公开(公告)号：US20070273877A1

公开(公告)日：2007-11-29

申请号：US10594311

申请日：2005-03-29

申请人： Yoshihiro Kawano ,  Keiji Shimizu ,  Minoru Sukekawa ,  Tsuyoshi Mochizuki ,  Susumu Honda ,  Kazuhiro Hayashi

发明人： Yoshihiro Kawano ,  Keiji Shimizu ,  Minoru Sukekawa ,  Tsuyoshi Mochizuki ,  Susumu Honda ,  Kazuhiro Hayashi

IPC分类号： G01J3/30 ,  G02B21/36

CPC分类号： G01N21/6458 ,  G02B21/248

摘要： Even when the magnifying power is reduced, an image can be obtained at high resolution without significantly reducing the numerical aperture, and examination accuracy is improved. There is provided a microscope examination apparatus including a light source for emitting excitation light or illumination light to a specimen placed on a stage; an objective lens opposing the stage and capable of focusing fluorescence or reflected light from the specimen; an image-forming lens for forming an image of the specimen obtained by the objective lens; and an image-capturing unit for capturing the image of the specimen forming by the image-forming lens, wherein a plurality of the objective lenses having different magnifying powers is provided, and an objective-lens switching mechanism for switching among the objective lenses is provided, and wherein a plurality of the image-forming lenses having different magnifying powers is provided, and an image-forming-lens switching mechanism for switching among the image-forming lenses 5a and 5b is provided.

摘要翻译： 即使放大倍数减小，也能够以高分辨率获得图像，而不会显着降低数值孔径，提高了检查精度。 提供了一种显微镜检查装置，其包括用于向放置在台架上的样本发射激发光或照明光的光源; 与舞台相对并且能够聚焦来自样本的荧光或反射光的物镜; 用于形成由所述物镜获得的所述样本的图像的图像形成透镜; 以及图像捕获单元，用于捕获由图像形成透镜形成的样本的图像，其中提供具有不同放大倍率的多个物镜，并且提供用于在物镜之间切换的物镜切换机构 并且其中提供了具有不同放大倍率的多个图像形成透镜，并且提供了用于在成像透镜5a和5b之间切换的图像形成透镜切换机构。

公开(公告)号：US07589839B2

公开(公告)日：2009-09-15

申请号：US10594311

申请日：2005-03-29

申请人： Yoshihiro Kawano ,  Keiji Shimizu ,  Minoru Sukekawa ,  Tsuyoshi Mochizuki ,  Susumu Honda ,  Kazuhiro Hayashi

发明人： Yoshihiro Kawano ,  Keiji Shimizu ,  Minoru Sukekawa ,  Tsuyoshi Mochizuki ,  Susumu Honda ,  Kazuhiro Hayashi

IPC分类号： G01N21/64

CPC分类号： G01N21/6458 ,  G02B21/248

摘要： A microscope examination apparatus is provided that includes a light source for emitting excitation light or illumination light to a specimen placed on a stage; an objective lens opposing the stage and capable of focusing fluorescence or reflected light from the specimen; an image-forming lens for forming an image of the specimen obtained by the objective lens; and an image-capturing unit for capturing the image of the specimen forming by the image-forming lens, wherein a plurality of the objective lenses having different magnifying powers is provided, and an objective-lens switching mechanism for switching among the objective lenses is provided, and wherein a plurality of the image-forming lenses having different magnifying powers is provided, and an image-forming-lens switching mechanism for switching among the image-forming lenses is provided.

摘要翻译： 本发明提供一种显微镜检查装置，其包括：向放置在台架上的试样发射激发光或照明光的光源; 与舞台相对并且能够聚焦来自样本的荧光或反射光的物镜; 用于形成由所述物镜获得的所述样本的图像的图像形成透镜; 以及图像捕获单元，用于捕获由图像形成透镜形成的样本的图像，其中提供具有不同放大倍率的多个物镜，并且提供用于在物镜之间切换的物镜切换机构 并且其中提供了具有不同放大倍率的多个图像形成透镜，并且提供了用于在成像透镜之间切换的图像形成透镜切换机构。

公开(公告)号：US06903869B2

公开(公告)日：2005-06-07

申请号：US10301631

申请日：2002-11-22

申请人： Takashi Fukano ,  Atsushi Miyawaki ,  Keiji Shimizu ,  Yoshihiro Kawano

发明人： Takashi Fukano ,  Atsushi Miyawaki ,  Keiji Shimizu ,  Yoshihiro Kawano

IPC分类号： G01N21/64 ,  G02B21/06 ,  G02B21/16 ,  G02B21/00

CPC分类号： G02B21/16

摘要： An illumination system for microscopy includes a light source, a first spectral element dispersing light from the light source, a reflecting member selectively reflecting light dispersed by the first spectral element, a second spectral element combining light reflected by the reflecting member, a dichroic mirror, an objective lens, and an image sensor. The first spectral element is placed at the front focal point of a first lens, the reflecting member is placed at a position where the back focal point of the first lens coincides with the front focal point of a second lens, and the second spectral element is placed at the back focal point of the second lens.

