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公开(公告)号：US20060247162A1
公开(公告)日：2006-11-02
申请号：US10553830
申请日：2003-05-07
CPC分类号： A61K35/20 , A23L33/18 , A23L33/19 , A61K8/64 , A61K38/018 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： It is intended to provide a skin collagen production promoter, foods and drinks for promoting skin collagen production and cosmetics for promoting skin collagen production which are useful in preventing skin chapping, wrinkles, worsening in skin fitness, etc. Namely, a skin collagen production promoter, foods and drinks for promoting skin collagen production and cosmetics for promoting skin collagen production which contain as the active ingredient(s) a milk-origin basic protein fraction and/or a basic peptide fraction obtained by digesting the above-described basic protein fraction with a protein digesting enzyme such as pepsin or pancreatin. The above basic protein fraction and basic peptide fraction have an effect of increasing skin collagen level.
摘要翻译： 旨在提供用于促进皮肤胶原蛋白生产的皮肤胶原蛋白生产促进剂，用于促进皮肤胶原蛋白生产的化妆品的食品和饮料，其可用于防止皮肤瘙痒，皱纹，皮肤适应性恶化等。也就是说，皮肤胶原产生促进剂 ，用于促进皮肤胶原蛋白产生的食品和饮料以及用于促进皮肤胶原蛋白生产的化妆品，其含有作为活性成分的乳源性碱性蛋白质级分和/或通过将上述碱性蛋白质级分消化而获得的碱性肽级分， 蛋白质消化酶如胃蛋白酶或胰酶。 上述碱性蛋白质级分和碱性肽级分具有增加皮肤胶原蛋白水平的作用。
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公开(公告)号：US06929806B2
公开(公告)日：2005-08-16
申请号：US10789193
申请日：2004-02-27
CPC分类号： A21D2/268 , A21D2/263 , A23J1/20 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , A61K38/1709 , A23V2250/5424 , A23V2250/5488 , A23V2250/61 , A23V2250/156 , A23V2250/032
摘要： A milk-derived basic protein fraction and a basic peptide fraction are provided for use as an effective component for agents for improving lipid metabolism and reducing high blood pressure which can be administered orally, are effective with a relatively small dosage, have good taste and are stable during storage.
摘要翻译： 提供乳衍生的碱性蛋白质级分和碱性肽级分作为口服改善脂质代谢和降低高血压的药剂的有效成分，其用量相当小，具有良好的味道，并且是有效的 储存时稳定。
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3.发明申请公开(公告)号：US20080206226A1
公开(公告)日：2008-08-28
申请号：US12102552
申请日：2008-04-14
CPC分类号： A61K38/1729 , A23K20/147 , A23K20/189 , A23L33/17 , A61K38/1725
摘要： Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of β2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and β defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.
摘要翻译： 本发明提供一种用于促进成骨和/或抑制骨吸收的新型药剂，其可以直接从日常饮食中口服长时间，没有任何麻烦的味道; 直接对骨骼发生促进作用，对骨吸收骨骼具有抑制作用; 并且可以预期具有预防或改善/治疗各种骨疾病的治疗效果。 作为活性成分，上述试剂包含β2 - 亚微球蛋白，组蛋白，补体成分3，单核细胞趋化蛋白1，溶菌酶，核糖核酸酶，凝血酶原，细胞色素P-450，纤溶酶原中的任何一种或多种 ，转铁蛋白，凝血酶，纤溶酶，补体成分4和β防御素及其酶消化产物。 这些物质通过促进成骨细胞的增殖和分化对破骨细胞的骨吸收和/或对成骨的促进作用具有显着的抑制作用。
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公开(公告)号：US20060286084A1
公开(公告)日：2006-12-21
申请号：US10573776
申请日：2004-09-30
CPC分类号： A61K38/1729 , A23K20/147 , A23K20/189 , A23L33/17 , A61K38/1725
摘要： Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of β2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and β defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the proliferation and differentiation of osteoblasts.
摘要翻译： 本发明提供一种用于促进成骨和/或抑制骨吸收的新型药剂，其可以直接从日常饮食中口服长时间，没有任何麻烦的味道; 直接对骨骼发生促进作用，对骨吸收骨骼具有抑制作用; 并且可以预期具有预防或改善/治疗各种骨疾病的治疗效果。 作为活性成分，上述试剂包含β2 - 亚微球蛋白，组蛋白，补体成分3，单核细胞趋化蛋白1，溶菌酶，核糖核酸酶，凝血酶原，细胞色素P-450，纤溶酶原中的任何一种或多种 ，转铁蛋白，凝血酶，纤溶酶，补体成分4和β防御素及其酶消化产物。 这些物质通过促进成骨细胞的增殖和分化对破骨细胞的骨吸收和/或对成骨的促进作用具有显着的抑制作用。
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公开(公告)号：US08647619B2
公开(公告)日：2014-02-11
申请号：US12573413
申请日：2009-10-05
IPC分类号： A61K38/43
CPC分类号： C12Y111/01007 , A23K20/189 , A23K50/10 , A23K50/40 , A23L33/19 , A23V2002/00 , A61K38/44 , A23V2250/5425 , A23V2200/306
摘要： It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.
