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    Polyethylene imine based pigment dispersants
    1.
    发明授权
    Polyethylene imine based pigment dispersants 失效
    聚乙烯亚胺基颜料分散剂

    公开(公告)号：US08268957B2

    公开(公告)日：2012-09-18

    申请号：US12225642

    申请日：2007-03-19

    申请人： Yanfei Liu ,  Frank Oliver Heinrich Pirrung ,  Haiyang Yu ,  Huiguang Kou

    发明人： Yanfei Liu ,  Frank Oliver Heinrich Pirrung ,  Haiyang Yu ,  Huiguang Kou

    IPC分类号： C08G73/00

    CPC分类号： C08G73/0206 ,  B01F17/005 ,  C09B67/009

    摘要： This invention refers to a novel process for the synthesis of polyethylene imine (PEI)-based pigment dispersants characterized by a “grafting from” approach, allowing the manufacture of solvent based dispersant systems. The polyethylene imine (PEI)-based pigment dispersant can be presented by the formula (I) X-(T)m-P-(T)n-H wherein P is a polyethyleneimine (PEI) back-bone; T is a residue —CO-A-O— wherein A is C2-C12 alkylene optionally substituted with C1-C6 alkyl with the proviso that each linkage between P and T is an amide bond and each linkage between X and T is an ester bond, X is a modifier or terminator residue R—CO— wherein R is a linear or branched, saturated or unsaturated alkanecarboxylic acids having from 1 to 22 carbon atoms or an unsaturated fatty acid residue or a hydroxycarboxylic residue or a polyester residue obtained from polycondensation of hydroxycarboxylic acids, or an acid terminated polyether; n, m independently are a number from 1 to 100.

    摘要翻译： 本发明涉及一种用于合成以“接枝”方式为特征的聚乙烯亚胺（PEI）的颜料分散剂的新方法，允许制造基于溶剂的分散剂体系。 基于聚乙烯亚胺（PEI）的颜料分散剂可以由式（I）X-（T）m-P-（T）n-H表示，其中P是聚乙烯亚胺（PEI）背骨; T是残基-CO-AO-，其中A是任选被C 1 -C 6烷基取代的C 2 -C 12亚烷基，条件是P和T之间的每个连接是酰胺键，X和T之间的每个连接是酯键，X 是改性剂或终止剂残基R-CO-，其中R是具有1至22个碳原子的直链或支链饱和或不饱和烷烃羧酸或不饱和脂肪酸残基或羟基羧酸残基或由羟基羧酸缩聚获得的聚酯残基 ，或酸封端的聚醚; n，m独立地为1至100的数。

    POLYETHYLENE IMINE BASED PIGMENT DISPERSANTS
    2.
    发明申请
    POLYETHYLENE IMINE BASED PIGMENT DISPERSANTS 失效
    聚乙烯基于颜料的颜料分散剂

    公开(公告)号：US20100174046A1

    公开(公告)日：2010-07-08

    申请号：US12225642

    申请日：2007-03-19

    申请人： Yanfei Liu ,  Frank Oliver Heinrich Pirrung ,  Haiyang Yu ,  Huiguang Kou

    发明人： Yanfei Liu ,  Frank Oliver Heinrich Pirrung ,  Haiyang Yu ,  Huiguang Kou

    IPC分类号： C08G73/00

    CPC分类号： C08G73/0206 ,  B01F17/005 ,  C09B67/009

    摘要： This invention refers to a novel process for the synthesis of polyethylene imine (PEI)-based pigment dispersants characterized by a “grafting from” approach, allowing the manufacture of solvent based dispersant systems. The polyethylene imine (PEI)-based pigment dispersant can be presented by the formula (I) X-(T)m-P-(T)n-H wherein P is a polyethyleneimine (PEI) back-bone; T is a residue —CO-A-O— wherein A is C2-C12 alkylene optionally substituted with C1-C6 alkyl with the proviso that each linkage between P and T is an amide bond and each linkage between X and T is an ester bond, X is a modifier or terminator residue R—CO— wherein R is a linear or branched, saturated or unsaturated alkanecarboxylic acids having from 1 to 22 carbon atoms or an unsaturated fatty acid residue or a hydroxycarboxylic residue or a polyester residue obtained from polycondensation of hydroxycarboxylic acids, or an acid terminated polyether, n, m independently are a number from 1 to 100.

