公开(公告)号：US07326579B2

公开(公告)日：2008-02-05

申请号：US11026830

申请日：2004-12-30

申请人： Yasuo Yamao ,  Narihiro Oku

发明人： Yasuo Yamao ,  Narihiro Oku

IPC分类号： G01N33/543

CPC分类号： G01N21/82 ,  G01N33/543 ,  G01N33/54313 ,  G01N2021/825

摘要： The present invention provides an immunoassay method in which blood can be measured even without pretreatment by means of a centrifuge etc. In the present invention, antibodies or antigens in a sample are subjected to agglutination reaction with insoluble carriers onto which antigens or antibodies specifically reacting with the antibodies or antigens in the sample have been immobilized and the resulting agglutination mixture is determined for the change in its absorbance or in its scattered light by irradiation with light, wherein said sample is whole blood and the whole blood is forcibly lyzed.

摘要翻译： 本发明提供了一种免疫测定方法，其中即使没有通过离心机等进行预处理也可以测量血液。在本发明中，样品中的抗体或抗原与不溶性载体进行凝集反应，抗原或抗体与 样品中的抗体或抗原已被固定，并且通过照射光确定所得到的凝集混合物的吸光度或其散射光的变化，其中所述样品是全血并且全血被强制溶解。

公开(公告)号：US6030845A

公开(公告)日：2000-02-29

申请号：US914039

申请日：1997-07-28

申请人： Yasuo Yamao ,  Narihiro Oku

发明人： Yasuo Yamao ,  Narihiro Oku

IPC分类号： G01N33/531 ,  G01N33/543 ,  G01N33/546 ,  G01N21/03 ,  G01N33/53

CPC分类号： G01N33/543 ,  G01N33/54313

摘要： An immunoassay method in which blood can be measured even without pretreatment by a centrifuge etc. In the present invention, antibodies or antigens in a sample are subjected to agglutination reaction with insoluble carriers onto which antigens or antibodies specifically reacting with the antibodies or antigens in the sample have been imrobilized and the resulting agglutination mixture is determined for the change in its absorbance or in its scattered light by irradiation with light, wherein said sample is whole blood and the whole blood is forcibly lysed.

摘要翻译： 其中即使没有通过离心机预处理也可以测量血液的免疫测定方法。在本发明中，样品中的抗体或抗原与不溶性载体进行凝集反应，抗原或抗体与其中抗体或抗原特异性反应 样品已经被破碎，并且所得到的凝集混合物通过用光照射来测定其吸光度的变化或其散射光的变化，其中所述样品是全血并且全血被强制裂解。

公开(公告)号：US6106778A

公开(公告)日：2000-08-22

申请号：US161127

申请日：1998-09-25

申请人： Narihiro Oku ,  Yasuo Yamao

发明人： Narihiro Oku ,  Yasuo Yamao

IPC分类号： G01N15/00 ,  G01N15/10 ,  G01N35/10 ,  G01N25/20 ,  B01J19/08 ,  G01N33/48 ,  G05B1/00 ,  G01N21/20

CPC分类号： G01N15/10 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2035/1032 ,  G01N35/10 ,  Y10S436/805 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A compact combination blood cell count and immunoassay apparatus for measuring drawn whole blood specimen includes a load station for receiving the whole blood specimen and a nozzle member that can selectively withdraw whole blood from the blood specimen. A blood cell count section and an immunoassay section are mounted along a unitary path of movement of the nozzle member so that a single nozzle member may be used for transporting the whole blood to the respective blood cell count section and immunoassay section. A controller can automatically direct a transport mechanism to use only the whole blood and to perform various steps of adding dilution liquid and reagents, along with appropriate washing of the nozzle and sample cells to insure an automatic operation. A hematozorit value can be determined from the blood cell count signal and used to correct the immunoassay signal when whole blood is used.