摘要翻译： 用于显微镜的照明系统包括光源，分散来自光源的光的第一光谱元件，选择性地反射由第一光谱元件分散的光的反射部件，组合由反射部件反射的光的第二光谱元件，二向色镜， 物镜和图像传感器。 第一光谱元件被放置在第一透镜的前焦点处，反射部件被放置在第一透镜的后焦点与第二透镜的前焦点重合的位置，第二光谱元件 放置在第二透镜的后焦点处。

公开(公告)号：US06898004B2

公开(公告)日：2005-05-24

申请号：US10252434

申请日：2002-09-23

申请人： Keiji Shimizu ,  Shuzo Mishima ,  Yoshihiro Kawano

发明人： Keiji Shimizu ,  Shuzo Mishima ,  Yoshihiro Kawano

IPC分类号： G02B21/06 ,  G02B21/00 ,  G02B21/16

CPC分类号： G02B21/16

摘要： In a microscope system, illumination light rays are emitted from a light source. The illumination light rays are collimated and reflected from a mirror to the optical element array. The optical element array is located at a conjugate position of a specimen, and includes a plurality of micro mirrors arranged in a matrix form. The micro mirrors are individually controlled to selectively reflect the illumination light rays for illuminating the specimen. Thus, a predetermined pattern of the light rays is reflected from the optical element array to an objective lens. The illumination light rays are projected on the specimen from the objective lens and the specimen is illuminated by the predetermined illumination pattern.

摘要翻译： 在显微镜系统中，照明光线从光源发射。 照明光线被准直并从反射镜反射到光学元件阵列。 光学元件阵列位于样本的共轭位置，并且包括以矩阵形式布置的多个微反射镜。 微镜被单独控制以选择性地反射用于照射样本的照明光线。 因此，光线的预定图案从光学元件阵列反射到物镜。 照明光线从物镜投影在样本上，并且样本被预定的照明图案照射。

公开(公告)号：US20070177259A1

公开(公告)日：2007-08-02

申请号：US11651558

申请日：2007-01-10

申请人： Susumu Honda ,  Yasuaki Natori ,  Chino Sasaoka ,  Yoshihiro Kawano ,  Hinako Kaji

发明人： Susumu Honda ,  Yasuaki Natori ,  Chino Sasaoka ,  Yoshihiro Kawano ,  Hinako Kaji

IPC分类号： G02B21/26

CPC分类号： G02B21/362

摘要： The present invention provides an examination apparatus which includes a base; a stage on which a specimen is mounted, the stage being movable relative to the base; and a movable image acquisition apparatus for acquiring an image of the specimen, the movable image acquisition apparatus being fixed on the stage.

摘要翻译： 本发明提供一种检查装置，包括：基座; 安装有试样的阶段，该台可相对于底座移动; 以及可动图像获取装置，用于获取样本的图像，所述可动图像获取装置固定在所述台上。

公开(公告)号：US20050237604A1

公开(公告)日：2005-10-27

申请号：US11095518

申请日：2005-04-01

申请人： Yoshihiro Kawano ,  Susumu Honda ,  Kenichi Koyama ,  Atsuhiro Tsuchiya ,  Kazuhiko Osa

发明人： Yoshihiro Kawano ,  Susumu Honda ,  Kenichi Koyama ,  Atsuhiro Tsuchiya ,  Kazuhiko Osa

IPC分类号： A61B19/00 ,  G02B21/00 ,  G02B21/08 ,  G02B21/26

CPC分类号： G02B21/26 ,  A61B90/20 ,  A61B90/50 ,  G02B21/0012 ,  G02B21/082 ,  G02B21/24

摘要： An in-vivo examination apparatus in which the examination angle can be changed while keeping an examination site in focus to carry out accurate in-vivo examination is provided. The in-vivo examination apparatus includes a stage on which a living organism is mounted, a measurement head that irradiates the living organism on the stage with light emitted from a light source and detects light returning from the living organism, and a rotation mechanism that rotates the measurement head about a fixed point on the stage.

摘要翻译： 提供一种体内检查装置，其中可以在保持检查部位聚焦的同时改变检查角度，以进行准确的体内检查。 体内检查装置包括安装有活体的台，测量头，用从光源发出的光照射舞台上的活体，并检测从活体返回的光;旋转机构，其旋转 测量头围绕舞台上的一个固定点。

公开(公告)号：US20070047071A1

公开(公告)日：2007-03-01

申请号：US11505336

申请日：2006-08-17

申请人： Susumu Honda ,  Yoshihiro Kawano

发明人： Susumu Honda ,  Yoshihiro Kawano

IPC分类号： G02B21/00

CPC分类号： G02B21/082 ,  G02B21/002

摘要： A microscope moving unit is provided, the microscope moving unit being capable of preventing an increase in size and a decrease in operation speed of a microscope apparatus by reducing the size of the movable parts, improving the operability of the objective lens by providing a large space around the objective lens, and allowing a specimen to be observed at various positions without affecting the specimen. The microscope moving unit includes an arm that is rotatable around an optical axis of a laser beam guided from a laser light source and that supports a microscope main body on the side closer to a tip of the arm, the microscope main body having an objective lens, and a rotatable deflecting member, which is fixed to the arm, configured to deflect the laser beam and emit the deflected laser beam towards the microscope main body at the side closer to the tip of the arm.

