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公开(公告)号:US09601891B2
公开(公告)日:2017-03-21
申请号:US13537687
申请日:2012-06-29
IPC分类号: H01R43/055 , H01R43/24 , H01R9/05
CPC分类号: H01R43/055 , H01R9/05 , H01R43/24 , Y10T29/53209
摘要: A cable assembling apparatus for allowing a terminal and a electric wire to be accurately crimped and to resolve increase of facility cost incurred by separation of a press and a crimping machine, includes a press having a downside press mold having a plurality of types of dies arranged in parallel, an electric wire support jig arranged in parallel, having a metal plate guide at an end thereof entering into between the plurality of types of dies, and a feeder adapted to lift the electric wire support jig together with the metal plate above the dies of the downside press mold, and advance and descend the electric wire support jig to an adjacent die of next process. Furthermore, an electric wire chuck disposed in a midstream die of the plurality of types of dies and supplying the electric wire support jig with the electric wire is disposed.
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公开(公告)号:US20140000102A1
公开(公告)日:2014-01-02
申请号:US13537687
申请日:2012-06-29
IPC分类号: H01R43/20
CPC分类号: H01R43/055 , H01R9/05 , H01R43/24 , Y10T29/53209
摘要: A cable assembling apparatus for allowing a terminal and a electric wire to be accurately crimped and to resolve increase of facility cost incurred by separation of a press and a crimping machine, includes a press having a downside press mold having a plurality of types of dies arranged in parallel, an electric wire support jig arranged in parallel, having a metal plate guide at an end thereof entering into between the plurality of types of dies, and a feeder adapted to lift the electric wire support jig together with the metal plate above the dies of the downside press mold, and advance and descend the electric wire support jig to an adjacent die of next process. Furthermore, an electric wire chuck disposed in a midstream die of the plurality of types of dies and supplying the electric wire support jig with the electric wire is disposed.
摘要翻译: 一种用于允许端子和电线被精确地卷曲并且解决由于压力机和压接机的分离引起的设备成本增加的电缆组装装置,包括具有下列压模的冲压机,所述下压模具具有多种类型的模具 并联布置有平行布置的电线支撑夹具,其金属板引导件在其末端进入多个类型的模具之间,以及馈线,其适于将电线支撑夹具与金属板一起提升在模具上方 的下压模具,并且将电线支撑夹具前进和下降到下一工序的相邻模具。 此外,设置设置在多种类型的模具的中游管芯中并将电线支撑夹具供给电线的电线卡盘。
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公开(公告)号:US07585886B2
公开(公告)日:2009-09-08
申请号:US11662539
申请日:2006-05-18
申请人: Shunichiro Hachiya , Makoto Oku , Hana Mukai , Takashi Shin , Keisuke Matsuura , Ryushi Seo , Takashi Kamikubo , Yoh Terada , Masanao Sanagi , Kousei Yoshihara , Taisuke Takahashi
发明人: Shunichiro Hachiya , Makoto Oku , Hana Mukai , Takashi Shin , Keisuke Matsuura , Ryushi Seo , Takashi Kamikubo , Yoh Terada , Masanao Sanagi , Kousei Yoshihara , Taisuke Takahashi
IPC分类号: C07D207/00 , A61K31/40
CPC分类号: C07D207/09 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/06 , C07D417/10
摘要: [Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism. [Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof, have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction. Based on the above, these novel pyrrolidine derivatives are useful as therapeutic agents for treating diseases in which CaSR is concerned (hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like).
