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    Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody
    1.
    发明授权
    Antibody that recognizes pyrazine derivative and method for measuring 1,2-dicarbonyl derivative using said antibody 失效
    识别吡嗪衍生物的抗体和使用所述抗体测量1,2-二羰基衍生物的方法

    公开(公告)号：US06291198B1

    公开(公告)日：2001-09-18

    申请号：US09134388

    申请日：1998-08-14

    申请人： Yoshiaki Uchida ,  Yoshihiro Kurano ,  Satoru Ito

    发明人： Yoshiaki Uchida ,  Yoshihiro Kurano ,  Satoru Ito

    IPC分类号： G01N33545

    CPC分类号： G01N33/5308 ,  C07K16/44 ,  G01N33/6893 ,  Y10S530/807

    摘要： A method for simply measuring a 1,2-dicarbonyl derivative in multiple specimens is provided, which comprises converting a 1,2-dicarbonyl derivative to a pyrazine derivative represented by the formula (I): wherein R1 and R2 independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyethyl group, a dihydroxyethyl group, a dihydroxypropyl group, a trihydroxypropyl group, or a trihydroxybutyl group, A represents a group that binds to the pyrazine ring to form a 6-membered aromatic hydrocarbon group, a 5- or 6-membered aromatic heterocyclic group, or a 5- or 6-membered alicyclic hydrocarbon group, and R3 represents a linking residue, wherein said 5-membered ring formed by A may have 1 or 2 substituents and said 6-membered ring may have 1 to 3 substituents, in addition to R3 and measuring the pyrazine derivative by an immunological method using an antibody that recognizes the pyrazine derivative.

    摘要翻译： 提供简单测定多个试样中的1,2-二羰基衍生物的方法，其包括将1,2-二羰基衍生物转化为由式（I）表示的吡嗪衍生物：其中R1和R2独立地表示氢原子， 甲基，羟甲基，羟乙基，二羟基乙基，二羟丙基，三羟基丙基或三羟基丁基，A表示与吡嗪环结合形成6元芳族烃基的基团， 5元或6元芳族杂环基，或5元或6元脂环烃基，R3表示连接残基，其中由A形成的所述5元环可以具有1或2个取代基，所述6元环 除了R3之外还可以具有1至3个取代基，并且通过使用识别吡嗪衍生物的抗体的免疫学方法测量吡嗪衍生物。

    Phenytoin derivatives
    2.
    发明授权
    Phenytoin derivatives 失效
    苯妥英衍生物

    公开(公告)号：US5306617A

    公开(公告)日：1994-04-26

    申请号：US744411

    申请日：1991-08-13

    申请人： Takafumi Uchida ,  Hiroshi Ishikawa ,  Koichi Koyama ,  Yoshihiro Kurano ,  Yoshiaki Uchida

    发明人： Takafumi Uchida ,  Hiroshi Ishikawa ,  Koichi Koyama ,  Yoshihiro Kurano ,  Yoshiaki Uchida

    IPC分类号： C12Q1/68 ,  C07H19/10 ,  C07H21/00 ,  C07H5/04 ,  C07H17/00 ,  C07H19/06

    CPC分类号： C07H21/00

    摘要： A phenytoin derivative represented by formula (I) ##STR1## wherein Ph denotes a phenyl group,X denotes --O--, --NH-- or --CH.sub.2 --,Y denotes --CO-- or --CH.sub.2 --,Z denotes a hydrogen atom or a hydroxyl group,M denotes a salt-forming cation, andm and n are each an integer of 0 to 8 and m+n is at least 2.Said compound is useful to produce a phenytoin-labelled DNA or RNA probe. When using such a probe, DNA or RNA in the specimen can be detected with high sensitivity.

