter a second time based on data in the array. The sensor may be an in vivo glucose sensor and the sensor parameter adjusted may be a current. The array may include historical as well as recent data, such as, for example, blood glucose readings and sensor electrode readings.

摘要翻译： 一种用于校准传感器的系统和方法。 该方法可以包括但不限于编译与传感器相关的数据阵列; 基于阵列中的数据首次调整传感器参数; 基于阵列中的数据调整表示传感器输出的曲线; 并且基于阵列中的数据再次调整传感器参数。 传感器可以是体内葡萄糖传感器，并且调节的传感器参数可以是电流。 阵列可以包括历史以及近来的数据，例如血糖读数和传感器电极读数。

公开(公告)号：US08777852B2

公开(公告)日：2014-07-15

申请号：US11843601

申请日：2007-08-22

申请人： Yanan Zhang ,  Lu Wang ,  Rajiv Shah

发明人： Yanan Zhang ,  Lu Wang ,  Rajiv Shah

IPC分类号： A61B5/00

CPC分类号： A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  G06F19/00

摘要： An implantable sensing system that includes a sensor for sensing a biological parameter, a processor connected to the sensor for processing the parameter and a drug delivery unit connected to the processor for responding to the processor based on the parameter. The processor is programmed to adjust an output of the sensor by compiling an array of data relating to the sensor, adjusting a sensor parameter a first time based on data in the array, adjusting a curve representing the sensor output based on data in the array and adjusting the sensor parameter a second time based on data in the array.

摘要翻译： 一种可植入感测系统，其包括用于感测生物参数的传感器，连接到所述传感器以用于处理所述参数的处理器以及连接到所述处理器的药物输送单元，以基于所述参数响应所述处理器。 处理器被编程为通过编译与传感器有关的数据阵列来调节传感器的输出，基于阵列中的数据首次调整传感器参数，基于阵列中的数据调整表示传感器输出的曲线， 基于阵列中的数据再次调整传感器参数。

公开(公告)号：US20080039822A1

公开(公告)日：2008-02-14

申请号：US11843601

申请日：2007-08-22

申请人： Yanan Zhang ,  Lu Wang ,  Rajiv Shah

发明人： Yanan Zhang ,  Lu Wang ,  Rajiv Shah

IPC分类号： A61M37/00

CPC分类号： A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  G06F19/00

摘要： An implantable sensing system that includes a sensor for sensing a biological parameter, a processor connected to the sensor for processing the parameter and a drug delivery unit connected to the processor for responding to the processor based on the parameter. The processor is programnmed to adjust an output of the sensor by compiling an array of data relating to the sensor, adjusting a sensor parameter a first time based on data in the array, adjusting a curve representing the sensor output based on data in the array and adjusting the sensor parameter a second time based on data in the array.

摘要翻译： 一种可植入感测系统，其包括用于感测生物参数的传感器，连接到所述传感器以用于处理所述参数的处理器以及连接到所述处理器的药物输送单元，以基于所述参数响应所述处理器。 处理器被编程以通过编译与传感器相关的数据阵列来调节传感器的输出，基于阵列中的数据首次调整传感器参数，基于阵列中的数据调整表示传感器输出的曲线，以及 基于阵列中的数据再次调整传感器参数。

公开(公告)号：US07384397B2

公开(公告)日：2008-06-10

申请号：US10751327

申请日：2003-12-30

申请人： Yanan Zhang ,  Lu Wang ,  Rajiv Shah

发明人： Yanan Zhang ,  Lu Wang ,  Rajiv Shah

IPC分类号： A61B5/00

CPC分类号： A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  G06F19/00

摘要： A system and method for calibrating a sensor. The method may include, without limitation, compiling an array of data relating to the sensor; adjusting a sensor parameter a first time based on data in the array; adjusting a curve representing the sensor output based on data in the array; and adjusting the sensor parameter a second time based on data in the array. The sensor may be an in vivo glucose sensor and the sensor parameter adjusted may be a current. The array may include historical as well as recent data, such as, for example, blood glucose readings and sensor electrode readings.