    摘要翻译： 本发明涉及一种用于合成以“接枝”方式为特征的聚乙烯亚胺（PEI）的颜料分散剂的新方法，允许制造基于溶剂的分散剂体系。 基于聚乙烯亚胺（PEI）的颜料分散剂可以由式（I）X-（T）m-P-（T）n-H表示，其中P是聚乙烯亚胺（PEI）背骨; T是残基-CO-AO-，其中A是任选被C 1 -C 6烷基取代的C 2 -C 12亚烷基，条件是P和T之间的每个连接是酰胺键，X和T之间的每个连接是酯键，X 是改性剂或终止剂残基R-CO-，其中R是具有1至22个碳原子的直链或支链饱和或不饱和烷烃羧酸或不饱和脂肪酸残基或羟基羧酸残基或由羟基羧酸缩聚获得的聚酯残基 或酸封端的聚醚，n，m独立地为1至100的数。

    NITROCELLULOSE BASED DISPERSANT
    3.
    发明申请
    NITROCELLULOSE BASED DISPERSANT 审中-公开
    基于NITROCELLULOSE的分散剂

    公开(公告)号：US20100184886A1

    公开(公告)日：2010-07-22

    申请号：US12667693

    申请日：2008-06-26

    申请人： Huiguang Kou ,  Frank Oliver Heinrich Pirrung ,  Haiyang Yu ,  Yinzhi Ma ,  Petrus Johannes Harbers

    发明人： Huiguang Kou ,  Frank Oliver Heinrich Pirrung ,  Haiyang Yu ,  Yinzhi Ma ,  Petrus Johannes Harbers

    IPC分类号： C09D11/14 ,  C08G63/91

    CPC分类号： C08G18/6484 ,  C08B37/00 ,  C08L1/00 ,  C08L2666/20

    摘要： The invention relates to a polysaccharide-g-polyether dispersant represented as a compound of Formula 1 or a mixture of compounds of Formula (I) and Formula (II) wherein, T is the backbone polymer and is a residue of a modified cellulose or chitosan, with a molecular weight of 500-1000,000 g/mol; A and B are each, independently, —O— or —NH—; R is linear or branched —(C1-C50alkylene)-, arylene, cyclo-C5-C8-alkylene, isophoronediyl, or linear or branched —(C2-C10alkylene)- which is interrupted by phenylene or cyclohexanediyl; P is the residue of a polyether and/or polyester chain with molecular weight between 100 and 10,000 g/mol, n is a number of 1-5000.

    摘要翻译： 本发明涉及以式1化合物或式（I）和式（II）化合物的混合物代表的多糖-g-聚醚分散剂，其中T是主链聚合物，并且是改性纤维素或壳聚糖的残基 ，分子量为500-1000,000g / mol; A和B各自独立地为-O-或-NH-; R是直链或支链 - （C 1 -C 50亚烷基） - ，亚芳基，环-C 5 -C 8 - 亚烷基，异佛尔酮二基，或被亚苯基或环己二基中断的直链或支链 - （C 2 -C 10亚烷基） P是分子量为100至10,000g / mol的聚醚和/或聚酯链的残基，n为1-5000的数。

    POLYETHYLENE IMINE BASED DENDRITIC DISPERSANT
    4.
    发明申请
    POLYETHYLENE IMINE BASED DENDRITIC DISPERSANT 有权
    聚乙烯基尼龙分散剂

    公开(公告)号：US20100113709A1

    公开(公告)日：2010-05-06

    申请号：US12442142

    申请日：2007-09-17

    申请人： Huiguang Kou ,  Haiyang Yu ,  Yanfei Liu ,  Weiqiu Hu

    发明人： Huiguang Kou ,  Haiyang Yu ,  Yanfei Liu ,  Weiqiu Hu

    IPC分类号： C07C69/02 ,  C08G73/02

    CPC分类号： B01F17/005 ,  B01J13/0034 ,  C09B67/0085 ,  C09C3/08 ,  C09D7/45

    摘要： The invention relates to a liquid dispersant of the formula I wherein T is selected from a polyethylene imine (PEI) or modified PEI moiety, polyvinylamine (PVA) or modified PVA, or polyallylamine (PAA) or modified PAA. B is a branched monomer selected from a monofunctional carboxylic acid moiety having at least two hydroxyl groups or a monofunctional carboxylic acid moiety having at least two hydroxyl groups wherein one or more of the hydroxyl groups are hydroxyalkyl substituted, R1 and R2 independently of one another are hydrophobic groups selected from a saturated or unsaturated fatty acid moiety with 3-24 carbon atoms, a monofunctional carboxylic acid moiety or a polymer moiety containing C3-C24 alkyl (hydroxyl)carboxylic acid moieties with MW ranges from 100 to 10,000 g/mol, X is B with —OH terminal group, or R1 or R2, q is a number between 5-2000, with the proviso that q is less than the sum of all amine groups of PEI, PVA, PAA. n is a number of 1-6.