摘要翻译: [问题]提供可用于治疗其中涉及钙感觉受体(CaSR)的疾病的化合物,特别是甲状旁腺机能亢进。 [解决方法]发现以芳基烷基等取代的氨甲基为特征的新型吡咯烷衍生物或其盐具有优异的CaSR激动调节活性,并且对于CYP2D6抑制活性也具有优异的选择性,具有 引起药物相互作用的可能性。 基于上述,这些新型吡咯烷衍生物可用作治疗涉及CaSR的疾病(甲状旁腺功能亢进,肾性骨营养不良,高钙血症等)的治疗剂。
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公开(公告)号:US09199927B2
公开(公告)日:2015-12-01
申请号:US14344377
申请日:2012-09-14
申请人: Jiro Fujiyasu , Kazuhiko Ohne , Susumu Yamaki , Tomoyoshi Imaizumi , Takeshi Hondo , Keisuke Matsuura , Tomohki Satou , Satoshi Sasamura
发明人: Jiro Fujiyasu , Kazuhiko Ohne , Susumu Yamaki , Tomoyoshi Imaizumi , Takeshi Hondo , Keisuke Matsuura , Tomohki Satou , Satoshi Sasamura
IPC分类号: A61K31/47 , C07C229/02 , C07D215/38 , C07C279/18 , C07D213/79 , C07D215/20 , C07D215/48 , C07D215/50 , C07D333/38 , C07D333/40 , C07D233/64 , C07D257/04 , C07D271/06 , C07D207/16 , C07D277/20 , C07D277/56 , C07D209/20 , C07D209/42 , C07D295/12 , C07D211/62 , C07D217/26 , C07D271/07 , C07D295/13
CPC分类号: C07C279/18 , C07B2200/07 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/20 , C07D209/42 , C07D211/62 , C07D213/79 , C07D215/20 , C07D215/48 , C07D215/50 , C07D217/26 , C07D233/64 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/56 , C07D295/12 , C07D295/13 , C07D333/38 , C07D333/40
摘要: [Problem]Provided is a compound which is useful as an agent for preventing and/or treating renal diseases.[Means for Solution]The present inventors have conducted extensive studies on compounds having a trypsin inhibitory action, and as a result, they have found that a guanidinobenzoic acid compound has a trypsin inhibitory action, thereby completing the present invention. The guanidinobenzoic acid compound of the present invention can be used as an agent for preventing and/or treating renal disease as an agent which will substitute low-protein diet therapy, and an agent for preventing and/or treating trypsin-related diseases, for example, pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like.
摘要翻译: [问题]提供可用作预防和/或治疗肾脏疾病的药剂的化合物。 [解决方案]本发明人对具有胰蛋白酶抑制作用的化合物进行了广泛的研究,结果发现胍基苯甲酸化合物具有胰蛋白酶抑制作用,从而完成了本发明。 本发明的胍基苯甲酸化合物可以用作预防和/或治疗肾脏疾病的药剂,作为代替低蛋白饮食疗法的药剂,以及用于预防和/或治疗胰蛋白酶相关疾病的药剂,例如 ,胰腺炎,胃食管反流病,肝性脑病,流行性感冒等。
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公开(公告)号:US20110144153A1
公开(公告)日:2011-06-16
申请号:US12992388
申请日:2009-05-12
申请人: Eisuke Nozawa , Ryotaro Ibuka , Kazuhiro Ikegai , Keisuke Matsuura , Tatsuya Zenkoh , Ryushi Seo , Susumu Watanuki , Michihito Kageyama
发明人: Eisuke Nozawa , Ryotaro Ibuka , Kazuhiro Ikegai , Keisuke Matsuura , Tatsuya Zenkoh , Ryushi Seo , Susumu Watanuki , Michihito Kageyama
IPC分类号: A61K31/4725 , C07D401/06 , A61K31/4709 , C07D405/06 , A61K31/403 , A61K31/4439 , A61K31/427 , C07D417/06 , C07D409/06 , C07D413/06 , A61K31/422 , A61K31/415 , C07D231/00 , C07D401/14 , A61K31/4545 , A61P13/12 , A61P3/10
CPC分类号: C07D401/06 , C07C233/47 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/66 , C07C271/14 , C07C271/22 , C07C2601/02 , C07C2602/08 , C07D207/34 , C07D209/08 , C07D213/64 , C07D215/48 , C07D217/04 , C07D231/14 , C07D235/24 , C07D263/58 , C07D333/68 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D471/04 , C07D491/048
摘要: [Problems] A compound, which is useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for treating chronic renal failure and/or diabetic nephropathy, is provided.[Solving Means] The present inventors have conducted extensive studies on a compound having an EP4 receptor antagonistic activity, and confirmed that the amide compound of the present invention has an EP4 receptor antagonistic activity, thereby completing the present invention. The amide compound of the present invention has an EP4 receptor antagonistic activity, and can be used as an active ingredient of a pharmaceutical composition for preventing and/or treating various EP4-related diseases, for example, chronic renal failure and/or diabetic nephropathy, and the like.