    摘要翻译： 式（I）表示的苯妥英衍生物（*化学结构*）（I）（*化学结构*）其中Ph表示苯基，X表示-O-，-NH-或-CH2-，Y表示-CO- 或-CH 2 - ，Z表示氢原子或羟基，M表示形成盐的阳离子，m和n各自为0至8的整数，m + n至少为2.所述化合物可用于产生 苯妥英标记的DNA或RNA探针。 当使用这样的探针时，可以高灵敏度地检测样品中的DNA或RNA。

    Anti-glycated hemoglobin monoclonal antibody and method for measuring glycated hemoglobin
    6.
    发明授权
    Anti-glycated hemoglobin monoclonal antibody and method for measuring glycated hemoglobin 失效
    抗糖化血红蛋白单克隆抗体及测定糖化血红蛋白的方法

    公开(公告)号：US5470759A

    公开(公告)日：1995-11-28

    申请号：US73340

    申请日：1993-06-07

    申请人： Masami Sugiyama ,  Yoshiaki Uchida ,  Yoshihiro Kurano ,  Aiko Tanaka ,  Tetsuji Tanimoto

    发明人： Masami Sugiyama ,  Yoshiaki Uchida ,  Yoshihiro Kurano ,  Aiko Tanaka ,  Tetsuji Tanimoto

    IPC分类号： G01N33/50 ,  C07K16/18 ,  C12P21/08 ,  G01N33/72 ,  G01N33/538

    CPC分类号： C07K16/18 ,  G01N33/723

    摘要： A method for measuring glycated hemoglobin is disclosed, which comprises contacting a sample with an anti-hemoglobin antibody being bound to a solid phase, adding thereto an anti-glycated hemoglobin antibody, and then measuring the anti-glycated hemoglobin antibody bound to the solid phase via glycated hemoglobin and the anti-hemoglobin antibody. A method for measuring glycated hemoglobin is further disclosed, which comprises mixing a sample with particles on which an anti-glycated hemoglobin antibody is bound to cause immunoagglutination reaction. A method for measuring glycated hemoglobin is furthermore disclosed, which comprises mixing a sample with a solution containing a monoclonal antibody specific for glycated hemoglobin, and then measuring the change in the turbidity of the resulting mixture. A method is disclosed for measuring glycated hemoglobin which comprises mixing a sample with unsensitized latex particles and an anti-glycated hemoglobin antibody, to cause immunoagglutination reaction. There is disclosed a method for measuring glycated hemoglobin which comprises mixing a sample with unsensitized latex particles and particles on which an anti-glycated hemoglobin antibody is bound, to cause immunoagglutination reaction. Still furthermore, an anti-glycated hemoglobin monoclonal antibody having a high specificity for human glycated hemoglobin is disclosed.

    摘要翻译： 公开了一种测定糖化血红蛋白的方法，其包括将样品与结合于固相的抗血红蛋白抗体接触，向其中加入抗糖化血红蛋白抗体，然后测定与固相结合的抗糖化血红蛋白抗体 通过糖化血红蛋白和抗血红蛋白抗体。 进一步公开了测定糖化血红蛋白的方法，其包括将样品与其上结合有抗糖基化血红蛋白抗体的颗粒混合以引起免疫凝集反应。 还公开了一种测定糖化血红蛋白的方法，其包括将样品与含有糖化血红蛋白特异性的单克隆抗体的溶液混合，然后测量所得混合物的浊度变化。 公开了一种用于测量糖化血红蛋白的方法，其包括将样品与未敏化的胶乳颗粒和抗糖化血红蛋白抗体混合以引起免疫凝集反应。 公开了一种测定糖化血红蛋白的方法，其包括将样品与未敏化的胶乳颗粒和抗糖基化血红蛋白抗体结合的颗粒混合，引起免疫凝集反应。 此外，公开了对人糖化血红蛋白具有高特异性的抗糖化血红蛋白单克隆抗体。

    Constituent part for fuel cell
    7.
    发明授权
    Constituent part for fuel cell 有权
    燃料电池组成部分