    摘要翻译： 本发明涉及式I的液体分散剂，其中T选自聚乙烯亚胺（PEI）或改性PEI部分，聚乙烯胺（PVA）或改性PVA，或聚烯丙胺（PAA）或改性PAA。 B是选自具有至少两个羟基的单官能羧酸部分或具有至少两个羟基的单官能羧酸部分的支链单体，其中一个或多个羟基被羟烷基取代，R 1和R 2彼此独立地是 选自具有3-24个碳原子的饱和或不饱和脂肪酸部分的疏水基团，单官能羧酸部分或含有C 3 -C 24烷基（羟基）羧酸部分的聚合物部分，MW为100至10,000g / mol，X 是具有-OH端基的B，或R1或R2，q是5-2000之间的数字，条件是q小于PEI，PVA，PAA的所有胺基的总和。 n是1-6的数。

    Methods and uses of KSR kinase, and mutations thereof
    7.
    发明申请
    Methods and uses of KSR kinase, and mutations thereof 有权
    KSR激酶的方法和用途及其突变

    公开(公告)号：US20120202233A1

    公开(公告)日：2012-08-09

    申请号：US13369220

    申请日：2012-02-08

    申请人： Andrey Shaw ,  Jiancheng Hu ,  Haiyang Yu

    发明人： Andrey Shaw ,  Jiancheng Hu ,  Haiyang Yu

    IPC分类号： C12N9/12 ,  C12N5/071 ,  C12Q1/48 ,  C07K19/00

    CPC分类号： C12N9/0069 ,  C07K2319/70 ,  C12N9/1205 ,  G01N2333/90241 ,  G01N2333/9121

    摘要： Mutant KSR proteins are disclosed. The mutants include single amino acid substitutions, leading to either a loss of kinase activity or a loss of scaffolding activity. Also disclosed are methods of screening compounds for inhibitors of KSR kinase activity or KSR scaffolding activity. In some embodiments, the screening methods include protein complementation assays in which nucleic acids encoding fusion constructs comprising enzyme portions and kinase dimerization domains are expressed in cells. Inhibitors of dimerization can be indicated by loss of enzyme activity.

    摘要翻译： 公开了突变型KSR蛋白。 突变体包括单个氨基酸取代，导致激酶活性丧失或脚手架活动丧失。 还公开了筛选KSR激酶活性抑制剂或KSR脚手架活性化合物的方法。 在一些实施方案中，筛选方法包括蛋白质互补测定法，其中编码包含酶部分和激酶二聚化结构域的融合构建体的核酸在细胞中表达。 二聚体的抑制剂可以通过酶活性的丧失来表示。

    METHOD FOR MICROPATTERNING A SUBSTRATE AND A PATTERNED SUBSTRATE FORMED THEREOF
    9.
    发明申请
    METHOD FOR MICROPATTERNING A SUBSTRATE AND A PATTERNED SUBSTRATE FORMED THEREOF 审中-公开
    用于微波基板和形成图案的基板的方法

    公开(公告)号：US20130273337A1

    公开(公告)日：2013-10-17

    申请号：US13881000

    申请日：2011-10-25

    申请人： Haiyang Yu ,  Lay Poh Tan

    发明人： Haiyang Yu ,  Lay Poh Tan

    IPC分类号： B32B37/00 ,  B32B38/10

    CPC分类号： B32B37/025 ,  A61L27/50 ,  A61L2400/18 ,  B32B38/10 ,  G01N33/54393 ,  Y10T428/24802

    摘要： A method of micropatterning a substrate is provided. The method comprises providing a template substrate having a patterned surface inked with a composition of interest; contacting the patterned surface with an intermediate substrate, thereby transferring the composition to the surface of the intermediate substrate; contacting the surface of the intermediate substrate comprising the composition with the substrate; and removing the intermediate substrate by dissolution using a solvent. A patterned substrate formed using the method, as well as a biosensor comprising the patterned substrate is also provided.

    摘要翻译： 提供了一种微图案化基板的方法。 该方法包括提供具有着色的感兴趣组合物的图案化表面的模板底物; 使图案化表面与中间基板接触，从而将组合物转移到中间基板的表面; 使包含所述组合物的中间基材的表面与基材接触; 并使用溶剂溶解除去中间基材。 还提供了使用该方法形成的图案化衬底以及包括图案化衬底的生物传感器。