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    Pharmaceutical Use of Alpha Antigen or Alpha Antigen Gene
    2.
    发明申请
    Pharmaceutical Use of Alpha Antigen or Alpha Antigen Gene 审中-公开
    α抗原或α抗原基因的药物用途

    公开(公告)号：US20090286734A1

    公开(公告)日：2009-11-19

    申请号：US12405844

    申请日：2009-03-17

    申请人： Yasuhiro Yasutomi ,  Hitoshi Mizutani

    发明人： Yasuhiro Yasutomi ,  Hitoshi Mizutani

    IPC分类号： A61K38/16 ,  A61P17/00

    CPC分类号： A61K39/04 ,  A61K2039/53

    摘要： The α antigen-encoding gene and the α antigen protein suppress the production of interleukin-4 etc., improve the Th2 type cytokine-dominant state, and furthermore inhibit various conditions of allergic diseases such as IgE production, histamine release and eosinophil infiltration, and therefore they are very effective for the prevention or treatment of atopic diseases such as atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis, and more broadly allergic diseases.

    摘要翻译： α抗原编码基因和α抗原蛋白抑制白细胞介素-4等的产生，改善Th2型细胞因子显性状态，进一步抑制IgE产生，组胺释放和嗜酸性粒细胞浸润等过敏性疾病的各种病症， 因此它们对预防或治疗特应性皮炎，哮喘，过敏性鼻炎和过敏性结膜炎等特应性疾病以及更广泛的过敏性疾病非常有效。

    Pharmaceutical use of α antigen or α antigen gene
    4.
    发明授权
    Pharmaceutical use of α antigen or α antigen gene 有权
    药物使用α抗原或α抗原基因

    公开(公告)号：US07622297B2

    公开(公告)日：2009-11-24

    申请号：US11896977

    申请日：2007-09-07

    申请人： Yasuhiro Yasutomi ,  Hitoshi Mizutani

    发明人： Yasuhiro Yasutomi ,  Hitoshi Mizutani

    IPC分类号： C12N15/03 ,  C12N15/10 ,  A61K31/711 ,  C07H21/04

    CPC分类号： A61K39/04 ,  A61K2039/53

    摘要： The α antigen-encoding gene and the α antigen protein suppress the production of interleukin-4 etc., improve the Th2 type cytokine-dominant state, and furthermore inhibit various conditions of allergic diseases such as IgE production, histamine release and eosinophil infiltration, and therefore they are very effective for the prevention or treatment of atopic diseases such as atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis, and more broadly allergic diseases.

    摘要翻译： α抗原编码基因和α抗原蛋白抑制白细胞介素-4等的产生，改善Th2型细胞因子显性状态，进一步抑制IgE产生，组胺释放和嗜酸性粒细胞浸润等过敏性疾病的各种病症， 因此它们对预防或治疗特应性皮炎，哮喘，过敏性鼻炎和过敏性结膜炎等特应性疾病以及更广泛的过敏性疾病非常有效。

    Pharmaceutical use of alpha antigen or alpha antigen gene
    5.
    发明申请
    Pharmaceutical use of alpha antigen or alpha antigen gene 有权
    药物使用α抗原或α抗原基因

    公开(公告)号：US20080132463A1

    公开(公告)日：2008-06-05

    申请号：US11896977

    申请日：2007-09-07

    申请人： Yasuhiro Yasutomi ,  Hitoshi Mizutani

    发明人： Yasuhiro Yasutomi ,  Hitoshi Mizutani

    IPC分类号： A61K31/70 ,  A61P43/00

    CPC分类号： A61K39/04 ,  A61K2039/53

    摘要： The α antigen-encoding gone and the α antigen protein suppress the production of interleukin-4 etc., improve the Th2 type cytokine-dominant state, and furthermore inhibit various conditions of allergic diseases such as IgE production, histamine release and eosinophil infiltration, and therefore they are very effective for the prevention or treatment of atopic diseases such as atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis, and more broadly allergic diseases.

    摘要翻译： α抗原编码去除和α抗原蛋白抑制白细胞介素-4等的产生，改善Th2型细胞因子主导状态，进而抑制IgE产生，组胺释放和嗜酸性粒细胞浸润等过敏性疾病的各种病症， 因此它们对预防或治疗特应性皮炎，哮喘，过敏性鼻炎和过敏性结膜炎等特应性疾病以及更广泛的过敏性疾病非常有效。

    INTRANASAL SPRAY-TYPE TUBERCULOSIS VACCINE USING PARAMYXOVIRUS VECTOR
    7.
    发明申请
    INTRANASAL SPRAY-TYPE TUBERCULOSIS VACCINE USING PARAMYXOVIRUS VECTOR 审中-公开
    使用PARAMYXOVIRUS矢量的INTRANASAL喷雾型TUBCCOSOSIS VACCINE

    公开(公告)号：US20120219582A1

    公开(公告)日：2012-08-30

    申请号：US13389816

    申请日：2010-11-01

    申请人： Yasuhiro Yasutomi ,  Mitsuo Kawano ,  Tetsuya Nosaka ,  Masayuki Fukumura

    发明人： Yasuhiro Yasutomi ,  Mitsuo Kawano ,  Tetsuya Nosaka ,  Masayuki Fukumura

    IPC分类号： A61K39/04 ,  A61P31/06

    CPC分类号： A61K35/76 ,  A61K39/04 ,  A61K2039/543 ,  C12N2760/18743

    摘要： Disclosed is a intranasal spray-type tuberculosis vaccine, which has a high prophylactic effect on human tuberculosis, particularly adult tuberculosis. The nebulizable tuberculosis vaccine for intranasal administration comprises a paramyxovirus gene (particularly rhPIV2) having, integrated therein, a gene encoding an α antigen derived from an acid-fast bacterium (e.g., an α antigen derived from Mycobacterium kansasii or Mycobacterium bovis BCG), an analogue of the gene, or a variant of the gene which has an equivalent function to that of the gene.

    摘要翻译： 公开了一种鼻内喷雾型结核疫苗，对人类结核病尤其是成人结核病具有较高的预防效果。 用于鼻内给药的可喷雾结核疫苗包括其中整合有编码来自耐酸细菌的α抗原的基因（例如，源自堪萨斯分枝杆菌或牛分枝杆菌BCG的α抗原）的副粘病毒基因（特别是rhPIV2），一种 基因的类似物，或与该基因具有等同功能的基因的变体。