    公开(公告)号：US07504173B2

    公开(公告)日：2009-03-17

    申请号：US10275282

    申请日：2001-05-22

    申请人： Yuichi Kuroki ,  Yoshihiro Kurano ,  Tomohiro Inoue

    发明人： Yuichi Kuroki ,  Yoshihiro Kurano ,  Tomohiro Inoue

    IPC分类号： H01M8/02 ,  H01M2/08 ,  H01M4/96 ,  H01M4/94

    CPC分类号： H01M8/0234 ,  H01M8/0213 ,  H01M8/0271 ,  H01M8/0276 ,  H01M8/0284 ,  H01M8/0286 ,  H01M8/1004 ,  H01M2008/1095

    摘要： In order to provide a constituting part for a fuel battery in which a number of steps of assembling the constituting parts for the fuel battery can be reduced, and in which the replacing property and the maintenance property of fuel battery cell parts can be improved and the cost for parts can be reduced, the structure is made such that a separator made of a carbon plate or substantially similar material, a gas diffusion layer made of a carbon fiber or substantially similar material, and a gasket made of a liquid rubber cured material or substantially similar material are integrally formed, and further, gaskets are respectively provided on both surfaces of a pair of gas diffusion layers holding an independent electrolyte membrane from both sides thereof between the pair.

    摘要翻译： 为了提供能够减少组装燃料电池的构成部件的多个步骤的燃料电池的构成部件，能够提高燃料电池单元部件的替换性能和维护性能， 可以降低部件成本，其结构使得由碳板或基本相似的材料制成的隔板，由碳纤维或基本上相似的材料制成的气体扩散层和由液体橡胶固化材料制成的垫圈或 大致相同的材料一体形成，并且在一对气体扩散层的两面分别设置有保持独立电解质膜的两面的垫圈。

    Gasket
    8.
    发明申请
    Gasket 有权
    垫片

    公开(公告)号：US20070148525A1

    公开(公告)日：2007-06-28

    申请号：US11708547

    申请日：2007-03-14

    申请人： Yuichi Kuroki ,  Kazuhisa Senda ,  Yoshihiro Kurano ,  Tomohiro Inoue

    发明人： Yuichi Kuroki ,  Kazuhisa Senda ,  Yoshihiro Kurano ,  Tomohiro Inoue

    IPC分类号： H01M2/08 ,  F16J15/02

    CPC分类号： H01M8/0276 ,  F16J15/0818 ,  F16J15/104 ,  F16J15/122 ,  F16J15/123 ,  F16J2015/085 ,  F16J2015/0856 ,  H01M8/0273 ,  H01M8/0284

    摘要： In order to provide a gasket which has a good handling property as a gasket used for a fuel battery or a gasket for an HDD, can be easily integrated with the other end mounting member even in the case that the other end mounting member such as a separator or the like is a material having low strength or a thin plate, and has good mounting workability, a gasket is having a sheet-shaped gasket mounting member provided with a sticking function on one face, and a gasket main body made of a rubber-type elastic member integrated with the sheet-shaped gasket mounting member, and the gasket is mounted to the other end mounting member on the basis of the sticking function of the sheet-shaped gasket mounting member.

    摘要翻译： 为了提供具有良好的处理性能的垫圈，作为用于燃料电池的垫圈或用于HDD的垫圈，即使在另一端安装构件例如 隔板等是具有低强度或薄板的材料，并且具有良好的安装加工性，垫圈具有在一个面上具有粘着功能的片状衬垫安装构件，以及由橡胶制成的衬垫主体 与片状衬垫安装构件一体形成的弹性构件，并且基于片状衬垫安装构件的粘附功能将衬垫安装到另一端安装构件。

    Fuel cell sealing structure comprising stepped gas diffusion layers
    9.
    发明授权
    Fuel cell sealing structure comprising stepped gas diffusion layers 有权
    包括阶梯式气体扩散层的燃料电池密封结构

