Abstract:
The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
Abstract:
The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.
Abstract:
An approach is provided for supporting carrier synchronization in a digital broadcast and interactive system. A carrier synchronization module receives one or more signals representing a frame that includes one or more overhead fields (e.g., preamble and optional pilot blocks and one or multiple segments separated by pilot blocks). The module estimates carrier frequency and phase on a segment by segment basis and tracks frequency between segments. Carrier phase of the signal is estimated based upon the overhead field. Estimates carrier phase of random data field are determined based upon the estimated phase values from the overhead fields, and upon both the past and future data signals. Further, the frequency of the signal is estimated based upon the overhead fields and/or the random data field. The above arrangement is particularly suited to a digital satellite broadcast and interactive system.
Abstract:
The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1-R11, X, Y, Z, and n are as defined herein.
Abstract:
As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds
Abstract:
Circuit and method for controlling circuitry in a power converter device during a soft-start process is provided. Synchronous rectifier control circuitry is adapted to gradually apply a gate drive signal derived from the main switch of the power converter device to a freewheeling synchronous rectifier of the switching circuitry during the soft-start process. The control circuitry gradually releases the amplitude or the pulse-width of the gate drive signal to the freewheeling synchronous rectifier to avoid a large duty ratio in the synchronous rectifier during start-up so that a negative current does not build up in the output inductor.
Abstract:
A regulation circuit for a voltage-fed power converter, a method of operation thereof and a power converter employing the circuit or the method. The power converter has an inverter switch adapted to transfer power to a transformer. In one embodiment, the regulation circuit includes a switching network coupled to a tapped winding of the transformer. The switching network is operable to vary a turns ratio of the transformer, thereby regulating an output voltage of the power converter.
Abstract:
An integrated three-phase power converter and method of operation thereof is provided. The integrated three-phase power converter includes: (1) first and second power switches coupled between corresponding rails of said power converter, (2) an input stage, including first, second and third L-C branches coupled between said first, second and third phase inputs and a node between said first and second power switches, adapted to receive phase voltages from a source of electrical power, and (3) an output stage, coupled to said first and second power switches, that provides a DC output voltage at said output, said first and second power switches cooperating to employ said input stage to reduce input current total harmonic distortion (THD) on all three of said phase inputs and said output stage to convert said phase voltages to said DC output voltage.
Abstract:
A split-boost converter having a main inductor, first and second main switches and floating and fixed outputs and a method of operating the same. In one embodiment, the converter includes an auxiliary diode coupled between the main inductor and a first rail of the floating output, and an auxiliary switch coupled to a node between the main inductor and the auxiliary diode and a second rail of the floating output. The converter is operable in a first mode, when an input voltage of the converter at least equals an output voltage of the converter, in which the auxiliary switch remains open and the first and second main switches are modulated to operate the converter. The converter is further operable in a second mode, when an input voltage of the converter is less than an output voltage of the converter, in which the first and second main switches remain closed and the auxiliary switch is modulated to operate the converter.
Abstract:
For use with a boost converter having first, second and third input inductors, a switching network, method of reducing input current total harmonic distortion (THD) associated with the boost converter, and boost converter employing the switching network and method. In one embodiment, the switching network includes a first switch coupled between corresponding rails of the boost converter. The switching network also includes first, second and third L-C resonant networks wye-coupled to a common node and coupled to the first, second and third input inductors, respectively. The first switch and the first, second and third L-C resonant networks cooperate to create resonant voltages across, and induce phase currents through, the first, second and third input inductors to reduce input current THD associated with the boost converter.