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    Novel immunoglobulin derivatives and process for the preparation thereof
    7.
    发明授权
    Novel immunoglobulin derivatives and process for the preparation thereof 失效
    新型免疫球蛋白衍生物及其制备方法

    公开(公告)号：US4059571A

    公开(公告)日：1977-11-22

    申请号：US555132

    申请日：1975-03-04

    申请人： Katsuhiko Tomibe ,  Yasuhiko Masuho ,  Kimihiko Matsuzawa ,  Sachio Ishimoto ,  Kazuo Satake ,  Tsuneo Watanabe

    发明人： Katsuhiko Tomibe ,  Yasuhiko Masuho ,  Kimihiko Matsuzawa ,  Sachio Ishimoto ,  Kazuo Satake ,  Tsuneo Watanabe

    IPC分类号： C07K16/06 ,  A23J1/06

    CPC分类号： C07K16/065

    摘要： Novel immunoglobulin derivatives which are characterized in that in which the interchain disulfide bonds of immunoglobulin are predominantly cleaved, on the average 3 to 5 of the interchain disulfide bonds or the inter- and intra-chain disulfide bonds being cleaved, and so produced sulfur atoms (S-) are S-sulfonated (--S-SO.sub.3). The above immunoglobulin derivatives are prepared by reacting native immunoglobulin withA. a compound capable of forming tetrathionate ion, andB. a compound capable of forming in water, sulfite ion whereby cleaving on the average 3 to 5 inter-chain disulfide bonds, or inter- and intra-chain disulfide bonds, of the native immunoglobulin, and S-sulfonating (S-SO.sub.3) the so formed sulfur atoms. This invention also provides a water-soluble composition for injection containing said immunoglobulin derivative having the titre of anti-diphtheria of at least 1.0 I.U./ml at its concentration of 10.0% by weight, and a pharmaceutically-acceptable solubilizing agent for said immunoglobulin derivative.

    摘要翻译： 新型免疫球蛋白衍生物，其特征在于其中免疫球蛋白的链间二硫键主要被切割，平均3至5个链间二硫键或链内和链内二硫键被切割，并因此产生硫原子（ S-）是S-磺化的（-S-SO 3）。 上述免疫球蛋白衍生物通过使天然免疫球蛋白与A.能够形成四硫酸根离子的化合物反应制备，和B.能够在水中形成的化合物，亚硫酸根离子，其中以平均3至5个链间二硫键切割， - 和链内二硫键，以及S-磺化（S-SO 3）如此形成的硫原子。 本发明还提供一种含有所述免疫球蛋白衍生物的水溶性组合物，所述组合物的浓度为10.0重量％时具有至少1.0I./ml至少为1.0I./ml的滴度，以及用于所述免疫球蛋白衍生物的药学上可接受的增溶剂。