摘要翻译： 用于测量全血标本的紧凑的组合型血细胞计数和免疫测定装置包括用于接收全血样本的装载站和能够选择性地从血液样本中取出全血的喷嘴构件。 沿着喷嘴构件的整体运动路径安装血细胞计数部分和免疫测定部分，使得可以使用单个喷嘴构件将全血传输到各个血细胞计数部分和免疫测定部分。 控制器可以自动引导运输机构仅使用全血，并执行添加稀释液和试剂的各种步骤，以及适当地洗涤喷嘴和样品池以确保自动操作。 可以从血细胞计数信号确定血液浓度值，并且当使用全血时用于校正免疫测定信号。

公开(公告)号：US06855562B1

公开(公告)日：2005-02-15

申请号：US09511824

申请日：2000-02-24

申请人： Yasuo Yamao ,  Narihiro Oku

发明人： Yasuo Yamao ,  Narihiro Oku

IPC分类号： G01N33/543 ,  C12M1/34

CPC分类号： G01N21/82 ,  G01N33/543 ,  G01N33/54313 ,  G01N2021/825

摘要： The present invention provides an immunoassay method in which blood can be measured even without pretreatment by means of a centrifuge etc. In the present invention, antibodies or antigens in a sample are subjected to agglutination reaction with insoluble carriers onto which antigens or antibodies specifically reacting with the antibodies or antigens in the sample have been immobilized and the resulting agglutination mixture is determined for the change in its absorbance or in its scattered light by irradiation with light, wherein said sample is whole blood and the whole blood is forcibly lyzed.

摘要翻译： 本发明提供了一种免疫测定方法，其中即使没有通过离心机等进行预处理也可以测量血液。在本发明中，样品中的抗体或抗原与不溶性载体进行凝集反应，抗原或抗体与 样品中的抗体或抗原已被固定，并且通过照射光确定所得到的凝集混合物的吸光度或其散射光的变化，其中所述样品是全血并且全血被强制溶解。

公开(公告)号：US20070089543A1

公开(公告)日：2007-04-26

申请号：US11526490

申请日：2006-09-25

申请人： Narihiro Oku ,  Toshikazu Ohnishi ,  Hiroshi Naya ,  Masaharu Matsumoto

发明人： Narihiro Oku ,  Toshikazu Ohnishi ,  Hiroshi Naya ,  Masaharu Matsumoto

IPC分类号： G01N1/00

CPC分类号： G01N35/1095

摘要： The present invention has been made to simplify assembly and maintenance of a sample analyzer including: a flow passageway 3 that flows fluid, such as a sample, air, or the like; one or more fluid control units 5 that control the flow of the fluid on the flow passageway 3; a measurement cell 41 that is provided on the flow passageway 3; a sample analysis part 6 that analyzes the sample inside the measurement cell 41; and a casing 7 that holds these parts mentioned above. At least one of the fluid control units 5 is formed by unitizing functions related to fluid control; integrally has a manifold 502 that forms an internal flow path 501, one or more control valves 503 that control flow of the fluid in the internal flow path 501 and connection ports 504 for connecting together the internal flow path 501 and the flow passageway 3; and is so configured as to be removable from the casing 7.

摘要翻译： 本发明是为了简化样品分析装置的组装和维护，包括：流动通道3，流体如样品，空气等; 一个或多个流体控制单元5，其控制流动通道3上的流体的流动; 设置在流路3上的测定单元41; 分析测量单元41内的样本的样本分析部6; 以及保持上述这些部件的壳体7。 流体控制单元5中的至少一个通过使与流体控制相关的功能成为一体而形成; 一体地形成有形成内部流路501的歧管502，控制内部流路501内的流体流动的一个以上的控制阀503以及内部流路501和流路3连接的连接口504。 并且被构造成可从壳体7移除。

公开(公告)号：US08974750B2

公开(公告)日：2015-03-10

申请号：US12810805

申请日：2008-12-18

申请人： Soichi Oue ,  Yoshihiro Yano ,  Narihiro Oku

发明人： Soichi Oue ,  Yoshihiro Yano ,  Narihiro Oku

IPC分类号： G01N1/02 ,  G01N1/10 ,  G01N1/22 ,  G01N35/10

CPC分类号： G01N35/1016 ,  G01N35/1079 ,  G01N2035/1023

摘要： A nozzle device which can perform accurate quantitative suction without being affected by a pressure when, for example, a nozzle (2) is inserted into a closed container (T). The nozzle device has the nozzle (2) that is inserted into the closed container(T) and that sucks a liquid in the closed container (T), an exposure to atmosphere mechanism (3) that opens the closed container (T) to the atmospheric air, and an opening/closing structure (4) that is arranged at a proximal end of the nozzle (2) and that has an internal flow channel (411) communicated with a flow channel in the nozzle (2) and an opening/closing mechanism for opening and closing the internal flow channel (411), and an opening/closing control section (5) that controls the opening/closing mechanism.