摘要翻译： 提供显微镜移动单元，显微镜移动单元能够通过减小可移动部件的尺寸来防止显微镜装置的尺寸增加和操作速度的降低，通过提供大的空间来提高物镜的可操作性 在物镜周围，并且允许在不影响样本的各个位置观察样本。 显微镜移动单元包括臂，其能够围绕从激光源引导的激光束的光轴旋转，并且在靠近臂的末端的一侧支撑显微镜主体，显微镜主体具有物镜 以及可旋转偏转构件，其被固定到所述臂，所述可旋转偏转构件被配置为使所述激光束偏转并且在靠近所述臂的尖端的一侧朝向所述显微镜主体发射偏转的激光束。

公开(公告)号：US07912267B2

公开(公告)日：2011-03-22

申请号：US12620268

申请日：2009-11-17

申请人： Yoshihiro Kawano ,  Mitsumori Hayashida ,  Keiji Kimura ,  Iwao Kanamori

发明人： Yoshihiro Kawano ,  Mitsumori Hayashida ,  Keiji Kimura ,  Iwao Kanamori

IPC分类号： G06K9/00

CPC分类号： G06K9/2009 ,  G02B21/34 ,  G02B21/36 ,  Y10S128/922

摘要： The present invention is a virtual-slide specimen image acquisition apparatus that captures images by dividing a specimen into a plurality of sections, having a conveying device in which a plurality of specimens can be arranged and that conveys the plurality of the arranged specimens in a first direction by a distance corresponding to the length of a side along the first direction in one of the divided sections and at first time intervals and an image capturing device that has an image capturing portion for capturing images of the specimens magnified at a predetermined magnification and that scans the specimens conveyed to a predetermined position in a second direction, by a predetermined length at second time intervals, such that the image capturing portion captures images of all of the sections that are positioned identically in the first direction and that are positioned differently in the second direction perpendicular to the first direction.

摘要翻译： 本发明是一种虚拟幻灯片样本图像获取装置，其通过将样本分割成多个部分来捕获图像，该多个部分具有其中可以布置多个样本的输送装置，并且将多个排列的样本以第一 在一个分割部分中以第一时间间隔对应于沿着第一方向的一侧的长度的方向的方向和具有用于捕获以预定倍数放大的样本的图像的图像捕获部分的图像捕获装置，以及 以第二时间间隔将传送到第二方向的预定位置的样本扫描预定长度，使得图像捕获部分捕获在第一方向上相同位置并且在第二方向上不同定位的所有部分的图像 第二方向垂直于第一方向。

公开(公告)号：US07564621B2

公开(公告)日：2009-07-21

申请号：US11975385

申请日：2007-10-18

申请人： Yoshihiro Kawano ,  Isao Ishibe ,  Yoshihisa Tanikawa ,  Atsuhiro Tsuchiya

发明人： Yoshihiro Kawano ,  Isao Ishibe ,  Yoshihisa Tanikawa ,  Atsuhiro Tsuchiya

IPC分类号： G02B21/00 ,  G02B7/04 ,  G02B27/40 ,  G02B27/64 ,  G01J3/30

CPC分类号： G02B21/002 ,  G02B21/245

摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.

摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。

公开(公告)号：US20080049215A1

公开(公告)日：2008-02-28

申请号：US11975385

申请日：2007-10-18

申请人： Yoshihiro Kawano ,  Isao Ishibe ,  Yoshihisa Tanikawa ,  Atsuhiro Tsuchiya

发明人： Yoshihiro Kawano ,  Isao Ishibe ,  Yoshihisa Tanikawa ,  Atsuhiro Tsuchiya

IPC分类号： G01N21/00

CPC分类号： G02B21/002 ,  G02B21/245

摘要： A focusing method for an examination apparatus that can quickly and easily perform focusing for fluoroscopy is provided. The focusing method, for an examination apparatus that can observe fluorescence emitted from a specimen, includes a first step of irradiating the specimen with light via an objective lens to generate reflected light and fluorescence; a second step of performing focusing with respect to the surface of the specimen using the reflected light from the specimen; and a third step of performing focusing for the fluorescence based on the focal position of the specimen surface in the second step.

摘要翻译： 提供了一种用于能够快速且容易地执行用于荧光透视的聚焦的检查装置的聚焦方法。 对于可以观察从样本发出的荧光的检查装置的聚焦方法包括：通过物镜用光照射样本以产生反射光和荧光的第一步骤; 使用来自样本的反射光对样本的表面进行聚焦的第二步骤; 以及在第二步骤中基于样品表面的焦点位置进行荧光聚焦的第三步骤。