摘要翻译： 旨在通过促进成骨细胞和用于促进成骨的食物，饮料，药物或饲料的分化来提供能够促进成骨的骨形成促进剂。 即，通过促进成骨细胞的分化来促进成骨的成骨促进剂，其包含作为活性成分的乳过氧化物酶和/或通过用蛋白酶如胰蛋白酶消化乳过氧化物酶获得的消化产物; 以及用于促进含有过氧化物酶和/或其消化产物的成骨的食物，饮料，药物或饲料。
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公开(公告)号：US20100099848A1
公开(公告)日：2010-04-22
申请号：US12529660
申请日：2008-02-29
申请人： Aiko Ono , Atsushi Serizawa , Yoshikazu Morita , Hiroshi Kawakami
发明人： Aiko Ono , Atsushi Serizawa , Yoshikazu Morita , Hiroshi Kawakami
IPC分类号： C07K14/00
CPC分类号： A61K38/018 , A23K20/147 , A23L33/19 , A23V2002/00 , A23V2200/306 , A23V2200/324 , A23V2250/5424
摘要： The production of RANKL may be inhibited by orally ingesting a milk-derived basic protein. Thus, a RANKL production inhibitor containing a milk-derived basic protein fraction as an active ingredient; a therapeutic agent for a metabolic bone disease and a therapeutic agent for an immune disease each containing the RANKL production inhibitor; and a food/beverage and a feed each containing a specified amount of the RANKL production inhibitor and being characterized by inhibiting the production of RANKL have a remarkable effect of inhibiting the production of RANKL, can be ingested on a daily basis, and exhibit high safety even when being ingested over a long period.
摘要翻译： 通过口服摄取乳源性碱性蛋白质可以抑制RANKL的产生。 因此，含有乳衍生的碱性蛋白质级分作为活性成分的RANKL产生抑制剂; 每种含有RANKL产生抑制剂的代谢骨疾病治疗剂和免疫疾病治疗剂; 并且每种含有特定量的RANKL产生抑制剂的食品/饮料和饲料，其特征在于抑制RANKL的产生具有显着的抑制RANKL产生的作用，可以每天摄取并显示高安全性 即使长时间摄入也是如此。
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公开(公告)号：US20060228345A1
公开(公告)日：2006-10-12
申请号：US10566711
申请日：2004-08-13
CPC分类号： C12Y111/01007 , A23K20/189 , A23L33/19 , A23V2002/00 , A61K38/44 , A23V2250/5425 , A23V2200/306
摘要： It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.
摘要翻译： 旨在通过促进成骨细胞和用于促进成骨的食物，饮料，药物或饲料的分化来提供能够促进成骨的骨形成促进剂。 即，通过促进成骨细胞的分化来促进成骨的成骨促进剂，其包含作为活性成分的乳过氧化物酶和/或通过用蛋白酶如胰蛋白酶消化乳过氧化物酶获得的消化产物; 以及用于促进含有过氧化物酶和/或其消化产物的成骨的食物，饮料，药物或饲料。
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公开(公告)号：US08221967B2
公开(公告)日：2012-07-17
申请号：US12521632
申请日：2007-12-27
申请人： Yoshikazu Morita , Aiko Ono , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yoshikazu Morita , Aiko Ono , Atsushi Serizawa , Hiroshi Kawakami
IPC分类号： C12Q1/00
CPC分类号： G01N33/6848 , G01N30/7233 , G01N2030/8831
摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.
摘要翻译： 测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。 通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列 或感兴趣的肽。
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公开(公告)号：US20110039287A1
公开(公告)日：2011-02-17
申请号：US12521632
申请日：2007-12-27
申请人： Yoshikazu Morita , Aiko Ono , Atsushi Serizawa , Hiroshi Kawakami
发明人： Yoshikazu Morita , Aiko Ono , Atsushi Serizawa , Hiroshi Kawakami
CPC分类号： G01N33/6848 , G01N30/7233 , G01N2030/8831
摘要： A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.
摘要翻译： 测定方法以高精度和简单的方式量化痕量含有的特定蛋白质或肽，而不需要使用任何昂贵的试剂。 通过使用作为内标的蛋白质或肽，可以通过LC / MS / MS来定量蛋白质或肽，所述蛋白质或肽包含具有重排洗涤蛋白质的氨基酸序列中的氨基酸残基的结合顺序的氨基酸序列 或感兴趣的肽。
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公开(公告)号：US09629878B2
公开(公告)日：2017-04-25
申请号：US14418285
申请日：2012-07-31
申请人： Aiko Ohmachi , Hiroaki Matsuyama , Yoshikazu Morita , Yuko Ishida , Takayuki Nara , Ken Kato , Atsushi Serizawa , Hiroshi Ueno , Hiroshi Urazono
发明人： Aiko Ohmachi , Hiroaki Matsuyama , Yoshikazu Morita , Yuko Ishida , Takayuki Nara , Ken Kato , Atsushi Serizawa , Hiroshi Ueno , Hiroshi Urazono
CPC分类号： A61K35/20 , A23C9/1213 , A23C9/1307 , A23C9/1315 , A23C9/1322 , A23C9/1465 , A23L2/38 , A23V2002/00 , A61K38/443 , A61K38/465 , C12Y111/01007 , C12Y301/27 , A23V2200/306
摘要： The invention relates to provide a fermented milk product includes angiogenin and/or angiogenin hydrolysate in an amount of 0.9 mg/100 g to 150 mg/100 g, and lactoperoxidase and/or lactoperoxidase hydrolysate in the mass ratio to the angiogenin and/or angiogenin hydrolysate of 0.3 to 23.
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