摘要翻译： 一种喷嘴装置，当例如将喷嘴（2）插入到密闭容器（T）中时，能够进行精确的定量抽吸而不受压力的影响。 喷嘴装置具有插入密闭容器（T）中并将密封容器（T）中的液体吸入的喷嘴（2），将密闭容器（T）打开的大气机构（3）暴露于 大气空气和布置在喷嘴（2）的近端并且具有与喷嘴（2）中的流动通道连通的内部流动通道（411）的打开/关闭结构（4） 用于打开和关闭内部流动通道（411）的关闭机构，以及控制打开/关闭机构的打开/关闭控制部分（5）。

公开(公告)号：US5287733A

公开(公告)日：1994-02-22

申请号：US765151

申请日：1991-09-23

申请人： Narihiro Oku ,  Hitoshi Mitani ,  Hiroaki Takahasi

发明人： Narihiro Oku ,  Hitoshi Mitani ,  Hiroaki Takahasi

IPC分类号： G01N33/49 ,  G01N15/10 ,  G01N35/00 ,  G01N35/10 ,  G01N33/48

CPC分类号： G01N15/10 ,  G01N35/00 ,  G01N35/1004 ,  G01N35/1083

摘要： A system collects fluid waste within a closed waste vessel where a waste disposal cycle is determined based upon the pressure level within the waste vessel. In the preferred embodiment, a closed liquid waste vessel accepts waste solutions through conduits having valves controlling conduit fluid communication with treatment vessels. A pressure sensor determines the level of pressure within the waste vessel. A pressurizing device reduces the level of pressure within the vessel. When the pressure within the vessel is lowered to a predetermined level, the valve is opened. When the pressure sensed within the liquid waste vessel then rises above an appointed value, the valve is closed, completing the waste collection of a treated sample. This corresponds to the point in time when the treatment vessel is empty, allowing a sudden rush of air into the waste vessel, raising the vessel pressure to ambient and closing the valve. When the pressure in the waste vessel does not rise to the appointed value after the lapse of a preset length of time, a warning signal is provided advising that the system is not working properly.

摘要翻译： 系统在封闭的废物容器内收集流体废物，其中基于废物容器内的压力水平来确定废物处理循环。 在优选实施例中，封闭的液体废物容器通过具有控制导管与流体与处理容器连通的阀的管道接收废液。 压力传感器确定废液容器内的压力水平。 加压装置降低了容器内的压力水平。 当容器内的压力降低至预定水平时，阀打开。 当在液体废物容器内感测到的压力升高到高于指定值时，阀门关闭，完成处理过的样品的废物收集。 这对应于处理容器为空的时间点，允许空气急剧地进入废物容器，将容器压力升高到环境并关闭阀门。 当经过预设时间后废物容器中的压力不会上升到指定值时，提供警告信号，建议系统不能正常工作。

公开(公告)号：US5188334A

公开(公告)日：1993-02-23

申请号：US796473

申请日：1991-11-22

申请人： Takao Yoshii ,  Narihiro Oku ,  Yoshio Horii ,  Kunio Terada

发明人： Takao Yoshii ,  Narihiro Oku ,  Yoshio Horii ,  Kunio Terada

IPC分类号： F16K7/04 ,  F16K11/02

CPC分类号： F16K11/027 ,  F16K7/045 ,  Y10T137/6116

摘要： An improved pinch valve assembly for opening and closing flexible tubular conduits is provided. A housing member is capable of supporting flexible tubular conduits and contains an engagement member that is capable of closing the passageways through the flexible tubular conduit. The engagement member can configure to receive a stop member that is capable of restraining the engagement member at a position which prohibits closing of a flexible tubular conduits during non-operative storage and transporting modes of operation.