摘要翻译: [问题]提供了可用作药物组合物的活性成分例如用于治疗慢性肾衰竭和/或糖尿病性肾病的药物组合物的化合物。 本发明人对具有EP4受体拮抗作用的化合物进行了广泛的研究,证实本发明的酰胺化合物具有EP4受体拮抗作用,从而完成了本发明。 本发明的酰胺化合物具有EP4受体拮抗作用,可用作预防和/或治疗各种EP4相关疾病例如慢性肾衰竭和/或糖尿病性肾病的药物组合物的活性成分, 等等。
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公开(公告)号:US08598355B2
公开(公告)日:2013-12-03
申请号:US12992388
申请日:2009-05-12
申请人: Eisuke Nozawa , Ryotaro Ibuka , Kazuhiro Ikegai , Keisuke Matsuura , Tatsuya Zenkoh , Ryushi Seo , Susumu Watanuki , Michihito Kageyama
发明人: Eisuke Nozawa , Ryotaro Ibuka , Kazuhiro Ikegai , Keisuke Matsuura , Tatsuya Zenkoh , Ryushi Seo , Susumu Watanuki , Michihito Kageyama
IPC分类号: C07D215/38
CPC分类号: C07D401/06 , C07C233/47 , C07C233/87 , C07C235/42 , C07C235/52 , C07C235/66 , C07C271/14 , C07C271/22 , C07C2601/02 , C07C2602/08 , C07D207/34 , C07D209/08 , C07D213/64 , C07D215/48 , C07D217/04 , C07D231/14 , C07D235/24 , C07D263/58 , C07D333/68 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D471/04 , C07D491/048
摘要: [Problems] A compound, which is useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for treating chronic renal failure and/or diabetic nephropathy, is provided.[Solving Means] The present inventors have conducted extensive studies on a compound having an EP4 receptor antagonistic activity, and confirmed that the amide compound of the present invention has an EP4 receptor antagonistic activity, thereby completing the present invention. The amide compound of the present invention has an EP4 receptor antagonistic activity, and can be used as an active ingredient of a pharmaceutical composition for preventing and/or treating various EP4-related diseases, for example, chronic renal failure and/or diabetic nephropathy, and the like.
摘要翻译: [问题]提供了可用作药物组合物的活性成分例如用于治疗慢性肾衰竭和/或糖尿病性肾病的药物组合物的化合物。 本发明人对具有EP4受体拮抗作用的化合物进行了广泛的研究,证实本发明的酰胺化合物具有EP4受体拮抗作用,从而完成了本发明。 本发明的酰胺化合物具有EP4受体拮抗作用,可用作预防和/或治疗各种EP4相关疾病例如慢性肾衰竭和/或糖尿病性肾病的药物组合物的活性成分, 等等。
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公开(公告)号:US20110082133A1
公开(公告)日:2011-04-07
申请号:US12999379
申请日:2009-06-16
申请人: Takashi Kamikubo , Masanori Miura , Takao Okuda , Keisuke Maki , Fukushi Hirayama , Ayako Moritomo , Yuriko Komiya , Keisuke Matsuura , Ryotaro Ibuka
发明人: Takashi Kamikubo , Masanori Miura , Takao Okuda , Keisuke Maki , Fukushi Hirayama , Ayako Moritomo , Yuriko Komiya , Keisuke Matsuura , Ryotaro Ibuka
IPC分类号: A61K31/5415 , A61K31/4725 , A61K31/4439 , A61K31/4412 , C07D417/06 , A61P9/10 , A61K31/444 , C07D417/12 , C07D401/06 , C07D211/72
CPC分类号: C07D401/06 , A61K31/13 , A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/538 , A61K31/5415 , C07D213/64 , C07D213/69 , C07D213/79 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/06 , C07D417/12
摘要: [Problems] A useful compound which can be used as a pharmaceutical, in particular, an agent for treating peripheral arterial occlusive disease is provided.[Means for Solution] The present inventors have conducted extensive studies on EP4 receptor agonists, and as a result, have found that a novel pyridone compound, in which a group having an acidic group is substituted at the 1-position of the pyridone ring, the 6-position is bonded with an aromatic ring group via a linking part, and the linking part contains a nitrogen atom, has an excellent EP4 receptor agonistic action, thereby completing the present invention. Since the compound of the present invention has an excellent EP4 receptor agonistic action, it is useful as a pharmaceutical, in particular, as an agent for treating peripheral arterial occlusive disease.