    公开(公告)号：US08628894B2

    公开(公告)日：2014-01-14

    申请号：US13124032

    申请日：2009-10-06

    申请人： Toshihiro Shimazoe ,  Yoshihiro Kurano ,  Shigeru Watanabe

    发明人： Toshihiro Shimazoe ,  Yoshihiro Kurano ,  Shigeru Watanabe

    IPC分类号： H01M8/02 ,  H01M8/10

    CPC分类号： H01M8/0276 ,  H01M8/0258 ,  H01M8/0284 ,  H01M2008/1095

    摘要： To effectively prevent deformation of an MEA and shift of GDLs, first GDLs, second GDLs, and separators are layered in order at both sides of the MEA in the thickness direction thereof, the gaskets which sandwich an end portion of the MEA outside the first GDLs and the second GDLs are made from rubber or a synthetic resin material having rubber-like elasticity and integrally provided on the separators respectively, the first GDLs have end portions which are formed so as to protrude beyond outer peripheries of the second GDLs, and the gaskets have support step portions which can position and support the end portions of the first GDLs at the same height as the support height by the second GDLs.

    摘要翻译： 为了有效地防止MEA的变形和GDL的移动，在MEA的厚度方向上的第一GDL，第二GDL和分离器的顺序层叠，在第一GDL之外夹着MEA的端部的垫圈 并且第二GDL由橡胶或具有橡胶状弹性的合成树脂材料制成，并且分别一体地设置在隔板上，第一GDL具有形成为突出超过第二GDL的外周的端部，并且垫圈 具有能够通过第二GDL以与支撑高度相同的高度来定位和支撑第一GDL的端部的支撑台阶部分。

    FUEL CELL SEALING STRUCTURE
    10.
    发明申请
    FUEL CELL SEALING STRUCTURE 有权
    燃料电池密封结构

    公开(公告)号：US20120107718A1

    公开(公告)日：2012-05-03

    申请号：US13378642

    申请日：2010-05-27

    申请人： Takeshi Masaka ,  Yoshihiro Kurano ,  Shinichiro Taguchi ,  Kenichi Kikuchi ,  Tetsuya Urakawa

    发明人： Takeshi Masaka ,  Yoshihiro Kurano ,  Shinichiro Taguchi ,  Kenichi Kikuchi ,  Tetsuya Urakawa

    IPC分类号： H01M8/02 ,  H01M8/10

    CPC分类号： H01M8/0273 ,  H01M8/0202 ,  H01M8/0247 ,  H01M8/0267 ,  H01M8/0276 ,  H01M8/0284 ,  H01M8/04029 ,  H01M8/1007 ,  Y02E60/521

    摘要： A fuel cell sealing structure has a power generating body, and first and second separators arranged in both sides in a thickness direction of the power generating body. On a surface in one side in a thickness direction of the first separator, formed integrally first and second sealing protrusions respectively brought into close contact with an outer peripheral portion of the power generating body and the second separator in an outer peripheral side of the first sealing protrusion, and a short circuit prevention rib protruding in line with the first and second sealing protrusions by an electrically insulating rubber-like elastic material. On a surface in another side thereof, formed integrally a third sealing protrusion brought into close contact with a surface in an opposite side to the power generating body in the second separator, by the electrically insulating rubber-like elastic material.

    摘要翻译： 燃料电池密封结构具有发电体，并且在发电体的厚度方向上的两侧配置有第一和第二隔板。 在第一隔板的厚度方向的一侧的表面上，一体地形成有第一密封突起和第二密封突起，分别在第一密封件的外周侧与发电体的外周部和第二隔板紧密接触 突出部以及通过电绝缘橡胶状弹性材料与第一密封突起和第二密封突起一直突出的防短路肋。 在其另一侧的表面上，通过电绝缘橡胶状弹性材料一体地形成与第二隔板中的发电体相反侧的表面紧密接触的第三密封突起。