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    Process for obtaining platelet factor-4
    1.
    发明授权
    Process for obtaining platelet factor-4 失效
    获得血小板因子-4的方法

    公开(公告)号：US5847084A

    公开(公告)日：1998-12-08

    申请号：US749401

    申请日：1996-11-15

    申请人： Yoshikazu Komurasaki ,  Chihiro Shindoh ,  Takashi Hirose ,  Keihide Koh ,  Satoshi Nishimuro

    发明人： Yoshikazu Komurasaki ,  Chihiro Shindoh ,  Takashi Hirose ,  Keihide Koh ,  Satoshi Nishimuro

    IPC分类号： A61K38/00 ,  A61K35/14 ,  A61P43/00 ,  C07K1/22 ,  C07K14/47 ,  C07K14/52 ,  C07K14/745 ,  C08B37/08 ,  C08B37/10

    CPC分类号： C07K14/522

    摘要： The present invention, using a readily available sulfated chitin as an adsorbent, can permit platelet factor-4 to be recovered through specific adsorption from a solution containing the same factor, in by far increased yields as compared with the conventional process utilizing a heparin-immobilized affinity column, and provides the process for isolating, through purification platelet factor-4 which is suited for a commercial-scale, mass production process, wherein there can be offered the advantages of utilization of more readily available sulfated chitin, simplified procedure and improved production yields for the objective substance.

    摘要翻译： 使用容易获得的硫酸化甲壳素作为吸附剂的本发明可以通过特定吸附从含有相同因子的溶液中回收血小板因子-4，与使用固定化肝素的常规方法相比，产率高得多 亲和柱，并提供了通过纯化适合于商业规模的大规模生产方法的血小板因子-4进行分离的方法，其中可以提供利用更容易获得的硫酸化甲壳素，简化程序和改进生产的优点 产量为目标物质。

    Electrode for electrical discharge machining and process for manufacturing the same
    5.
    发明授权
    Electrode for electrical discharge machining and process for manufacturing the same 失效
    电动放电用电极及其制造方法

    公开(公告)号：US5108555A

    公开(公告)日：1992-04-28

    申请号：US649485

    申请日：1991-02-01

    申请人： Satoshi Nishimuro ,  Takeo Hori ,  Kiyoko Ban

    发明人： Satoshi Nishimuro ,  Takeo Hori ,  Kiyoko Ban

    IPC分类号： B23H1/04 ,  B23H1/06 ,  B23H9/06

    CPC分类号： B23H1/06 ,  B23H1/04 ,  B23H9/06

    摘要： Disclosed is an electrode for electrical discharge used for diesinking, comprising an electrode member produced by subjecting a base and binder of gypsum hemihydrate powder and a filler of conductive metal powder to modeling and/or molding and setting into a desired form of electrode, and followed by plating the electrode member with a conductive metal; and a process for manufacturing the same, wherein a gypsum hemihydrate powder, a gypsum dihydrate powder in an amount of 1% by weight of the gypsum hemihydrate powder and a conductive metal powder are kneaded in vacuo, and water is added thereto to continue further kneading in vacuo, followed by casting into a mold having a predetermined shape transferred thereon to carry out hydration, molding and setting to provide an electrode member; after the electrode member is dried, it is plated with a conductive metal to enhance mutual continuity in the conductivity of the former conductive metal powder and also to form a thin metal layer on the surface of the electrode member. Since the present electrode for electrical discharge machining is based on a gypsum, even one having a subtle and complicated shape can easily be produced using an easy-to-make mold made of a silicone rubber and the like with high accuracy at low cost, so that it is particularly suitable for producing dental crown and bridge one by one. Further, the strength of the electrode is enhanced synergistically by the base of gypsum hemihydrate and the conductive metal layer formed on the surface of the electrode member, allowing precise electrical discharge machining of hard materials such as titanium at the desired speed which was impossible by use of the conventional electrode impregnated with a conductive solution containing a graphite and the like dispersed therein instead of the plating treatment.

    摘要翻译： 公开了一种用于去金属化的放电用电极，其特征在于，包括：通过使半石膏石膏和粘结剂与导电性金属粉末的填料进行成型和/或成型而成为所需形式的电极而制成的电极部件， 通过用导电金属镀覆电极部件; 以及其制造方法，其中将石膏半水合物粉末，二水合石膏粉末的量为石膏半水合物粉末的1重量％和导电金属粉末在真空中捏合，并向其中加入水以继续进一步捏合 然后在其上转移到预定形状的模具中进行水合，成型和固化以提供电极部件; 在电极构件干燥之后，用导电金属镀覆以增强前导电金属粉末的导电性的相互连续性，并且还在电极构件的表面上形成薄金属层。 由于本发明的放电电极是以石膏为基础的，所以即使以微细的复杂形状形成微细复杂形状也能以低成本高精度地利用硅橡胶等易于制造的模具来制造。 它特别适合一个接一个地生产牙冠和桥。 此外，通过石膏半水合物的基部和形成在电极构件的表面上的导电金属层，电极的强度协同增强，允许以不希望的速度对所需速度的硬质材料例如钛进行精确的放电加工，这是不可能的 的常规电极浸渍有分散在其中的石墨等的导电溶液而不是电镀处理。