摘要翻译: [问题]提供了可用作药物,特别是用于治疗外周动脉闭塞性疾病的药剂的有用化合物。 [解决方案]本发明人对EP4受体激动剂进行了广泛的研究,结果发现,其中具有酸性基团的基团在吡啶酮环的1位被取代的新的吡啶酮化合物, 6-位通过连接部分与芳环基团键合,并且连接部分含有氮原子,具有优异的EP4受体激动作用,从而完成了本发明。 由于本发明的化合物具有优异的EP4受体激动作用,所以作为药物,特别是作为治疗外周动脉闭塞性疾病的药剂是有用的。
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公开(公告)号:US20140378459A1
公开(公告)日:2014-12-25
申请号:US14344377
申请日:2012-09-14
申请人: Jiro Fujiyasu , Kazuhiko Ohne , Susumu Yamaki , Tomoyoshi Imaizumi , Takeshi Hondo , Keisuke Matsuura , Tomohki Satou , Satoshi Sasamura
发明人: Jiro Fujiyasu , Kazuhiko Ohne , Susumu Yamaki , Tomoyoshi Imaizumi , Takeshi Hondo , Keisuke Matsuura , Tomohki Satou , Satoshi Sasamura
IPC分类号: C07C279/18 , C07D215/48 , C07D209/42 , C07D295/13 , C07D333/40 , C07D257/04 , C07D271/07 , C07D233/64 , C07D217/26
CPC分类号: C07C279/18 , C07B2200/07 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/20 , C07D209/42 , C07D211/62 , C07D213/79 , C07D215/20 , C07D215/48 , C07D215/50 , C07D217/26 , C07D233/64 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/56 , C07D295/12 , C07D295/13 , C07D333/38 , C07D333/40
摘要: [Problem]Provided is a compound which is useful as an agent for preventing and/or treating renal diseases. [Means for Solution]The present inventors have conducted extensive studies on compounds having a trypsin inhibitory action, and as a result, they have found that a guanidinobenzoic acid compound has a trypsin inhibitory action, thereby completing the present invention. The guanidinobenzoic acid compound of the present invention can be used as an agent for preventing and/or treating renal disease as an agent which will substitute low-protein diet therapy, and an agent for preventing and/or treating trypsin-related diseases, for example, pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like.
摘要翻译: [问题]提供可用作预防和/或治疗肾脏疾病的药剂的化合物。 [解决方案]本发明人对具有胰蛋白酶抑制作用的化合物进行了广泛的研究,结果发现胍基苯甲酸化合物具有胰蛋白酶抑制作用,从而完成了本发明。 本发明的胍基苯甲酸化合物可以用作预防和/或治疗肾脏疾病的药剂,作为代替低蛋白饮食疗法的药剂,以及用于预防和/或治疗胰蛋白酶相关疾病的药剂,例如 ,胰腺炎,胃食管反流病,肝性脑病,流行性感冒等。
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公开(公告)号:US20090062366A1
公开(公告)日:2009-03-05
申请号:US11662539
申请日:2006-05-18
申请人: Shunichiro Hachiya , Makoto Oku , Hana Mukai , Takashi Shin , Keisuke Matsuura , Ryushi Seo , Takashi Kamikubo , Yoh Terada , Masanao Sanagi , Kousei Yoshihara , Taisuke Takahashi
发明人: Shunichiro Hachiya , Makoto Oku , Hana Mukai , Takashi Shin , Keisuke Matsuura , Ryushi Seo , Takashi Kamikubo , Yoh Terada , Masanao Sanagi , Kousei Yoshihara , Taisuke Takahashi
IPC分类号: A61K31/40 , C07D207/04
CPC分类号: C07D207/09 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/10 , C07D417/06 , C07D417/10
摘要: [Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism.[Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof, have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction. Based on the above, these novel pyrrolidine derivatives are useful as therapeutic agents for treating diseases in which CaSR is concerned (hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like).
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公开(公告)号:US5394307A
公开(公告)日:1995-02-28
申请号:US68624
申请日:1993-05-27
申请人: Keisuke Matsuura
发明人: Keisuke Matsuura
CPC分类号: G03B15/05 , G03B2215/0525 , G03B2215/0532
摘要: A photographic flash device includes a bar-like flash discharge tube for emitting light, and a reflector having a rectangular-shaped opening for irradiating light beams emitted from the flash discharge tube toward and through the rectangular-shaped opening. The dimension of the depth of opposing side wall portions of the reflector for reflecting light beams along the long side of the opening of the flash discharge tube is longer than that of an inner part of the reflector whose cross section is a curved surface nearly substantially semi-elliptical in shape, which cross section covers the flash discharge tube. Light beams directed beyond an angle of view are reflected by the elongated opposing side wall portions so that they are kept within the angle of view. The opposing extreme edge portions of the upper and lower reflection plates along the long side of the opening of the reflector are extended toward the front by means of parallel flat reflection plates whose inner surfaces are reflective.
摘要翻译: 照相闪光装置包括用于发射光的棒状闪光放电管和具有矩形开口的反射器,用于将从闪光放电管发射的光束朝向并穿过矩形开口照射。 用于沿着闪光放电管的开口的长边反射光束的反射器的相对侧壁部分的深度的尺寸比反射镜的内部部分的尺寸长,该反射器的横截面是几乎基本上为半 - 椭圆形,其横截面覆盖闪光放电管。 指向超过视角的光束被细长的相对的侧壁部分反射,使得它们保持在视角范围内。 沿着反射器的开口的长边的上反射板和下反射板的相对的极端边缘部分通过其内表面是反射的平行平面反射板向前延伸。
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