摘要翻译： 提供了一种用于打开和关闭柔性管状导管的改进的夹管组件。 壳体构件能够支撑柔性管状导管并且包含能够关闭通过柔性管状导管的通道的接合构件。 接合构件可以构造为接收止动构件，该止动构件能够在非操作性存储和运输操作模式期间将接合构件限制在禁止柔性管状导管的关闭位置。

公开(公告)号：US4626512A

公开(公告)日：1986-12-02

申请号：US737036

申请日：1985-05-22

申请人： Narihiro Oku ,  Seiji Usui ,  Hiroaki Uematsu ,  Takeshi Kohno

发明人： Narihiro Oku ,  Seiji Usui ,  Hiroaki Uematsu ,  Takeshi Kohno

IPC分类号： G01N27/26 ,  G01N27/416 ,  G01N33/84 ,  G01N31/00

CPC分类号： G01N27/4165 ,  G01N33/84 ,  Y10T436/10 ,  Y10T436/108331

摘要： A standard solution for simultaneously calibrating a plurality of ion electrodes for determining a plurality of ion electrodes for determining a plurality of ions including at least potassium ions and calcium ions in blood, the improvement wherein the concentration of the standard solution for a potassium ion electrode and a calcium ion electrode is adjusted in accordance with the following equations: ##EQU1## As for potassium ion,C=C.sub.o .multidot.10.sup.-.DELTA.E/60As for calcium ion,C=C.sub.o .multidot.10.sup.-.DELTA.E/30As for potassium ion,A=-0.130 to -0.065As for calcium ion,A=-0.240 to -0.172whereinE: is the potential difference when an ionic strength of 150 mM is used as the standard;.mu.: is the ionic strength;C.sub.o : is the calibrated concentration;C: is the concentration of reagent added; andA: is the correction factor.

摘要翻译： 一种用于同时校准多个离子电极以用于确定多个离子电极以用于确定血液中至少包含钾离子和钙离子的多个离子的标准溶液，其中所述改进是将钾离子电极的标准溶液和 钙离子电极根据以下等式进行调整：对于钾离子，C = Co×10 -3 DELTA E / 60对于钙离子，C = Co×10 -3 DELTA E / 30对于钾离子，A = - 0.130〜-0.065对于钙离子，A = -0.240〜-0.172其中E：当以150mM的离子强度作为标准时的电位差; mu：离子强度; Co：是校准浓度; C：加入试剂的浓度; A：是校正因子。

公开(公告)号：US4519890A

公开(公告)日：1985-05-28

申请号：US614225

申请日：1984-05-24

申请人： Hiroaki Uematsu ,  Junji Aoki ,  Narihiro Oku

发明人： Hiroaki Uematsu ,  Junji Aoki ,  Narihiro Oku

IPC分类号： G01N27/28 ,  G01N27/36

CPC分类号： G01N27/28 ,  G01N27/36

摘要： A flow system glass electrode in use for pH measurement, which houses the glass electrode body in a resin block to improve an impact resistance, the glass electrode body being sealed by a packing to be small-sized and improve the degree of freedom in the direction of the use, sample flow tubes each being equal in an inner diameter to a response film and separate from the glass electrode body in order to eliminate stagnation of a sample liquid, enable the measurement of a minute sample, and facilitate manufacture and assembly of the electrode, the sample flow tubes being connected with a liquid inlet and a liquid outlet at the glass electrode body through couplings respectively.

摘要翻译： 一种用于pH测量的流动系统玻璃电极，其将玻璃电极体容纳在树脂块中以提高耐冲击性，玻璃电极体被填料密封成小尺寸并提高了方向的自由度 使用时，样品流管​​各自在内径相等于响应膜并与玻璃电极体分离，以消除样品液体的滞留，使得能够测量微小的样品，并且有助于制造和组装 电极，样品流管​​分别通过耦合与玻璃电极体的液体入口和液体出口连接。