摘要翻译： 一种用于校准传感器的系统和方法。 该方法可以包括但不限于编译与传感器相关的数据阵列; 基于阵列中的数据首次调整传感器参数; 基于阵列中的数据调整表示传感器输出的曲线; 并且基于阵列中的数据再次调整传感器参数。 传感器可以是体内葡萄糖传感器，并且调节的传感器参数可以是电流。 阵列可以包括历史以及近来的数据，例如血糖读数和传感器电极读数。

公开(公告)号：US07468033B2

公开(公告)日：2008-12-23

申请号：US10935954

申请日：2004-09-08

申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Wang ,  Kent L. Clark

IPC分类号： A61B5/00 ,  A61M37/00

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。

公开(公告)号：US07162289B2

公开(公告)日：2007-01-09

申请号：US10335574

申请日：2002-12-31

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： A61B5/00 ,  A61B5/05 ,  C12M1/00 ,  C12Q1/00

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US20110203923A1

公开(公告)日：2011-08-25

申请号：US12862690

申请日：2010-08-24

申请人： Ronald J. Lebel ,  Rajiv Shah ,  Yanan Zhang ,  Edward Chernoff ,  Rudolph A. Montalvo

发明人： Ronald J. Lebel ,  Rajiv Shah ,  Yanan Zhang ,  Edward Chernoff ,  Rudolph A. Montalvo

IPC分类号： G01N27/30 ,  H01R43/16

CPC分类号： A61N1/05 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/14865 ,  Y10T29/49204

摘要： A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.

摘要翻译： 具有连接器，传感器引线和传感器模块的感测装置，其具有放置在已经沉积在基板上的电极上的隔离物。 间隔物可以具有用于接受酶的空间。 传感器模块的端部可以被封装，例如用模制的珠子。 传感器引线可以附接到传感器模块，并且可以具有穿过模块并且附接到传感器模块的端部处的珠的外管。 传感器引线还可以附接到连接器，使得感测装置可以电耦合到泵，电子设备或其他装置。 感测装置可以植入静脉或动脉。

公开(公告)号：US07912525B2

公开(公告)日：2011-03-22

申请号：US11606837

申请日：2006-11-30

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US07552522B2

公开(公告)日：2009-06-30

申请号：US10928863

申请日：2004-08-26

申请人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

发明人： Rajiv Shah ,  Yanan Zhang ,  Rebecca Gottlieb ,  Bahar Reghabi ,  Michael Miller

IPC分类号： G01R3/00

CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B5/686 ,  A61B2562/02 ,  G01N33/5438 ,  Y10T29/49002 ,  Y10T29/49007 ,  Y10T29/49128 ,  Y10T29/49155

摘要： A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.

摘要翻译： 一种用于增强可植入传感器的完整性的方法和装置。 形成在外管和传感器基底或间隔元件之间的空隙可以用可固化的可植入材料反填充，从而最小化不希望的流体在传感器内扩散的程度。 传感器窗口下面的酶或蛋白质基质颗粒可以用还原剂进行预处理，以增强其粘合稳定性，并减少可能导致传感器窗口分离或泄漏的不期望的膨胀。 可以通过使用诸如人血清白蛋白（HSA）的蛋白质材料的介入粘合层来增强酶颗粒与水凝胶层之间的结合。 通过最小化底层电极的尺寸，提供减小的通量和延长传感器，可以使窗口的尺寸最小化。 涂层可沉积在传感器引线的表面上，提供加强和润滑。

公开(公告)号：US08352011B2

公开(公告)日：2013-01-08

申请号：US12264810

申请日：2008-11-04

申请人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Larry Wang ,  Kent L. Clark

发明人： Nannette M. Van Antwerp ,  Bradley J. Enegren ,  John J. Mastrototaro ,  Rajiv Shah ,  Udo Hoss ,  Yanan Zhang ,  Jenn-Hann Larry Wang ,  Kent L. Clark

IPC分类号： A61B5/05

CPC分类号： A61B5/153 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992

摘要： The invention provides methods and apparatus for detecting an analyte in blood. The apparatus is particularly suited for bringing a sensor into direct contact with blood in vivo. The apparatus comprises a sensor that detects the presence of an analyte and an assembly means. The assembly means has a sensor end, wherein the sensor end of the assembly means is affixed to the sensor, and the assembly means is adapted for coupling with a venous flow device. By coupling with a venous flow device, the assembly means brings the sensor into direct contact with blood flowing through the venous flow device. Examples of venous flow devices that bring the sensor into direct contact with the blood of a subject include, but are not limited to, intravenous catheters and external blood loops, such as are used in extra corporeal membrane oxygenation or hemodialysis.

摘要翻译： 本发明提供了用于检测血液中分析物的方法和装置。 该装置特别适于使传感器在体内与血液直接接触。 该装置包括检测分析物和组装装置的存在的传感器。 组装装置具有传感器端，其中组装装置的传感器端固定到传感器，并且组装装置适于与静脉流装置联接。 通过与静脉流动装置联接，组装装置使传感器与流过静脉流装置的血液直接接触。 将传感器与受试者的血液直接接触的静脉流动装置的实例包括但不限于静脉内导管和外部血液回路，例如用于额外的体外膜氧合或血液透析。